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Research Articles

Curcumin-loaded microemulsion: formulation, characterization, and in vitro skin penetration

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Pages 42-51 | Received 05 Aug 2022, Accepted 07 Dec 2022, Published online: 03 Mar 2023

References

  • Heger M, van Golen RF, Broekgaarden M, et al. The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer. Pharmacol Rev. 2014;66(1):222–307.
  • Hatcher H, Planalp R, Cho J, et al. Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci. 2008;65(11):1631–1652.
  • Schallreuter KU, Rokos H. Turmeric (curcumin): a widely used curry ingredient, can contribute to oxidative stress in Asian patients with acute vitiligo. Indian J Dermatol Venereol Leprol. 2006;72(1):57–59.
  • Iriventi P, Gupta N. Topical delivery of curcumin and caffeine mixture-loaded nanostructured lipid carriers for effective treatment of psoriasis. Pharmacogn Mag. 2020;16:S206–S217.
  • Feng T, Wei Y, Lee RJ, et al. Liposomal curcumin and its application in cancer. Int J Nanomedicine. 2017;12:6027–6044.
  • Tomeh M, Hadianamrei R, Zhao X. A review of curcumin and its derivatives as anticancer agents. Int J Mol Sci. 2019;20(5):1033.
  • González-Albadalejo J, Sanz D, Claramunt RM, et al. Curcumin and curcuminoids: chemistry, structural studies and biological properties. An R Acad Farm. 2015;81(4):278–310.
  • Yixuan L, Qaria MA, Sivasamy S, et al. Curcumin production and bioavailability: a comprehensive review of the curcumin extraction, synthesis, biotransformation and delivery systems. Ind Crops Prod. 2021;172:114050, 1–20.
  • Xie X, Tao Q, Zou Y, et al. PLGA nanoparticles improve the oral bioavailability of curcumin in rats: characterizations and mechanisms. J Agric Food Chem. 2011;59(17):9280–9289.
  • Amuti A, Wang X, Zan M, et al. Formulation and characterization of curcumin-loaded microemulsions: evaluation of antioxidant stability and in vitro release. J Mol Liq. 2021;336:116881, 1–8.
  • Bergonzi MC, Hamdouch R, Mazzacuva F, et al. Optimization, characterization and in vitro evaluation of curcumin microemulsions. LWT. 2014;59:148–155.
  • Sintov AC. Transdermal delivery of curcumin via microemulsion. Int J Pharm. 2015;481(1–2):97–103.
  • Zainuddin N, Ahmad I, Zulfakar MH, et al. Cetyltrimethylammonium bromide-nanocrystalline cellulose (CTAB-NCC) based microemulsions for enhancement of topical delivery of curcumin. Carbohydr Polym. 2021;254:117401.
  • Carlucci A, Vidal MC, Bregni C. Las microemulsiones como vehículos Para administración de drogas. Acta Farm Bonaerense. 2004;23(4):550–557.
  • Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev. 2000;45(1):89–121.
  • Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm Res. 1995;12(11):1561–1572.
  • Liu C-H, Chang F-Y, Hung D-K. Terpene microemulsions for transdermal curcumin delivery: effects of terpenes and cosurfactants. Colloids Surf B Biointerfaces. 2011;82(1):63–70.
  • Tashtoush BM, Bennamani AN, Al-Taani BM. Preparation and characterization of microemulsion formulations of nicotinic acid and its prodrugs for transdermal delivery. Pharm Dev Technol. 2013;18(4):834–843.
  • Mexicana NO, Ssa1-2015 NOM-073. Estabilidad de fármacos y medicamentos, así como de remedios herbolarios, diario oficial de la federación [Official mexican standard NOM-073-SSA1-2015, stability of drugs and medications, as well as herbal remedies]. Official Journal of the Federation. 2016. https://dof.gob.mx/nota_detalle.php?codigo=5440183&fecha=07/06/2016#gsc.tab=0
  • Ben-Zichri S, Kolusheva S, Danilenko M, et al. Cardiolipin mediates curcumin interactions with mitochondrial membranes. Biochim Biophys Acta Biomembr. 2019;1861(1):75–82.
  • Tønnesen HH, Másson M, Loftsson T. Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: solubility, chemical and photochemical stability. Int J Pharm. 2002;244(1-2):127–135.
  • Yamashita F, Koyama Y, Kitano M, et al. Analysis of in vivo skin penetration enhancement by oleic acid based on a two-layer diffusion model with polar and nonpolar routes in the stratum corneum. Int J Pharm. 1995;117:173–179.
