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Review Articles

The Role of Carnitine and Carnitine Supplementation During Exercise in Man and in Individuals with Special Needs

, MD, PhD & , MD
Pages 207-215 | Received 01 Jan 1998, Accepted 01 Mar 1998, Published online: 07 Jun 2013

REFERENCES

  • Holloszy JO, Coyle EF: Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol 56: 831–838, 1984.
  • Berthon P, Freyssenet D, Chatard J-C, Castells J, Mujika I, Geyssant A, Guezennec C-Y, Denis C: Mitochondrial ATP production rate in 55 to 73-year-old-men: effect of endurance training. Acta Physiol Scand 154: 269–274, 1995.
  • Elliott DL, Buist NRM, Goldberg L, Kennaway NG, Powell BR, Kuehl MS: Metabolic myopathies: evaluation by graded exercise testing. Medicine 68: 163–172, 1989.
  • Bremer J: Carnitine—metabolism and functions. Physiol Rev 63: 1420–1480, 1983.
  • Wasserman K, Whipp BJ: Exercise physiology in health and disease. Am Rev Resp Dis 112: 219–249, 1975.
  • Brass EP: Overview of coenzyme A metabolism and its role in cellular toxicity. Chem-Biol Interact 90: 203–214, 1994.
  • Gilbert EF: Carnitine deficiency. Pathol 17: 161–169, 1985.
  • Hiatt WR, Wolfel EE, Regensteiner JG, Ruff L, Brass EP: Carnitine metabolism during exercise in humans: dependence on skeletal muscle metabolic state. J Clin Invest 84: 1167–1173, 1989.
  • Sahlin K: Muscle carnitine metabolism during incremental dynamic exercise in humans. Acta Physiol Scand 138: 259–262, 1990.
  • Minkler PE, Brass EP, Hiatt WR, Ingalls ST, Hoppel CL: Quantification of carnitine, acetylcarnitine and total carnitine in tissues by high-performance liquid chromatography: the effect of exercise on carnitine homeostasis in man. Analyt Biochem 231: 315–322, 1995.
  • Constantin-Teodosiu D, Carlin JI, Cederblad G, Harris RC, Hultman E: Acetyl group accumulation and pyruvate dehydrogenase activity in human muscle during incremental exercise. Acta Physiol Scand 143: 367–372, 1991.
  • Bremer J: The role of carnitine in intracellular metabolism. J Clin Chem Biochem 28: 297–301, 1990.
  • Goa KL, Brogden RN: L-Carnitine. Drugs 34: 1–24, 1987.
  • Brass EP: Pharmacokinetic considerations for the therapeutic use of carnitine in hemodialysis patients. Clin Ther 17: 176–185, 1995.
  • Cerretelli P, Marconi C: L-Carnitine supplementation in humans. The effects on physical performance. Int J Sports Med 11: 1–14, 1990.
  • Brass EP, Hiatt WR: Carnitine metabolism during exercise. Life Sci 54: 1383–1393, 1994.
  • Brass EP: Supplemental carnitine and exercise. Am J Clin Nutr (in press)
  • Costill DL, Coyle E, Dalsky G, Evans W, Fink W, Hoopes D: Effects of elevated plasma FFA and insulin on muscle glycogen usage during exercise. J Appl Physiol 43: 395–699, 1977.
  • Green HJ: How important is endogenous muscle glycogen to fatigue in prolonged exercise? Can J Physiol Pharmacol 69: 290–297, 1991.
  • Livesey G, Elia M: Estimation of energy expenditure, net carbohydrate utilization and net fat oxidation and synthesis by indirect calorimetry: evaluation of errors with special reference to the detailed consumption of fuels. Am J Clin Nutr 47: 608–628, 1988.
  • Marconi C, Sassi G, Carpinelli A, Cerretelli P: Effects of L-carnitine loading on the aerobic and anaerobic performance of endurance athletes. Eur J Appl Physiol 54: 131–135, 1985.
  • Otto RM, Shores KVM, Wygand JW, Perez MR: The effect of L-carnitine supplementation on endurance exercise. Med Sci Sports Exer 19: S68, 1987.
  • Oyono-Enguelle S, Freund H, Ott C, Gartner M, Heitz A, Marbach J, Maccari F, Grey A, Bigot M, Bach AC: Prolonged submaximal exercise and L-carnitine in humans. Eur J Appl Physiol 58: 53–61, 1988.
  • Soop M, Bjorkman O, Cederblad G, Hegenfeldt L, Wahren J: Influence of carnitine supplementation on muscle substrate and carnitine metabolism during exercise. J Appl Physiol 64: 2394–2399, 1988.
