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Research Articles

Development of bifunctional vaginal suppositories by joint use terconazole and probiotic for treatment and prophylaxis of vulvovaginal candidiasis

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Pages 1424-1431 | Received 16 Dec 2020, Accepted 21 Oct 2021, Published online: 15 Nov 2021

References

  • Sobel J. Vulvovaginal candidosis. Lancet. 2007;369(9577):1961–1971.
  • Sobel J, Chaim W. Vaginal microbiology of women with acute recurrent vulvovaginal candidiasis. J Clin Microbiol. 1996; 34(10):2497–2499.
  • Borges S, Silva J, Teixeira P. The role of lactobacilli and probiotics in maintaining vaginal health. Arch Gynecol Obstet. 2014;289(3):479–489.
  • Dover SE, Aroutcheva AA, Faro S, et al. Natural antimicrobials and their role in vaginal health: a short review. Int J Probiotics Prebiotics. 2008; 3(4):219–230.
  • Uehara S, Monden K, Nomoto K, et al. A pilot study evaluating the safety and effectiveness of lactobacillus vaginal suppositories in patients with recurrent urinary tract infection. Int J Antimicrob Agents . 2006; 28:30–34.
  • Slaver CM. Lactobacillus: a review. Clin. Microbiol Newsletter. 2008; 30:23–27.
  • Klebanoff SJ, Hillier SL, Eschenbach DA, et al. Control of the microbial flora of the vagina by H2O2-generating lactobacilli. J Infect Dis. 1991;164(1):94–100.
  • Hawes SE, Hillier SL, Benedetti J, et al. Hydrogen peroxide-producing lactobacilli and acquisition of vaginal infections. J Infect Dis. 1996;174(5):1058–1063.
  • Strus M, Brzychczy-Wloch M, Kucharska A, et al. Inhibitory activity of vaginal lactobacillus bacteria on yeasts causing vulvovaginal candidiasis. Med Dosw Mikrobiol. 2005;57(1):7–17.
  • Vallor AC, Antonio MA, Hawes SE, et al. Factors associated with acquisition of, or persistent colonization by, vaginal lactobacilli: role of hydrogen peroxide production. J Infect Dis. 2001;184(11):1431–1433.
  • Heeres J, Hendrickx R, Van Cutsem J. Antimycotic azoles. 6. Synthesis and antifungal properties of terconazole, a novel triazole ketal. J Med Chem. 1983;26(4):611–613.
  • Thomason L. Clinical evaluation of terconazole. United States experience. J Reprod Med. 1989;34(8 Suppl):597–601.
  • Slavin MB, Benrubi GI, Parker R, et al. Single dose oral fluconazole vs intravaginal terconazole in treatment of candida vaginitis. J Florida Med Assoc. 1992; 79:693–696.
  • Anukam K, Osazuwa E, Ahonkhai I, et al. Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial. Microbes Infect. 2006; 8(6):1450–1454.
  • Martinez RCR, Franceschin SA, Patta MC, et al. Improved treatment of vulvovaginal candidiasis with fluconazole plus probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14. Lett Appl Microbiol. 2009;48(3):269–386.
  • Reiko Y, Hiraku O, Yoshiharu M. Preparation and evaluation of double-phased mucoadhesive suppositories of lidocaine utilizing carbopol and white beeswax. J Controlled Release. 1999; 61:1–8.
  • Pashayan M. Formulation and investigation of vaginal double layer suppositories containing lactobacilli and herbal extract. N Armenian Med J. 2011; 5(2):54–59.
  • Pashayan M, Hovhannisyan H. Isolation and characterization of hydrogen peroxide producing vaginal lactobacilli. J Microb Epidemiol Immunobiol. 2011; 6:90–93.
  • Margareth RC, Raimar L, May A. Simulated biological fluids with possible application in dissolution testing. Dissolut Technol. 2011;18(3):15–28.
