Mass Spectrometry, Review of the Basics: Ionization

References

• Wood, M., Laloup, M., Samyn, N., del Mar Ramirez Fernandez, M., de Bruijn, E.A., Maes, R.A., and De Boeck, G. (2006) Recent applications of liquid chromatography–mass spectrometry in forensic science. J. Chrom., 1130: 3–15.
   PubMed Web of Science ®Google Scholar
• Ojanperä, I., Kolmonen, M., and Pelander, A. (2012) Current use of high-resolution mass spectrometry in drug screening relevant to clinical and forensic toxicology and doping control. Anal. Bioanal. Chem., 403: 1203–1220.
   PubMed Web of Science ®Google Scholar
• Peters, R., Stolker, A., Mol, J., Lommen, A., Lyris, E., Angelis, Y., Vonaparti, A., Stamou, M., Georgakopoulos, C., and Nielen, M. (2010) Screening in veterinary drug analysis and sports doping control based on full-scan, accurate-mass spectrometry. TrAC: Trends in Analytical Chemistry, 29: 1250–1268.
   Web of Science ®Google Scholar
• Gan, H.-H., Soukoulis, C., and Fisk, I. (2014) Atmospheric pressure chemical ionisation mass spectrometry analysis linked with chemometrics for food classification–A case study: Geographical provenance and cultivar classification of monovarietal clarified apple juices. Food Chem., 146: 149–156.
   PubMed Web of Science ®Google Scholar
• Vaclavik, L., Schreiber, A., Lacina, O., Cajka, T., and Hajslova, J. (2012) Liquid chromatography–mass spectrometry-based metabolomics for authenticity assessment of fruit juices. Metabolomics, 8: 793–803.
   Web of Science ®Google Scholar
• Hopfgartner, G., Tonoli, D., and Varesio, E. (2012) High-resolution mass spectrometry for integrated qualitative and quantitative analysis of pharmaceuticals in biological matrices. Anal. Bioanal. Chem., 402: 2587–2596.
   PubMed Web of Science ®Google Scholar
• Persike, M. and Karas, M. (2009) Rapid simultaneous quantitative determination of different small pharmaceutical drugs using a conventional matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry system. Rapid Comm. Mass Spectrom., 23: 3555–3562.
   PubMed Web of Science ®Google Scholar
• El-Aneed, A., Cohen, A., and Banoub, J. (2009) Mass spectrometry, review of the basics: electrospray, MALDI, and commonly used mass analyzers. Appl. Spectros. Rev., 44: 210–230.
   Web of Science ®Google Scholar
• Donkuru, M., Chitanda, J.M., Verrall, R.E., and El‐Aneed, A. (2014) Multi‐stage tandem mass spectrometric analysis of novel β‐cyclodextrin‐substituted and novel bis‐pyridinium gemini surfactants designed as nanomedical drug delivery agents. Rapid Comm. Mass Spectrom., 28: 757–772.
   PubMed Web of Science ®Google Scholar
• Buse, J., Badea, I., Verrall, R.E., and El‐Aneed, A. (2011) Tandem mass spectrometric analysis of novel diquaternary ammonium gemini surfactants and their bromide adducts in electrospray‐positive ion mode ionization. J. Mass Spectrom., 46: 1060–1070.
   PubMed Web of Science ®Google Scholar
• Elias, J.E., Haas, W., Faherty, B.K., and Gygi, S.P. (2005) Comparative evaluation of mass spectrometry platforms used in large-scale proteomics investigations. Nature Methods, 2: 667–675.
   PubMed Web of Science ®Google Scholar
• Glauser, G., Veyrat, N., Rochat, B., Wolfender, J.-L., and Turlings, T.C. (2013) Ultra-high pressure liquid chromatography–mass spectrometry for plant metabolomics: a systematic comparison of high-resolution quadrupole-time-of-flight and single stage Orbitrap mass spectrometers. J. Chrom., 1292: 151–159.
