Functional vinorelbine plus schisandrin B liposomes destroying tumor metastasis in treatment of gastric cancer

References

• Sitarz R , Skierucha M , Mielko J , et al. Gastric cancer: epidemiology, prevention, classification, and treatment. Cancer Manag Res. 2018;10:239–248.
   PubMed Web of Science ®Google Scholar
• O'Connor A , O'Morain CA , Ford AC. Population screening and treatment of Helicobacter pylori infection. Nat Rev Gastroenterol Hepatol. 2017;14(4):230–240.
   PubMed Web of Science ®Google Scholar
• Gambardella V , Castillo J , Tarazona N , et al. The role of tumor-associated macrophages in gastric cancer development and their potential as a therapeutic target. Cancer Treat Rev. 2020;86:102015.
   PubMed Web of Science ®Google Scholar
• Li X-T , Tang W , Xie H-J , et al. The efficacy of RGD modified liposomes loaded with vinorelbine plus tetrandrine in treating resistant brain glioma. J Liposome Res. 2019;29(1):21–34.
   PubMed Web of Science ®Google Scholar
• Cassandri M , Butera A , Amelio I , et al. ZNF750 represses breast cancer invasion via epigenetic control of prometastatic genes. Oncogene. 2020;39(22):4331–4343.
   PubMed Web of Science ®Google Scholar
• Tai YL , Chen LC , Shen TL. Emerging roles of focal adhesion kinase in cancer. Biomed Res Int. 2015;2015:690690.
   PubMed Web of Science ®Google Scholar
• Friedl P , Wolf K , Lammerding J. Nuclear mechanics during cell migration. Curr Opin Cell Biol. 2011;23(1):55–64.
   PubMed Web of Science ®Google Scholar
• Chen Y , Keskin D , Sugimoto H , et al. Podoplanin + tumor lymphatics are rate limiting for breast cancer metastasis. PLoS Biol. 2018;16(12):e2005907.
   PubMed Web of Science ®Google Scholar
• Jiang WG , Sanders AJ , Katoh M , et al. Tissue invasion and metastasis: molecular, biological and clinical perspectives. Semin Cancer Biol. 2015;35 Suppl:S244–S275.
   PubMed Web of Science ®Google Scholar
• Kawahara R , Niwa Y , Simizu S . Integrin β1 is an essential factor in vasculogenic mimicry of human cancer cells. Cancer Sci. 2018;109(8):2490–2496.
   PubMed Web of Science ®Google Scholar
• Liu Y , Li F , Yang YT , et al. IGFBP2 promotes vasculogenic mimicry formation via regulating CD144 and MMP2 expression in glioma. Oncogene. 2019;38(11):1815–1831.
   PubMed Web of Science ®Google Scholar
• Chen Y , Gu H , Zhang DS-Z , et al. Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier. Biomaterials. 2014;35(38):10058–10069.
   PubMed Web of Science ®Google Scholar
• Taleb M , Ding Y , Wang B , et al. Dopamine delivery via pH-sensitive nanoparticles for tumor blood vessel normalization and an improved effect of cancer chemotherapeutic drugs. Adv Healthc Mater. 2019;8(18):e1900283.
   PubMed Web of Science ®Google Scholar
• Xiao H , Guo Y , Liu H , et al. Structure-based design of charge-conversional drug self-delivery systems for better targeted cancer therapy. Biomaterials. 2020;232:119701.
   PubMed Web of Science ®Google Scholar
• Lakkadwala S , Dos Santos Rodrigues B , Sun C , et al. Biodistribution of TAT or QLPVM coupled to receptor targeted liposomes for delivery of anticancer therapeutics to brain in vitro and in vivo. Nanomedicine. 2020;23:102112.
   PubMed Web of Science ®Google Scholar
• Tang B , Peng Y , Yue Q , et al. Design, preparation and evaluation of different branched biotin modified liposomes for targeting breast cancer. Eur J Med Chem. 2020;193:112204.
