Bicyclol alleviates high-fat diet-induced hepatic ER stress- and autophagy-associated non-alcoholic fatty liver disease/non-alcoholic steatohepatitis in mice

References

• Fabbrini E, Sullivan S, Klein SJH. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology. 2010;51(2):679–689.
   PubMed Web of Science ®Google Scholar
• Tomic D, Kemp WW, Roberts SK. Nonalcoholic fatty liver disease: current concepts, epidemiology and management strategies. Eur J Gastroenterol Hepatol. 2018;30(10):1103–1115.
   PubMed Web of Science ®Google Scholar
• Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2018;67(1):328–357.
   PubMed Web of Science ®Google Scholar
• Diehl AM, Day C. Cause, pathogenesis, and treatment of nonalcoholic steatohepatitis. N Engl J Med. 2017;377(21):2063–2072.
   PubMed Web of Science ®Google Scholar
• Younossi ZM, Koenig AB, Abdelatif D, et al. Global epidemiology of nonalcoholic fatty liver disease—meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64(1):73–84.
   PubMed Web of Science ®Google Scholar
• Patton H, Nyberg A, Chiang K, et al. Clinical characteristics and epidemiology of patients with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in a large community-based healthcare delivery system in the U.S. J Hepatol. 2018;68:S839–S840.
   Web of Science ®Google Scholar
• Drew L. Fighting the fatty liver. Nature. 2017;550(7675):S102–S103.
   PubMed Web of Science ®Google Scholar
• Tanaka N, Kimura T, Fujimori N, et al. Current status, problems, and perspectives of non-alcoholic fatty liver disease research. World J Gastroenterol. 2019;25(2):163–177.
   PubMed Web of Science ®Google Scholar
• Chi X, Xiao H, Shi M, et al. Histological improvement in chronic hepatitis B patients treated with bicyclol: real world experience. BMC Gastroenterol. 2019;19(1):88.
   PubMedGoogle Scholar
• Han Y, Shi J, Ma A, et al. Randomized, vitamin E-controlled trial of bicyclol plus metformin in non-alcoholic fatty liver disease patients with impaired fasting glucose. Clin Drug Investig. 2014;34(1):1–7.
   PubMed Web of Science ®Google Scholar
• Li X, Zhou J, Chen S, et al. Role of bicyclol in preventing chemotherapeutic agent-induced liver injury in patients over 60 years of age with cancer. J Int Med Res. 2014;42(4):906–914.
   PubMed Web of Science ®Google Scholar
• Liu GT, Li Y, Wei HL, et al. Mechanism of protective action of bicyclol against CCl4-induced liver injury in mice. Liver Int. 2005;25(4):872–879.
   PubMed Web of Science ®Google Scholar
• Su HL, Zhu YX, Gao ZJ, et al. Efficacy comparison between bicyclol and polyene phosphatidylcholine treatments for the patients with nonalcoholic fatty liver disease. Zhonghua Gan Zang Bing Za Zhi. 2011;19(7):552–553.
   PubMedGoogle Scholar
• Wang H, Li Y. Protective effect of bicyclol on acute hepatic failure induced by lipopolysaccharide and d-galactosamine in mice. Eur J Pharmacol. 2006;534(1–3):194–201.
   PubMed Web of Science ®Google Scholar
• Yao XM, Li Y, Li HW, et al. Bicyclol attenuates tetracycline-induced fatty liver associated with inhibition of hepatic ER stress and apoptosis in mice. Can J Physiol Pharmacol. 2016;94(1):1–8.
   PubMed Web of Science ®Google Scholar
• Larter CZ, Yeh MM. Animal models of NASH: getting both pathology and metabolic context right. J Gastroenterol Hepatol. 2008;23(11):1635–1648.
   PubMed Web of Science ®Google Scholar
• Schwarz DS, Blower MD. The endoplasmic reticulum: structure, function and response to cellular signaling. Cell Mol Life Sci. 2016;73(1):79–94.
   PubMed Web of Science ®Google Scholar
• Buzzetti E, Pinzani M, Tsochatzis EA. The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metabolism. 2016;65(8):1038–1048.
   PubMed Web of Science ®Google Scholar
• Yang Y, Dong F, Liu X, et al. Crosstalk of oxidative damage, apoptosis, and autophagy under endoplasmic reticulum (ER) stress involved in thifluzamide-induced liver damage in zebrafish (Danio rerio). Environ Pollut. 2018;243(Pt B):1904–1911.
