Sirolimus-exuding core-shell nanofibers as an implantable carrier for breast cancer therapy: preparation, characterization, in vitro cell studies, and in vivo anti-tumor activity

References

• Lopes CM, Dourado A, Oliveira R. Phytotherapy and nutritional supplements on breast cancer. Biomed Res Int. 2017;2017:7207983.
   PubMed Web of Science ®Google Scholar
• Siegel RL, Miller KD, Fuchs HE, et al. Cancer statistics, 2021. CA A Cancer J Clin. 2021;71(1):7–33.
   PubMed Web of Science ®Google Scholar
• Pan H, Gray R, Braybrooke J, et al. 20-Year risks of breast-cancer recurrence after stopping endocrine therapy at 5 years. N Engl J Med. 2017;377(19):1836–1846.
   PubMed Web of Science ®Google Scholar
• Livshits Z, Rao RB, Smith SW. An approach to chemotherapy-associated toxicity. Emerg Med Clin North Am. 2014;32(1):167–203.
   PubMed Web of Science ®Google Scholar
• Belz JE, Kumar R, Baldwin P, et al. Sustained release talazoparib implants for localized treatment of BRCA1-deficient breast cancer. Theranostics. 2017;7(17):4340–4349.
   PubMed Web of Science ®Google Scholar
• Ahmed KK, Tamer MA, Ghareeb MM, et al. Recent advances in polymeric implants. AAPS PharmSciTech. 2019;20(7):300.
   PubMed Web of Science ®Google Scholar
• Leach DG, Young S, Hartgerink JD. Advances in immunotherapy delivery from implantable and injectable biomaterials. Acta Biomater. 2019;88:15–31.
   PubMed Web of Science ®Google Scholar
• Michalik T, Matkowski R, Biecek P, et al. Ultralow anterior resection with implantation of gentamicin-collagen sponge and no defunctioning stoma: anastomotic leakage and local cancer relapse. Radiol Oncol. 2019;53(1):77–84.
   PubMed Web of Science ®Google Scholar
• Sonvico F, Barbieri S, Colombo P, et al. Combined hyaluronate-based films loaded with pemetrexed and cisplatin for the treatment of malignant pleural mesothelioma: preliminary evaluation in an orthotopic tumor recurrence model. Eur J Pharm Sci. 2018;123:89–97.
   PubMed Web of Science ®Google Scholar
• Puente P, Fettig N, Luderer MJ, et al. Injectable hydrogels for localized chemotherapy and radiotherapy in brain tumors. J Pharm Sci. 2018;107(3):922–933.
   PubMed Web of Science ®Google Scholar
• Shen H, Gao Q, Ye Q, et al. Peritumoral implantation of hydrogel-containing nanoparticles and losartan for enhanced nanoparticle penetration and antitumor effect. Int J Nanomed. 2018;13:7409–7426.
   PubMed Web of Science ®Google Scholar
• Irani M, Sadeghi GMM, Haririan I. The sustained delivery of temozolomide from electrospun PCL-Diol-b-PU/gold nanocompsite nanofibers to treat glioblastoma tumors. Mater Sci Eng C Mater Biol Appl. 2017;75:165–174.
   PubMed Web of Science ®Google Scholar
• Padmakumar S, Menon D. Nanofibrous polydioxanone depots for prolonged intraperitoneal paclitaxel delivery. Curr Drug Deliv. 2019;16(7):654–662.
   PubMed Web of Science ®Google Scholar
• Contreras-Cáceres R, Cabeza L, Perazzoli G, et al. Electrospun nanofibers: recent applications in drug delivery and cancer therapy. Nanomaterials. 2019;9(4):656.
   Web of Science ®Google Scholar
• Rasouli R, Barhoum A, Bechelany M, et al. Nanofibers for biomedical and healthcare applications. Macromol Biosci. 2019;19(2):e1800256.
   PubMed Web of Science ®Google Scholar
• Luo H, Jie T, Zheng L, et al. Electrospun nanofibers for cancer therapy. Adv Exp Med Biol. 2021;1295:163–190.
   PubMed Web of Science ®Google Scholar
• Kaplan JA, Liu R, Freedman JD, et al. Prevention of lung cancer recurrence using cisplatin-loaded superhydrophobic nanofiber meshes. Biomaterials. 2016;76:273–281.
   PubMed Web of Science ®Google Scholar
• Liu S, Wang X, Zhang Z, et al. Use of asymmetric multilayer polylactide nanofiber mats in controlled release of drugs and prevention of liver cancer recurrence after surgery in mice. Nanomedicine. 2015;11(5):1047–1056.
