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Original Research

Bioavailability of Alpha-Linolenic Acid in Subjects after Ingestion of Three Different Forms of Flaxseed

, , MSc, , PhD, , MSc, , PhD, , MSc & , PhD show all
Pages 214-221 | Received 19 Oct 2006, Accepted 09 Nov 2007, Published online: 14 Jun 2013

REFERENCES

  • Bloedon LT, Szapary PO: Flaxseed and cardiovascular risk. Nutr Rev62 :18– 27,2004 .
  • Kris-Etherton PM, Harris WS, Appel LJ: Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation106 :2747– 2757,2002 .
  • Djoussé L, Arnett DK, Pankow JS, Hopkins PN, Province MA, Ellison RC: Dietary linolenic acid is associated with a lower prevalence of hypertension in the NHLBI Family Heart Study. Hypertension45 :368– 373,2005 .
  • Djoussé L, Arnett DK, Carr JJ, Eckfeldt JH, Hopkins PN, Province MA, Ellison RC, Investigators of the NHLBI FHS: Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the National Heart, Lung, and Blood Institute Family Heart Study. Circulation111 :2921– 2926,2005 .
  • Djoussé L, Pankow JS, Eckfeldt JH, Folsom AR, Hopkins PN, Province MA, Hong Y, Ellison RC: Relation between dietary linolenic acid and coronary artery disease in the National Heart, Lung and Blood Institute Family Heart Study. Am J Clin Nutr74 :612– 619,2001 .
  • Djoussé L, Hunt SC, Arnett DK, Province MA, Eckfeldt JH, Ellison RC: Dietary linolenic acid is inversely associated with plasma triacylglycerol: the National Heart, Lung, and Blood Institute Family Heart Study. Am J Clin Nutr78 :1098– 1102,2003 .
  • Djoussé L, Folsom AR, Province MA, Hunt SC, Ellison RC: Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. Am J Clin Nutr77 :819– 825,2003 .
  • De Lorgeril M, Salen P: Use and misuse of dietary fatty acids for the prevention and treatment of coronary heart disease. Reprod Nutr Dev44 :283– 288,2004 .
  • De Lorgeril M, Salen P, Martin JL, Monjaud I, Delave J, Mamelle N: Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation99 :779– 785,1999 .
  • Hu FB, Stampfer MJ, Manson JE, Rimm EB, Wolk A, Colditz GA, Hennekens CH, Willett WC: Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women. Am J Clin Nutr69 :890– 897,1999 .
  • Lemaitre RN, King IB, Mozaffarian D, Kuller LH, Tracy RP, Siscovick DS: n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study. Am J Clin Nutr77 :319– 325,2003 .
  • Ascherio A, Rimm EB, Giovannucci EL, Spiegelman D, Stampfer M, Willett WC: Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. BMJ313 :84– 90,1996 .
  • Dolecek TA: Epidemiological evidence of relationships between dietary polyunsaturated fatty acids and mortality in the multiple risk factor intervention trial. Proc Soc Exp Biol Med200 :177– 182,1992 .
  • Simon JA, Fong J, Bernert JT, Browner WS: Serum fatty acids and the risk of stroke. Stroke26 :778– 782,1995 .
  • Burdge GC, Calder PC: Dietary α-linolenic acid and health-related outcomes: a metabolic perspective. Nutr Res Rev19 :26– 52,2006 .
  • Prasad K: Flaxseed: a source of hypocholesterolemic and antiatherogenicagents. Drug News Perspect13 :99– 104,2000 .
  • Ander BP, Weber AR, Rampersad PP, Gilchrist JS, Pierce GN, Lukas A: Dietary flaxseed protects against ventricular fibrillation induced by ischemia-reperfusion in normal and hypercholesterolemic rabbits. J Nutr134 :3250– 3256,2004 .
  • Prasad K: Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. Circulation99 :1355– 1362,1999 .
  • Prasad K: Dietary flaxseed in prevention of hypercholesterolemic atherosclerosis. Atherosclerosis132 :69– 76,1997 .
