Effect of Zinc Supplementation on GH, IGF1, IGFBP3, OCN, and ALP in Non-Zinc-Deficient Children

REFERENCES

• Prasad AS, Miale A Jr, Farid Z, Sandstead HH, Schulert AR, Darby WJ: Biochemical studies on dwarfism, hypogonadism, and anemia. Arch Intern Med 111:407–428, 1963.
   PubMed Web of Science ®Google Scholar
• Prasad AS: Impact of the discovery of human zinc deficiency on health. J Am Coll Nutr 28:257–265, 2009.
   PubMed Web of Science ®Google Scholar
• Imamoğlu S, Bereket A, Turan S, Taga Y, Haklar G: Effect of zinc supplementation on growth hormone secretion, IGF-I, IGFBP-3, somatomedin generation, alkaline phosphatase, osteocalcin and growth in prepubertal children with idiopathic short stature. J Pediatr Endocrinol Metab 18:69–74, 2005.
   PubMed Web of Science ®Google Scholar
• Yu ZP, Le GW, Shi YH: Effect of zinc sulphate and zinc methionine on growth, plasma growth hormone concentration, growth hormone receptor and insulin-like growth factor-I gene expression in mice. Clin Exp Pharmacol Physiol 32:273–278, 2005.
   PubMed Web of Science ®Google Scholar
• Nissensohn M, Villegas AS, Lugo DF, Sánchez PH, Alonso JD, Lowe NM, Moran VH, Skinner AL, Medina MW, Serra-Majem L: Effect of zinc intake on serum/plasma zinc status in infants: a meta-analysis. Matern Child Nutr 9:285–298, 2013.
   PubMed Web of Science ®Google Scholar
• Prasad AS: Zinc deficiency in women, infants and children. J Am Coll Nutr 15:113–120, 1996.
   PubMed Web of Science ®Google Scholar
• Alves CX, Vale SHL, Dantas MMG, Maia AA, Franca MC, Marchini JS, Leite LD, Brandao-Neto J: Positive effects of zinc supplementation on growth, GH, IGF1, and IGFBP3 in eutrophic children. J Pediatr Endocrinol Metab 25:881–887, 2012.
   PubMed Web of Science ®Google Scholar
• LaBella F, Dular R, Vivian S, Queen G: Pituitary hormone releasing or inhibiting activity of metal ions present in hypothalamic extracts. Biochem Biophys Res Commun 52:786–791, 1973.
   PubMed Web of Science ®Google Scholar
• Sun P, Wang S, Jiang Y, Tao Y, Tian Y, Zhu K, Wan H, Zhang L, Zhang L: Zip1, Zip2, and Zip8 mRNA expressions were associated with growth hormone level during the growth hormone provocation test in children with short stature. Biol Trace Elem Res 155:11–22, 2013.
   PubMed Web of Science ®Google Scholar
• Oner G, Bhaumick B, Bala RM: Effect of zinc deficiency on serum somatomedin levels and skeletal growth in young rats. Endocrinology 114:1860–1863, 1984.
   PubMed Web of Science ®Google Scholar
• Herington AC: Effect of zinc on the binding and action of GH in isolated rat adipocytes. Biochem Int 11:853–862, 1985.
   PubMedGoogle Scholar
• Dattani MT, Hindmarsh PC, Brook CG, Robinson IC, Weir T, Marshall NJ: Enhancement of GH bioactivity by zinc in the eluted stain assay system. Endocrinology 133:2803–2808, 1993.
   PubMed Web of Science ®Google Scholar
• Petkovic V, Miletta MC, Eblé A, Iliev DI, Binder G, Flück CE, Mullis PE: Effect of zinc binding residues in growth hormone (GH) and altered intracellular zinc content on regulated GH secretion. Endocrinology 154:4215–4225, 2013.
   PubMed Web of Science ®Google Scholar
• Lefebvre D, Beckers F, Ketelslegers JM, Thissen JP: Zinc regulation of insulin-like growth factor-I (IGF-I), growth hormone receptor (GHR) and binding protein (GHBP) gene expression in rat cultured hepatocytes. Mol Cell Endocrinol 138:127–136, 1998.