   PubMed Web of Science ®Google Scholar
• Buse, J., Purves, R.W., Verrall, R.E., Badea, I., Zhang, H., Mulligan, C.C., Peru, K.M., Bailey, J., Headley, J.V., and El-Aneed, A. (2014) The development and assessment of high-throughput mass spectrometry–based methods for the quantification of a nanoparticle drug delivery agent in cellular lysate. J. Mass Spectrom. (in press).
   Google Scholar
• Nordström, A., Want, E., Northen, T., Lehtiö, J., and Siuzdak, G. (2008) Multiple ionization mass spectrometry strategy used to reveal the complexity of metabolomics. Anal. Chem., 80: 421–429.
   PubMed Web of Science ®Google Scholar
• Wiseman, J.M., Ifa, D.R., Song, Q., and Cooks, R.G. (2006) Tissue imaging at atmospheric pressure using desorption electrospray ionization (DESI) mass spectrometry. Angew. Chem. Int. Ed., 45: 7188–7192.
   PubMed Web of Science ®Google Scholar
• Bunch, J., Clench, M.R., and Richards, D.S. (2004) Determination of pharmaceutical compounds in skin by imaging matrix‐assisted laser desorption/ionisation mass spectrometry. Rapid Comm. Mass Spectrom., 18: 3051–3060.
   PubMed Web of Science ®Google Scholar
• Fenn, J.B., Mann, M., Meng, C.K., Wong, S.F., and Whitehouse, C.M. (1989) Electrospray ionization for mass spectrometry of large biomolecules. Science, 246: 64–71.
   PubMed Web of Science ®Google Scholar
• Mann, M., Meng, C.K., and Fenn, J.B. (1989) Interpreting mass spectra of multiply charged ions. Anal. Chem., 61: 1702–1708.
   Web of Science ®Google Scholar
• Horning, E., Horning, M., Carroll, D., Dzidic, I., and Stillwell, R. (1973) New picogram detection system based on a mass spectrometer with an external ionization source at atmospheric pressure. Anal. Chem., 45: 936–943.
   Web of Science ®Google Scholar
• Carroll, D., Dzidic, I., Stillwell, R., Haegele, K., and Horning, E. (1975) Atmospheric pressure ionization mass spectrometry. Corona discharge ion source for use in a liquid chromatograph–mass spectrometer–computer analytical system. Anal. Chem., 47: 2369–2373.
   Web of Science ®Google Scholar
• Robb, D.B., Covey, T.R., and Bruins, A.P. (2000) Atmospheric pressure photoionization: an ionization method for liquid chromatography–mass spectrometry. Anal. Chem., 72: 3653–3659.
   PubMed Web of Science ®Google Scholar
• Karas, M., Bachmann, D., Bahr, U., and Hillenkamp, F. (1987) Matrix-assisted ultraviolet laser desorption of non-volatile compounds. Int. J. Mass Spectrom. Ion Process., 78: 53–68.
   Web of Science ®Google Scholar
• Karas, M. and Hillenkamp, F. (1988) Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. Anal. Chem., 60: 2299–2301.
   PubMed Web of Science ®Google Scholar
• Domon, B. and Aebersold, R. (2006) Mass spectrometry and protein analysis. Science's STKE, 312: 212–217.
   Google Scholar
• Hoffmann, E. and Stroobant, V. (2007) Mass Spectrometry: Principles and Applications, 3rd ed. John Wiley: Chichester, West Sussex, UK.
   Google Scholar
• Weston, D.J. (2010) Ambient ionization mass spectrometry: current understanding of mechanistic theory; analytical performance and application areas. Analyst, 135: 661–668.
   PubMed Web of Science ®Google Scholar
• Ifa, D.R., Wu, C., Ouyang, Z., and Cooks, R.G. (2010) Desorption electrospray ionization and other ambient ionization methods: current progress and preview. Analyst, 135: 669–681.
   PubMed Web of Science ®Google Scholar
• Kebarle, P. and Verkerk, U.H. (2009) Electrospray: from ions in solution to ions in the gas phase, what we know now. Mass Spectrom. Rev., 28: 898–917.
   PubMed Web of Science ®Google Scholar
• Kebarle, P. (2000) A brief overview of the present status of the mechanisms involved in electrospray mass spectrometry. J. Mass Spectrom., 35: 804–817.
