Choline: Needed for Normal Development of Memory

REFERENCES

• Institute of Medicine and National Academy of Sciences USA: ‘Dietary Reference Intakes for Folate, Thiamin, Riboflavin, Niacin, Vitamin B12, Panthothenic Acid, Biotin, and Choline.’ Washington DC: National Academy Press, 1998.
   Google Scholar
• Zeisel SH, Blusztajn JK: Choline and human nutrition. Ann Rev Nutr 14: 269–296, 1994.
   PubMed Web of Science ®Google Scholar
• Kuksis A, Mookerjea S: Choline. Nutr Rev 36: 201–207, 1978.
   PubMed Web of Science ®Google Scholar
• Zeisel SH, daCosta KA, Franklin PD, Alexander EA, Lamont JT, Sheard NF, Beiser A: Choline, an essential nutrient for humans. FASEB J 5: 2093–2098, 1991.
   PubMed Web of Science ®Google Scholar
• Hershey JM, Soskin S: Substitution of ‘lecithin’ for raw pancreas in a diet of depancreatized dog. Am J Physiol 93: 657–658, 1931.
   Google Scholar
• Hoffbauer FW, Zaki FG: Choline deficiency in the baboon and rat compared. Arch Path 79: 364–369, 1965.
   PubMedGoogle Scholar
• daCosta K, Cochary EF, Blusztajn JK, Garner SC, Zeisel SH: Accumulation of 1,2-sn-diradylglycerol with increased membrane-associated protein kinase C may be the mechanism for spontaneous hepatocarcinogenesis in choline deficient rats. J Biol Chem 268: 2100–2105, 1993.
   PubMed Web of Science ®Google Scholar
• Newberne PM, Rogers AE: Labile methyl groups and the promotion of cancer. Ann Rev Nutr 6: 407–432, 1986.
   PubMed Web of Science ®Google Scholar
• Lieber CS, Robins SJ, Li J, DeCarliL M, Mak KM, Fasulo JM, Leo MA: Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon. Gastroenterology 106: 152–159, 1994.
   PubMed Web of Science ®Google Scholar
• Buchman AL, Dubin M, Jenden D, Moukarzel A, Roch MH, Rice K, Gornbein J, Ament ME, Eckhert CD: Lecithin increases plasma free choline and decreases hepatic steatosis in long-term total parenteral nutrition patients. Gastroenterology 102: 1363–1370, 1992.
   PubMed Web of Science ®Google Scholar
• Buchman A, Dubin M, Moukarzel A, Jenden D, Roch M, Rice K, Gornbein J, Ament M: Choline deficiency: a cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation. Hepatology 22: 1399–1403, 1995.
   PubMed Web of Science ®Google Scholar
• Buchman AL, Moukarzel A, Jenden DJ, Roch M, Rice K, Ament ME: Low plasma free choline is prevalent in patients receiving long term parenteral nutrition and is associated with hepatic aminotransferase abnormalities. Clin Nutr 12: 33–37, 1993.
   PubMedGoogle Scholar
• Chawla RK, Wolf DC, Kutner MH, Bonkovsky HL: Choline may be an essential nutrient in malnourished patients with cirrhosis. Gastroenterology 97: 1514–1520, 1989.
   PubMed Web of Science ®Google Scholar
• Shapira G, Chawla RK, Berry CJ, Williams PJ, Roy RGB, Rudman D: Cysteine, tyrosine, choline and carnitine supplementation of patients on total parenteral nutrition. Nutr Internat 2: 334–339, 1986.
   Google Scholar
• Sheard NF, Tayek JA, Bistrian BR, Blackburn GL, Zeisel SH: Plasma choline concentration in humans fed parenterally. Am J Clin Nutr 43: 219–224, 1986.
   PubMed Web of Science ®Google Scholar
• Vance JE: Secretion of VLDL, but not HDL, by rat hepatocytes is inhibited by the ethanolamine analogue N-monomethylethanolamine. J Lipid Res 32: 1971–1982, 1991.
   PubMed Web of Science ®Google Scholar
• Fast D, Vance D: Nascent VLDL phospholipid composition is altered when phosphatidylcholine biosynthesis is inhibited: evidence for a novel mechanism that regulates VLDL secretion. Biochim Biophys Acta 1258: 159–168, 1995.
   PubMedGoogle Scholar
• Handler P, Bernheim F: Choline deficiency in the hamster. Proc Soc Exptl Med 72: 569, 1949.
   PubMed Web of Science ®Google Scholar
• Fairbanks BW, Krider JL: Significance of B vitamins in swine nutrition. N Am Vet 26: 18–23, 1945.