  • Decombaz J, Deriaz O, Acheson K, Giavemder B, Jeguier E: Effect of L-carnitine on submaximal exercise metabolism after depletion of muscle glycogen. Med Sci Sports Exerc 25: 733–7410, 1993.
  • Brass EP, Hoppel CL, Hiatt WR: Effect of intravenous L-carnitine on carnitine homeostasis and fuel metabolism during exercise in humans. Clin Pharmacol Ther 55: 681–692, 1994.
  • Vukovich MD, Costill DL, Fink WJ: Carnitine supplementation: effect on muscle carnitine and glycogen content during exercise. Med Sci Sports Exerc 26: 1122–1129, 1994.
  • Gorostiaga EM, Maurer CA, Eclache JP: Decreases in respiratory quotient during exercise following L-carnitine supplementation. Int J Sports Med 10: 169–174, 1989.
  • Decombaz JE, Roffet B, Bloemhard Y: L-carnitine supplementation, caffeine and fuel oxidation in the exercising rat. Nutr Res 7: 923–933, 1987.
  • Decombaz JE, Roffet B, Bloemhard Y: Effect of L-carnitine and stimulated lipolysis on muscle substrates in the exercising rat. Experientia 46: 457–458, 1990.
  • Simi B, Mayet MH, Sempure B, Favier RJ: Large variations in skeletal muscle carnitine level fail to modify energy metabolism in exercising rate. Comp Biochem Physiol 97A: 543–549, 1990.
  • Lysiak W, Lilly K, DiLisa F, Toth PP, Bieber LL: Quantitation of the effect of L-carnitine on the levels of acid-soluble short-chain acyl-CoA and CoASH in rat heart and liver mitochondria. J Biol Chem 263: 1151–1156, 1988.
  • Uziel G, Garavaglia B, DiDonato S: Carnitine stimulation of pyruvate dehydrogenase complex (PDHC) in isolated human skeletal muscle mitochondria. Muscle Nerve 11: 720–724, 1988.
  • Brass EP, Hoppel CL: Effect of carnitine on mitochondrial oxidation of palmitoylcarnitine. Biochem J 188: 451–458, 1980.
  • Brass EP, Hoppel CL: Relationship between acid-soluble carnitine and coenzyme A pools in vivo. Biochem J 190: 495–504, 1980.
  • Putman CT, Spriet LL, Hultman E, Dyek DJ, Heigenhauser GJF: Skeletal muscle pyruvate dehydrogenase activity during acetate infusion in humans. Am J Physiol 268: E1007–E1017, 1995.
  • Bremer J: Pyruvate dehydrogenase, substrate specificity and product inhibition. Eur J Biochem 8: 535–540, 1969.
  • Davis JM: Central and peripheral factors in fatigue. J Sports Sci 13: 549–554, 1995.
  • Miller RG, Kent-Braun JA, Sharma KR, Weiner MW: Mechanisms of human muscle fatigue. Quantitating the contribution of metabolic factors and activation impairment. Adv Exp Med Biol 384: 195–210, 1995.
  • Dubelaar M-L, Lucas CMHB, Hulsmann WC: Acute effect of L-carnitine on skeletal muscle force tests in dogs. Am J Physiol 260: E189–E193, 1993.
  • Brass EP, Scarrow AM, Ruff LJ, Masterson K, van Lunteren E: Carnitine delays rat skeletal muscle fatigue in vitro. J Appl Physiol 75: 1959–1600, 1993.
  • Dubelaar M-L, Lucas CMBH, Hulsmann WC: The effect of L-carnitine on force development of the latissimus dorsi muscle in dogs. J Cardiac Surg 6(Suppl): 270–275, 1991.
  • Cevese A, Schena F, Poltronieri R, Cerutti G: Short term effects of intra-arterial propionyl-L-carnitine on isolated canine hind-limbs. Cardioscience 6: 59–64, 1995.
  • Hulsmann WC, Dubelaar M-L: Carnitine requirement of vascular endothelial and smooth muscle cells in imminent ischemia. Mol Cell Biochem 116: 125–129, 1992.
  • Harper P, Elwin C-E, Cederblad G: Pharmacokinetics of bolus intravenous and oral doses of L-carnitine in healthy subjects. Eur J Clin Pharmacol 35: 69–75, 1988.
  • Segre G, Bianchi E, Corsi M, D’Iddio S, Ghirardi O, Maccari F: Plasma and urine pharmacokinetics of free and of short-chain carnitine after administration of carnitine in man. Arzneim-Forsch Drug Res 11: 1830–1834, 1988.
