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Review Series: Antioxidants and Their Clinical Applications

Vitamin E and its Role in the Prevention of Atherosclerosis and Carcinogenesis: A Review

, BSc & , MD
Pages 258-268 | Received 12 Sep 2002, Accepted 13 May 2003, Published online: 27 Jun 2013

REFERENCES

  • Carey M, Small D: The characteristics of mixed micellar solutions with particular references to bile. Am J Med49 :590– 608,1970 .
  • Ingold K, Webb A, Witter D, Burton G, Metcalfe T, Muller D: Vitamin E remains the major lipid soluble chain breaking antioxidant in human plasma even in individuals suffering severe vitamin e deficiency. Arch Biochem Biophys259 :224– 225,1987 .
  • Burton G, Ingold K: Vitamin E: application of the principles of physical organic chemistry to the exploration of its structure and function. Acc Chem Res19 :194– 201,1896 .
  • Kornbrust D, Mavis R: Relative susceptibility of microsomes from lung, heart, liver, kidney, brain and testes to lipid peroxidation: correlation with vitamin E content. Lipids15 :315– 322,1980 .
  • Kline K, Yu W, Sanders B: Vitamin E: mechanisms of action as tumor cell growth inhibitors. J Nutr131 :161S– 163S,2001 .
  • US Department of Agriculture, Human Nutrition Information Service: “Nationwide Food Consumption Survey, 1987–88. Individual Intakes, 3 Days.” Computer Tape PB 90-504044. Springfield, VA: National Technical Information Service,1990 .
  • Ong A: Natural sources of tocotrienols. In Packer L, Fuchs J (eds): “Vitamin E in Health and Disease,” 1st ed. New York: Marcel Dekker, pp3– 8,1993 .
  • Machlin L: “Handbook of Vitamins.” New York: Marcel Dekker,1984 .
  • Traber M, Kayden H, Green J, Green M: Absorption of water miscible forms of vitamin E in a patient cholestasis and in rats. Am J Clin Nutr44 :914– 923,1986 .
  • Tijburg LB, Haddeman E, Kivits GA, Westrate JA, Brink EJ: Dietary linoleic acid at high and reduced dietary fat level decreases the faecal excretion of vitamin E in young rats. Br J Nutr77 :327– 336,1997 .
  • Iuliano L, Michelatta F, Maranghi M, Frati G, Diczfalusy U, Violi F: Bioavailability of vitamin E as function of food intake in healthy subjects: effects on plasma peroxide-scavenging activity and cholesterol-oxidation products. Arterioscler Thromb Vasc Biol21 :E34– 37,2001 .
  • Behrens WA, Thompson JN, Madere R: Distribution of alpha tocopherol in human plasma lipoproteins. Am J Clin Nutr35 :691– 696,1982 .
  • Jeffrey G, Muller D, Burroughs A, Matthews S, Kemp C, Epstein O, Metcalfe TA, Southam E, Tazir-Melboucy M, Thomas PK, et al.: Vitamin E deficiency and its clinical significance in adults with primary biliary cirrhosis and other forms of chronic liver disease. J Hepatol4 :307– 317,1987 .
  • Traber MG, Olivecrona T, Kayden HJ: Bovine milk lipoprotein lipase transfers tocopherol to human fibroblasts during triglyceride hydrolysis in vitro. J Clin Invest75 :1729– 1734,1985 .
  • Thellman C, Shireman R: In vitro uptake of [3H]-α-tocopherol from low density lipoprotein by cultured human fibroblasts. J Nutr115 :1673– 1679,1985 .
  • Goti D, Hrzenjak A, Levak-Frank S, Frank S, van der Westhuyzen D, Malle E, Sattler W: Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL-associated vitamin E. J Neurochem.76 :498– 508,2001 .
  • Vatassery G, Nelson M, Maletta G, Kuskowski M: Vitamin E (tocopherols) in human cerebrospinal fluid. Am J Clin Nutr53 :95– 99,1991 .
  • Stocker A, Azzi A: Tocopherol binding proteins: their function and physiological significance. Antiox Redox Signal2 :397– 404,2000 .
  • Diaz M, Frei B, Vita J, Keaney J: Antioxidants and atherosclerotic heart disease. N Eng J Med337 :408– 416,1997 .
  • Henriksen T, Mahoney EM, Steinberg D: Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins. Proc Natl Acad Sci USA85 :6499– 6503,1981 .