   PubMed Web of Science ®Google Scholar
• Cech, N.B. and Enke, C.G. (2002) Practical implications of some recent studies in electrospray ionization fundamentals. Mass Spectrom. Rev., 20: 362–387.
   Web of Science ®Google Scholar
• Iribarne, J.V. and Thomson, B.A. (1976) On the evaporation of small ions from charged droplets. J. Chem. Phys., 64, p. 2287.
   Web of Science ®Google Scholar
• Dole, M., Hines, R.L., Mack, L.L., Mobley, R.C., Ferguson, L.D., and Alice, M.B. (1968) Gas phase macroions. Macromolecules, 1: 96–97.
   Google Scholar
• Ekman, R., Silberring, J., Westman-Brinkmalm, A., and Kraj, A. (2008) Mass Spectrometry: Instrumentation, Interpretation, and Applications (A Mass Spectrometer's Building Blocks & Tandem Mass Spectrometry), vol. 50. Wiley: Hoboken, NJ.
   Google Scholar
• Annesley, T.M. (2003) Ion suppression in mass spectrometry. Clin. Chem., 49: 1041–1044.
   PubMed Web of Science ®Google Scholar
• King, R., Bonfiglio, R., Fernandez-Metzler, C., Miller-Stein, C., and Olah, T. (2000) Mechanistic investigation of ionization suppression in electrospray ionization. J. Am. Soc. Mass Spectrom., 11: 942–950.
   PubMed Web of Science ®Google Scholar
• Gosetti, F., Mazzucco, E., Zampieri, D., and Gennaro, M.C. (2010) Signal suppression/enhancement in high-performance liquid chromatography tandem mass spectrometry. J. Chrom., 1217: 3929–3937.
   PubMed Web of Science ®Google Scholar
• Van Eeckhaut, A., Lanckmans, K., Sarre, S., Smolders, I., and Michotte, Y. (2009) Validation of bioanalytical LC-MS/MS assays: evaluation of matrix effects. J. Chrom. B, 877: 2198–2207.
   PubMed Web of Science ®Google Scholar
• Chambers, E., Wagrowski-Diehl, D.M., Lu, Z., and Mazzeo, J.R. (2007) Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses. J. Chrom. B, 852: 22–34.
   PubMed Web of Science ®Google Scholar
• Hanold, K.A., Fischer, S.M., Cormia, P.H., Miller, C.E., and Syage, J.A. (2004) Atmospheric pressure photoionization. 1. General properties for LC/MS. Anal. Chem., 76: 2842–2851.
   PubMed Web of Science ®Google Scholar
• Wilm, M. and Mann, M. (1996) Analytical properties of the nanoelectrospray ion source. Anal. Chem., 68: 1–8.
   PubMed Web of Science ®Google Scholar
• Buse, J., Badea, I., Verrall, R.E., and El-Aneed, A. (2013) A general liquid chromatography tandem mass spectrometry method for the quantitative determination of diquaternary ammonium gemini surfactant drug delivery agents in mouse keratinocytes’ cellular lysate. J. Chrom., 1294: 98–105.
   PubMed Web of Science ®Google Scholar
• Wang, S., Cyronak, M., and Yang, E. (2007) Does a stable isotopically labeled internal standard always correct analyte response?: A matrix effect study on a LC/MS/MS method for the determination of carvedilol enantiomers in human plasma. J. Pharmaceut. Biomed. Anal., 43: 701–707.
   PubMed Web of Science ®Google Scholar
• Westman-Brinkmalm, A. and Brinkmalm, G. (2008) Mass spectrometry: instrumentation, interpretation, and applications. Ekman, R., Silberring, J., Westman-Brinkmalm, A., and Kraj, A. Eds. Wiley: Hoboken, NJ, 24–25.
   Google Scholar
• Liang, H., Foltz, R., Meng, M., and Bennett, P. (2003) Ionization enhancement in atmospheric pressure chemical ionization and suppression in electrospray ionization between target drugs and stable‐isotope‐labeled internal standards in quantitative liquid chromatography/tandem mass spectrometry. Rapid Comm. Mass Spectrom., 17: 2815–2821.