  • Hovhannisyan Hg Grigoryan GG. Evolution of adhesive and aggregative properties of lactic acid bacteria, isolated from healthy Armenian women vagina. Int J Med Pharm Sci. 2015; 6(3):1–4.
  • Allen L. Quality control of suppositories. Suppositories. 1st ed. UK: The Pharmaceutical Press; 2008. p. 39–58.
  • Srilakshmi M, Renuka Devi GN, Sharmila S, et al. Spectrophotometric determination water soluble drug terconazole using hydrotropic solubilization technique. Indo Am J Pharm Res. 2013; 3(5):3527–3534.
  • God SC. Pharmaceutical manufacturing handbook. New Jersey (NJ): Wiley-Interscience; 2008. p. 811–815.
  • Falagas M, Betsi GI, Athanasiou S. Probiotics for prevention of recurrent vulvovaginal candidiasis: a review. J Antimicrob Chemother. 2006; 58(2):266–272.
  • Osset J, García E, Bartolomé RM, et al. Role of lactobacillus as protector against vaginal candidiasis. Med Clin. 2001;117(8):285–288.
  • Verdenelli M, Coman M, Cecchini C, et al. Evaluation of antipathogenic activity and adherence properties of human lactobacillus strains for vaginal formulations. J Appl Microbiol. 2014; 116(5):1297–1307.
  • Ferreira C, Pereira A, Pereira M, et al. Biofilm control with new microparticles with immobilized biocide. J Heat Transfer Eng. 2013; 34(8-9):712–718.
  • Todorov SD, Botes M, Danova ST, et al. Probiotic properties of Lactococcus lactis ssp. lactis HV219, isolated from human vaginal secretions. J Appl Microbiol. 2007;103(3):629–639.
  • Nader-Macías MEF, Silva de Ruiz C, Ocaña VS, et al. Advances in the knowledge and clinical applications of lactic acid bacteria as probiotics in the urogenital tract. Curr Womens Health Rev. 2008;4(4):240–257.
  • Osset J, Bartolome RM, Garcıa E, et al. Assessment of the capacity of lactobacillus to inhibit the growth of uropathogens and block their adhesion to vaginal epithelial cells. J Infect Dis. 2001;183(3):485–491.
  • Boris S, Suárez JE, Barbés C. Characterization of the aggregation promoting factor from Lactobacillus gasseri, a vaginal isolate. J Appl Microbiol. 1997;83(4):413–420.
  • Goodarzi A, Hovhannisyan H, Barseghyan A. The use of str mutations for enhancement of hydrogen peroxide formation by Lactobacillus delbrueckii MH-10 at refrigeration conditions. J Food Sci Eng. 2016; 6:90–97.
  • Tanaka M, Kuwahara E, Takahashi M, et al. Enhanced rectal absorption of amphotericin B lyophilized with glycyrrhizinate in rabbits. Biol Pharm Bull. 1998;21(8):853–857.
  • Kaewnopparat S, Kaewnopparat N. Formulation and evaluation of vaginal suppositories containing lactobacillus. Int J Med Health Biomed Bioeng Pharm Eng. 2009; 3(7):117–120.
  • Yahagi R, Machida Y, Onishi H, et al. Mucoadhesive suppositories of ramosetron hydrochloride utilizing carbopol®. Int J Pharm. 2000;193(2):205–212.
  • Hiorth M, Nilsen S, Tho I. Bioadhesive mini-tablets for vaginal drug delivery. Pharmaceutics. 2014; 6(3):494–511.
  • Mirmonsef P, Modur S, Burgad D, et al. An exploratory comparison of vaginal glycogen and lactobacillus levels in pre- and post-menopausal women. Menopause. 2015; 22(7):702–709.
  • Rodrigues F, Maia MJ, Neves J, et al. Vaginal suppositories containing Lactobacillus acidophilus: development and characterization. Drug Dev Ind Pharm. 2015;41(9):1518–1525.
  • Tachedjian G, O'Hanlon DE, Ravel J. The implausible “in vivo” role of hydrogen peroxide as an antimicrobial factor produced by vaginal microbiota. Microbiome. 2018;6(1):29–25.

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