586
Views
96
CrossRef citations to date
0
Altmetric
Reviews

The Risks of Copper Toxicity Contributing to Cognitive Decline in the Aging Population and to Alzheimer's Disease

, MD, MACN
Pages 238-242 | Published online: 09 Jun 2013

References

  • WaldmanMLambM: “Dying for a Hamburger: Modern Meat Processing and the Epidemic of Alzheimer's Disease.” New York: Thomas Dunne Books, St. Martin's Press, 2004.
  • NelsonTJAlkonDL: Oxidation of cholesterol by amyloid precursor protein and beta amyloid peptide. J Biol Chem 280: 7377– 7387, 2005.
  • LeeuwenburghCRasmussenJEHsuFFMuellerDMPennathurSHeinekeJW: Mass spectrometric quantification of markers for protein oxidation by tyrosyl radical copper, and hydroxy radical in low density lipoprotein isolated from human atherosclerotic plaques. J Biol Chem 272: 3520– 3526, 1997.
  • MulthaupGSchlicksuppAHesseLBeherDRuppertTMastersCLBeyreutherK: The amyloid precursor protein of Alzheimer's disease in the reduction of copper (II) to copper (I). Science 271: 1406– 1409, 1996.
  • WhiteARMulthaupGGalatisDMcKinstryWJParkerMWPipkornRBeyruetherKMastersCLCappaiR: Contrasting species-dependant modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein. J Neurosci 22: 365– 376, 2002.
  • AngelettiBWaldronKJFreemanKBBawaganHIMillerCCLauKFTennantMEDennisonCRobinsonNJDingwallC: BACE I cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper. J Biol Chem 280: 17930– 17937, 2005.
  • MaOLiYDuJLiuHKanazawaKNemotoTNakanishiHZhaoY: Copper binding properties of a tau peptide associated with Alzheimer's disease studied by CD, NMR and MALDI-TOF MS. Peptides 27: 841– 849, 2006.
  • SeshadriSBeiserASelhubIJacquesPFRosenbergIHD'AgostinoRBWilsonPWWolfPA: Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. New Engl J Med 346: 476– 483, 2002.
  • NakanoEWilliamsonMPWilliamsNHPowersHI: Copper-medicated LDL oxidation by homocysteine and related compounds depends largely on copper ligation. Biochim Biophys Acta 1688: 3342, 2004.
  • SquittiRPasqualettiPDal FornGMoffaFCassettaELupoiDVernieriFRossiLBaldassiniMRossiniPM: Excess of serum copper not related to ceruloplasmin in Alzheimer's disease. Neurology 64: 1040– 1046, 2005.
  • SquittiRBarbatiGRossiLVentrigliaMDal FornoGCesarettiSMoffaFCaridiICasettaEPasqualettiPCalabreseLLupoiDRossiniPM: Excess of non-ceruloplasmin serum copper in AD correlates with MMSE, CSF β-amyloid and H tau. Neurology 67: 76– 82, 2006.
  • SquittiRBressiFPasqualettiPBonominiCGhidoniRBinettiGCasettaEMoffaFVentrigliaMVernieriFRossiniPM: Longetudinal prognostic value of serum “Free” copper in patients with Alzheimer's disease. Neurology 72: 50– 55, 2009.
  • SparksDSchreursB: Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease. Proc Natl Acad Sci USA 100: 11065– 11069, 2003.
  • SparksDFriedlandRRetanceskaSSchreursBGShiJPerryGSmithMASharmaADerosaSZiolkowskiCStankovicG: Trace copper levels in the drinking water, but not zinc or aluminum, influence CNS Alzheimer's like pathology. J Nutr Health Aging 10: 247– 254, 2006.
  • MorrisMCEvansDATangneyCCBeniasJLSchneiderJAWilsonRSScherrPA: Dietary copper and high saturated and trans fat intakes associated with cognitive decline. Arch Neurol 63: 1085– 1088, 2006.
  • HillGMBrewerGJJuniJEPrasadASDickRD: Treatment of Wilson's disease with zinc. II. Validation of oral 64 copper uptake with copper balance. Am J Med Sci 12: 344– 349, 1986.
  • BrewerGJNewsomeDA: “Copper Proof: How Chronic Copper Toxicity is Causing the Epidemics of Alzheimer's Disease and Dementia.” Ann Arbor: George J. Brewer Inc., 2009.
  • LiebmanB: The real cost of red meat. Nutrition Action Health Letter, June, 2009.
  • SinhaRCrossAJGraubardBILeitzmannMFSchatzkinA: Meat intake and mortality: A prospective study of over half a million people. Arch Intern Med 169: 562– 571, 2009.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.