   PubMed Web of Science ®Google Scholar
• Souverain, S., Rudaz, S., and Veuthey, J.-L. (2004) Matrix effect in LC-ESI-MS and LC-APCI-MS with off-line and on-line extraction procedures. J. Chrom., 1058: 61–66.
   PubMed Web of Science ®Google Scholar
• Raffaelli, A. and Saba, A. (2003) Atmospheric pressure photoionization mass spectrometry. Mass Spectrom. Rev., 22: 318–331.
   PubMed Web of Science ®Google Scholar
• Smoker, M., Tran, K., and Smith, R.E. (2010) Determination of polycyclic aromatic hydrocarbons (PAHs) in shrimp. J. Agr. Food Chem., 58: 12101–12104.
   PubMed Web of Science ®Google Scholar
• Ghislain, T., Faure, P., and Michels, R. (2012) Detection and monitoring of PAH and Oxy-PAHs by high resolution mass spectrometry: comparison of ESI, APCI and APPI source detection. J. Am. Soc. Mass Spectrom., 23: 530–536.
   PubMed Web of Science ®Google Scholar
• Imbert, L., Gaudin, M., Libong, D., Touboul, D., Abreu, S., Loiseau, P.M., Laprévote, O., and Chaminade, P. (2012) Comparison of electrospray ionization, atmospheric pressure chemical ionization and atmospheric pressure photoionization for a lipidomic analysis of Leishmania donovani. J. Chrom., 1242: 75–83.
   PubMed Web of Science ®Google Scholar
• Keski‐Rahkonen, P., Huhtinen, K., Desai, R., Harwood, D.T., Handelsman, D.J., Poutanen, M., and Auriola, S. (2013) LC‐MS analysis of estradiol in human serum and endometrial tissue: comparison of electrospray ionization, atmospheric pressure chemical ionization and atmospheric pressure photoionization. J. Mass Spectrom., 48: 1050–1058.
   PubMed Web of Science ®Google Scholar
• Syage, J.A. (2004) Mechanism of [M+ H]+ formation in photoionization mass spectrometry. J. Am. Soc. Mass Spectrom., 15: 1521–1533.
   PubMed Web of Science ®Google Scholar
• Marotta, E., Seraglia, R., Fabris, F., and Traldi, P. (2003) Atmospheric pressure photoionization mechanisms: 1. The case of acetonitrile. Int. J. Mass Spectrom., 228: 841–849.
   Web of Science ®Google Scholar
• Stump, M.J., Fleming, R.C., Gong, W.H., Jaber, A.J., Jones, J.J., Surber, C.W., and Wilkins, C.L. (2002) Matrix-assisted laser desorption mass spectrometry. Appl. Spectros. Rev., 37: 275–303.
   Web of Science ®Google Scholar
• Hillenkamp, F. and Peter-Katalinić, J. (2007) MALDI MS. A Practical Guide to Instrumentation, Methods and Applications. Wiley-VCH Verlag GmbH & Co: Germany.
   Google Scholar
• Batoy, S.M.A.B., Akhmetova, E., Miladinovic, S., Smeal, J., and Wilkins, C.L. (2008) Developments in MALDI mass spectrometry: the quest for the perfect matrix. Appl. Spectros. Rev., 43: 485–550.
   Web of Science ®Google Scholar
• Knochenmuss, R. and Zenobi, R. (2003) MALDI ionization: the role of in-plume processes. Chem. Rev., 103: 441–452.
   PubMed Web of Science ®Google Scholar
• Knochenmuss, R. (2006) Ion formation mechanisms in UV-MALDI. Analyst, 131: 966–986.
   PubMed Web of Science ®Google Scholar
• Zenobi, R. and Knochenmuss, R. (1998) Ion formation in MALDI mass spectrometry. Mass Spectrom. Rev., 17: 337–366.
   Web of Science ®Google Scholar
• Cole, R.B. (2011) Electrospray and MALDI Mass Spectrometry: Fundamentals, Instrumentation, Practicalities, and Biological Applications, 2nd ed. Wiley: Hoboken, NJ.