   PubMed Web of Science ®Google Scholar
• Pant B, Park M, Park SJ. Drug delivery applications of core-sheath nanofibers prepared by coaxial electrospinning: a review. Pharmaceutics. 2019;11(7):305.
   PubMed Web of Science ®Google Scholar
• Yoon J, Yang HS, Lee BS, et al. Recent progress in coaxial electrospinning: new parameters, various structures, and wide applications. Adv Mater. 2018;30(42):e1704765.
   PubMed Web of Science ®Google Scholar
• Li J, Liu Y, Abdelhakim HE. Drug delivery applications of coaxial electrospun nanofibres in cancer therapy. Molecules. 2022;27(6):1803.
   PubMed Web of Science ®Google Scholar
• Chen X, Li H, Lu W, et al. Antibacterial porous coaxial drug-carrying nanofibers for sustained drug-releasing applications. Nanomaterials. 2021;11(5):1316.
   Web of Science ®Google Scholar
• Sultanova Z, Kaleli G, Kabay G, et al. Controlled release of a hydrophilic drug from coaxially electrospun polycaprolactone nanofibers. Int J Pharm. 2016;505(1-2):133–138.
   PubMed Web of Science ®Google Scholar
• Zupančič Š, Sinha-Ray S, Sinha-Ray S, et al. Controlled release of ciprofloxacin from core-shell nanofibers with monolithic or blended core. Mol Pharm. 2016;13(4):1393–1404.
   PubMed Web of Science ®Google Scholar
• Xu H, Xu X, Li S, et al. The effect of drug heterogeneous distributions within core-sheath nanostructures on its sustained release profiles. Biomolecules. 2021;11(9):1330.
   PubMed Web of Science ®Google Scholar
• Gu J, Yagi S, Meng J, et al. High-efficiency production of core-sheath nanofiber membrane via co-axial electro-centrifugal spinning for controlled drug release. J Membr Sci. 2022;654:120571.
   Web of Science ®Google Scholar
• Siddiqui N, Asawa S, Birru B, et al. PCL-Based composite scaffold matrices for tissue engineering applications. Mol Biotechnol. 2018;60(7):506–532.
   PubMed Web of Science ®Google Scholar
• Nejati-Koshki K, Pilehvar-Soltanahmadi Y, Alizadeh E, et al. Development of emu oil-loaded PCL/collagen bioactive nanofibers for proliferation and stemness preservation of human adipose-derived stem cells: possible application in regenerative medicine. Drug Dev Ind Pharm. 2017;43(12):1978–1988.
   PubMed Web of Science ®Google Scholar
• Haeri A, Osouli M, Bayat F, et al. Nanomedicine approaches for sirolimus delivery: a review of pharmaceutical properties and preclinical studies. Artif Cells Nanomed Biotechnol. 2018;46(sup1):1–14.
   PubMed Web of Science ®Google Scholar
• Law BK. Rapamycin: an anti-cancer immunosuppressant? Crit Rev Oncol Hematol. 2005;56(1):47–60.
   PubMed Web of Science ®Google Scholar
• Hare SH, Harvey AJ. mTOR function and therapeutic targeting in breast cancer. Am J Cancer Res. 2017;7(3):383–404.
   PubMed Web of Science ®Google Scholar
• Chaoul N, Fayolle C, Desrues B, et al. Rapamycin impairs antitumor CD8+ T-cell responses and vaccine-induced tumor eradication. Cancer Res. 2015;75(16):3279–3291.
   PubMed Web of Science ®Google Scholar
• Ohkawa K, Cha D, Kim H, et al. Electrospinning of chitosan. Macromol Rapid Commun. 2004;25(18):1600–1605.
   Web of Science ®Google Scholar
• Azouz L, Dahmoune F, Rezgui F, et al. Full factorial design optimization of anti-inflammatory drug release by PCL-PEG-PCL microspheres. Mater Sci Eng C Mater Biol Appl. 2016;58:412–419.
   PubMed Web of Science ®Google Scholar
• Tavares MR, Menezes L, Dutra Filho JC, et al. Surface-coated polycaprolactone nanoparticles with pharmaceutical application: structural and molecular mobility evaluation by TD-NMR. Polym Test. 2017;60:39–48.
   Web of Science ®Google Scholar
• França D, Medina ÂF, Messa LL, et al. Chitosan spray-dried microcapsule and microsphere as fertilizer host for swellable - controlled release materials. Carbohydr Polym. 2018;196:47–55.
   PubMed Web of Science ®Google Scholar
• Liu DQ, Cheng ZQ, Feng QJ, et al. Polycaprolactone nanofibres loaded with 20(S)-protopanaxadiol for in vitro and in vivo anti-tumour activity study. R Soc Open Sci. 2018;5(5):180137.
