215
Views
12
CrossRef citations to date
0
Altmetric
Research Articles

Development, characterization, comparative pharmacokinetic and pharmacodynamic studies of iloperidone solid SMEDDS and liquisolid compact

, &
Pages 587-596 | Received 13 Aug 2019, Accepted 08 Mar 2020, Published online: 31 Mar 2020

References

  • Katja C, Alenka Z, Franc V, et al. Development of a solid self-microemulsifying drug delivery system (SMEDDS) for solubility enhancement of naproxen. Drug Dev Ind Pharm. 2014;41(9):1548–1557.
  • Khames A. Investigation of the effect of solubility increase at the main absorption site on bioavailability of BCS class II drug (Risperidone) using liquisolid technique. Drug Deliv. 2017;24(1):328–338.
  • Prakash K, Jieun R, Hyeongmin K, et al. Pharmaceutical particle technologies: an approach to improve drug solubility, dissolution and bioavailability. Asian J Pharm Sci. 2014;9:304–316.
  • Arun B, Narendar D, Kishan V. Development of olmesartan medoxomil lipid-based nanoparticles and nanosuspension: preparation, characterization and comparative pharmacokinetic evaluation. Artif cells. Nanomed and Biotechnol. 2017;46(1):126–137.
  • Moriwaki C, Costa GL, Ferracini CN, et al. Enhancement of solubility of albendazole by complexation with cyclodextrin. Braz J Chem Eng. 2008;25(2):255–267.
  • Rasenack N, Müller BW. Dissolution rate enhancement by in situ micronization of poorly water-soluble drugs. Pharm Res. 2002;19(12):1894–1900.
  • Yanbin H, Wei-Guo D. Fundamental aspects of solid dispersion technology for poorly soluble drugs. Acta Pharm Sin B. 2014;4(1):18–25.
  • Mei L, Haonan X, Jingzheng J, et al. Liquisolid technique and its applications in pharmaceutics. Asian J Pharm Sci. 2017;12:115–123.
  • Serajuddin AT. Salt formation to improve drug solubility. Adv Drug Deliv Rev. 2007;59(7):603–616.
  • William NC, Christopher JHP, Sabena M, et al. Physicochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH. J Pharm Sci. 1997;86(3):269–282.
  • Christopher JHP, Natalie LT, William NC. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov. 2007;6(3):231–248.
  • Fang L, Rongfeng H, Bin W, et al. Self-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake. Acta Pharm Sin B. 2017;7(3):353–360.
  • Shambhu D, Amita KJ. Self-microemulsifying drug delivery system (SMEDDS) Challenges and road ahead. Drug Deliv. 2015;22(6):675–690.
  • Son HY, Chae BR, Choi JY, et al. Optimization of self-microemulsifying drug delivery system for phospholipid complex of telmisartan using D- optimal mixture design. PLoS One. 2018;13(12):e0208339–17.
  • Dong SK, Jung HC, Jong HP, et al. Self - microemulsifying drug delivery system (SMEDDS) for improved oral delivery and photostability of methotrexate. Int J Nanomedicine. 2019;14:4949–4960.
  • Ankur G, Burak Erat H, Alan Hatton T, et al. Nanoemulsions: formation, properties and applications. Soft Matter. 2016;12(11):2826–2841.
  • Tso P, Balint JA. Formation and transport of chylomicrons by enterocytes to the lymphatics. Am J Physiol Gastrointest Liver Physiol. 1986;250(6):G715–G726.
  • Seljak KB, Berginc K, Trontelj J, et al. A self-microemulsifying drug delivery system to overcome intestinal resveratrol toxicity and presystemic metabolism. J Pharm Sci. 2014;103(11):3491–3500.
  • Anna CK, Marta S, Aleksandra A, et al. Development and evaluation of liquid and solid self-emulsifying drug delivery systems for atorvastatin. Molecules. 2015;20:21010–21022.
  • Cirri M, Roghi A, Valleri M, et al. Development and characterization of fast-dissolving tablet formulations of glyburide based on solid self-microemulsifying systems. Eur J Pharm Biopharm. 2016;104:19–29.
  • Spiro S, Srinivas S. Enhancement of prednisolone dissolution properties using liquisolid compacts. Int J Pharm. 1998;166:177–188.
  • Yousef J, Baharak JN, Ali N. Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine). Int J Pharm. 2007;341:26–34.
  • Patel DS, Pipaliya RM, Naazneen S. Liquisolid tablets for dissolution enhancement of a hypolipidemic drug. Indian J Pharm Sci. 2015;77(3):290–298.
  • Fahim Jahangir S, Sachin Laxman T, Umesh Bhupal K. Design and development of liquisolid compacts of candesartan cilexetil to enhance dissolution. J Pharm Res. 2013;7:381–388.
  • Hentzschel CM, Alnaief M, Smirnova I, et al. Enhancement of griseofulvin release from liquisolid compacts. Eur J Pharm Biopharm. 2012;80(1):130–135.
  • Brian LC, John M. Iloperidone for the management of adults with schizophrenia. Clin Ther. 2011;33:330–345.
  • Mandpe L, Pokharkar V. Quality by design approach to understand the process of optimization of iloperidone nanostructured lipid carriers for oral bioavailability enhancement. Pharm Dev Technol. 2015;20(3):320–329.
  • Ralf B, Arthur S, Rainer W, et al. The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: Old fashioned, but still in vogue. Front Psychiatry. 2014;5(47):1–11.