   Google Scholar
• Eagle H: The minimum vitamin requirements of the L and Hela cells in tissue culture, the production of specific vitamin deficiencies, and their cure. J Exptl Med 102: 595–600, 1955.
   PubMed Web of Science ®Google Scholar
• Albright CD, Lui R, Bethea TC, daCosta KA, Salganik RI, Zeisel SH: Choline eficiency induces apoptosis in SV40-immortalized CWSV-1 rat hepatocytes in culture. FASEB J 10: 510–516, 1996.
   PubMed Web of Science ®Google Scholar
• Shin OH, Mar MH, Albright CD, Citarella MT, daCosta KA, Zeisel SH: Methyl-group donors cannot prevent apoptotic death of rat hepatocytes induced by choline-deficiency. J Cell Biochem 64: 196–208, 1997.
   PubMed Web of Science ®Google Scholar
• James S, Miller B, Basnakian A, Pogribny I, Pogribna M, Muskhelishvili L: Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in liver of folate/methyl deficient rats. Carcinogenesis 18: 287–293, 1997.
   PubMed Web of Science ®Google Scholar
• Bremer J, Greenberg D: Methyl transfering enzyme system of microsomes in the biosynthesis of lecithin (phosphatidylcholine). Biochim Biophys Acta 46: 205–216, 1961.
   Web of Science ®Google Scholar
• Varela-Moreiras G, Selhub J, daCosta K, Zeisel SH: Effect of chronic choline deficiency in rats on liver folate content and distribution. J Nutr Biochem 3: 519–522, 1992.
   Web of Science ®Google Scholar
• Zeisel SH, Zola T, daCosta K, Pomfret EA: Effect of choline deficiency on S-adenosylmethionine and methionine concentrations in rat liver. Biochem J 259: 725–729, 1989.
   PubMed Web of Science ®Google Scholar
• Holmes-McNary M, Cheng WL, Mar MH, Fussell S, Zeisel SH: Choline and choline esters in human and rat milk and infant formulas. Am J Clin Nutr 64: 572–576, 1996.
   PubMed Web of Science ®Google Scholar
• Zeisel SH, Growdon JH, Wurtman RJ, Magil SG, Logue M: Normal plasma choline responses to ingested lecithin. Neurology 30: 1226–1229, 1980.
   PubMed Web of Science ®Google Scholar
• Savendahl L, Mar MH, Underwood L, Zeisel S: Prolonged fasting results in diminished plasma choline concentration but does not cause liver dysfunction. Am J Clin Nutr 66: 622–625, 1997.
   PubMed Web of Science ®Google Scholar
• Zeisel SH, Mar MH, Zhou ZW, daCosta KA: Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. J Nutr 125: 3049–3054, 1995.
   PubMed Web of Science ®Google Scholar
• Welsch F: Studies on accumulation and metabolic fate of (N-Me3H)choline in human term placenta fragments. Biochem. Pharmacol 25: 1021–1030, 1976.
   PubMed Web of Science ®Google Scholar
• Gwee MC, Sim MK: Free choline concentration and cephalin-N-methyltransferase activity in the maternal and foetal liver and placenta of pregnant rats. Clin Exper Pharmacol Physiol 5: 649–653, 1978.
   PubMed Web of Science ®Google Scholar
• Zeisel SH, Epstein MF, Wurtman RJ: Elevated choline concentration in neonatal plasma. Life Sci 26: 1827–1831, 1980.
   PubMed Web of Science ®Google Scholar
• Zeisel SH, Wurtman RJ: Developmental changes in rat blood choline concentration. Biochem J 198: 565–570, 1981.
   PubMed Web of Science ®Google Scholar
• Zeisel SH: Choline: an important nutrient in brain development, liver function and carcinogenesis. J Am Coll Nutr 11: 473–481, 1992.
   PubMed Web of Science ®Google Scholar
• McMahon KE, Farrell PM: Measurement of free choline concentrations in maternal and neonatal blood by micropyrolysis gas chromatography. Clin Chim Acta 149: 1–12, 1985.
   PubMed Web of Science ®Google Scholar
• Braun LD, Cornford EM, Oldendorf WH: Newborn rabbit blood-brain barrier is selectively permeable and differs substantially from the adult. J Neurochem 34: 147–152, 1980.
   PubMed Web of Science ®Google Scholar
• Cornford EM, Braun LD, Oldendorf WH: Developmental modulations of blood-brain barrier permeability as an indicator of changing nutritional requirements in the brain. Pediatr Res 16: 324–328, 1982.
