In vitro characterization of tofacitinib loaded novel nanoemulgel for topical delivery for the management of rheumatic arthritis

References

• Abbasi M, Mousavi MJ, Jamalzehi S, et al. Strategies toward rheumatoid arthritis therapy; the old and the new. J Cell Physiol. 2019;234(7):10018–10031.
   PubMed Web of Science ®Google Scholar
• Tadwee IK, Gore S, Giradkar P. Advances in topical drug delivery system: a review. Int J Pharm Res Allied Sci. 2012;1(1):14–23.
   Google Scholar
• Thakur S, Riyaz B, Patil A, et al. Novel drug delivery systems for NSAIDs in management of rheumatoid arthritis: an overview. Biomed Pharmacother. 2018;106:1011–1023.
   PubMed Web of Science ®Google Scholar
• Nigro F, Cerqueira Pinto C, dos Santos EP, et al. Niosome-based hydrogel as a potential drug delivery system for topical and transdermal applications. Int J Polym Mater Polym Biomater. 2022;71(6):444–461.
   Web of Science ®Google Scholar
• Md S, Alhakamy NA, Aldawsari HM, et al. Improved analgesic and anti-inflammatory effect of diclofenac sodium by topical NEG: formulation development—in vitro and in vivo studies. J Chem. 2020;2020:1–10.
   Web of Science ®Google Scholar
• Alivernini S, Tolusso B, Petricca L, et al. Rheumatoid arthritis. Mosaic of autoimmunity. Rome: Elsevier; 2019. p. 501–526.
   Google Scholar
• O'Shea JJ, Schwartz DM, Villarino AV, et al. The JAK-STAT pathway: impact on human disease and therapeutic intervention. Annu Rev Med. 2015;66:311–328.
   PubMed Web of Science ®Google Scholar
• Yamaoka K. Janus kinase inhibitors for rheumatoid arthritis. Curr Opin Chem Biol. 2016;32:29–33.
   PubMed Web of Science ®Google Scholar
• Norman P. Selective JAK inhibitors in development for rheumatoid arthritis. Expert Opin Investig Drugs. 2014;23(8):1067–1077.
   PubMed Web of Science ®Google Scholar
• Brendan J. Crystalline pyrrolo2,3-dipyrimidine compounds. United States patent US 2012/0258976A1. 2012 [cited 2022 May 27]. Available from: https://patentimages.storage.googleapis.com/73/af/e8/cd186967a54cdb/US20120258976A1.pdf
   Google Scholar
• Chen CM, Lu GW, Liaw LY, et al. Topical formulations comprising tofacitinib. United States patent US 16/254,076. 2019 [cited 2022 May 27]. Available from: https://patentimages.storage.googleapis.com/a9/46/a0/a33533549ea5ca/US20190231782A1.pdf
   Google Scholar
• Kathuria H, Nguyen DT, Handral HK, et al. Proposome for transdermal delivery of tofacitinib. Int J Pharm. 2020;585:119558.
   PubMed Web of Science ®Google Scholar
• Beg S, Jain S, Kushwah V, et al. Novel surface-engineered solid lipid nanoparticles of rosuvastatin calcium for low-density lipoprotein-receptor targeting: a quality by design-driven perspective. Nanomedicine. 2017;12(4):333–356.
   PubMed Web of Science ®Google Scholar
• Beg S, Rahman M, Swain S. Quality by design applications in pharmaceutical product development. Pharma Focus Asia. 2020;38:1–5.
   Google Scholar
• Nastiti CM, Ponto T, Abd E, et al. Topical nano and microemulsions for skin delivery. Pharmaceutics. 2017;9(4):37.
   PubMed Web of Science ®Google Scholar
• Campani V, Biondi M, Mayol L, et al. Development of NE for topical delivery of vitamin K1. Int J Pharm. 2016;511(1):170–177.
   PubMed Web of Science ®Google Scholar
• Hamed R, Basil M, AlBaraghthi T, et al. Nanoemulsion-based gel formulation of diclofenac diethylamine: design, optimization, rheological behavior and in vitro diffusion studies. Pharm Dev Technol. 2016;21(8):980–989.
   PubMed Web of Science ®Google Scholar
• Savale SK. Design and development of curcumin nanoemulsion by applying centre composite rotable design response surface model (CCRD-RSM). Asian J Res Biol Pharm Sci. 2017;5(3):96–104.
   Google Scholar
• Beg S, Rahman M, Kohli K. Quality-by-design approach as a systematic tool for the development of nanopharmaceutical products. Drug Discov Today. 2019;24(3):717–725.
   PubMed Web of Science ®Google Scholar
• Singh A, Vaish A, Shukla R. Box–Behnken design optimized silibinin loaded glycerylmonooleate nanoliquid crystal for brain targeting. Chem Phys Lipids. 2022;244:105193.