   PubMed Web of Science ®Google Scholar
• Hassan MI, Sultana N. Characterization, drug loading and antibacterial activity of nanohydroxyapatite/polycaprolactone (nHA/PCL) electrospun membrane. 3 Biotech. 2017;7(4):249.
   PubMedGoogle Scholar
• Falamarzpour P, Behzad T, Zamani A. Preparation of nanocellulose reinforced chitosan films, cross-linked by adipic acid. IJMS. 2017;18(2):396.
   Google Scholar
• Kumar D, Pandey J, Kumar P. Synthesis and characterization of modified chitosan via microwave route for novel antibacterial application. Int J Biol Macromol. 2018;107(Pt B):1388–1394.
   PubMedGoogle Scholar
• Devi N, Dutta J. Preparation and characterization of chitosan-bentonite nanocomposite films for wound healing application. Int J Biol Macromol. 2017;104(Pt B):1897–1904.
   PubMedGoogle Scholar
• Rasib SZM, Ahmad Z, Khan A, et al. Synthesis and evaluation on pH- and temperature-responsive chitosan-p(MAA-co-NIPAM) hydrogels. Int J Biol Macromol. 2018;108:367–375.
   PubMed Web of Science ®Google Scholar
• Kajdič S, Planinšek O, Gašperlin M, et al. Electrospun nanofibers for customized drug-delivery systems. J Drug Delivery Sci Technol. 2019;51:672–681.
   Web of Science ®Google Scholar
• Han D, Sasaki M, Yoshino H, et al. In-vitro evaluation of MPA-loaded electrospun coaxial fiber membranes for local treatment of glioblastoma tumor cells. J Drug Delivery Sci Technol. 2017;40:45–50.
   Web of Science ®Google Scholar
• Bazzazzadeh A, Dizaji BF, Kianinejad N, et al. Fabrication of poly(acrylic acid) grafted-chitosan/polyurethane/magnetic MIL-53 metal organic framework composite core-shell nanofibers for co-delivery of temozolomide and paclitaxel against glioblastoma cancer cells. Int J Pharm. 2020;587:119674.
   PubMed Web of Science ®Google Scholar
• Acevedo F, Hermosilla J, Sanhueza C, et al. Gallic acid loaded PEO-core/zein-shell nanofibers for chemopreventive action on gallbladder cancer cells. Eur J Pharm Sci. 2018;119:49–61.
   PubMed Web of Science ®Google Scholar
• Zhu LF, Zheng Y, Fan J, et al. A novel core-shell nanofiber drug delivery system intended for the synergistic treatment of melanoma. Eur J Pharm Sci. 2019;137:105002.
   PubMed Web of Science ®Google Scholar
• Qasim SB, Zafar MS, Najeeb S, et al. Electrospinning of chitosan-based solutions for tissue engineering and regenerative medicine. IJMS. 2018;19(2):407.
   Google Scholar
• Chen Y-P, Liu H-Y, Liu Y-W, et al. Determination of electrospinning parameters’ strength in poly (D, L)-lactide-co-glycolide micro/nanofiber diameter tailoring. J Nanomater. 2019;2019:1–8.
   Web of Science ®Google Scholar
• Afshar S, Rashedi S, Nazockdast H, et al. Preparation and characterization of electrospun poly(lactic acid)-chitosan (core-shell) nanofibers with a new solvent system. Int J Biol Macromol. 2019;138:1130–1137.
   PubMed Web of Science ®Google Scholar
• Pakravan M, Heuzey MC, Ajji A. Core-shell structured PEO-chitosan nanofibers by coaxial electrospinning. Biomacromolecules. 2012;13(2):412–421.
   PubMed Web of Science ®Google Scholar
• Li T, Tian L, Liao S, et al. Fabrication, mechanical property and in vitro evaluation of poly (L-lactic acid-co-epsilon-caprolactone) core-shell nanofiber scaffold for tissue engineering. J Mech Behav Biomed Mater. 2019;98:48–57.
   PubMed Web of Science ®Google Scholar
• He M, Jiang H, Wang R, et al. Fabrication of metronidazole loaded poly (epsilon-caprolactone)/zein core/shell nanofiber membranes via coaxial electrospinning for guided tissue regeneration. J Colloid Interface Sci. 2017;490:270–278.
   PubMed Web of Science ®Google Scholar
• Zargarian SS, Haddadi-Asl V. Surfactant-assisted water exposed electrospinning of novel super hydrophilic polycaprolactone based fibers. Artif Cells Nanomed Biotechnol. 2017;45(5):871–880.