   PubMedGoogle Scholar
• Liu H, Lai W, Liu X, et al. Exposure to copper oxide nanoparticles triggers oxidative stress and endoplasmic reticulum (ER)-stress induced toxicology and apoptosis in male rat liver and BRL-3A cell. J Hazard Mater. 2021;401:123349.
   PubMed Web of Science ®Google Scholar
• Pagliassotti MJ. Endoplasmic reticulum stress in nonalcoholic fatty liver disease. Annu Rev Nutr. 2012;32(1):17–33.
   PubMedGoogle Scholar
• Lee WS, Yoo WH, Chae HJ. ER stress and autophagy. Curr Mol Med. 2015;15(8):735–745.
   PubMed Web of Science ®Google Scholar
• B'chir W, Maurin A-C, Carraro V, et al. The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression. Nucleic Acids Res. 2013;41(16):7683–7699.
   PubMed Web of Science ®Google Scholar
• Li M, Liu G-T. Inhibition of fas/FasL mRNA expression and TNF-alpha release in concanavalin A-induced liver injury in mice by bicyclol. World J Gastroenterol. 2004;10(12):1775–1779.
   PubMed Web of Science ®Google Scholar
• Hu QW, Liu GT. Effects of bicyclol on dimethylnitrosamine-induced liver fibrosis in mice and its mechanism of action. Life Sci. 2006;79(6):606–612.
   PubMed Web of Science ®Google Scholar
• Osawa Y, Kojika E, Hayashi Y, et al. Tumor necrosis factor-α-mediated hepatocyte apoptosis stimulates fibrosis in the steatotic liver in mice. Hepatol Commun. 2018;2(4):407–420.
   PubMed Web of Science ®Google Scholar
• Sheka AC, Adeyi O, Thompson J, et al. Nonalcoholic steatohepatitis: a review. JAMA. 2020;323(12):1175–1183.
   PubMed Web of Science ®Google Scholar
• Vallee D, Blanc M, Lebeaupin C, et al. Endoplasmic reticulum stress response and pathogenesis of non-alcoholic steatohepatitis [La reponse au stress du reticulum endoplasmique dans la physiopathologie des maladies chroniques du foie. DEP – 20200304]. Med Sci. 2020;36:119–129.
   Google Scholar
• Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell. 2010;140(6):900–917.
   PubMed Web of Science ®Google Scholar
• Bhardwaj M, Leli NM, Koumenis C, et al. Regulation of autophagy by canonical and non-canonical ER stress responses. Semin Cancer Biol. 2020;66:116–128.
   PubMed Web of Science ®Google Scholar
• Allaire M, Rautou P-E, Codogno P, et al. Autophagy in liver diseases: time for translation? J Hepatol. 2019;70(5):985–998.
   PubMed Web of Science ®Google Scholar
• González-Rodríguez Á, Mayoral R, Agra N, et al. Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. Cell Death Dis. 2014;5(4):e1179.
   PubMedGoogle Scholar
• Itakura E, Mizushima N. Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins. Autophagy. 2010;6(6):764–776.
   PubMed Web of Science ®Google Scholar
• Li JX, Yan Q, Liu N, et al. The prognostic value of autophagy-related markers bclin-1 and LC-3 in colorectal cancers: a systematic review and meta-analysis. Evid Based Complement Alternat Med. 2020;2020:1–11.
   Web of Science ®Google Scholar
• Cao W, Li J, Yang K, et al. An overview of autophagy: mechanism, regulation and research progress. Bull Cancer. 2021;108(3):304–322.
   PubMed Web of Science ®Google Scholar
• Wang Y, Nie H, Zhao X, et al. Bicyclol induces cell cycle arrest and autophagy in HepG2 human hepatocellular carcinoma cells through the PI3K/AKT and Ras/Raf/MEK/ERK pathways. BMC Cancer. 2016;16(1):742.
   PubMedGoogle Scholar
• Zhao TM, Wang Y, Deng Y, et al. Bicyclol attenuates acute liver injury by activating autophagy, anti-oxidative and anti-inflammatory capabilities in mice. Front Pharmacol. 2020;11:463.
   PubMed Web of Science ®Google Scholar
• Wree A, Eguchi A, McGeough MD, et al. NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology. 2014;59(3):898–910.
   PubMed Web of Science ®Google Scholar
• Etulain J, Martinod K, Wong SL, et al. P-selectin promotes neutrophil extracellular trap formation in mice. Blood. 2015;126(2):242–246.
   PubMed Web of Science ®Google Scholar
• Bui TM, Wiesolek HL, Sumagin R. ICAM-1: a master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis. J Leukoc Biol. 2020;108(3):787–799.
   PubMed Web of Science ®Google Scholar