Microemulsion loaded hydrogel as a promising vehicle for dermal delivery of the antifungal sertaconazole: design, optimization and ex vivo evaluation

References

• Piérard GE, Arrese JE, Piérard-Franchimont C. Treatment and prophylaxis of tinea infections. Drugs. 1996;52:209–224.
   PubMed Web of Science ®Google Scholar
• Kumar N, Goindi S. Statistically designed nonionic surfactant vesicles for dermal delivery of itraconazole: characterization and in vivo evaluation using a standardized Tinea pedis infection model. Int J Pharm. 2014;472:224–240.
   PubMed Web of Science ®Google Scholar
• Detandt M, Nolard N. Fungal contamination of the floors of swimming pools, particularly subtropical swimming paradises. Mycoses. 1995;38:509–513.
   PubMed Web of Science ®Google Scholar
• Aggarwal N, Goindi S. Preparation and evaluation of antifungal efficacy of griseofulvin loaded deformable membrane vesicles in optimized guinea pig model of Microsporum canis-dermatophytosis. Int J Pharm. 2012;437:277–287.
   PubMed Web of Science ®Google Scholar
• da Silva Barros ME, de Assis Santos D, Hamdan JS. Evaluation of susceptibility of Trichophyton mentagrophytes and Trichophyton rubrum clinical isolates to antifungal drugs using a modified CLSI microdilution method (M38-A). J Med Microbiol. 2007;56:514–518.
   PubMed Web of Science ®Google Scholar
• Torres J, Marquez M, Camps F. Sertaconazole in the treatment of mycoses: from dermatology to gynecology. Int J Gynecol Obstet. 2000;71:3–20.
   PubMed Web of Science ®Google Scholar
• Carrillo-Muñoz AJ, Giusiano G, Ezkurra PA, et al. Sertaconazole: updated review of a topical antifungal agent. Expert Rev Anti Infect Ther. 2005;3:333–342.
   PubMedGoogle Scholar
• Pfaller MA, Sutton DA. Review of in vitro activity of sertaconazole nitrate in the treatment of superficial fungal infections. Diagn Microbiol Infect Dis. 2006;56:147–152.
   PubMed Web of Science ®Google Scholar
• Lopez-Montero E, Rosa dos Santos J, Torres-Labandeira JJ, et al. Sertaconazole-loaded cyclodextrin–polysaccharide hydrogels as antifungal devices. TODDJ. 2009;3:1–9.
   Google Scholar
• M Soliman G, A Attia MA, Mohamed R. Poly (ethylene glycol)-block-poly (ɛ-caprolactone) nanomicelles for the solubilization and enhancement of antifungal activity of sertaconazole. Curr Drug Deliv. 2014;11:753–762.
   PubMed Web of Science ®Google Scholar
• Balata G, Mahdi M, Bakera RA. Improvement of solubility and dissolution properties of ketoconazole by solid dispersions and inclusion complexes. Asian J Pharm Sci. 2010;5:1–12.
   Google Scholar
• Singh PK, Iqubal MK, Shukla VK, et al. Microemulsions: current trends in novel drug delivery systems. J Pharm Chem Biol Sci. 2014;1:39–51.
   Google Scholar
• Hashem FM, Shaker DS, Ghorab MK, et al. Formulation, characterization, and clinical evaluation of microemulsion containing clotrimazole for topical delivery. AAPS PharmSciTech. 2011;12:879–886.
   PubMed Web of Science ®Google Scholar
• Sahoo S, Pani NR, Sahoo SK. Microemulsion based topical hydrogel of sertaconazole: formulation, characterization and evaluation. Colloids Surf B Biointerfaces. 2014;120:193–199.
   PubMed Web of Science ®Google Scholar
• Sahoo S, Pani NR, Sahoo SK. Effect of microemulsion in topical sertaconazole hydrogel: in vitro and in vivo study. Drug Deliv. 2016;23:338–345.
   PubMed Web of Science ®Google Scholar
• Tayel SA, El-Nabarawi MA, Tadros MI, et al. Promising ion-sensitive in situ ocular nanoemulsion gels of terbinafine hydrochloride: design, in vitro characterization and in vivo estimation of the ocular irritation and drug pharmacokinetics in the aqueous humor of rabbits. Int J Pharm. 2013;443:293–305.
   PubMed Web of Science ®Google Scholar
• Ammar HO, Salama H, Ghorab M, et al. Nanoemulsion as a potential ophthalmic delivery system for dorzolamide hydrochloride. AAPS PharmSciTech. 2009;10:808–819.
