Design and characteristics of gellan gum beads for modified release of meloxicam

References

• Kadajji VG, Betageri GV. Water soluble polymers for pharmaceutical applications. Polymers (Basel). 2011;3:1972–2009.
   Web of Science ®Google Scholar
• Kumar S, Gupta SK. Natural polymers, gums and mucilages as excipients in drug delivery. Polim Med. 2012;42:191–197.
   PubMedGoogle Scholar
• Kulkarni V, Butte K, Rathod S. Natural polymers – a comprehensive review. Int J Res Pharm Biomed Sci. 2012;3:1597–1613.
   Google Scholar
• Schmid J, Sieber V, Rehm B. Bacterial exopolysaccharides: biosynthesis pathways and engineering strategies. Front Microbiol. 2015;6:496.
   PubMed Web of Science ®Google Scholar
• Moscovici M. Present and future medical applications of microbial exopolysaccharides. Front Microbiol. 2015;6:1012.
   PubMed Web of Science ®Google Scholar
• Becker A, Katzen F, Pühler A, et al. Xanthan gum biosynthesis and application: a biochemical/genetic perspective. Appl Microbiol Biotechnol. 1998;50:145–152.
   PubMed Web of Science ®Google Scholar
• Osmałek T, Froelich A, Tasarek S. Application of gellan gum in pharmacy and medicine. Int J Pharm. 2014;466:328–340.
   PubMed Web of Science ®Google Scholar
• Kaur V, Bera MB, Panesar PS, et al. Welan gum: microbial production, characterization and applications. Int J Biol Macromol. 2014;65:454–461.
   PubMed Web of Science ®Google Scholar
• Nampoothiri KM, Singhania RR, Sabarinath C, et al. Fermentative production of gellan using Sphingomonas paucimobilis. Process Biochem. 2003;38:1513–1519.
   Web of Science ®Google Scholar
• Bajaj IB, Survase SA, Saudagar PS, et al. Gellan gum: fermentative production, downstream processing and applications. Food Technol Biotechnol. 2007;45:341–354.
   Web of Science ®Google Scholar
• Gonçalves VMF, Reis A, Domingues MRM, et al. Structural analysis of gellans produced by Sphingomonas elodea strains by electrospray tandem mass spectrometry. Carbohydr Polym. 2009;77:10–19.
   Web of Science ®Google Scholar
• Grasdalen H, Smidsrod O. Gelation of gellan gum. Carbohydr Polym. 1987;7:371–393.
   Web of Science ®Google Scholar
• Morris ER, Gothard MGE, Hember MWN, et al. Conformational and rheological transitions of welan, rhamsan and acylated gellan. Carbohydr Polym. 1996;30:165–175.
   Web of Science ®Google Scholar
• Chandrasekaran R, Radha A, Thailambal VG. Roles of potassium ions, acetyl and l-glyceryl groups in native gellan double helix: an X-ray study. Carbohydr Res. 1992;224:1–17.
   PubMed Web of Science ®Google Scholar
• Harding NE, Patel YN, Coleman RJJ. Organization of genes required for gellan polysaccharide biosynthesis in Sphingomonas elodea ATCC 31461. Ind Microbiol Biotechnol. 2004;31:70–82.
   PubMed Web of Science ®Google Scholar
• Gellan Gum Book. 5th ed. [Internet]. Kelcogel; [cited 2016 Aug 18]. Available from: http://www.appliedbioscience.com/docs/Gellan_Book_5th_Edition.pdf
   Google Scholar
• Narkar M, Sher P, Pawar A. Stomach-specific controlled release gellan beads of acid-soluble drug prepared by ionotropic gelation method. AAPS PharmSciTech. 2010;11:267–277.
   PubMed Web of Science ®Google Scholar
• Agnihotri SA, Jawalkar SS, Aminabhavi TM. Controlled release of cephalexin through gellan gum beads: effect of formulation parameters on entrapment efficiency, size, and drug release. Eur J Pharm Biopharm. 2006;63:249–261.