   PubMed Web of Science ®Google Scholar
• Mae M , Langel U. Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery. Curr Opin Pharmacol. 2006;6(5):509–514.
   PubMed Web of Science ®Google Scholar
• Ponnappan N , Budagavi DP , Chugh A. CyLoP-1: membrane-active peptide with cell-penetrating and antimicrobial properties. Biochim Biophys Acta Biomembr. 2017;1859(2):167–176.
   PubMed Web of Science ®Google Scholar
• Ponnappan N , Chugh A. Cell-penetrating and cargo-delivery ability of a spider toxin-derived peptide in mammalian cells. Eur J Pharm Biopharm. 2017;114:145–153.
   PubMed Web of Science ®Google Scholar
• Ju R-J , Cheng L , Xiao Y , et al. PTD modified paclitaxel anti-resistant liposomes for treatment of drug-resistant non-small cell lung cancer. J Liposome Res. 2018;28(3):236–248.
   PubMed Web of Science ®Google Scholar
• Liu J-J , Tang W , Fu M , et al. Development of R8 modified epirubicin-dihydroartemisinin liposomes for treatment of non-small-cell lung cancer. Artif Cells Nanomed Biotechnol. 2019;47(1):1947–1960.
   PubMed Web of Science ®Google Scholar
• Cao W , Zheng W , Chen T. Ruthenium polypyridyl complex inhibits growth and metastasis of breast cancer cells by suppressing FAK signaling with enhancement of TRAIL-induced apoptosis. Sci Rep. 2015;5:9157.
   PubMed Web of Science ®Google Scholar
• Briasoulis E , Pappas P , Puozzo C , et al. Dose-ranging study of metronomic oral vinorelbine in patients with advanced refractory cancer. Clin Cancer Res. 2009;15(20):6454–6461.
   PubMed Web of Science ®Google Scholar
• Qin R-S , Zhang Z-H , Zhu N-P , et al. Enhanced antitumor and anti-angiogenic effects of metronomic Vinorelbine combined with Endostar on Lewis lung carcinoma. BMC Cancer. 2018;18(1):967.
   PubMed Web of Science ®Google Scholar
• Jiang Y , Zhang Q , Bao J , et al. Schisandrin B suppresses glioma cell metastasis mediated by inhibition of mTOR/MMP-9 signal pathway. Biomed Pharmacother. 2015;74:77–82.
   PubMed Web of Science ®Google Scholar
• Thandavarayan RA , Giridharan VV , Arumugam S , et al. Schisandrin B prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of MAPK/p53 signaling. PLoS One. 2015;10(3):e0119214.
   PubMed Web of Science ®Google Scholar
• Kong L , Cai F-Y , Yao X-M , et al. RPV-modified epirubicin and dioscin co-delivery liposomes suppress non-small cell lung cancer growth by limiting nutrition supply. Cancer Sci. 2020;111(2):621–636.
   PubMed Web of Science ®Google Scholar
• Fu M , Tang W , Liu J-J , et al. Combination of targeted daunorubicin liposomes and targeted emodin liposomes for treatment of invasive breast cancer. J Drug Target. 2020;28(3):245–258.
   PubMed Web of Science ®Google Scholar
• Palle J , Rochand A , Pernot S , et al. Human epidermal growth factor receptor 2 (HER2) in advanced gastric cancer: current knowledge and future perspectives. Drugs. 2020;80(4):401–415.
   PubMed Web of Science ®Google Scholar
• Mei B , Chen J , Yang N , et al. The regulatory mechanism and biological significance of the Snail-miR590-VEGFR-NRP1 axis in the angiogenesis, growth and metastasis of gastric cancer. Cell Death Dis. 2020;11(4):241.
   PubMed Web of Science ®Google Scholar
• Ding X , Su Y , Wang C , et al. Synergistic suppression of tumor angiogenesis by the co-delivering of vascular endothelial growth factor targeted siRNA and candesartan mediated by functionalized carbon nanovectors. ACS Appl Mater Interfaces. 2017;9(28):23353–23369.