  • Millington DS, Dubag G: Dietary supplement L-carnitine: analysis of different brands to determine bioavailability and content. Clin Res Regulatory Affairs 10: 71–80, 1993.
  • Greig C, Finch KM, Jones DA, Cooper M, Sargeant AJ, Forte CA: The effects of oral supplementation with L-carnitine on maximum and submaximum exercise capacity. Eur J Appl Physiol 56: 457–460, 1987.
  • Dragan GI, Vasiliu A, Georgeseu E, Dumas I: Studies concerning chronic and acute effects of L-carnitine on some biological parameters in elite athletes. Physiologie 24: 23–28, 1987.
  • Vecchiet L, Di Lisa F, Pieralisi G, Ripari P, Menabo R, Giamberardino MA, Siliprandi N: Influence of L-carnitine administration on maximal physical exercise. Eur J Appl Physiol 61: 486–490, 1990.
  • Wyss V, Ganzit GP, Rienzi A: Effects of L-carnitine administration on VO2max and aerobic-anaerobic threshold in normoxia and acute hypoxia. Eur J Appl Physiol 60: 1–6, 1990.
  • Hultman E, Cederblad G, Harper P: Carnitine administration as a tool to modify energy metabolism during exercise. Eur J Appl Physiol 6: 450, 1991.
  • Barnett C, Costill DL, Vukovich MD, Cole KJ, Goodpaster BH, Trappe SW, Fink WJ: Effect of L-carnitine supplementation on muscle and blood carnitine content and lactate accumulation during high-intensity sport cycling. Int J Sports Nutr 4: 280–288, 1994.
  • Swart I, Rossouw J, Loots JM, Kruger MC: The effect of L-carnitine supplementation on plasma carnitine levels and various performance parameters of male marathon athletes. Nutr Res 17: 405–414, 1997.
  • Trappe SW, Costill DL, Goodpaster B, Vukovich MD, Fink WJ: The effects of L-carnitine supplementation on performance during interval swimming. Int J Sports Med 15: 181–185, 1994.
  • Columbani P, Werk C, Kurz I, Krahenbuhl S, Kuhut M, Arnold M, Frey-Rindora P, Frey W, Langhans W: Effects of L-carnitine supplementation on physical performance and energy metabolism of endurance—trained athletes: A double-blind crossover field study. Eur J Appl Physiol 73: 434–439, 1996.
  • Arenas J, Ricoy JR, Encinas AR, Pola P, D’Iddio S, Zeviani M, Di Donato S, Corsi M: Carnitine in muscle, serum and urine of nonprofessional athletes: effect of physical exercise, training and L-carnitine administration. Muscle Nerve 14: 598–604, 1991.
  • Huertas R, Campos Y, Diaz E, Esteban J, Vechietti L, Montanari G, D’Iddio S, Corsi M, Arenas J: Respiratory chain enzymes in muscle of endurance athletes: effect of L-carnitine. Biochem Biophys Res Commun 188: 102–107, 1992.
  • Arenas J, Huertas R, Campos Y, Diaz AE, Villalon JM, Vilas E: Effects of L-carnitine on the pyruvate dehydrogenase complex and carnitine palmitoyltransferase activities of endurance athletes. FEBS Lett 341: 91–93, 1994.
  • Friolet R, Hoppeler H, Krahenbuhl S: Relationship between the coenzyme A pools in human skeletal muscle at rest and after exhaustive exercise under normoxic and acutely hypoxic conditions. J Clin Invest 94: 1490–1495, 1995.
  • Barnea N, Drory Y, Iaina A, Lapidot C, Reisen E, Eliahou H, Kellermann JJ: Exercise tolerance in patients on chronic hemodialysis. Isr J Med Sci 16: 17–21, 1980.
  • Ricanati ES, Tserng K, Hoppel CL: Abnormal fatty acid utilization during prolonged fasting in chronic uremia. Kidney Int 32(Suppl 22): S145–S148, 1987.
  • Wanner C, Horl WH: Carnitine abnormalities in patients with renal insufficiency. Nephron 50: 89–102, 1988.
  • Brass EP: Carnitine in renal failure. In Kopple JD, Massry SG (eds): “Nutritional Management of Renal Disease.” Baltimore: Williams and Wilkens, pp 191–201, 1997.
  • Hiatt WR, Koziol BS, Shapiro JI, Brass EP: Carnitine metabolism during exercise in patients on chronic hemodialysis. Kidney Int 41: 1613–1619, 1992.