  • Schwartz CJ, Valente AJ, Sprague EA, Kelley JL, Nerem RM: The pathogenesis of atherosclerosis: an overview. Clin Cardiol14(Suppl I) :I1– I16,1991 .
  • Deveraj S, Li D, Jialal I: The effect of alpha-tocopherol supplementation on monocyte function: decreased lipid oxidation, interleukin-1β secretion and monocyte adhesion to endothelium. J Clin Investig98 :756– 763,1996 .
  • Jialal I, Deveraj S, Kaul N: The effect of α-tocopherol on monocyte proatherogenic activity. J Nutr131 :389S– 394S,2001 .
  • van Tits L, Demacker P, de Graaf J, Lemmers H, Stalenhoef A: Alpha-tocopherol supplementation decreases production of superoxide and cytokines by leukocytes ex vivo in both normolipidemic and hypertriglyceridemic individuals. Am J Clin Nutr71 :458– 464,2000 .
  • Islam K, Deveraj S, Jialal I: α-Tocopherol enrichment of monocytes decreases agonist-induced adhesion to human endothelial cells. Circulation98 :2255– 2261,1998 .
  • Terentis A, Thomas S, Burr J, Liebler D, Stocker R: Vitamin E oxidation in human atherosclerotic lesions. Circ Res90 :333– 339,2002 .
  • Krol E, Kramer-Stickland K, Liebler D: Photoprotective actions of topically applied vitamin E. Drug Metab Revs32 :413– 420,2000 .
  • Shklar G, Schwartz J: Tumor necrosis factor in experimental cancer: regression with alpha tocopherol, beta-carotene, and algae extract. Eur J Cancer Clin Oncol24 :839– 850,1988 .
  • Schwartz J, Shklar G, Trickler D: p53 in the anticancer mechanism of vitamin E. Oral Oncol Eur J Cancer29B :313– 318,1993 .
  • Turley J, Funakoshi S, Ruscetti R, Kasper J, Murphy W, Longo D, Birchenall-Roberts M. Growth inhibition and apoptosis of RL human B lymphoma cells by vitamin E succinate and retinoic acid: role for transforming growth factor beta. Cell Growth Differ6 :655– 663,1995 .
  • Neuzil J, Weber T, Schroder A, Lu M, Ostermann G, Gellert N, Mayne G, Olejnicka B, Negre-Salvayre A, Sticha M, Coffey R, Weber C: Induction of cancer cell apoptosis by α-tocopheryl succinate: molecular pathways and structural requirements. FASEB J15 :403– 415,2001 .
  • Wang R, Zhang L, Yin D, Mufson R, Shi Y: Protein kinase C regulates Fas (CD95/APO-1) expression. J Immunol161 :2201– 2207,1998 .
  • Ito T, Deng X, Carr B, May W: Bcl-2 phosphorylation required for anti-apoptosis function. J Biol Chem272 :11671– 11673,1997 .
  • Israel K, Yu W, Sanders B, Kline K: Vitamin E succinate induces apoptosis in human prostate cancer cells: role for Fas in vitamin E succinate-triggered apoptosis. Nutr Cancer36 :90– 100,2000 .
  • Shklar G, Schwartz J: Effects of vitamin E on oral carcinogenesis and oral cancer. In Packer L, Fuchs J, (eds): “Vitamin E in Health and Disease,” 1st ed. New York: Marcel Dekker, pp497– 511,1993 .
  • Carew T, Schwenke D, Steinberg D: Antiatherogenic effect of probucol unrelated to its hypercholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the watanabe heritable hyperlipidemic rabbit. Proc Natl Acad Sci USA84 :7725– 7729,1987 .
  • Ferre N, Camps J, Paul A, Cabre M, Calleja L, Osada J, Joven J: Effects of high-fat, low-cholesterol diets on hepatic lipid peroxidation and antioxidants in apolipoprotein E-deficient mice. Mol Cell Biochem218 :165– 169,2001 .
  • Thomas S, Leichtweis S, Pettersson K, Croft K, Mori T, Brown A, Stocker R: Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice. Arterioscler Thromb Vasc Biol21 :585– 593,2001 .
  • Shklar G: Inhibition of oral mucosal carcinogenesis by vitamin E. J Natl Cancer Inst68 :791– 797,1987 .
  • Woutersen RA, Appel MJ, Van Garderen-Hoetmer A: Modulation of pancreatic carcinogenesis by antioxidants. Food Chem Tox37 :981– 984,1999 .
