234
Views
4
CrossRef citations to date
0
Altmetric
Research Articles

Formulation and performance evaluation of polymeric mixed micelles encapsulated with baicalein for breast cancer treatment

, , , , , & show all
Pages 1512-1522 | Received 04 Jun 2021, Accepted 11 Nov 2021, Published online: 06 Dec 2021

References

  • Globocan Observatory. W. I., (IARC), I. A. for R. on C., (WHO) Breast Cancer. Source: Globocan 2018. World Health Organization International Agency for Research on Cancer W. H. O. 2019. 876. Available from: http://gco.iarc.fr/today%0Ahttps://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf
  • Greenwell M, Rahman PKS. Europe PMC funders group medicinal plants : their use in anticancer treatment. Int J Pharm Sci Res. 2015;6(10):4103–4112.
  • Seca AML, Pinto DCGA. Plant secondary metabolites as anticancer agents: successes in clinical trials and therapeutic application. IJMS. 2018;19(1):263.
  • Li-Weber M. New therapeutic aspects of flavones: the anticancer properties of scutellaria and its main active constituents wogonin, baicalein and baicalin. Cancer Treat Rev. 2009;35(1):57–68.
  • Gao Y, Snyder SA, Smith JN, et al. Anticancer properties of baicalein: a review. Med Chem Res. 2016;25(8):1515–1523.
  • Lee JH, Li YC, Ip SW, et al. The role of Ca2+ in baicalein-induced apoptosis in human breast MDA-MB-231 cancer cells through mitochondria- and caspase-3-dependent pathway. Anticancer Res. 2008;28(3A):1701–1711.
  • Wang L, Ling Y, Chen Y, et al. Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells. Cancer Lett. 2010;297(1):42–48.
  • Chung H, Choi HS, Seo EK, et al. Baicalin and baicalein inhibit transforming growth factor-β1-mediated epithelial-mesenchymal transition in human breast epithelial cells. Biochem Biophys Res Commun. 2015;458(3):707–713.
  • Zhang L, Lin G, Chang Q, et al. Role of intestinal first-pass metabolism of baicalein in its absorption process. Pharm Res. 2005;22(7):1050–1058.
  • Zhang J, Lv H, Jiang K, et al. Enhanced bioavailability after oral and pulmonary administration of baicalein nanocrystal. Int J Pharm. 2011;420(1):180–188.
  • He X, Pei L, Tong HHY, et al. Comparison of spray freeze drying and the solvent evaporation method for preparing solid dispersions of baicalein with pluronic F68 to improve dissolution and oral bioavailability. AAPS PharmSciTech. 2011;12(1):104–113.
  • Yin J, Xiang C, Wang P, et al. Biocompatible nanoemulsions based on hemp oil and less surfactants for oral delivery of baicalein with enhanced bioavailability. Int J Nanomedicine. 2017;12:2923–2931.
  • Gao Y, Zhang Y, Wang B, et al. Oral absorption and lymphatic transport of baicalein following drug-phospholipid complex incorporation in self-microemulsifying drug delivery systems. Int J Nanomedicine. 2019;14:7291–7306.
  • Liang J, Wu W, Liu Q, et al. Long-circulating nanoliposomes (LCNs) sustained delivery of baicalein (BAI) with desired oral bioavailability in vivo. Drug Deliv. 2013;20(8):319–323.
  • Shen H, Liu Y, Zhang H, et al. Enhancing the oral bioavailability of baicalein via Solutol® HS15 and poloxamer 188 mixed micelles system. J Pharm Pharmacol. 2019;71(5):765–773.
  • Gaucher G, Satturwar P, Jones MC, et al. Polymeric micelles for oral drug delivery. Eur J Pharm Biopharm. 2010;76(2):147–158.
  • Xu W, Ling P, Zhang T. Polymeric micelles, a promising drug delivery system to enhance bioavailability of poorly water-soluble drugs. J Drug Deliv. 2013;2013:340315–340315.
  • Alhakamy NA, Ahmed OAA, Fahmy UA, et al. Development and in vitro evaluation of 2-methoxyestradiol loaded polymeric micelles for enhancing anticancer activities in prostate cancer. Polymers. 2021;13(6):884.
  • Khonkarn R, Daowtak K, Okonogi S. Chemotherapeutic efficacy enhancement in P-gp-overexpressing cancer cells by flavonoid-loaded polymeric micelles. AAPS PharmSciTech. 2020; 21(4):121.
  • Alven S, Aderibigbe BA. The therapeutic efficacy of dendrimer and micelle formulations for breast cancer treatment. Pharmaceutics. 2020;12(12):1212–1249.
  • Yang C, Wu T, Qi Y, et al. Recent advances in the application of vitamin E TPGS for drug delivery. Theranostics. 2018;8(2):464–485.