   PubMed Web of Science ®Google Scholar
• Quigley KJ, Deasy PB. Use of deacetylated gellan gum (Gelrite) for the production of sulphamethizole containing beads. J Microencapsul. 1992;9:1–7.
   PubMed Web of Science ®Google Scholar
• Singh BN, Trombetta LD, Kim KH. Biodegradation behavior of gellan gum in simulated colonic media. Pharm Dev Technol. 2004;9:399–407.
   PubMed Web of Science ®Google Scholar
• Sanderson GR, Clark RC. Gellan gum. Food Technol. 1983;37:63–70.
   Web of Science ®Google Scholar
• Kedzierewicz F, Lombry C, Rios R, et al. Effect of the formulation on the in-vitro release of propranolol from gellan beads. Int J Pharm. 1999;178:129–136.
   PubMed Web of Science ®Google Scholar
• Miyazaki S, Kawasaki N, Kubo W, et al. Comparison of in situ gelling formulations for the oral delivery of cimetidine. Int J Pharm. 2001;220:161–168.
   PubMed Web of Science ®Google Scholar
• Miyazaki S, Aoyama H, Kawasaki N, et al. In situ-gelling gellan formulations as vehicles for oral drug delivery. J Control Release. 1999;60:287–295.
   PubMed Web of Science ®Google Scholar
• Vilela JAP, Perrechil FA, Picone CSF, et al. Preparation, characterization and in vitro digestibility of gellan and chitosan-gellan microgels. Carbohydr Polym. 2015;117:54–62.
   PubMed Web of Science ®Google Scholar
• Smith AM, Ingham A, Grover LM, et al. Polymer film formulations for the preparation of enteric pharmaceutical capsules. J Pharm Pharmacol. 2010;62:167–172.
   PubMed Web of Science ®Google Scholar
• Türck D, Roth W, Busch U. A review of the clinical pharmacokinetics of meloxicam. Br J Rheumatol. 1996;35:13–16.
   PubMedGoogle Scholar
• Compound Summary for CID 54677470 [Internet]. PubChem; 2011 [updated 2016 Aug 8; cited 2016 Aug 18]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/meloxicam#section=Top
   Google Scholar
• Euller-Ziegler L, Vélicitat P, Bluhmki E, et al. Meloxicam: a review of its pharmacokinetics, efficacy and tolerability following intramuscular administration. Inflamm Res. 2001;50 Suppl 1:S5–S9.
   PubMed Web of Science ®Google Scholar
• Del Tacca M, Colucci R, Fornai M, et al. Efficacy and tolerability of meloxicam, a COX-2 preferential nonsteroidal anti-inflammatory drug. Clin Drug Investig. 2002;22:799–818.
   Web of Science ®Google Scholar
• Sapra K, Singh SK. Formulation development and optimization of self-emulsifying drug delivery system (SEDDS) of meloxicam. Int J Pharm Pharm Sci. 2013;5:524–530.
   Google Scholar
• Shende PK, Gaud RS, Bakal R, et al. Effect of inclusion complexation of meloxicam with β-cyclodextrin and β-cyclodextrin-based nanosponges on solubility, in vitro release and stability studies. Colloids Surf B Biointerfaces. 2015;136:105–110.
   PubMed Web of Science ®Google Scholar
• Babu PR, Subrahmanyam CV, Thimmasetty J, et al. Solubility of meloxicam in mixed solvent systems. Eth Pharm J. 2007;25:23–28.
   Google Scholar
• Seedher N, Bhatia S. Solubility enhancement of COX-2 inhibitors using various solvent systems. AAPS PharmSciTech. 2003;4:1–9.
   Google Scholar
• Süleyman H, Demircan B, Karagöz Y. Anti-inflammatory and side effects of cyclooxygenase inhibitors. Pharmacol Rep. 2007;59:247–258.
   PubMed Web of Science ®Google Scholar
• Distel M, Mueller C, Bluhmki E, et al. Safety of meloxicam: a global analysis of clinical trials. Br J Rheumatol. 1996;35 Suppl 1:68–77.
