216
Views
107
CrossRef citations to date
0
Altmetric
Original Papers

Zinc May Regulate Serum Leptin Concentrations in Humans

, MD, , MD, MACN, , PhD, , PhD, , MD, , RD & , MD, FACN show all
Pages 270-275 | Received 01 Apr 1997, Accepted 01 Dec 1997, Published online: 07 Jun 2013

REFERENCES

  • Rink TJ: In search of a satiety factor. Nature 372: 406–407, 1995.
  • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse ob gene and its human homologue. Nature 372: 425–432, 1994.
  • Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543–546, 1995.
  • Frederich RC, Hamann A, Anderson S, Lollman B, Lowell BB, Flier JS: Leptin reflects body lipid content in mice: evidence for diet-induced leptin resistance. Nature Med 1: 1311–1314, 1995.
  • Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med 1: 1155–1161, 1995.
  • Pelleymounter MA, Cullen MJ, Baker MB, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540–543, 1995.
  • Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P: Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546–548, 1995.
  • Weigle DS, Bukowski TR, Foster DC, et al. Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest 96: 2065–2070, 1995.
  • Mantzoros CS, Qu D, Frederich R, et al. Activation of beta 3 adrenergic receptors suppresses leptin expression and mediates a leptin independent suppression of food intake in mice. Diabetes 45: 909–914, 1996.
  • Ahima R, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature 382: 250–252, 1996.
  • Prasad AS: Zinc: the biology and therapeutics of an ion. Ann Intern Med 125: 142–144, 1996.
  • McClain G, Stuart M, Kasarskis E, Humphries L: Zinc, appetite regulation and eating disorders. In Prasad AS (ed): “Essential and Toxic Trace Elements in Human Health and Disease: An update.” New York: Wiley-Liss Inc, pp 47–64, 1993.
  • Prasad AS: Discovery of human zinc deficiency and studies in an experimental human model. Am J Clin Nutr 53: 403–412, 1991.
  • Ninh NX, Thissen JP, Collette L, Gerard G, Khoi HH, Ketelslegers JM: Zinc supplementation increases growth and circulating insulin-like growth factor I (IGF-I) in growth retarded Vietnamese children. Am J Clin Nutr 63: 514–519, 1996.
  • Halas ES, Wallwork JS, Sandstead HH: Mild zinc deficiency and undernutrition during the prenatal and postnatal periods in rats: effects on weight, food consumption and brain catecholamine concentrations. J Nutr 112: 542–551, 1982.
  • Ashley DWH, Anderson GH: Correlation between plasma tryptophan to neutral amino acid ratio and protein intake in the self-selecting weanling rat. J Nutr 105: 1412–1421, 1975.
  • Essatara MB, Morley JE, Levine AS, Elson MK, Shafer RB, McLain CJ: The role of the endogenous opiates in zinc deficiency anorexia. Physiology and Behavior 32: 475–478, 1984.
  • Silverstone T: Appetite suppressants: a review. Drugs 43: 820–836, 1992.
  • Wurtman RJ: Effects of their nutrient precursors on the synthesis and release of serotonin, catecholamines and acetylcholine: Implications for behavioral disorders. Clin Neuropharmacol 11: S187–193, 1988.
  • Anderson GH: Control of protein and energy intake: role of plasma aminoacids and brain neurotransmitters. Can J Pharmacol 57: 1043–1057, 1979.
  • Mangian HF, Lig, Paul GL, Shay NF: Blood leptin levels are reduced during zinc deficiency induced anorexia. (Abstract). FASEB 11(3): A1124, 1997.
  • Prasad AS, Mantzoros CS, Beck FWJ, Hess JW, Brewer GJ: Zinc status and serum testosterone levels of healthy adults. Nutrition 12: 344–348, 1996.
  • Meftah S, Prasad AS, Lee DY, et al. Ecto nucleotidase (5′NT) as a sensitive indicator of human zinc deficiency. J Lab Clin Med 118: 309–316, 1991.
  • Grinspoon S, Gulick T, Askari H, et al. Serum leptin levels in women with anorexia nervosa. J Clin Endocrinol Metab 81: 3861–3863, 1996.
  • Kotler DP, Burastero S, Wang J, Pierson RN: Prediction of body cell mass, fat free mass, and total body water with bioelectrical impedance analysis: Effects of race, sex and disease. Am J Clin Nutr 64:(suppl), 1996.
  • Mantzoros CS, Rosen HN, Greenspan SL, Flier JS, Moses AC: Short-term hyperthyroidism has no effect on leptin levels in man. J Clin Endocrinol Metab 82: 497–501, 1997.
  • Mantzoros CS, Flier JS, Rogol AD: A longitudinal assessment of homonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. J Clin Endocrinol Metab 82: 1066–1070, 1997.
  • Beck FWJ, Prasad AS, Kaplan J, Fitzgerald JT, Brewer GJ: Changes in cytokine production and T cell subpopulations in experimentally induced zinc deficient humans. Am J Physiol 272: E1002–E1007, 1997.
  • Slieker LJ, Sloop KW, Surface PL, et al. Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J Biol Chem 271: 5301–5304, 1996.
  • Saladin R, De Voos P, Guerre-Millo M, et al. Transient increase in obese gene expression after food intake or insulin administration. Nature 377: 527–529, 1995.
  • Grunfeld C, Zhao C, Fuller J, et al. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J Clin Invest 97: 2152–2157, 1996.
  • Plata-Salaman CR, Borkoski JP: Chemokines/integrines and central regulation of feeding. Am J Physiol 266: R1711–1715, 1994.
  • Schwartz MW, Dallmann MF, Woods SC: Hypothalamic response to starvation: Implications for the study of wasting disorders. Am J Physiol 269: R949–957, 1995.
  • Prasad AS: “Biochemistry of Zinc: Clinical Spectrum of Human Zinc Deficiency.” New York: Plenum Press, pp 219–258, 1993.
  • Hambidge KM, Walravens PA, Brown RM, et al. Zinc nutrition of preschool children in the Denver Head Start Program. Am J Clin Nutr 29: 734–738, 1976.
  • Boukaiba N, Flament C, Acher S, et al. A physiological amount of zinc supplementation: effects of nutritional, lipid and thymic status in an elderly population. Am J Clin Nutr 57: 566–572, 1993.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.