  • Chiara SH, Jaya LP, Paulo L, et al. Recent advances in understanding schizophrenia. F1000Prime Rep. 2014;6(57):1–11.
  • Matcheri K, Rajiv T, Nash NB, et al. Schizophrenia, just the facts: what we know in 2008 part 3: neurobiology. Schizophr Res. 2008;106:89–107.
  • Peter JW. Iloperidone for the treatment of schizophrenia: an updated clinical review. Clin Schizophr Relat Psychoses. 2012;6(1):34–44.
  • O’Neill MF, Hicks CA, Shaw G, et al. Effects of 5-hydroxytryptamine2 receptor antagonism on the behavioral activation and immediate early gene expression induced by dizocilpine. J Pharmacol Exp Ther. 1998;287(3):839–846.
  • Su YA, Si TM, Zhou DF, et al. Risperidone attenuates MK-801-induced hyperlocomotion in mice via the blockade of serotonin 5-HT 2A/2C receptors. Eur J Pharmacol. 2007;564(1-3):123–130.
  • Venu Madhav K, Kishan V. Self microemulsifying particles of loratadine for improved oral bioavailability: preparation, characterization and in vivo evaluation. J Pharm Investig. 2018;48(4):497–508.
  • Ramesh J, Afzal Syed M, Prabhakar K, et al. Development of a self-microemulsifying drug delivery system of domperidone: In vitro and in vivo characterization. Acta Pharm. 2013;63:241–251.
  • Ashok RP, Pradeep RV. Preparation and in vivo evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate. AAPS J. 2007;9(3):E344–E352.
  • Venu Madhav K, Kishan V. Cationic solid self microemulsifying drug delivery system (SSMED) of losartan: Formulation development, characterization and in vivo evaluation. J Drug Deliv Sci Technol. 2016;35:190–199.
  • Pranav VP, Hitesh KP, Shital SP, et al. Self microemulsifying drug delivery system of tacrolimus: Formulation, in vitro evaluation and stability studies. Int J Pharm Investig. 2013;3(2):95–104.
  • Narendar D, Kishan V. Candesartan cilexetil loaded solid lipid nanoparticles for oral delivery: characterization, pharmacokinetic and pharmacodynamic evaluation. Drug Deliv. 2014;23(2):395–404.
  • Paola M, Maurizio V, Marzia C, et al. New solid self-microemulsifying systems to enhance dissolution rate of poorly water soluble drugs. Pharm Dev Technol. 2012;17(3):277–284.
  • Hamzah M, Omar S. A review on the angle of repose of granular materials. Powder Technol. 2018;330:397–417.
  • Naveen C, Nalini S, Rama Rao T. Use of the liquisolid compact technique for improvement of the dissolution rate of valsartan. Acta Pharm Sin B. 2012;2(5):502–508.
  • Arjun N, Kishan V. Preparation, characterization and evaluation of quetiapine fumarate solid lipid nanoparticles to improve the oral bioavailability. J Pharm. 2013; 2013:1–7.
  • Vijaykumar N, Raviraj P, Venkateshwarlu V, et al. Development and characterization of solid oral dosage form incorporating candesartan nanoparticles. Pharm Dev Technol. 2009;14(3):290–298.
  • Vinay Kumar V, Chandrasekar D, Ramakrishna S, et al. Development and evaluation of nitrendipine loaded solid lipid nanoparticles: influence of wax and glyceride lipids on plasma pharmacokinetics. Int J Pharm. 2007;335(1-2):167–175.
  • Scheubel E, Lindenberg M, Beyssac E, et al. Small volume dissolution testing as a powerful method during pharmaceutical development. Pharmaceutics. 2010;2(4):351–363.
  • Van Herck H, Baumans V, Brandt C, et al. Blood sampling from the retro-orbital plexus, the saphenous vein and the tail vein in rats: comparative effects on selected behavioural and blood variables. Lab Anim. 2001;35(2):131–139.
  • Mandpe L, Kyadarkunte A, Pokharkar V. High-performance liquid chromatographic method for simultaneous determination of iloperidone and idebenone in spiked plasma. IJCAS. 2013;4(1):19–23.
  • Uma B, Radha Y, Pophale P, et al. Study of CNS depressant and behavioral activity of an ethanol extract of Achyranthes Aspera (Chirchita) in mouse model. Ann Neurosci. 2011;18(2):44–47.
  • Sun F, Zhengxing S, Cheng S, et al. Studies on the acute toxicity, pharmacokinetics and pharmacodynamics of paliperidone derivatives – comparison to paliperidone and risperidone in mice and rats. Basic Clin Pharmacol. 2010;107(2):656–662.
  • Mitali HP, Krutika KS. Self microemulsifying drug delivery system of lurasidone hydrochloride for enhanced oral bioavailability by lymphatic targeting: In vitro, Caco-2 cell line and in vivo evaluation. Eur J Pharm Sci. 2019;138:105027.
  • Sun M, Xuezhen Z, Kewen X, et al. Intestinal absorption and intestinal lymphatic transport of sirolimus from self-microemulsifying drug delivery systems assessed using the single - pass intestinal perfusion (SPIP) technique and a chylomicron flow blocking approach: Linear correlation with oral bioavailabilities in rats. Eur J Pharm Sci. 2011;43:132–140.
  • Bhupinder S, Ramandeep S, Shantanu B, et al. Optimized nanoemulsifying systems with enhanced bioavailability of carvedilol. Colloids Surf B. 2013;101:465–474.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.