   Google Scholar
• Zhang, C., Zhang, H., Litchfield, D.W., and Yeung, K.K.-C. (2010) CHCA or DHB? Systematic comparison of the two most commonly used matrices for peptide mass fingerprint analysis with MALDI MS. Spectroscopy. Available at: http://www.spectroscopyonline.com/spectroscopy/Feature/CHCA-or-DHB-Systematic-Comparison-of-the-Two-Most-/ArticleStandard/Article/detail/659272
   Google Scholar
• Karas, M., Glückmann, M., and Schäfer, J. (2000) Ionization in matrix‐assisted laser desorption/ionization: singly charged molecular ions are the lucky survivors. J. Mass Spectrom., 35: 1–12.
   PubMed Web of Science ®Google Scholar
• Jaskolla, T.W. and Karas, M. (2001) Compelling evidence for lucky survivor and gas phase protonation: the unified MALDI analyte protonation mechanism. J. Am. Soc. Mass Spectrom., 22: 976–988.
   Google Scholar
• Ouyang, Z. and Zhang, X. (2010) Ambient Mass Spectrometry. Analyst. 135: 659–660.
   Google Scholar
• Harris, G.A., Nyadong, L., and Fernandez, F.M. (2008) Recent developments in ambient ionization techniques for analytical mass spectrometry. Analyst, 133: 1297–1301.
   PubMed Web of Science ®Google Scholar
• Takats, Z., Wiseman, J.M., Gologan, B., and Cooks, R.G. (2004) Mass spectrometry sampling under ambient conditions with desorption electrospray ionization. Science, 306: 471–473.
   PubMed Web of Science ®Google Scholar
• Takats, Z., Wiseman, J.M., and Cooks, R.G. (2005) Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology. J. Mass Spectrom., 40: 1261–1275.
   PubMed Web of Science ®Google Scholar
• Bedair, M. and Sumner, L.W. (2008) Current and emerging mass-spectrometry technologies for metabolomics. TrAC: Trends in Analytical Chemistry, 27: 238–250.
   Web of Science ®Google Scholar
• Gobom, J., Nordhoff, E., Mirgorodskaya, E., Ekman, R., and Roepstorff, P. (1999) Sample purification and preparation technique based on nano‐scale reversed‐phase columns for the sensitive analysis of complex peptide mixtures by matrix‐assisted laser desorption/ionization mass spectrometry. J. Mass Spectrom., 34: 105–116.
   PubMed Web of Science ®Google Scholar
• Venter, A., Sojka, P.E., and Cooks, R.G. (2006) Droplet dynamics and ionization mechanisms in desorption electrospray ionization mass spectrometry. Anal. Chem., 78: 8549–8555.
   PubMed Web of Science ®Google Scholar
• Cooks, R.G., Ouyang, Z., Takats, Z., and Wiseman, J.M. (2006) Ambient mass spectrometry. Science, 311: 1566–1570.
   PubMed Web of Science ®Google Scholar
• Costa, A.B. and Cooks, R.G. (2008) Simulated splashes: elucidating the mechanism of desorption electrospray ionization mass spectrometry. Chem. Phys. Lett., 464: 1–8.
   Web of Science ®Google Scholar
• Gross, J.H. (2014) Direct analysis in real time—a critical review on DART-MS. Anal. Bioanal. Chem., 406: 63–80.
   PubMed Web of Science ®Google Scholar
• Talaty, N., Takáts, Z., and Cooks, R.G. (2005) Rapid in situ detection of alkaloids in plant tissue under ambient conditions using desorption electrospray ionization. Analyst, 130: 1624–1633.
   PubMed Web of Science ®Google Scholar
• Vismeh, R., Waldon, D.J., Teffera, Y., and Zhao, Z. (2012) Localization and quantification of drugs in animal tissues by use of desorption electrospray ionization mass spectrometry imaging. Anal. Chem., 84: 5439–5445.
   PubMed Web of Science ®Google Scholar
• Li, M., Chen, H., Yang, X., Chen, J., and Li, C. (2009) Direct quantification of organic acids in aerosols by desorption electrospray ionization mass spectrometry. Atmos. Environ., 43: 2717–2720.