   PubMed Web of Science ®Google Scholar
• Garner SC, Mar MH, Zeisel SH: Choline distribution and metabolism in pregnant rats and fetuses are influenced by the choline content of the maternal diet. J Nutr 125: 2851–2858, 1995.
   PubMed Web of Science ®Google Scholar
• Cermak JM, Blusztajn JK, Meck WH, Williams CL, Fitzgerald CM, RoseneDL, LoyR: Prenatal availability of choline alters the development of acetylcholinesterase in the rat hippocampus. Dev Neurosci 21: 94–104, 1999.
   PubMed Web of Science ®Google Scholar
• Loy R, Heyer D, Williams CL, Meek WH: Choline-induced spatial memory facilitation correlates with altered distribution and morphology of septal neurons. Adv Exp Med Biol 295: 373–382, 1991.
   PubMedGoogle Scholar
• Meck W, Williams C: Perinatal choline supplementation increases the threshold for chunking in spatial memory. Neuroreport 8: 3053–3059, 1997.
   PubMed Web of Science ®Google Scholar
• Meck W, Williams C: Characterization of the facilitative effects of perinatal choline supplementation on timing and temporal memory. Neuroreport 8: 2831–2835, 1997.
   PubMed Web of Science ®Google Scholar
• Meck W, Williams C: Simultaneous temporal processing is sensitive to prenatal choline availability in mature and aged rats. Neuroreport 8: 3045–3051, 1997.
   PubMed Web of Science ®Google Scholar
• Pyapali G, Turner D, Williams C, Meck W, Swartzwelder HS: Prenatal choline supplementation decreases the threshold for induction of long-term potentiation in young adult rats. J Neurophysiol 79: 1790–1796, 1998.
   PubMed Web of Science ®Google Scholar
• Williams C, Meck W, Heyer D, Loy R: Hypertrophy of basal forebrain neurons and enhanced visuospatial memory in perinatally choline-supplemented rats. Brain Res 794: 225–238, 1998.
   PubMed Web of Science ®Google Scholar
• Meck WH, Williams CL: Choline supplementation during prenatal development reduces proactive interference in spatial memory. Dev Brain Res 118: 51–59, 1999.
   PubMedGoogle Scholar
• Tees RC: The influences of rearing environment and neonatal choline dietary supplementation on spatial learning and memory in adult rats. Behav Brain Res 105: 173–188, 1999.
   PubMed Web of Science ®Google Scholar
• Tees RC: The influences of sex, rearing environment, and neonatal choline dietary supplementation on spatial and nonspatial learning and memory in adult rats. Dev Psychobiol 35: 328–342, 1999.
   PubMed Web of Science ®Google Scholar
• Oppenheim RW: Cell death during the development of the nervous system. Ann Rev Neurosci 14: 453–501, 1991.
   PubMed Web of Science ®Google Scholar
• Thompson CB: Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456–1462, 1995.
   PubMed Web of Science ®Google Scholar
• Merry D, Korsmeyer S: Bcl-2 gene family in the nervous system. Annu Rev Neurosci 20: 245–267, 1997.
   PubMed Web of Science ®Google Scholar
• Albright CD, Tsai AY, Friedrich CB, Mar MH, Zeisel SH: Choline availability alters embryonic development of the hippocampus and septum in the rat. Dev Brain Res 113: 13–20, 1999.
   PubMedGoogle Scholar
• Albright CD, Tsai AY, Mar MH, Zeisel SH: Choline availability modulates the expression of TGFβ1 and cytoskeletal proteins in the hippocampus of developing rat brain. Neurochem Res 23: 751–758, 1997.
   Web of Science ®Google Scholar
• Albright CD, Zeisel SH: Choline deficiency causes increased localization of TGFb1 signaling proteins and apoptosis in rat liver. Pathobiology 65: 264–270, 1997.
   PubMed Web of Science ®Google Scholar
• Holmes-McNary MQ, Loy R, Mar MH, Albright CD, Zeisel SH: Apoptosis is induced by choline deficiency in fetal brain and in PC12 cells. Devel Brain Res 101: 9–16, 1997.
   PubMedGoogle Scholar
• Cermak J, Holler T, Jackson D, Blusztajn J: Prenatal availability of choline modifies the development of the hippocampal cholinergic system. FASEB J 12: 349–357, 1998.
   PubMed Web of Science ®Google Scholar
• Eriksson, P.S., Perfilieva E., Bjork-Eriksson T., Alborn A.M., Nordborg C., Peterson D.A. and Gage F.H. Neurogenesis in the adult human hippocampus. Nat Med 4: 1313–1317, 1998.
   PubMed Web of Science ®Google Scholar