  • Batrakova EV, Kabanov AV. Pluronic block copolymers : evolution of drug delivery concept from inert nanocarriers to biological response modifiers. J Control Release. 2008;130(2):98–106.
  • Barry AP, Barry NPE. Pluronic® block-copolymers in medicine: from chemical and biological versatility to rationalisation and clinical advances. Polym Chem. 2014;5(10):3291–3297.
  • Zhao L, Du J, Duan Y, et al. Curcumin loaded mixed micelles composed of pluronic P123 and F68: preparation, optimization and in vitro characterization. Colloids Surf B Biointerfaces. 2012;97:101–108.
  • Saxena V, Hussain MD. Polymeric mixed micelles for delivery of curcumin to multidrug resistant ovarian cancer. J Biomed Nanotechnol. 2013;9(7):1146–1154.
  • Hao T, Chen D, Liu K, et al. Micelles of d-α-Tocopheryl polyethylene glycol 2000 succinate (TPGS 2K) for doxorubicin delivery with reversal of multidrug resistance. ACS Appl Mater Interfaces. 2015;7(32):18064–18075.
  • Guo Y, Luo J, Tan S, et al. The applications of vitamin e TPGS in drug delivery. Eur J Pharm Sci. 2013;49(2):175–186.
  • Neophytou CM, Constantinou C, Papageorgis P, et al. D-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces cell cycle arrest and apoptosis selectively in survivin-overexpressing breast cancer cells. Biochem Pharmacol. 2014;89(1):31–42.
  • Dumortier G, Grossiord JL, Agnely F, et al. A review of poloxamer 407 pharmaceutical and pharmacological characteristics. Pharm Res. 2006;23(12):2709–2728.
  • Werle M. Natural and synthetic polymers as inhibitors of drug efflux pumps. Pharm Res. 2008;25(3):500–511.
  • Chen T, Li Y, Li C, et al. Pluronic P85/F68 micelles of baicalein could interfere with mitochondria to overcome MRP2-Mediated efflux and offer improved anti-Parkinsonian activity. Mol Pharmaceutics. 2017;14(10):3331–3342.
  • Zhang L, Yang S, Huang L, et al. Poly (ethylene glycol)-block-poly (D, L-lactide) (PEG-PLA) micelles for brain delivery of baicalein through nasal route for potential treatment of neurodegenerative diseases due to oxidative stress and inflammation: an in vitro and in vivo study. Int J Pharm. 2020;591:119981.
  • You G, Feng T, Zhang G, et al. Preparation, optimization, characterization and in vitro release of baicalein-solubilizing glycyrrhizic acid nano-micelles. Int J Pharm. 2021;601:120546.
  • Golombek EE, May JN, Theek B, et al. Tumor targeting via EPR: strategies to enhance patient responses. Adv Drug Deliv Rev. 2018;130:17–38.
  • Saxena V, Hussain MD. Poloxamer 407/TPGS mixed micelles for delivery of gambogic acid to breast and multidrug-resistant cancer. Int J Nanomedicine. 2012;7:713–721.
  • Maeda H, Nakamura H, Fang J. The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo. Adv Drug Deliv Rev. 2013;65(1):71–79.
  • Butt AM, Amin MCIM, Katas H, et al. In vitro characterization of pluronic F127 and D-α-tocopheryl polyethylene glycol 1000 succinate mixed micelles as nanocarriers for targeted anticancer-drug delivery. J Nanomater. 2012;2012:1–11.
  • Gao Y, Li LB, Zhai G. Preparation and characterization of pluronic/TPGS mixed micelles for solubilization of camptothecin. Colloids Surf B Biointerfaces. 2008;64(2):194–199.
  • Meng X, Liu J, Yu X, et al. Pluronic F127 and D-α-Tocopheryl polyethylene glycol succinate (TPGS) mixed micelles for targeting drug delivery across the blood brain barrier. Sci Rep. 2017;7(1):1–12.
  • Ji S, Lin X, Yu E, et al. Curcumin-Loaded mixed micelles: preparation, characterization, and in vitro antitumor activity. J Nanotechnol. 2018;2018:1–9.
  • Melik-Nubarov NS, Pomaz OO, Dorodnych T, et al. Interaction of tumor and normal blood cells with ethylene oxide and propylene oxide block copolymers. FEBS Letters. 1999;446(1):194–3468.
  • Zhou Q-M, Wang S, Zhang H, et al. The combination of baicalin and baicalein enhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells. Acta Pharmacol Sin. 2009;30(12):1648–1658.
  • Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol. 2007;35(4):495–516.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.