320
Views
1
CrossRef citations to date
0
Altmetric
Research Articles

Microneedles assisted controlled and improved transdermal delivery of high molecular drugs via in situ forming depot thermoresponsive poloxamers gels in skin microchannels

ORCID Icon, , ORCID Icon &
Pages 265-278 | Received 21 Feb 2022, Accepted 25 Jul 2022, Published online: 05 Aug 2022

References

  • Thakur RRS, Fallows SJ, McMillan HL, et al. Microneedle-mediated intrascleral delivery of in situ forming thermoresponsive implants for sustained ocular drug delivery. J Pharm Pharmacol. 2014;66(4):584–595.
  • Nguyen KT, Ita KB, Parikh SJ, et al. Transdermal delivery of captopril and metoprolol tartrate with microneedles; [cited 2017 Nov 10]. Available from: http://www.ingentaconnect.com/content/ben/ddl/2014/00000004/00000003/art00006
  • Nguyen J, Ita K, Morra M, et al. The influence of solid microneedles on the transdermal delivery of selected antiepileptic drugs. Pharmaceutics. 2016;8(4):33.
  • Sullivan SP, Koutsonanos DG, del Pilar Martin M, et al. Dissolving polymer microneedle patches for influenza vaccination. Nat Med. 2010;16(8):915–920.
  • Scott JA, Banga AK. Cosmetic devices based on active transdermal technologies. Ther Deliv. 2015;6(9):1089–1099.
  • Matsuo K, Yokota Y, Zhai Y, et al. A low-invasive and effective transcutaneous immunization system using a novel dissolving microneedle array for soluble and particulate antigens. J Control Release. 2012;161(1):10–17.
  • Naito S, Ito Y, Kiyohara T, et al. Antigen-loaded dissolving microneedle array as a novel tool for percutaneous vaccination. Vaccine. 2012;30(6):1191–1197.
  • Gomaa YA, Garland MJ, McInnes F, et al. Laser-engineered dissolving microneedles for active transdermal delivery of nadroparin calcium. Eur J Pharm Biopharm. 2012;82(2):299–307.
  • Carey JB, Vrdoljak A, O’Mahony C, et al. Microneedle-mediated immunization of an adenovirus-based malaria vaccine enhances antigen-specific antibody immunity and reduces anti-vector responses compared to the intradermal route. Sci Rep. 2014;4:1–13.
  • Fourtanier A, Berrebi C. Miniature pig as an animal model to study photoaging. Photochem Photobiol. 1989;50(6):771–784.
  • Sivaraman A, Banga AK. Novel in situ forming hydrogel microneedles for transdermal drug delivery. Drug Deliv Transl Res. 2017;7(1):16–26.
  • Nguyen HX, Banga AK. Fabrication, characterization and application of sugar microneedles for transdermal drug delivery. Ther Deliv. 2017;8:249–264.
  • Raj R, Thakur S, Tekko IA, et al. Rapidly dissolving polymeric microneedles for minimally invasive intraocular drug delivery. Drug Deliv Transl Res. 2016;6(6):800–815.
  • Tuan-Mahmood TM, McCrudden MTC, Torrisi BM, et al. Microneedles for intradermal and transdermal drug delivery. Eur J Pharm Sci. 2013;50:623–637.
  • Park JH, Allen MG, Prausnitz MR. Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery. J Control Release. 2005;104(1):51–66.
  • Aoyagi S, Izumi H, Fukuda M. Biodegradable polymer needle with various tip angles and consideration on insertion mechanism of mosquito’s proboscis. Sens Actuators A Phys. 2008;143:20–28.
  • Khan S, Minhas MU, Tekko IA, et al. Evaluation of microneedles-assisted in situ depot forming poloxamer gels for sustained transdermal drug delivery. Drug Deliv Transl Res. 2019;9:764–782.
  • Tobin KV, Fiegel J, Brogden NK. Thermosensitive gels used to improve microneedle-assisted transdermal delivery of naltrexone. Polymers. 2021;13:933.
  • Bhattaccharjee S, Beck-Broichsitter M, Banga AK. In situ gel formation in microporated skin for enhanced topical delivery of niacinamide. Pharmaceutics. 2020;12:472.
  • Khan S, Akhtar N, Minhas MU, et al. pH/thermo-dual responsive tunable in situ cross-linkable depot injectable hydrogels based on poly(N-isopropylacrylamide)/carboxymethyl chitosan with potential of controlled localized and systemic drug delivery. AAPS PharmSciTech. 2019;20:119.
  • Khan S, Minhas MU, Ahmad M, et al. Self-assembled supramolecular thermoreversible β-cyclodextrin/ethylene glycol injectable hydrogels with difunctional pluronic 127 as controlled delivery depot of curcumin. Development, characterization and in vitro evaluation. J Biomater Sci Polym Ed. 2018;29(1):1–34.