   PubMed Web of Science ®Google Scholar
• Shafiq S, Shakeel F, Talegaonkar S, et al. Development and bioavailability assessment of ramipril nanoemulsion formulation. Eur J Pharm Biopharm. 2007;66:227–243.
   PubMed Web of Science ®Google Scholar
• Das MK, Bhattacharya A, Ghosal SK. Effect of different terpene-containing essential oils on percutaneous absorption of trazodone hydrochloride through mouse epidermis. Drug Deliv. 2006;13:425–431.
   PubMed Web of Science ®Google Scholar
• Maghraby GME, Williams AC, Barry BW. Skin delivery of oestradiol from deformable and traditional liposomes: mechanistic studies. J Pharm Pharmacol. 1999;51:1123–1134.
   PubMed Web of Science ®Google Scholar
• Alomrani AH, Shazly GA, Amara AA, et al. Itraconazole-hydroxypropyl-β-cyclodextrin loaded deformable liposomes: in vitro skin penetration studies and antifungal efficacy using Candida albicans as model. Colloids Surf B Biointerfaces. 2014;121:74–81.
   PubMed Web of Science ®Google Scholar
• Gupta RR, Jain SK, Varshney M. AOT water-in-oil microemulsions as a penetration enhancer in transdermal drug delivery of 5-fluorouracil. Colloids Surf B Biointerfaces. 2005;41:25–32.
   PubMed Web of Science ®Google Scholar
• ElMeshad AN, Tadros MI. Transdermal delivery of an anti-cancer drug via w/o emulsions based on alkyl polyglycosides and lecithin: design, characterization, and in vivo evaluation of the possible irritation potential in rats. AAPS PharmSciTech. 2011;12:1–9.
   PubMed Web of Science ®Google Scholar
• Al-mahallawi AM, Khowessah OM, Shoukri RA. Nano-transfersomal ciprofloxacin loaded vesicles for non-invasive trans-tympanic ototopical delivery: in-vitro optimization, ex-vivo permeation studies, and in-vivo assessment. Int J Pharm. 2014;472:304–314.
   PubMed Web of Science ®Google Scholar
• El-Hadidy GN, Ibrahim HK, Mohamed MI, et al. Microemulsions as vehicles for topical administration of voriconazole: formulation and in vitro evaluation. Drug Dev Ind Pharm. 2012;38:64–72.
   PubMed Web of Science ®Google Scholar
• Gad HA, El-Nabarawi MA, El-Hady SSA. Formulation and evaluation of PLA and PLGA in situ implants containing secnidazole and/or doxycycline for treatment of periodontitis. AAPS PharmSciTech. 2008;9:878–884.
   PubMed Web of Science ®Google Scholar
• Morsi NM, Abdelbary GA, Ahmed MA. Silver sulfadiazine based cubosome hydrogels for topical treatment of burns: development and in vitro/in vivo characterization. Eur J Pharm Biopharm. 2014;86:178–189.
   PubMed Web of Science ®Google Scholar
• ElMeshad AN, Mohsen AM. Enhanced corneal permeation and antimycotic activity of itraconazole against Candida albicans via a novel nanosystem vesicle. Drug Deliv. 2014; 23: 2115–2123.
   PubMed Web of Science ®Google Scholar
• Jibry N, Murdan S. In vivo investigation, in mice and in man, into the irritation potential of novel amphiphilogels being studied as transdermal drug carriers. Eur J Pharm Biopharm. 2004;58:107–119.
   PubMed Web of Science ®Google Scholar
• Draize JH, Woodard G, Calvery HO. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J Pharmacol Exp Ther. 1944;82:377–390.
   Web of Science ®Google Scholar
• Banchroft JD, Stevens A, Turner DR. Theory and practice of histological techniques. 4th ed. New York: Churchil Livingstone; 1996.
   Google Scholar
• Kumar N. D-optimal experimental approach for designing topical microemulsion of itraconazole: characterization and evaluation of antifungal efficacy against a standardized Tinea pedis infection model in Wistar rats. Eur J Pharm Sci. 2015;67:97–112.
   PubMed Web of Science ®Google Scholar
• Kommuru T, Gurley B, Khan M, et al. Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment. Int J Pharm. 2001;212:233–246.
   PubMed Web of Science ®Google Scholar
• Chudasama A, Patel V, Nivsarkar M, et al. Investigation of microemulsion system for transdermal delivery of itraconazole. J Adv Pharm Tech Res. 2011;2:30.
