330
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

Palatability of pediatric formulations: do rats predict aversiveness?

, ORCID Icon & ORCID Icon
Pages 1121-1126 | Received 04 May 2021, Accepted 30 Aug 2021, Published online: 29 Sep 2021

References

  • Everitt JI. The future of preclinical animal models in pharmaceutical discovery and development: a need to bring in cerebro to the in vivo discussions. Toxicol Pathol. 2015;43(1):70–77.
  • Batchelor HK, Marriott JF. Formulations for children: problems and solutions. Br J Clin Pharmacol. 2015;79(3):405–418.
  • Bahia MS, Nissim I, Niv MY. Bitterness prediction in-silico: a step towards better drugs. Int J Pharm. 2018;536(2):526–529.
  • Clapham D, Kirsanov D, Legin A, et al. Assessing taste without using humans: rat brief access aversion model and electronic tongue. Int J Pharm. 2012;435(2):137–139.
  • Münster M, Mohamed-Ahmed AHA, Immohr LI, et al. Comparative in vitro and in vivo taste assessment of liquid praziquantel formulations. Int J Pharm. 2017;529(1–2):310–318.
  • Devantier HR, Long DJ, Brennan FX, et al. Quantitative assessment of TRPM5-dependent oral aversiveness of pharmaceuticals using a mouse brief-access taste aversion assay. Behav Pharmacol. 2008;19(7):673–682.
  • Soto J, Sheng Y, Standing JF, et al. Development of a model for robust and exploratory analysis of the rodent brief-access taste aversion data. Eur J Pharm Biopharm. 2015;91:47–51.
  • Gast A, Mathes T. Medication adherence influencing factors-an (updated) overview of systematic reviews. Syst Rev. 2019;8(1):112.
  • Stegemann S, Gosch M, Breitkreutz J. Swallowing dysfunction and dysphagia is an unrecognized challenge for oral drug therapy. Int J Pharm. 2012;430(1–2):197–206.
  • Faisal W, Farag F, Abdellatif AAH, et al. Taste masking approaches for medicines. Curr Drug Deliv. 2018;15(2):167–185.
  • Sohi H, Sultana Y, Khar RK. Taste masking technologies in oral pharmaceuticals: recent developments and approaches. Drug Dev Ind Pharm. 2004;30(5):429–448.
  • Walsh J, Cram A, Woertz K, European Formulation Initiative, et al. Playing hide and seek with poorly tasting paediatric medicines: do not forget the excipients. Adv Drug Deliv Rev. 2014;73:14–33.
  • Sharma A, Amarnath S, Thulasiman M, et al. Artificial sweeteners as a sugar substitute: are they really safe? Indian J Pharmacol. 2016;48(3):237–240.
  • Loney GC, Torregrossa A-M, Smith JC, et al. Rats display a robust bimodal preference profile for sucralose. Chem Senses. 2011;36(8):733–745.
  • Loney GC, Torregrossa A-M, Carballo C, et al. Preference for sucralose predicts behavioral responses to sweet and bittersweet tastants. Chem Senses. 2012;37(5):445–453.
  • Brasser SM, Mozhui K, Smith DV. Differential covariation in taste responsiveness to bitter stimuli in rats. Chem Senses. 2005;30(9):793–799.
  • Medeiros MDSG, Garruti DDS, Batista LAA, et al. Taste acceptance of captopril and furosemide extemporaneous oral pediatric formulations among hospitalized children. J Pharma Care Health Sys. 2016;3(2):1000156.
  • Jijo A, Flowerlet M. Taste masking of pediatric formulation: a review on technologies and recent trends and regulatory aspects. Int J Pharm Pharm Sci. 2014;6(1):12–18.
  • Margulis E, Dagan-Wienera A, Ives RS, et al. Intense bitterness of molecules: machine learning for expediting drug discovery. Comput Struct Biotechnol J. 2021;19:568–576.
  • Soto J, Keeley A, Keating AV, et al. Rats can predict aversiveness of active pharmaceutical ingredients. Eur J Pharm Biopharm. 2018;133:77–84.
  • Lye MY, Yow KL, Lim LY, et al. Effects of ingredients on stability of captopril in extemporaneously prepared oral liquids. Am J Health Syst Pharm. 1997;54(21):2483–2487.
  • Chikukwa MTR, Wesoly M, Korzeniowska AB, et al. Assessment of taste masking of captopril by ion-exchange resins using electronic gustatory system. Pharm Dev Technol. 2020;25(3):281–289.
  • Fregly MJ. Effect of the angiotensin converting enzyme inhibitor, captopril, on NaCl appetite of rats. J Pharmacol Exp Ther. 1980;215(2):407–412.
  • Abu-Hamdan DK, Desai H, Sondheimer J, et al. Taste acuity and zinc metabolism in captopril-treated hypertensive male patients. Am J Hypertens. 1988;1(3 Pt 3):303S–308S.
  • Hubrecht RC, Carter E. The 3Rs and humane experimental technique: implementing change. Animals. 2019;9(10):754.
  • Sclafani A, Clare RA. Female rats show a bimodal preference response to the artificial sweetener sucralose. Chem Senses. 2004;29(6):523–528.
  • Bacharach SZ, Calu DJ. Stability of individual differences in sucralose taste preference. PLOS One. 2019;14(5):e0216431.
  • Mennella JA, Beauchamp GK. Optimizing oral medications for children. Clin Ther. 2008;30(11):2120–2132.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.