  • Ganem-Quintanar A, Lafforgue C, Falson-Rieg F, et al. Evaluation of the transepidermal permeation of diethylene glycol monoethyl ether and skin water loss. Int J Pharm. 1997;147(2):165–171.
  • Mura P, Faucci MT, Bramanti G, et al. Evaluation of transcutol as a clonazepam transdermal permeation enhancer from hydrophilic gel formulations. Eur J Pharm Sci. 2000;9(4):365–372.
  • Kajbafvala A, Salabat A, Salimi A. Formulation, characterization, and in vitro/ex vivo evaluation of quercetin-loaded microemulsion for topical application. Pharm Dev Technol. 2018;23(8):741–750.
  • Hathout RM, Nasr M. Transdermal delivery of betahistine hydrochloride using microemulsions: physical characterization, biophysical assessment, confocal imaging and permeation studies. Colloids Surf B. 2013;110:254–260.
  • Ramírez-Navas JS. Introducción a la reología de los alimentos. Revista ReCiTeIA. 2006;6(1):1–46.
  • Liu C-H, Chang F-Y. Development and characterization of eucalyptol microemulsions for topic delivery of curcumin. Chem Pharm Bull. 2011;59(2):172–178.
  • Fanun M, editor. Microemulsions: properties and applications. Vol. 144, Surfactant science series. Boca Raton: CRC Press, Taylor & Francis Group; 2009. p. 560.
  • Arpornpong N, Attaphong C, Charoensaeng A, et al. Ethanol-in-palm oil/diesel microemulsion-based biofuel: phase behavior, viscosity, and droplet size. Fuel. 2014;132:101–106.
  • Dhingra D, Bisht M, Bhawna B, et al. Enhanced solubility and improved stability of curcumin in novel water-in-deep eutectic solvent microemulsions. J Mol Liq. 2021;339:117037.
  • Liu W, Pan N, Han Y, et al. Solubilization, stability and antioxidant activity of curcumin in a novel surfactant-free microemulsion system. LWT. 2021;147:111583.
  • Espinosa-Olivares MA, Delgado-Buenrostro NL, Chirino YI, et al. Nanostructured lipid carriers loaded with curcuminoids: physicochemical characterization, in vitro release, ex vivo skin penetration, stability and antioxidant activity. Eur J Pharm Sci. 2020;155:105533.
  • Kottmann J, Rey JM, Sigrist MW. Mid-Infrared photoacoustic detection of glucose in human skin: towards Non-Invasive diagnostics. Sensors. 2016;16(10):1663, 1–14.
  • Prince LM. Microemulsions versus micelles. J. Colloid Interface Sci. 1975;52(1):182–188.
  • Schmidts T, Dobler D, Nissing C, et al. Influence of hydrophilic surfactants on the properties of multiple W/O/W emulsions. J Colloid Interface Sci. 2009;338(1):184–192.
  • Szymczyk K. Comparative study of the physicochemical properties of aqueous solutions of the hydrocarbon and fluorocarbon surfactants and their ternary mixtures. Chem Phys. 2014;433:42–47.
  • Malik MA, Wani MY, Hashim MA. Microemulsion method: a novel route to synthesize organic and inorganic nanomaterials. Arab J Chem. 2012;5(4):397–417.
  • Zhang H, Taxipalati M, Que F, et al. Microstructure characterization of a food-grade U-type microemulsion system by differential scanning calorimetry and electrical conductivity techniques. Food Chem. 2013;141(3):3050–3055.
  • Godin B, Touitou E. Transdermal skin delivery: predictions for humans from in vivo, ex vivo and animal models. Adv Drug Deliv Rev. 2007;59(11):1152–1161.
  • Silva Garcia Praca F, Silva Garcia Medina W, Eloy JO, et al. Evaluation of critical parameters for in vitro skin permeation and penetration studies using animal skin models. Eur J Pharm Sci. 2018;111:121–132.
  • Shukla T, Upmanyu N, Agrawal M, et al. Biomedical applications of microemulsion through dermal and transdermal route. Biomed Pharmacother. 2018;108:1477–1494.
  • Machado M, Lima Dantas I, Gouveia Galvao J, et al. Microemulsion systems to enhance the transdermal permeation of ivermectin in dogs: a preliminary in vitro study. Res Vet Sci. 2020;133:31–38.
  • Alonso C, Collini I, Carrer V, et al. Permeation kinetics of active drugs through lanolin-based artificial membranes. Colloids Surf B. 2020;192:111024.

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