   PubMedGoogle Scholar
• Tenjarla S. Microemulsions: an overview and pharmaceutical applications. Crit Rev Ther Drug Carrier Syst. 1999;16:461–521.
   PubMed Web of Science ®Google Scholar
• Chen H, Chang X, Weng T, et al. A study of microemulsion systems for transdermal delivery of triptolide. J Control Release. 2004;98:427–436.
   PubMed Web of Science ®Google Scholar
• Yuan Y, Li S-M, Mo F-k, et al. Investigation of microemulsion system for transdermal delivery of meloxicam. Int J Pharm. 2006;321:117–123.
   PubMed Web of Science ®Google Scholar
• Buyukozturk F, Benneyan JC, Carrier RL. Impact of emulsion-based drug delivery systems on intestinal permeability and drug release kinetics. J Control Release. 2010;142:22–30.
   PubMed Web of Science ®Google Scholar
• James-Smith MA, Alford K, Shah DO. A novel method to quantify the amount of surfactant at the oil/water interface and to determine total interfacial area of emulsions. J Colloid Interface Sci. 2007;310:590–598.
   PubMed Web of Science ®Google Scholar
• Gao Z-G. Thermal reversible microemulsion for oral delivery of poorly water-soluble drugs. Croatia: INTECH Open Access Publisher; 2012.
   Google Scholar
• Soliman KA, Ibrahim HK, Ghorab MM. Formulation of avanafil in a solid self-nanoemulsifying drug delivery system for enhanced oral delivery. Eur J Pharm Sci. 2016;93:447–455.
   PubMed Web of Science ®Google Scholar
• Elsayed I, Abdelbary AA, Elshafeey AH. Nanosizing of a poorly soluble drug: technique optimization, factorial analysis, and pharmacokinetic study in healthy human volunteers. Int J Nanomed. 2014;9:2943.
   PubMed Web of Science ®Google Scholar
• El-Laithy HM, Basalious EB, El-Hoseiny BM, et al. Novel self-nanoemulsifying self-nanosuspension (SNESNS) for enhancing oral bioavailability of diacerein: simultaneous portal blood absorption and lymphatic delivery. Int J Pharm. 2015;490:146–154.
   PubMed Web of Science ®Google Scholar
• Jiang J, Oberdörster G, Biswas P. Characterization of size, surface charge, and agglomeration state of nanoparticle dispersions for toxicological studies. J Nanopart Res. 2009;11:77–89.
   Web of Science ®Google Scholar
• Hoeller S, Sperger A, Valenta C. Lecithin based nanoemulsions: a comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation. Int J Pharm. 2009;370:181–186.
   PubMed Web of Science ®Google Scholar
• Nekkanti V, Karatgi P, Prabhu R, et al. Solid self-microemulsifying formulation for candesartan cilexetil. Aaps Pharmscitech. 2010;11:9–17.
   PubMed Web of Science ®Google Scholar
• Shah R, Magdum CS, Patil SS, et al. Preparation and evaluation of aceclofenac topical microemulsion. Iran J Pharm Res. 2010;9:5–11.
   PubMed Web of Science ®Google Scholar
• Chen H, Mou D, Du D, et al. Hydrogel-thickened microemulsion for topical administration of drug molecule at an extremely low concentration. Int J Pharm. 2007;341:78–84.
   PubMed Web of Science ®Google Scholar
• Laba D. Rheological properties of cosmetics and toiletries. Boca Raton (FL): CRC Press; 1993.
   Google Scholar
• Ellaithy H, El-Shaboury K. The development of Cutina lipogels and gel microemulsion for topical administration of fluconazole. AAPS PharmSciTech. 2002;3:77–85.
   Google Scholar
• El-Leithy ES, Ibrahim HK, Sorour RM. In vitro and in vivo evaluation of indomethacin nanoemulsion as a transdermal delivery system. Drug Deliv. 2015;22:1010–1017.
   PubMed Web of Science ®Google Scholar
• Peltola S, Saarinen-Savolainen P, Kiesvaara J, et al. Microemulsions for topical delivery of estradiol. Int J Pharm. 2003;254:99–107.
   PubMed Web of Science ®Google Scholar
• Kansagra H, Mallick S. Microemulsion-based antifungal gel of luliconazole for dermatophyte infections: formulation, characterization and efficacy studies. J Pharm Invest. 2016;46:21–28.
   Google Scholar
• Prasanthi D, Lakshmi P. Effect of chemical enhancers in transdermal permeation of alfuzosin hydrochloride. ISRN Pharm. 2012;2012:965280.
   PubMedGoogle Scholar