   PubMedGoogle Scholar
• Patel MM, Amin AF. Formulation and development of release modulated colon targeted system of meloxicam for potential application in the prophylaxis of colorectal cancer. Drug Deliv. 2011;18:281–293.
   PubMed Web of Science ®Google Scholar
• Goldman AP, Williams CS, Sheng H, et al. Meloxicam inhibits the growth of colorectal cancer cells. Carcinogenesis. 1998;19:2195–2199.
   PubMed Web of Science ®Google Scholar
• Gupta RA, Dubois RN. Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat Rev Cancer. 2001;1:11–21.
   PubMed Web of Science ®Google Scholar
• Srivastava R, Kumar D, Pathak K. Colonic luminal surface retention of meloxicam microsponges delivered by erosion based colon-targeted matrix tablet. Int J Pharm. 2012;427:153–162.
   PubMed Web of Science ®Google Scholar
• Ruiz EN, Álvarez-Álvarez C, García-Rodriguez JJ, et al. New multi-particle systems for colon-targeted meloxicam. Pharm Anal Acta. 2016;7:165.
   Google Scholar
• Sharma S, Pawar A. Low density multiparticulate system for pulsatile release of meloxicam. Int J Pharm. 2006;313:150–158.
   PubMed Web of Science ®Google Scholar
• Hussein AA, Ghareeb M, Abdulhussain RA. Preparation and characterization of meloxicam colon targeted coated tablets. Int J Pharm Pharm Sci. 2013;5:338–342.
   Google Scholar
• Kumar S, Parthiban S, Kumar SKS. Formulation and evaluation of meloxicam loaded microspheres for colon targeted drug delivery. Int J Biopharm. 2013;4:80–89.
   Google Scholar
• Eroglu H, Burul-Bozkurt N, Uma S, et al. Preparation and in vitro/in vivo evaluation of microparticle formulations containing meloxicam. AAPS PharmSciTech. 2012;13:46–52.
   PubMed Web of Science ®Google Scholar
• Gao C, Huang J, Jiao Y, et al. In vitro release and in vivo absorption in beagle dogs of meloxicam from Eudragit® FS 30 d-coated pellets. Int J Pharm. 2006;322:104–112.
   PubMed Web of Science ®Google Scholar
• Mahdi MH, Conway BR, Mills T, et al. Gellan gum fluid gels for topical administration of diclofenac. Int J Pharm. 2016;515:535–542.
   PubMed Web of Science ®Google Scholar
• Nayak AK, Pal D, Santra K. Swelling and drug release behavior of metformin HCl-loaded tamarind seed polysaccharide-alginate beads. Int J Biol Macromol. 2016;82:1023–1027.
   Google Scholar
• Taranalli SS, Dandagi PM, Mastiholimath VS. Development of hollow/porous floating beads of metoprolol for pulsatile drug delivery. Eur J Drug Metab Pharmacokinet. 2015;40:225–233.
   PubMed Web of Science ®Google Scholar
• Sruti J, Patra CN, Swain S, et al. Cefuroxime axetil dissolution improvement by preparation of solid dispersions with porous carrier. Adv Pharm Res. 2012;3:42–48.
   Google Scholar
• Kassaye L, Genete G. Evaluation and comparison of in-vitro dissolution profiles for different brands of amoxicillin capsules. Afr Health Sci. 2013;13:369–375.
   PubMed Web of Science ®Google Scholar
• Liu J, Zhang L, Hu W, et al. Preparation of konjac glucomannan-based pulsatile capsule for colonic drug delivery system and its evaluation in vitro and in vivo. Carbohydr Polym. 2012;87:377–382.
   PubMed Web of Science ®Google Scholar
• Wong TW, Colombo G, Sonvico F. Pectin matrix as oral drug delivery vehicle for colon cancer treatment. AAPS PharmSciTech. 2011;12:201–214.
   PubMed Web of Science ®Google Scholar
• Tuynman JB, Vermeulen L, Boon EM, et al. Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer. Cancer Res. 2008;68:1213–1220.
