Synthesis and characterization of poly(N-vinylcaprolactam)-based spray-dried microparticles exhibiting temperature and pH-sensitive properties for controlled release of ketoprofen

References

• Vilos C, Velasquez LA. Therapeutic strategies based on polymeric microparticles. J Biomed Biotechnol. 2012;2012:1–9.
   PubMedGoogle Scholar
• Rejinold NS, Chennazhi KP, Nair SV, et al. Biodegradable and thermo-sensitive chitosan-g-poly(N-vinylcaprolactam) nanoparticles as a 5-fluorouacil carrier. Carbohydrate Polym. 2011;83:776–786.
   Web of Science ®Google Scholar
• Devi N, Karati DK. Smart porous microparticles based on gelatin/sodium alginate polyelectrolyte complex. J Food Eng. 2013;117:193–204.
   Web of Science ®Google Scholar
• Takami K, Murakami Y. Development of PEG-PLA/PLGA microparticles for pulmonary drug delivery prepared by a novel emulsification technique assisted with amphiphilic block copolymers. Colloid Surf B Biointerf. 2011;87:433–438.
   PubMed Web of Science ®Google Scholar
• Shah M, Naseer MI, Choi MH, et al. Amphiphilic PHA-mPEG copolymeric nanocontainers for drug delivery: preparation, characterization and in vitro evaluation. Pharm Technol. 2010;400:165–175.
   Google Scholar
• Jeong B, Gutowska A. Lessons from nature: Stimuli-responsive polymers and their biomedical applications. Biotechnology. 2002;20:305–311.
   Google Scholar
• Kopecek J. Smart and genetically engineered biomaterials and drug delivery systems. Eur J Pharm Sci. 2003;20:1–16.
   PubMed Web of Science ®Google Scholar
• Malmstadt N, Hoffman AS, Stayton PS. “Smart” mobile affinity matrix for microfluidic immunoassays. Lab Chip. 2004;4:412–415.
   PubMed Web of Science ®Google Scholar
• Hoffmann R. How chemistry and physics meet in solid state. Angew Chem Int Ed Engl. 1987;26:846–878.
   Web of Science ®Google Scholar
• Shah S, Pal A, Gude R, et al. Synthesis and characterization of thermo-responsive copolymeric nanoparticles of poly(methyl methacrylate-co-N-vinylcaprolactam). Eur Polym J. 2010;46:958–967.
   Web of Science ®Google Scholar
• Kost J, Langer R. Responsive polymeric delivery systems. Adv Drug Deliv Rev. 2001;46:125–148.
   PubMed Web of Science ®Google Scholar
• Coughlan DC, Quilty FP, Corrigan OIJ. Effect of drug physicochemical properties on swelling/deswelling kinetics and pulsatile drug release from thermoresponsive poly (N-isopropylacrylamide) hydrogel. J Control Release. 2004;98:97–114.
   PubMed Web of Science ®Google Scholar
• Piskin E. Molecularly designed water soluble, intelligent, nanosize polymeric carriers. Int J Pharm. 2004;277:105–118.
   PubMed Web of Science ®Google Scholar
• Coughan DC, Corrigan OI. Drug-polymer interaction and their effect on thermoresponsive poly(N-isopropylacrylamide) drug delivery systems. Int J Pharm. 2006;312:163–174.
   Web of Science ®Google Scholar
• Schmaljohann D, Oswald J, Jorgensen B, et al. Werner C, Thermo-responsive pnipaam-g-peg films for controlled cell detachment. Biomacromolecules. 2003;4:1733–1739.
   PubMed Web of Science ®Google Scholar
• Dimitrov I, Trzebicza B, Müller AHE, et al. Thermosensitive water-soluble copolymers with doubly responsive interacting entities. Prog Polym Sci. 2007;32:1275–1343.
   Web of Science ®Google Scholar
• Shtanko NI, Lequieu W, Goethals EJ, et al. pH-and thermo-responsive properties of poly(N-vinylcaprolactam-co-acrylic acid) copolymers. Polym Int. 2003;52:1605–1610.
   Web of Science ®Google Scholar
• Vihola H, Laukkanen A, Hivornen J, et al. Binding and release of drugs into and from thersensitive poly(N-vinylcaprolactam) nanoparticles. Eur J Pharm Sci. 2002;16:69–74.
   PubMed Web of Science ®Google Scholar
• Imaz A, Forcada J. N-vinylcaprolactam-based microgels for biomedical applications. J Polym Sci A Polym Chem. 2011;48:1173–1181.
   Web of Science ®Google Scholar
• Medeiros SF, Barboza JCS, Giudici R, et al. Solution polymerization of N-vinylcaprolactam in 1,4-dioxane. Kinetic dependence on temperature, monomer and initiator concentrations. J Appl Polym Sci. 2010;118:229–240.
   Web of Science ®Google Scholar
• Medeiros SF, Santos AM, Fessi H, et al. Synthesis of biocompatible and thermally-sensitive poly(N-vinylcaprolactam) nanogels via inverse miniemulsion polymerization: effect of the surfactant concentration. J Polym Sci A Polym Chem. 2010;48:3932–3941.