   PubMed Web of Science ®Google Scholar
• Saisyo A , Nakamura H , Fang J , et al. pH-sensitive polymeric cisplatin-ion complex with styrene-maleic acid copolymer exhibits tumor-selective drug delivery and antitumor activity as a result of the enhanced permeability and retention effect. Colloids Surf B Biointerfaces. 2016;138:128–137.
   PubMed Web of Science ®Google Scholar
• Zhao L , Liu Y , Tong D , et al . MeCP2 promotes gastric cancer progression through regulating FOXF1/Wnt5a/β-catenin and MYOD1/caspase-3 signaling pathways. EBioMedicine. 2017;16:87–100.
   PubMed Web of Science ®Google Scholar
• Chauhan A , Kumar R , Singh P , et al. RF hyperthermia by encapsulated Fe3O4 nanoparticles induces cancer cell death via time-dependent caspase-3 activation. Nanomedicine (Lond). 2020;15(4):355–379.
   PubMed Web of Science ®Google Scholar
• Xiao Y , Cheng L , Xie H-J , et al. Vinorelbine cationic liposomes modified with wheat germ agglutinin for inhibiting tumor metastasis in treatment of brain glioma. Artif Cells Nanomed Biotechnol. 2018;46(Suppl. 3):S524–S537.
   PubMed Web of Science ®Google Scholar
• Gou J , Liang Y , Miao L , et al. Improved tumor tissue penetration and tumor cell uptake achieved by delayed charge reversal nanoparticles. Acta Biomater. 2017;62:157–166.
   PubMed Web of Science ®Google Scholar
• Blanchoin L , Boujemaa-Paterski R , Sykes C , et al. Actin dynamics, architecture, and mechanics in cell motility. Physiol Rev. 2014;94(1):235–263.
   PubMed Web of Science ®Google Scholar
• Rosenthal DT , Iyer H , Escudero S , et al . p38γ promotes breast cancer cell motility and metastasis through regulation of RhoC GTPase, cytoskeletal architecture, and a novel leading edge behavior. Cancer Res. 2011;71(20):6338–6349.
   PubMed Web of Science ®Google Scholar
• Ito H , Tsunoda T , Riku M , et al. Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7-PAK1 complex. Oncogene. 2020;39(9):1931–1943.
   PubMed Web of Science ®Google Scholar
• Yu T , Tang B , Sun X. Development of inhibitors targeting hypoxia-inducible factor 1 and 2 for cancer therapy. Yonsei Med J. 2017;58(3):489–496.
   PubMed Web of Science ®Google Scholar
• Shen W , Xi H , Wei B , et al. The prognostic role of matrix metalloproteinase 2 in gastric cancer: a systematic review with meta-analysis. J Cancer Res Clin Oncol. 2014;140(6):1003–1009.
   PubMed Web of Science ®Google Scholar
• Liu H-T , Ma R-R , Lv B-B , et al. LncRNA-HNF1A-AS1 functions as a competing endogenous RNA to activate PI3K/AKT signalling pathway by sponging miR-30b-3p in gastric cancer. Br J Cancer. 2020;122(12):1825–1836.
   PubMed Web of Science ®Google Scholar
• Tegtmeyer N , Wittelsberger R , Hartig R , et al. Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori . Cell Host Microbe. 2011;9(6):520–531.
   PubMed Web of Science ®Google Scholar
• Yang Y , Yang Y , Xie X , et al. PEGylated liposomes with NGR ligand and heat-activable cell-penetrating peptide–doxorubicin conjugate for tumor-specific therapy. Biomaterials. 2014;35(14):4368–4381.
   PubMed Web of Science ®Google Scholar
• Goos JACM , Cho A , Carter LM , et al. Delivery of polymeric nanostars for molecular imaging and endoradiotherapy through the enhanced permeability and retention (EPR) effect. Theranostics. 2020;10(2):567–584.
   PubMed Web of Science ®Google Scholar