  • Stephens N, Parsons A, Schofield P, Kelly F, Cheeseman K, Mitchinson M, Brown M: Randomized controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet347 :781– 786,1996 .
  • Boaz M, Smetana S, Weinstein T, Matas Z, Gafter U, Iaina A, Knecht A, Weissgarten Y, Brunner D, Fainaru M, Green M: Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial. Lancet356 :1213– 1218,2000 .
  • Harnett J, Kent G, Foley R, Parfrey P: Cardiac function and hematocrit level. Am J Kidney Dis25(Suppl 1) :S3– S7,1995 .
  • Parfrey P: Cardiac and cerebrovascular disease in chronic uremia. Am J Kidney Dis21 :77– 80,1993 .
  • Toborek M, Wasik T, Drodz M, Klin M, Magner-Wrobel K, Kopieczna-Grzebieniak E: Effect of hemodialysis in lipid peroxidation and antioxidant systems in patients with chronic renal failure. Metabolism41 :1229– 1232,1992 .
  • Salonen J, Nyyssonen K, Salonen R, Lakka H, Kaikkonen J, Porkkala-Sarataho E, Voutilainen S, Lakka TA, Rissanen T, Leskinen L, Tuomainen TP, Valkonen VP, Ristonmaa U, Poulsen HE: Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis. J Int Med248 :377– 386,2000 .
  • Stampfer MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B, Willett WC: Vitamin E consumption and the risk of coronary disease in women. N Eng J Med328 :1444– 1449,1993 .
  • Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC: Vitamin E consumption and the risk of coronary heart disease in men. N Eng J Med328 :1450– 1456,1993 .
  • Weinberg R, VanderWerken B, Anderson R, Stegner J, Thomas M: Pro-oxidant effect of Vitamin E in cigarette smokers consuming a high polyunsaturated fat diet. Arterioscler Thromb Vasc Biol21 :1029– 1033,2001 .
  • Cheung M, Zhao X-Q, Chait A, Albers J, Brown G: Antioxidant supplements block the response of HDL to simvistatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol21 :1320– 1326,2001 .
  • Brown BG, Zhao XQ, Chait A, Fisher LD, Cheung MC, Morse JS, Dowdy AA, Marino EK, Bolson EL, Alaupovic P, Frohlich J, Albers JJ: Simvistatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med345 :1583– 1592,2001 .
  • Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico: Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet354 :447– 455,1999 .
  • Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G: Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med342 :145– 153,2000 .
  • Meydani M: Vitamin E and atherosclerosis: beyond prevention of LDL oxidation. J Nutr131 :366S– 368S,2001 .
  • de Gaetano G: Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Collaborative Group of the Primary Prevention Project. Lancet357 :89– 95,2001 .
  • Keith ME, Keith ME, Jeejeebhoy KN, Langer A, Kurian R, Barr A, O’Kelly B, Sole MJ: A controlled clinical trial of vitamin E supplementation in patients with congestive heart failure. Am J Clin Nutr73 :219– 224,2001 .
  • Hodis HN, Mack WJ, LaBree L, Mahrer PR, Sevanian A, Liu CR, Liu CH, Hwang J, Selzer RH, Azen SP: Alpha-tocopherol supplementation in healthy individuals reduced low-density lipoprotein oxidation but not atherosclerosis: the Vitamin E Atherosclerosis Prevention Study (VEAPS). Circulation106 :1453– 1459,2002 .
  • Heart Protection Study Collaborative Group: MRC/BHF Heart protection study of antioxidant vitamin supplementation in 20,536 high risk individuals: a randomised placebo-controlled trial. Lancet360 :23– 33,2002 .
  • The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group: The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Eng J Med330 :1029– 1035,1994 .
  • Blot W, Li JY, Taylor PR, Guo W, Dawsey S, Wang GQ, Yang CS, Zheng SF, Gail M, Li GY, et al.: Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease specific mortality in the general population. J Natl Cancer Inst85 :1483– 1492,1993 .

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