   PubMed Web of Science ®Google Scholar
• Suri R, Neupane YR, Mehra N, et al. Sirolimus loaded chitosan functionalized poly (lactic-co-glycolic acid) (PLGA) nanoparticles for potential treatment of age-related macular degeneration. Int J Biol Macromol. 2021;191:548–559.
   PubMed Web of Science ®Google Scholar
• Sedghi R, Shaabani A, Sayyari N. Electrospun triazole-based chitosan nanofibers as a novel scaffolds for bone tissue repair and regeneration. Carbohydr Polym. 2020;230:115707.
   PubMed Web of Science ®Google Scholar
• Zhang M, Li Z, Liu L, et al. Preparation and characterization of vancomycin-loaded electrospun rana chensinensis skin collagen/poly (L-lactide) nanofibers for drug delivery. J Nanomater. 2016;2016:1–8.
   Web of Science ®Google Scholar
• Mao Z, Li J, Huang W, et al. Preparation of poly (lactic acid)/graphene oxide nanofiber membranes with different structures by electrospinning for drug delivery. RSC Adv. 2018;8(30):16619–16625.
   PubMed Web of Science ®Google Scholar
• Abid S, Hussain T, Raza ZA, et al. Current applications of electrospun polymeric nanofibers in cancer therapy. Mater Sci Eng C Mater Biol Appl. 2019;97:966–977.
   PubMed Web of Science ®Google Scholar
• He M, Xue J, Geng H, et al. Fibrous guided tissue regeneration membrane loaded with anti-inflammatory agent prepared by coaxial electrospinning for the purpose of controlled release. Appl Surf Sci. 2015;335:121–129.
   Web of Science ®Google Scholar
• Shamsipour M, Mansouri AM, Moradipour P. Temozolomide conjugated carbon quantum dots embedded in core/shell nanofibers prepared by coaxial electrospinning as an implantable delivery system for cell imaging and sustained drug release. AAPS PharmSciTech. 2019;20(7):259.
   PubMed Web of Science ®Google Scholar
• Guimarães PP, Oliveira MF, Gomes AD, et al. PLGA nanofibers improves the antitumoral effect of daunorubicin. Colloids Surf B Biointerfaces. 2015;136:248–255.
   PubMed Web of Science ®Google Scholar
• Guo G, Fu S, Zhou L, et al. Preparation of curcumin loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) nanofibers and their in vitro antitumor activity against glioma 9L cells. Nanoscale. 2011;3(9):3825–3832.
   PubMed Web of Science ®Google Scholar
• Amna T, Barakat NA, Hassan MS, et al. Camptothecin loaded poly (ε-caprolactone) nanofibers via one-step electrospinning and their cytotoxicity impact. Colloids Surf A. 2013;431:1–8.
   Google Scholar
• Li J, Xu W, Li D, et al. Locally deployable nanofiber patch for sequential drug delivery in treatment of primary and advanced orthotopic hepatomas. ACS Nano. 2018;12(7):6685–6699.
   PubMed Web of Science ®Google Scholar
• Liu R, Wolinsky JB, Walpole J, et al. Prevention of local tumor recurrence following surgery using low-dose chemotherapeutic polymer films. Ann Surg Oncol. 2010;17(4):1203–1213.
   PubMed Web of Science ®Google Scholar
• Boedtkjer E, Pedersen SF. The acidic tumor microenvironment as a driver of cancer. Annu Rev Physiol. 2020;82:103–126.
   PubMed Web of Science ®Google Scholar
• Yang GG, Zhang H, Zhang DY, et al. Cancer-specific chemotherapeutic strategy based on the vitamin K3 mediated ROS regenerative feedback and visualized drug release in vivo. Biomaterials. 2018;185:73–85.
   PubMed Web of Science ®Google Scholar
• Eloy JO, Petrilli R, Topan JF, et al. Co-loaded paclitaxel/rapamycin liposomes: development, characterization and in vitro and in vivo evaluation for breast cancer therapy. Colloids Surf B Biointerfaces. 2016;141:74–82.
   PubMed Web of Science ®Google Scholar
• Cui N, Hu M, Khalil RA. Biochemical and biological attributes of matrix metalloproteinases. Prog Mol Biol Transl Sci. 2017;147:1–73.
   PubMed Web of Science ®Google Scholar
• Gialeli C, Theocharis AD, Karamanos NK. Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting. FEBS J. 2011;278(1):16–27.
   PubMed Web of Science ®Google Scholar
• Roomi MW, Monterrey JC, Kalinovsky T, et al. Patterns of MMP-2 and MMP-9 expression in human cancer cell lines. Oncol Rep. 2009;21(5):1323–1333.
   PubMed Web of Science ®Google Scholar