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Research Article

Facile development, characterization, and optimization of new metformin-loaded nanocarrier system for efficient colon cancer adjunct therapy

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Pages 1158-1170 | Received 16 Nov 2017, Accepted 01 Feb 2018, Published online: 19 Feb 2018

References

  • Benedict M, Neto AG, Zhang X. Interval colorectal carcinoma: an unsolved debate. World J Gastroenterol. 2015;21:12735.
  • Kobayashi H, Watanabe R, Choyke PL. Improving conventional enhanced permeability and retention (EPR) effects; what is the appropriate target? Theranostics 2013;4:81–89.
  • Alexis F, Pridgen E, Molnar LK, et al. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharm. 2008;5:505–515.
  • Raja MA, Zeenat S, Arif M, et al. Self-assembled nanoparticles based on amphiphilic chitosan derivative and arginine for oral curcumin delivery. Int J Nanomedicine. 2016;11:4397–4412.
  • Manaspon C, Viravaidya-Pasuwat K, Pimpha N. Preparation of folate-conjugated pluronic F127/chitosan core-shell nanoparticles encapsulating doxorubicin for breast cancer treatment. J Nanomater. 2012;2012:1–11.
  • Sun H, Meng Q, Tang S, et al. Inhibition of breast cancer metastasis by pluronic copolymers with moderate hydrophilic-lipophilic balance. Mol Pharm. 2015;12:3323–3331.
  • Kapse-Mistry S, Govender T, Srivastava R, Yergeri M. Nanodrug delivery in reversing multidrug resistance in cancer cells. Front Pharmacol. 2014;5:159.
  • Kourelis TV, Siegel RD. Metformin and cancer: new applications for an old drug. Med Oncol. 2012;29:1314–1327.
  • dos Santos Guimarães I, Ladislau-Magescky T, Tessarollo NG, et al. Chemosensitizing effects of metformin on cisplatin-and paclitaxel-resistant ovarian cancer cell lines. Pharmacol Rep. 2017 [Nov 21]. doi:10.1016/j.pharep.2017.11.007
  • Nangia-Makker P, Yu Y, Vasudevan A, et al. Metformin: a potential therapeutic agent for recurrent colon cancer. PLoS One. 2014;9:e84369.
  • Butler JM, Dressman JB. The developability classification system: application of biopharmaceutics concepts to formulation development. J Pharm Sci. 2010;99:4940–4954.
  • Khajuria DK, Patil ON, Karasik D, et al. Development and evaluation of novel biodegradable chitosan based metformin intrapocket dental film for the management of periodontitis and alveolar bone loss in a rat model. Arch Oral Biol. 2018;85:120–129.
  • Shariatinia Z, Zahraee Z. Controlled release of metformin from chitosan-based nanocomposite films containing mesoporous MCM-41 nanoparticles as novel drug delivery systems. J Colloid Interface Sci. 2017;501:60–76.
  • Xu Q, Zhu T, Yi C, et al. Characterization and evaluation of metformin-loaded solid lipid nanoparticles for cellular and mitochondrial uptake. Drug Dev Ind Pharm. 2016;42:701–706.
  • Sanjeev D. A chitosan–polymer hydrogel bead system for a metformin HCl controlled release oral dosage form. Toledo (OH): BiblioLabsII; 2011.
  • Sander C, Nielsen HM, Jacobsen J. Buccal delivery of metformin: TR146 cell culture model evaluating the use of bioadhesive chitosan discs for drug permeability enhancement. Int J Pharm. 2013;458:254–261.
  • Khalid M, Ho L, Agnely F, et al. Swelling properties and mechanical characterization of a semi-interpenetrating chitosan/polyethylene oxide network: comparison with a chitosan reference gel. STP Pharma Sci. 1999;9:359–364.
  • Calvo P, Remunan-Lopez C, Vila-Jato JL, et al. Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines. Pharm Res. 1997;14:1431–1436.
  • Hosseinzadeh H, Atyabi F, Dinarvand R, et al. Chitosan-Pluronic nanoparticles as oral delivery of anticancer gemcitabine: preparation and in vitro study. Int J Nanomedicine. 2012;7:1851–1863.
  • Rampino A, Borgogna M, Blasi P, et al. Chitosan nanoparticles: preparation, size evolution and stability. Int J Pharm. 2013;455:219–228.