   PubMed Web of Science ®Google Scholar
• Teng F, He M, Xu J, et al. Effect of ultrasonication on the stability and storage of a soy protein isolate-phosphatidylcholine NE. Sci Rep. 2020;10(1):1–9.
   PubMed Web of Science ®Google Scholar
• Song H, Liu C, Ruan J, et al. Effect of the combination of permeation enhancer and ion-pairs strategies on transdermal delivery of tofacitinib. Int J Pharm. 2022;611:121190.
   PubMedGoogle Scholar
• Gharibzahedi SM, Jafari SM. Fabrication of nanoemulsions by ultrasonication. In: Jafari SM, McClements DJ, editors. Nanoemulsions. Academic Press; 2018. p. 233–285.
   Google Scholar
• Choudhury H, Gorain B, Pandey M, et al. Recent update on NEG as topical drug delivery system. J Pharm Sci. 2017;106(7):1736–1751.
   PubMed Web of Science ®Google Scholar
• Arora R, Aggarwal G, Harikumar S, et al. Nanoemulsion based hydrogel for enhanced transdermal delivery of ketoprofen. Adv Pharm. 2014;2014:1–12.
   Google Scholar
• Najafi-Taher R, Ghaemi B, Amani A. Delivery of adapalene using a novel topical gel based on tea tree oil nano-emulsion: permeation, antibacterial and safety assessments. Eur J Pharm Sci. 2018;120:142–151.
   PubMed Web of Science ®Google Scholar
• Bhattacharya S, Prajapati BG. Formulation and optimization of celecoxib NEG. Asian J Pharm Clin Res. 2017;10(8):353–356.
   Google Scholar
• Srivastava M, Kohli K, Ali M. Formulation development of novel in situ nanoemulgel (NEG) of ketoprofen for the treatment of periodontitis. Drug Deliv. 2016;23(1):154–166.
   PubMed Web of Science ®Google Scholar
• Yeo E, Chieng CJY, Choudhury H, et al. Tocotrienols-rich naringenin NEG for the management of diabetic wound: fabrication, characterization and comparative in vitro evaluations. Curr Res Pharmacol Drug Discov. 2021;2:100019.
   PubMedGoogle Scholar
• Diwan R, Ravi PR, Pathare NS, et al. Pharmacodynamic, pharmacokinetic and physical characterization of cilnidipine loaded solid lipid nanoparticles for oral delivery optimized using the principles of design of experiments. Colloids Surf B. 2020;193:111073.
   PubMed Web of Science ®Google Scholar
• Eid AM, Elmarzugi NA, Jaradat NA. Influence of sonication and in vitro evaluation of nifedipine self-nanoemulsifying drug delivery system. Braz J Pharm Sci. 2019;55.
   Google Scholar
• Ahmad J, Gautam A, Komath S, et al. Topical nano-emulgel for skin disorders: formulation approach and characterization. Recent Pat Antiinfect Drug Discov. 2019;14(1):36–48.
   PubMedGoogle Scholar
• Ghica M, Hîrjău M, Lupuleasa D, et al. Flow and thixotropic parameters for rheological characterization of hydrogels. Molecules. 2016;21(6):786.
   PubMed Web of Science ®Google Scholar
• Diwan R, Khan S, Ravi PR. Comparative study of cilnidipine loaded PLGA nanoparticles: process optimization by DoE, physico-chemical characterization and in vivo evaluation. Drug Deliv Transl Res. 2020;10(5):1442–1458.
   PubMed Web of Science ®Google Scholar
• Narala A, Guda S, Veerabrahma K. Lipid NE of rebamipide: formulation, characterization, and in vivo evaluation of pharmacokinetic and pharmacodynamic effects. AAPS PharmSciTech. 2019;20(1):1–9.
   Web of Science ®Google Scholar
• Siddiqui B, Rehman AU, Haq I-U, et al. Development, optimisation, and evaluation of nanoencapsulated diacerein emulgel for potential use in osteoarthritis. J Microencapsul. 2020;37(8):595–608.
   PubMed Web of Science ®Google Scholar
• Costa P, Lobo JMS. Modeling and comparison of dissolution profiles. Eur J Pharm Sci. 2001;13(2):123–133.
   PubMed Web of Science ®Google Scholar
• Gouda R, Baishya H, Qing Z. Application of mathematical models in drug release kinetics of carbidopa and levodopa ER tablets. J Dev Drugs. 2017;6(2):1–8.
   Google Scholar
• Sengupta P, Chatterjee B. Potential and future scope of NEG formulation for topical delivery of lipophilic drugs. Int J Pharm. 2017;526(1–2):353–365.
   PubMed Web of Science ®Google Scholar