   Web of Science ®Google Scholar
• Mundargi RC, Rangaswamy V, Aminabhavi TM. Poly(N-vinylcaprolactam-co-methacrylic acid) hydrogel microparticles for oral insulin delivery. J Microencapsul. 2011;28:384–394.
   PubMed Web of Science ®Google Scholar
• Kozanoglu S, Özdemor T, Usanmaz A. Polymerization of N-vinylcaprolactam and characterization of poly(N-vinylcaprolactam). J Macromol Sci Part A Pure Appl Chem. 2011;48:467–477.
   Web of Science ®Google Scholar
• Fernández-Barbero A, Suérez IJ, Sierra-Matín B, et al. Gels and microgels for nanotechnology applications. Adv Colloid Interf Sci. 2009;147-48:88–108.
   Web of Science ®Google Scholar
• Liu F, Urban MW. Recent advances and challenges in designing stimuli-responsive polymers. Prog Polym Sci. 2010;35:3–23.
   Web of Science ®Google Scholar
• Tsinman K, Avdeef A, Tsinman O, et al. Powder dissolution method for estimating rotating disk intrinsic dissolution rates of low solubility drugs. Pharm Res. 2009;26:2093–2100.
   PubMed Web of Science ®Google Scholar
• Rençber S, Karavana SY, Özyazici M. Bioavailability file: ketoprofen fabad. J Pharm Sci. 2009;34:203–216.
   Google Scholar
• Matsui H, Shimokawa O, Kaneko T, et al. The pathophysiology of non-steroidal anti-inflammatory drug (NSAID)-induced mucosal injuries in stomach and small intestine. J Clin Biochem Nutr. 2011;48:107–111.
   PubMed Web of Science ®Google Scholar
• Vueba ML, Batista de Carvalho LA, Veiga F, et al. Influence of cellulose ether polymers on ketoprofen release from hydrophilic matrix tablets. Eur J Pharm Biopharm. 2004;58:51–59.
   PubMed Web of Science ®Google Scholar
• Ré MI, Biscans B. preparations of microspheres of ketoprofen with acrylic polymers by a quasi-emulsion solvent diffusion method. Powder Technol. 1999;101:120–133.
   Web of Science ®Google Scholar
• Boppana R, Kulkarni RV, Mohan GK, et al. In vitro and in vivo assessment of novel pH-sensitive interpenetrating polymer networks of a graft copolymer for gastro-protective delivery of ketoprofen. RSC Adv. 2016;6:64344–64356.
   Web of Science ®Google Scholar
• Vihola H, Laukkanen A, Tenhu H, et al. Drug release characteristics of physically cross-linked thermosensitive poly(N-vinylcaprolactam) hydrogel particles. J Pharm Sci. 2008;97:4783–4793.
   PubMed Web of Science ®Google Scholar
• Korzenieweski C, Callewart DM. An enzyme-release assay for natural cytotoxicity. J Immunol Methods. 1963;64:313–320.
   Web of Science ®Google Scholar
• Green LC, Wagner DA, Glogowski J, et al. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem. 1982;126:131–138.
   PubMed Web of Science ®Google Scholar
• Mendyk A, Jachowicz R, Fijorek K, et al. Kinet DS: an open source software for dissolution test data analysis. Dissolution Technol. 2012;19:6–11.
   Web of Science ®Google Scholar
• Singhvi G, Singh M. Review: in vitro drug release characterization models. Int J Pharm Stud Res. 2011;2:77–84.
   Google Scholar
• Salgado-Rodríguez R, Claveríe AL, Arndt KF. Random copolymers of N-isorpopylacrylamide and methacrylic acid monomers with hydrophobic spacers: pH-tunable temperature sensitive materials. Eur Polym J. 2004;40:1931–1946.
   Web of Science ®Google Scholar
• Gross M, Salame T-M, Jung S. Guardians of the gut - murine intestinal macrophages and dendritic cells. Front Immunol. 2015;6:254.
   PubMed Web of Science ®Google Scholar
• Moyes SM, Morris JF, Carr KE. Macrophages increase microparticle uptake by enterocyte-like Caco-2 cell monolayers. J Anat. 2010;217:740–754.
   PubMed Web of Science ®Google Scholar
• Bogdan C. Nitric oxide and the immune response. Nat Immunol. 2001;2:907–916.
   PubMed Web of Science ®Google Scholar
• Cirino G, Wheeler-Jones CP, Wallace JL, et al. Inhibition of inducible nitric oxide synthase expression by novel nonsteroidal anti-inflammatory derivates with gastrointestinal-sparing properties. Br J Pharmacol. 1996;117:1421–1426.
   PubMed Web of Science ®Google Scholar
• Sheng JJ, Kasim NA, Chandrasekharan R, et al. Solubilization and dissolution of insoluble weak acid, ketoprofen: effects of pH combined with surfactant. Eur J Pharm Sci. 2006;29:306–314.
   PubMed Web of Science ®Google Scholar
• Peppas M. Analysis of Fickian and non-Fickian drug release from polymers. Pharm Acta Helv. 1965;60:110–111.
   Google Scholar
• Blasi P, Schoubben A, Giovagnoli S, et al. Ketoprofen poly(lactide-co-glycolide) physical interaction. AAPS Pharm Sci Tech. 2007;8:Article 37.
   Web of Science ®Google Scholar