  • Fagher B, Cederblad G, Eriksson M, Menti M, Moritz U, Nillson-Ehle P, Thysell H: 1-Carnitine and hemodialysis: double blind study on muscle function and metabolism and peripheral nerve function. Scand J Clin Lab Invest 45: 169–178, 1985.
  • Golper TS, Wolfson M, Ahmad S, Hirschberg R, Kurtin P, Katz LA, Nicora R, Ashbrook D, Kopple JD: Multicenter trial of 1-Carnitine in hemodialysis patients. I. Carnitine concentrations and lipid effects. Kidney Int 38: 904–911, 1990.
  • Ahmad S, Robertson T, Golper TA, Wolfson M, Kurtin P, Katz LA, Hirschberg R, Nicora R, Ashbrook DW, Kopple JD: Multicenter trial of 1-Carnitine in hemodialysis patients. II. Clinical and biochemical effects. Kidney Int 38: 912–918, 1990.
  • Spagnoli LG, Palmieri G, Mauriello A, Vacha GM, D’Iddio S, Giorcelli G, Corsi M: Morphometric evidence of the trophic effect of L-carnitine on human skeletal muscle. Nephron 55: 16–23, 1990.
  • Siami G, Clinton ME, Mrak R, Griffis J, Stone W. Evaluation of the effect of intravenous 1-carnitine therapy on function, structure and fatty acid metabolism of skeletal muscle in patients receiving chronic hemodialysis. Nephron 57: 306–313, 1991.
  • Bellinghieri G, Savica V, Mallamace A, Di Stefano C, Consolo F, Spagnoli LG, Villaschi S, Palmieri G, Corsi M, Maccari F: Correlation between increased serum and tissue l-carnitine levels and improved muscle symptoms in hemodialysis patients. Am J Clin Nutr 38: 523–531, 1983.
  • Janssen E, Johansson J, Sylven C, Kaijser L: Calf muscle adaptation in intermittent claudication. Side differences in muscle metabolic characteristics in patients with unilateral arterial disease. Clin Physiol 8: 17–29, 1988.
  • Hiatt WR, Wolfel EE, Regensteiner JG, Brass EP: Skeletal muscle carnitine metabolism in patients with unilateral peripheral arterial disease. J Appl Physiol 73: 346–353, 1992.
  • Brass EP: Skeletal muscle metabolism as a target for drug therapy in peripheral arterial disease. Vasc Med 1: 55–59, 1996.
  • Brevetti G, Chiariello M, Ferulano G, Policicchio A, Nevola E, Rossini A, Attisano T, Ambrosio G, Siliprandi N, Angelini C: Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: a double-blind, cross-over study. Circulation 77: 767–773, 1988.
  • DiLisa F, Menabo R, Siliprandi N: L-Propionylcarnitine protection of mitochondria in ischemic rat hearts. Mol Cell Biochem 88: 169–173, 1989.
  • Paulson DJ, Taxler J, Schmidt M, Noonan J, Shug AL: Protection of the ischemic myocardium by L- propionylcarnitine: effects on the recovery of cardiac output after ischemia and reperfusion, carnitine transport, and fatty acid oxidation. Cardiovasc Res 20: 536–541, 1986.
  • Brevetti G, Perna S, Sabba C, Martone VD, Condurelli M: Propionyl-L-carnitine in intermittent claudication: double-blind, placebo-controlled, dose titration, multicenter study. J Am Coll Cardiol 26: 1411–1416, 1995.
  • Brevetti G, Perna S, Sabba C, Martone VD, Di Lorio A, Barletta G: Effect of Propionyl-L-carnitine on quality of life in intermittent claudication. Am J Cardiol 79: 777–780, 1997.
  • Hiatt WR: Current and future drug therapies for claudication. Vasc Med (in press).
  • Plioplys AV, Plioplys S: Amantadine and L-carnitine treatment of chronic fatigue syndrome. Neuropsychobiology 35: 16–23, 1997.
  • Cherchi A, Lai C, Angelino F, Trucco G, Caponnetto S, Mereto PE, Rosolen G, Manzoli U, Schiavoni G, Reale A, Romeo F, Rizzon P, Sorgente L, Strano A, Novo S, Immordino R: Effects of L-carnitine on exercise tolerance in chronic stable angina: a multicenter, double-blind, randomized, placebo controlled crossover study. Int J Clin Pharmacol Ther Toxicol 23: 569–572, 1985.
  • Dal Negro R, Turco P, Pomari C, De Conti F: Effects of L-carnitine on physical performance in chronic respiratory insufficiency. Int J Clin Pharmacol Ther Toxicol 26: 269–272, 1988.

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