  • Chung HJ, Lee Y, Park TG. Thermo-sensitive and biodegradable hydrogels based on stereocomplexed pluronic multi-block copolymers for controlled protein delivery. J Control Release. 2008;127(1):22–30.
  • Nasir F, Iqbal Z, Khan JA, et al. Development and evaluation of diclofenac sodium thermoreversible subcutaneous drug delivery system. Int J Pharm. 2012;439(1–2):120–126.
  • Khan S, Anwar N. Gelatin/carboxymethyl cellulose based stimuli-responsive hydrogels for controlled delivery of 5-fluorouracil, development, in vitro characterization, in vivo safety and bioavailability evaluation. Carbohydr Polym. 2021;257:117617.
  • Mad-Ali S, Benjakul S, Prodpran T, et al. Characteristics and gelling properties of gelatin from goat skin as affected by drying methods. J Food Sci Technol. 2017;54(6):1646–1654.
  • Chen JP, Leu YL, Fang CL, et al. Thermosensitive hydrogels composed of hyaluronic acid and gelatin as carriers for the intravesical administration of cisplatin. J Pharm Sci. 2011;100(2):655–666.
  • Alaikov T, Konstantinov SM, Tzanova T, et al. Antineoplastic and anticlastogenic properties of curcumin. Ann N Y Acad Sci. 2007;1095(1):355–370.
  • O'Connell MA, Rushworth SA. Curcumin: potential for hepatic fibrosis therapy? Br J Pharmacol. 2008;153(3):403–405.
  • Bruck R, Ashkenazi M, Weiss S, et al. Prevention of liver cirrhosis in rats by curcumin. Liver Int. 2007;27(3):373–383.
  • Sowasod N, Nakagawa K, Tanthapanichakoon W, et al. Development of encapsulation technique for curcumin loaded O/W emulsion using chitosan based cryotropic gelation. Mater Sci Eng C. 2012;32(4):790–798.
  • Khan S, Akhtar N, Minhas MU, et al. A difunctional Pluronic®127-based in situ formed injectable thermogels as prolonged and controlled curcumin depot, fabrication, in vitro characterization and in vivo safety evaluation. J Biomater Sci Polym Ed. 2021;32(3):281–319.
  • Derakhshandeh K, Fashi M, Seifoleslami S. Thermosensitive Pluronic® hydrogel: prolonged injectable formulation for drug abuse. Drug Des Devel Ther. 2010;4:255–262.
  • Baskan T, Tuncaboylu DC, Okay O. Tough interpenetrating pluronic F127/polyacrylic acid hydrogels. Polymer. 2013;54(12):2979–2987.
  • Moreira HR, Munarin F, Gentilini R, et al. Injectable pectin hydrogels produced by internal gelation: pH dependence of gelling and rheological properties. Carbohydr Polym. 2014;103:339–347.
  • Modepalli N, Shivakumar HN, McCrudden MTC, et al. Transdermal delivery of iron using soluble microneedles: dermal kinetics and safety. J Pharm Sci. 2016;105(3):1196–1200.
  • Larrañeta E, Stewart S, Fallows SJ, et al. A facile system to evaluate in vitro drug release from dissolving microneedle arrays. Int J Pharm. 2016;497(1–2):62–69.
  • Donnelly RF, Garland MJ, Morrow DIJ, et al. Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution. J Control Release. 2010;147:333–341.
  • Mccrudden MTC, Zaid A, Mccrudden CM, et al. Design and physicochemical characterisation of novel dissolving polymeric microneedle arrays for transdermal delivery of high dose, low molecular weight drugs. J Control Release. 2014;180:71–80.
  • Ripolin A, Quinn J, Larrañeta E, et al. Successful application of large microneedle patches by human volunteers. Int J Pharm. 2017;521(1–2):92–101.
  • Khan S, Akhtar N, Minhas MU. Fabrication, rheological analysis, and in vitro characterization of in situ chemically cross-linkable thermogels as controlled and prolonged drug depot for localized and systemic delivery. Polym Adv Technol. 2019;30:755–771.
  • Hathout RM, Woodman TJ, Mansour S, et al. Microemulsion formulations for the transdermal delivery of testosterone. Eur J Pharm Sci. 2010;40(3):188–196.
  • ElMasry SR, Hathout RM, Abdel-Halim M, et al. In vitro transdermal delivery of sesamol using oleic acid chemically-modified gelatin nanoparticles as a potential breast cancer medication. J Drug Deliv Sci Technol. 2018;48:30–39.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.