  • Jain AK, Soderlind E, Viriden A, et al. The influence of hydroxypropyl methylcellulose (HPMC) molecular weight, concentration and effect of food on in vivo erosion behavior of HPMC matrix tablets. J Control Release. 2014;187:50–58.
  • Kassaye L, Genete G. Evaluation and comparison of in-vitro dissolution profiles for different brands of amoxicillin capsules. Afr Health Sci. 2013;13:369–375.
  • Nguyen KT, Le DV, Do DH, et al. Development of chitosan graft pluronic® F127 copolymer nanoparticles containing DNA aptamer for paclitaxel delivery to treat breast cancer cells. Adv Nat Sci Nanosci Nanotechnol. 2016;7:025018.
  • Fan W, Yan W, Xu Z, et al. Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique. Colloids Surf B. 2012;90:(1):21–7.
  • Asasutjarit R, Sorrachaitawatwong C, Tipchuwong N, et al. Effect of formulation compositions on particle size and zeta potential of diclofenac sodium-loaded chitosan nanoparticles. Int J Med Health Pharm Biomed Eng 2013;7:568–570.
  • Bhoyar P, Amgaonkar Y. Taste masking and molecular properties of metformin hydrochloride-indion 234 complexes. J Young Pharm. 2011;3:112–118.
  • Snima KS, Jayakumar R, Unnikrishnan AG, et al. O-carboxymethyl chitosan nanoparticles for metformin delivery to pancreatic cancer cells. Carbohydr Polym. 2012;89:1003–1007.
  • Gundogdu N, Cetin M. Chitosan-poly (lactide-co-glycolide) (CS-PLGA) nanoparticles containing metformin HCl: preparation and in vitro evaluation. Pak J Pharm Sci. 2014;27:1923–1929.
  • Talasaz AH, Ghahremankhani AA, Moghadam SH, et al. In situ gel forming systems of poloxamer 407 and hydroxypropyl cellulose or hydroxypropyl methyl cellulose mixtures for controlled delivery of vancomycin. J Appl Polym Sci. 2008;109:2369–2374.
  • Basalious EB, El-Sebaie W, El-Gazayerly O. Application of pharmaceutical QbD for enhancement of the solubility and dissolution of a class II BCS drug using polymeric surfactants and crystallization inhibitors: development of controlled-release tablets. AAPS PharmSciTech. 2011;12:799–810.
  • Shamma RN, Aburahma MH. Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia. Int J Nanomedicine. 2014;9:5449–5460.
  • Jose P, Sundar K, Anjali CH, et al. Metformin-loaded BSA nanoparticles in cancer therapy: a new perspective for an old antidiabetic drug. Cell Biochem Biophys. 2015;71:627–636.
  • Brown W, Schillen K, Hvidt S. Triblock copolymers in aqueous solution studied by static and dynamic light scattering and oscillatory shear measurements. Influence of relative block sizes. J Phys Chem. 1992;96:6038–6044.
  • El-Sherbiny I, Smyth H. Novel cryomilled physically cross-linked biodegradable hydrogel microparticles as carriers for inhalation therapy. J Microencapsul. 2010;27:657–668.
  • Varshney M, Morey TE, Shah DO, et al. Pluronic microemulsions as nanoreservoirs for extraction of bupivacaine from normal saline. J Am Chem Soc. 2004;126:5108–5112.
  • Hasan AA, Madkor H, Wageh S. Formulation and evaluation of metformin hydrochloride-loaded niosomes as controlled release drug delivery system. Drug Deliv. 2013;20:120–126.
  • Banerjee P, Deb J, Roy A, et al. Fabrication and development of pectin microsphere of metformin hydrochloride. ISRN Pharm. 2012;2012:230621.
  • Salehizadeh H, Hekmatian E, Sadeghi M, et al. Synthesis and characterization of core-shell Fe3O4-gold-chitosan nanostructure. J Nanobiotechnol. 2012;10:3.
  • Rajath O, Santosh K, Kumar V. Development and characterization of chitosan-pluronic polymeric nanoparticles for breast cancer treatment. Int J Mech Eng Robot. 2013;1:71–79.
  • Song H, He R, Wang K, et al. Anti-HIF-1alpha antibody-conjugated pluronic triblock copolymers encapsulated with Paclitaxel for tumor targeting therapy. Biomaterials. 2010;31:2302–2312.
  • Corti G, Cirri M, Maestrelli F, et al. Sustained-release matrix tablets of metformin hydrochloride in combination with triacetyl-beta-cyclodextrin. Eur J Pharm Biopharm. 2008;68:303–309.
