Advanced search
Publication Cover
Drug Development and Industrial Pharmacy Volume 47, 2021 - Issue 10
Submit an article Journal homepage
177
Views
2
CrossRef citations to date
0
Altmetric
Research Articles

Physico-chemical properties of two anhydrous azathioprine forms and their interaction with typical pharmaceutical excipients: highlighting new findings in drug formulation development

Adrian Bărbatua SARA Pharm Solutions S.R.L, Bucharest-5, RomaniaORCID Iconhttps://orcid.org/0000-0003-3184-5682View further author information
ORCID Icon,
Maria-Andreea Lungana SARA Pharm Solutions S.R.L, Bucharest-5, RomaniaORCID Iconhttps://orcid.org/0000-0002-9633-2186View further author information
ORCID Icon,
N’ghaya Toulbeb National Institute of Materials Physics, Laboratory of Optical Processes in Nanostructured Materials, Bucharest, RomaniaORCID Iconhttps://orcid.org/0000-0002-3828-9159View further author information
ORCID Icon,
Ion Smarandab National Institute of Materials Physics, Laboratory of Optical Processes in Nanostructured Materials, Bucharest, RomaniaORCID Iconhttps://orcid.org/0000-0002-0235-967XView further author information
ORCID Icon,
Monica Daescub National Institute of Materials Physics, Laboratory of Optical Processes in Nanostructured Materials, Bucharest, RomaniaORCID Iconhttps://orcid.org/0000-0003-3178-5237View further author information
ORCID Icon,
Mihaela Baibaracb National Institute of Materials Physics, Laboratory of Optical Processes in Nanostructured Materials, Bucharest, RomaniaORCID Iconhttps://orcid.org/0000-0003-1107-514XView further author information
ORCID Icon &
Corina-Mihaela Mantaa SARA Pharm Solutions S.R.L, Bucharest-5, RomaniaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3506-6945View further author information
ORCID Icon show all
Pages 1598-1606 | Received 16 Dec 2020, Accepted 18 Jan 2022, Published online: 07 Feb 2022

References

  • Júlio TA, Zâmara IrF, Garcia JS, et al. Compatibility and stability of valsartan in a solid pharmaceutical formulation. Braz J Pharm Sci. 2013;49(4):645–651.
  • Good manufacturing practices: supplementary guidelines for the manufacture of pharmaceutical ingredients annex 5. WHO Technical Report Series. 1999;35(885):54–55.
  • Karthik Varma V. Excipients used in the formulation of tablets. Rrjchem. 2016;5(2):143–154.
  • Ullmann P. Practice update: excipient selection for compounded pharmaceutical capsules: they're only fillers, right? Australian J Pharm. 2017;98:78–83.
  • Li J, Wu Y. Lubricants in pharmaceutical solid dosage forms. Lubr. 2014;2(1):21–43.
  • Prasanna KD, Vaishnavi G, Divya K, et al. An overview on preformulation studies. Iajps. 2015;2(10):1399–1407.
  • Pinak P. Preformulation studies: an integral part of formulation design. in: Usama A. and Juber A., editors. Pharmaceutical formulation design – recent practices. London, United Kingdom (UK); 2020. Section 1, Preformulation Study; p. 3–19.
  • Mottet C, Schoepfer AM, Juillerat P, et al. Experts opinion on the practical use of azathioprine and 6-mercaptopurine in inflammatory bowel disease. Inflamm Bowel Dis. 2016;22(11):2733–2747.
  • Covaci O-I, Samohvalov D, Manta C-M, et al. Novel anhydrous solid-state form of azathioprine: the assessing of crystal structure by powder X-Ray diffraction, infrared absorption spectroscopy and Raman scattering. J Mol Struct. 2019;1178:702–710.
  • Smaranda I, Nila A, Manta C-M, et al. The influence of UV light on the azathioprine photodegradation: new evidences by photoluminescence. Results Phys. 2019;14(102443):102443–102449.
  • Samohvalov D, Lungan M-A, Shova S, et al. Isomorphic channel-type pseudopolymorphs of azathioprine: from structural confirmations to a rational polymorph screening. Cryst Growth Des. 2021;21(9):4837–4846.
  • Kathpalia H, Sharma K, Doshi G. Recent trends in hard gelatin capsule delivery system. J Adv Pharm Edu Res. 2014;4(2):165–177.
  • Van Os EC, McKinney JA, Zins BJ, et al. Simultaneous determination of azathioprine and 6-mercaptopurine by high-performance liquid chromatography. J Chromatogr. B. 1996;679(1–2):147–154.
  • Bacchi A, Carcelli M, Chiodo T, et al. Inclusion properties, polymorphism and desolvation kinetics in a new 2-pyridyl iminophenol compound with 1D nanochannels. Cryst Growth Des. 2009;9(8):3749–3758.
  • Braga D, Chelazzi L, Grepioni F, et al. Imazamox: a quest for polymorphic modifications of a chiral and racemic herbicide. Cryst Growth Des. 2014;14(3):1430–1437.
  • Khankari RK, Grant DJW. Pharmaceutical hydrates thermochim. Acta. 1995;248:61–79.
  • Cerpeley DM, Alder BJ. Ground state of the electron gas by a stochastic method. Phys Rev Lett. 1980;45:566–569.
  • Bharate SS, Bharateb SB, Bajaj AN. Interactions and incompatibilities of pharmaceutical excipients with active pharmaceutical ingredients: a comprehensive review. J Excip Food Chem. 2010;1(3):3–26.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.