   Web of Science ®Google Scholar
• Cotte-Rodríguez, I., Takáts, Z., Talaty, N., Chen, H., and Cooks, R.G. (2005) Desorption electrospray ionization of explosives on surfaces: sensitivity and selectivity enhancement by reactive desorption electrospray ionization. Anal. Chem., 77: 6755–6764.
   PubMed Web of Science ®Google Scholar
• Cotte-Rodríguez, I., Chen, H., and Cooks, R.G. (2006) Rapid trace detection of triacetone triperoxide (TATP) by complexation reactions during desorption electrospray ionization. Chem. Comm., (9): 953–955. doi: 10.1039/B515122H.
   PubMedGoogle Scholar
• Zhang, Y. and Chen, H. (2010) Detection of saccharides by reactive desorption electrospray ionization (DESI) using modified phenylboronic acids. Int. J. Mass Spectrom., 289: 98–107.
   Web of Science ®Google Scholar
• Huang, G., Chen, H., Zhang, X., Cooks, R.G., and Ouyang, Z. (2007) Rapid screening of anabolic steroids in urine by reactive desorption electrospray ionization. Anal. Chem., 79: 8327–8332.
   PubMed Web of Science ®Google Scholar
• Nyadong, L., Hohenstein, E.G., Johnson, K., Sherrill, C.D., Green, M.D., and Fernández, F.M. (2008) Desorption electrospray ionization reactions between host crown ethers and the influenza neuraminidase inhibitor oseltamivir for the rapid screening of Tamiflu®. Analyst, 133: 1513–1522.
   PubMed Web of Science ®Google Scholar
• Wu, C., Ifa, D.R., Manicke, N.E., and Cooks, R.G. (2009) Rapid, direct analysis of cholesterol by charge labeling in reactive desorption electrospray ionization. Anal. Chem., 81: 7618–7624.
   PubMed Web of Science ®Google Scholar
• Jackson, A.T., Williams, J.P., and Scrivens, J.H. (2006) Desorption electrospray ionisation mass spectrometry and tandem mass spectrometry of low molecular weight synthetic polymers. Rapid Comm. Mass Spectrom., 20: 2717–2727.
   PubMed Web of Science ®Google Scholar
• Song, Y. and Cooks, R.G. (2007) Reactive desorption electrospray ionization for selective detection of the hydrolysis products of phosphonate esters. J. Mass Spectrom., 42: 1086–1092.
   PubMed Web of Science ®Google Scholar
• Chen, H., Li, M., Zhang, Y.-P., Yang, X., Lian, J.-J., and Chen, J.-M. (2008) Rapid analysis of SVOC in aerosols by desorption electrospray ionization mass spectrometry. J. Am. Soc. Mass Spectrom., 19: 450–454.
   PubMed Web of Science ®Google Scholar
• Cody, R.B., Laramée, J.A., and Durst, H.D. (2005) Versatile new ion source for the analysis of materials in open air under ambient conditions. Anal. Chem., 77: 2297–2302.
   PubMed Web of Science ®Google Scholar
• Alberici, R.M., Simas, R.C., Sanvido, G.B., Romão, W., Lalli, P.M., Benassi, M., Cunha, I.B., and Eberlin, M.N. (2010) Ambient mass spectrometry: bringing MS into the “real world.” Anal. Bioanal. Chem., 398: 265–294.
   PubMed Web of Science ®Google Scholar
• Chernetsova, E.S. and Morlock, G.E. (2011) Ambient desorption ionization mass spectrometry (DART, DESI) and its bioanalytical applications. Bioanal. Rev., 3: 1–9.
   Google Scholar
• Nyadong, L., Harris, G.A., Balayssac, S., Galhena, A.S., Malet-Martino, M., Martino, R., Parry, R.M., Wang, M.D., Fern´ndez, F.M., and Gilard, V. (2009) Combining two-dimensional diffusion-ordered nuclear magnetic resonance spectroscopy, imaging desorption electrospray ionization mass spectrometry, and direct analysis in real-time mass spectrometry for the integral investigation of counterfeit pharmaceuticals. Anal. Chem., 81: 4803–4812.