  • Dupasquier CMC, Weber A-M, Ander BP, Rampersad PP, Steigerwald S, Wigle JT, Mitchell RW, Kroeger EA, Gilchrist JSC, Moghadasian MM, Lukas A, Pierce GN: The effects of dietary flaxseed on vascular contractile function and atherosclerosis in rabbits during prolonged hypercholesterolemia. Am J Physiol Heart Circ Physiol291 :H2987– H2996,2006 .
  • Dupasquier CMC, Dibrov E, Kneesh AL, Cheung PKM, Lee KGY, Alexander HK, Yeganeh BK, Moghadasian MH, Pierce GN: Dietary flaxseed inhibits atherosclerosis in the LDL receptor deficient mouse in part through anti-proliferative and anti-inflammatory actions. Am J Physiol Heart Circ Physiol293 :H2394– H2402,2007 .
  • Cunnane SC, Hamadeh MJ, Liede AC, Thompson LU, Wolever TM, Jenkins DJ: Nutritional attributes of traditional flaxseed in healthy young adults. Am J Clin Nutr61 :62– 68,1995 .
  • Cunnane SC, Ganguli S, Menard C, Liede AC, Hamadeh MJ, Chen ZY, Wolever TM, Jenkins DJ: High alpha-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humans. Br J Nutr69 :443– 4531993 .
  • Tarpila S, Aro A, Salminen I, Tarpila A, Kleemola P, Akkila J, Adlercreutz H: The effect of flaxseed supplementation in processed foods on serum fatty acids and enterolactone. Eur J Clin Nutr56 :157– 1652002 .
  • Lepage G, Roy CC: Direct transesterification of all classes of lipids in a one-step reaction. J Lipid Res27 :114– 120,1986 .
  • Kaul N, Kreml R, Austria JA, Landry MN, Edel AL, Dibrov E, Hirono S, Zettler ME, Pierce GN: A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr27 :51– 58,2008 .
  • Liu S, Sylvester DM: The inhibitory effect of 9-amino-1,2,3,4 tetrahydroacridine (THA) on platelet function. Thromb Res67 :533– 544,1992 .
  • Cardinal DC, Flower RJ: The electronic aggregometer: a novel device for assessing platelet behavior in blood. J Pharmacol Methods3 :135– 158,1980 .
  • Lucas EA, Wild RD, Hammond LJ, Khalil DA, Juma S, Daggy BP, Stoecker BJ, Arjmandi BH: Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women. J Clin Endocrinol Metab87 :1527– 1532,2002 .
  • Dodin S, Lemay A, Jacques A, Légaré F, Forest J-C, Mâsse B: The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: A randomized, double-blind, wheat germ placebo-controlled clinical trial. J Clin Endocrinol Metab90 :1390– 1397,2005 .
  • Zipes DP: Complimentary and alternative medicine: Ignore at doctors’ and patients’ peril. J Am Coll Cardiol37 :2166– 2169,2001 .
  • Harper CR, Edwards MJ, DeFilipis AP, Jacobson TA: Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. J Nutr136 :2844– 2848,2006 .
  • Burdge GC, Jones AE, Wootton SA: Eicosapentaenoic and docosapentaenoic acids are the principal products of α-linolenic acid metabolism in young men. Br J Nutr88 :355– 363,2002 .
  • Rodriguez BL, Sharp DS, Abbott RD, Burchfiel CM, Masaki K, Chyou PH, Huang B, Yano K, Curb JD: Fish intake may limit the increase in risk of coronary heart disease morbidity and mortality among heavy smokers. The Honolulu Heart Program. Circulation94 :952– 956,1996 .
  • Harris WS: N-3 Fatty Acids and serum lipoproteins: human studies. Am J Clin Nutr65 (Suppl):1645S– 1654S,1997 .
  • Ander BP, Hurtado C, Raposo CS, Maddaford TG, Deniset JF, Hryshko LV, Pierce GN, Lukas A: Differential sensitivities of the NCX 1.1 and NCX 1.3 isoforms of the Na+-Ca2+ exchanger to alpha-linolenic acid. Cardiovasc Res73 :395– 403,2006 .
  • Lucas EA, Lightfoot SA, Hammond JL, Devareddy L, Khalil DA, Daggy BP, Smith BJ, Westcott N, Mocanu V, Soung DY, Arjmandi BH: Flaxseed reduces plasma cholesterol and atherosclerotic lesion formation in ovariectomized Golden Syrian hamsters.Atherosclerosis173 :223– 229,2004 .

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