  • de Moura MR, Aouada FA, Mattoso LH. Preparation of chitosan nanoparticles using methacrylic acid. J Colloid Interface Sci. 2008;321:477–483.
  • Pandit V, Pai RS, Yadav V, et al. Pharmacokinetic and pharmacodynamic evaluation of floating microspheres of metformin hydrochloride. Drug Dev Ind Pharm. 2013;39:117–127.
  • Ma Y. Controlled delivery of nanoparticles to the colon for tumour targeting. PhD Thesis, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Queensland, Australia; 2015.
  • Cerchiara T, Abruzzo A, Di Cagno M, et al. Chitosan based micro- and nanoparticles for colon-targeted delivery of vancomycin prepared by alternative processing methods. Eur J Pharm Biopharm. 2015;92:112–119.
  • Nath B, Nath L. Design, development and optimization of oral colon targeted drug delivery system of azathioprine using biodegradable polymers. Pharm Dev Technol. 2013;18:1131–1139.
  • Bilensoy E, Çırpanlı Y, Şen M, et al. Thermosensitive mucoadhesive gel formulation loaded with 5-Fu: cyclodextrin complex for HPV-induced cervical cancer. J Incl Phenom Macrocycl Chem. 2007;57:363–370.
  • Fonte P, Soares S, Costa A, et al. Effect of cryoprotectants on the porosity and stability of insulin-loaded PLGA nanoparticles after freeze-drying. Biomatter. 2012;2:329–339.
  • Blasi P, Schoubben A, Romano GV, et al. Lipid nanoparticles for brain targeting II. Technological characterization. Colloids Surf B Biointerfaces. 2013;110:130–137.
  • Abdelwahed W, Degobert G, Stainmesse S, et al. Freeze-drying of nanoparticles: formulation, process and storage considerations. Adv Drug Deliv Rev. 2006;58:1688–1713.
  • Huang S-L, MacDonald RC. Acoustically active liposomes for drug encapsulation and ultrasound-triggered release. Biochim Biophys Acta (BBA): Biomembr. 2004;1665:134–141.
  • Garud N, Garud A. Preparation and in-vitro evaluation of metformin microspheres using non-aqueous solvent evaporation technique. Trop J Pharm Res. 2012;11:577–583.
  • Lee J-H, Park TG, Choi H-K. Effect of formulation and processing variables on the characteristics of microspheres for water-soluble drugs prepared by w/o/o double emulsion solvent diffusion method. Int J Pharm. 2000;196:75–83.
  • Zien E, Ghorab M, Gad S, et al. Design and characterization of diclofenac sodium microspheres prepared by ionotropic gelation technique for oral controlled drug delivery. Int J Adv Pharm Bio Chem. 2015;4:321–329.
  • Karewicz A, Zasada K, Szczubiałka K, et al. “Smart” alginate–hydroxypropylcellulose microbeads for controlled release of heparin. Int J Pharm. 2010;385:163–169.
  • Jaipal A, Pandey MM, Charde SY, et al. Effect of HPMC and mannitol on drug release and bioadhesion behavior of buccal discs of buspirone hydrochloride: in-vitro and in-vivo pharmacokinetic studies. Saudi Pharm J. 2015;23:315–326.
  • Jelvehgari M, Valizadeh H, Ziapour S, et al. Comparative study of different combinational mucoadhesive formulations of sumatriptan-metoclopramide. Adv Pharm Bull. 2016;6:119–130.
  • Elbaz NM, Khalil IA, Abd-Rabou AA, et al. Chitosan-based nano-in-microparticle carriers for enhanced oral delivery and anticancer activity of propolis. Int J Biol Macromol. 2016;92:254–269.
  • Richard SM, Martinez Marignac VL. Sensitization to oxaliplatin in HCT116 and HT29 cell lines by metformin and ribavirin and differences in response to mitochondrial glutaminase inhibition. J Can Res Ther. 2015;11:336–340.
  • Chakraborti CK, Sahoo S, Behera PK. Role of different biodegradable polymers on the permeability of ciprofloxacin. J Adv Pharm Technol Res. 2014;5:140–146.
  • Piktel E, Niemirowicz K, Wątek M, et al. Recent insights in nanotechnology-based drugs and formulations designed for effective anti-cancer therapy. J Nanobiotechnol. 2016;14:39. doi: 10.1186/s12951-016-0193-x

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