   PubMed Web of Science ®Google Scholar
• Petucci, C., Diffendal, J., Kaufman, D., Mekonnen, B., Terefenko, G., and Musselman, B. (2007) Direct analysis in real time for reaction monitoring in drug discovery. Anal. Chem., 79: 5064–5070.
   PubMed Web of Science ®Google Scholar
• Morlock, G. and Ueda, Y. (2007) New coupling of planar chromatography with direct analysis in real time mass spectrometry. J. Chrom., 1143: 243–251.
   PubMed Web of Science ®Google Scholar
• Jagerdeo, E. and Abdel-Rehim, M. (2009) Screening of cocaine and its metabolites in human urine samples by direct analysis in real-time source coupled to time-of-flight mass spectrometry after online preconcentration utilizing microextraction by packed sorbent. J. Am. Soc. Mass Spectrom., 20: 891–899.
   PubMed Web of Science ®Google Scholar
• Chernetsova, E.S. and Morlock, G.E. (2011) Determination of drugs and drug‐like compounds in different samples with direct analysis in real time mass spectrometry. Mass Spectrom. Rev., 30: 875–883.
   PubMed Web of Science ®Google Scholar
• Nilles, J.M., Connell, T.R., and Durst, H.D. (2009) Quantitation of chemical warfare agents using the direct analysis in real time (DART) technique. Anal. Chem., 81: 6744–6749.
   PubMed Web of Science ®Google Scholar
• Saang’onyo, D.S. and Smith, D.L. (2012) Optimization of direct analysis in real time (DART) linear ion trap parameters for the detection and quantitation of glucose. Rapid Comm. Mass Spectrom., 26: 385–391.
   PubMed Web of Science ®Google Scholar
• Zhao, Y., Lam, M., Wu, D., and Mak, R. (2008) Quantification of small molecules in plasma with direct analysis in real time tandem mass spectrometry, without sample preparation and liquid chromatographic separation. Rapid Comm. Mass Spectrom., 22: 3217–3224.
   PubMed Web of Science ®Google Scholar
• Pérez, J.J., Harris, G.A., Chipuk, J.E., Brodbelt, J.S., Green, M.D., Hampton, C.Y., and Fernández, F.M. (2010) Transmission-mode direct analysis in real time and desorption electrospray ionization mass spectrometry of insecticide-treated bednets for malaria control. Analyst, 135: 712–719.
   PubMed Web of Science ®Google Scholar
• Sauer, S. and Kliem, M. (2010) Mass spectrometry tools for the classification and identification of bacteria. Nat. Rev. Microbiol., 8: 74–82.
   PubMed Web of Science ®Google Scholar
• Richardson, S.D. (2008) Environmental mass spectrometry: emerging contaminants and current issues. Anal. Chem., 80: 4373–4402.
   PubMed Web of Science ®Google Scholar
• Griffiths, W.J. and Wang, Y. (2009) Mass spectrometry: from proteomics to metabolomics and lipidomics. Chem. Soc. Rev., 38: 1882–1896.
   PubMed Web of Science ®Google Scholar
• Malik, A.K., Blasco, C., and Picó, Y. (2010) Liquid chromatography–mass spectrometry in food safety. J. Chrom., 1217: 4018–4040.
   PubMed Web of Science ®Google Scholar
• Peters, F.T. (2011) Recent advances of liquid chromatography–(tandem) mass spectrometry in clinical and forensic toxicology. Clin. Biochem., 44: 54–65.
   PubMed Web of Science ®Google Scholar
• Radpour, R., Kohler, C., Haghighi, M., Fan, A., Holzgreve, W., and Zhong, X. (2009) Methylation profiles of 22 candidate genes in breast cancer using high-throughput MALDI-TOF mass array. Oncogene, 28: 2969–2978.
   PubMed Web of Science ®Google Scholar
• Singh, R. and Farmer, P.B. (2006) Liquid chromatography–electrospray ionization–mass spectrometry: the future of DNA adduct detection. Carcinogenesis, 27: 178–196.
   PubMed Web of Science ®Google Scholar
• Aebersold, R. and Mann, M. (2003) Mass spectrometry–based proteomics. Nature, 422: 198–207.
   PubMed Web of Science ®Google Scholar