   PubMed Web of Science ®Google Scholar
• Woraphatphadung T, Sajomsang W, Gonil P, et al. Synthesis and characterization of pH-responsive N-naphthyl-N,O-succinyl chitosan micelles for oral meloxicam delivery. Carbohydr Polym. 2015;121:99–106.
   PubMed Web of Science ®Google Scholar
• Babu RJ, Sathigari S, Kumar MT, et al. Formulation of controlled release gellan gum macro beads of amoxicillin. Curr Drug Deliv. 2010;7:36–43.
   PubMedGoogle Scholar
• Rajinikanth P, Mishra B. Preparation and in vitro characterization of gellan based floating beads of acetohydroxamic acid for eradication of H. pylori. Acta Pharm. 2007;57:413–427.
   PubMedGoogle Scholar
• Bhattacharya SS, Banerjee S, Chowdhury P, et al. Tranexamic acid loaded gellan gum-based polymeric microbeads for controlled release: in vitro and in vivo assessment. Colloids Surf B Biointerfaces. 2013;112:483–491.
   PubMed Web of Science ®Google Scholar
• Patil P, Chavanke D, Wagh M. A review on ionotropic gelation method: novel approach for controlled gastroretentive gelispheres. Int J Pharm Pharm Sci. 2012;4:27–32.
   Google Scholar
• Pawar HA, Lalitha KG, Ruckmani K. Alginate beads of captopril using galactomannan containing Senna tora gum, guar gum and locust bean gum. Int J Biol Macromol. 2015;76:119–131.
   PubMed Web of Science ®Google Scholar
• Tang J, Tung MA, Zeng YJ. Gelling temperature of gellan solutions containing calcium ions. J Food Sci. 1997;62:276–280.
   Web of Science ®Google Scholar
• Coppi L; Sanmarti M, inventor; Clavo M, inventor. Crystalline forms of meloxicam and processes for their preparation and interconversion. United States Patent US 20,030,109,701 A1. 2003 Jun 12.
   Google Scholar
• Luger P, Daneck K, Engel W, et al. Structure and physiochemical properties of meloxicam, a new NSAID. Eur J Pharm Sci. 1996;4:175–187.
   Web of Science ®Google Scholar
• Cheney ML, Weyna DR, Shan N, et al. Supramolecular architectures of meloxicam carboxylic acid cocrystals, a crystal engineering case study. Cryst Growth Des. 2010;10:4401–4413.
   Google Scholar
• Nassab PR, Rajkó R, Szabó-Révész PJ. Physicochemical characterization of meloxicam-mannitol binary systems. Pharm Biomed Anal. 2006;41:1191–1197.
   PubMed Web of Science ®Google Scholar
• Sharma S, Sher P, Badve S, et al. Adsorption of meloxicam on porous calcium silicate: characterization and tablet formulation. AAPS PharmSciTech. 2005;6:E618–E625.
   PubMed Web of Science ®Google Scholar
• Baboota S, Agarwal SP. Preparation and characterization of meloxicam hydroxy propyl β-cyclodextrin inclusion complex. J Incl Phenom Macrocycl Chem. 2005;51:219–224.
   Web of Science ®Google Scholar
• Pomázi A, Ambrus R, Sipos P, et al. Analysis of co-spray-dried meloxicam-mannitol systems containing crystalline microcomposites. J Pharm Biomed Anal. 2011;56:83–190.
   Web of Science ®Google Scholar
• Prezotti FG, Cury BSF, Evangelista RC. Mucoadhesive beads of gellan gum/pectin intended to controlled delivery of drugs. Carbohydr Polym. 2014;113:286–295.
   PubMed Web of Science ®Google Scholar
• Montgomery DC. Design and analysis of experiments. 8th ed. Hoboken (NJ): John Wiley & Sons, Inc.; 2012.
   Google Scholar
• Lewis GA, Mathieu D, Phan-Tan-Luu R. Pharmaceutical experimental design. 1st ed. New York (NY): Marcel Dekker, Inc.; 1998.
   Google Scholar