   PubMed Web of Science ®Google Scholar
• Karaca Z, Tanriverdi F, Kurtoglu S, Tokalioglu S, Unluhizarci K, Kelestimur F: Case report. Pubertal arrest due to Zn deficiency. The effect of zinc supplementation. Hormones 6:71–74, 2007.
   PubMedGoogle Scholar
• Juul A, Dalgaard P, Blum WF, Bang P, Hall K, Michaelsen KF, Müller J, Skakkebaek NE: Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation. J Clin Endocrinol Metab 80:2534–2542, 1995.
   PubMed Web of Science ®Google Scholar
• Cesur Y, Yordaman N, Doğan M: Serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels in children with zinc deficiency and the effect of zinc supplementation on these parameters. J Pediatr Endocrinol Metab 22:1137–1143, 2009.
   PubMed Web of Science ®Google Scholar
• Hadley KB, Newman SM, Hunt JR: Dietary zinc reduces osteoclast resorption activities and increases markers of osteoblast differentiation, matrix maturation, and mineralization in the long bones of growing rats. J Nutr Biochem 21:297–303, 2010.
   PubMed Web of Science ®Google Scholar
• MacDonald RS: The role of zinc in growth and cell proliferation. J Nutr 130:S1500–S1508, 2000.
   PubMed Web of Science ®Google Scholar
• Ninh NX, Thissen JP, Maiter D, Adam E, Mulumba N, Ketelslegers JM: Reduced liver insulin-like growth factor-I gene expression in young zinc-deprived rats is associated with a decrease in liver growth hormone (GH) receptors and serum GH-binding protein. J Endocrinol 144:449–456, 1995.
   PubMed Web of Science ®Google Scholar
• Neve A, Corrado A, Cantatore FP: Osteocalcin: skeletal and extra-skeletal effects. J Cell Physiol 228:1149–1153, 2013.
   PubMed Web of Science ®Google Scholar
• Bayer M: Reference values of osteocalcin and procollagen type I N-propeptide plasma levels in a healthy Central European population aged 0–18 years. Osteoporos Int 25:729–736, 2014.
   PubMed Web of Science ®Google Scholar
• Nagata M, Lönnerdal B: Role of zinc in cellular zinc trafficking and mineralization in a murine osteoblast-like cell line. J Nutr Biochem 22:172–178, 2011.
   PubMed Web of Science ®Google Scholar
• Nakamura T, Nishiyama S, Futagoishi-Suginohara Y, Matsuda I, Higashi A: Mild to moderate zinc deficiency in short children: effect of zinc supplementation on linear growth velocity. J Pediatr 123:65–69, 1993.
   PubMed Web of Science ®Google Scholar
• Tanner JM, Whitehouse RH: Clinical longitudinal standards for height, weight, height velocity, weight velocity and stages of puberty. Arch Dis Child 51:170–179, 1976.
   PubMed Web of Science ®Google Scholar
• Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J: Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ 85:660–667, 2007.
   PubMed Web of Science ®Google Scholar
• World Health Organization: Growth reference data for 5–19 years. 2007. Accessed at: http://www.who.int/growthref/en/
   Google Scholar
• Universidade Federal de São Paulo: Support program for nutrition. 2007. Accessed at http://sourceforge.net/projects/nutwin/
   Google Scholar
• Universidade Estadual de Campinas: “Núcleo de Estudos e Pesquisasem Alimentação (NEPA): Tabela Brasileira de Composição de Alimentos (TACO).” Campinas, Brazil: NEPA-UNICAMP, 2011.
   Google Scholar
• Lowe NM, Fekete K, Decsi T: Methods of assessment of zinc status in humans: a systematic review. Am J Clin Nutr 89:S2040–S2051, 2009.
   PubMed Web of Science ®Google Scholar
• Joint FAO/WHO/UNU Expert Consultation: Human energy requirements. 2001. Accessed at: http://www.fao.org/docrep/007/y5686e/y5686e00.htm
   Google Scholar
• Food and Nutrition Board, Institute of Medicine: “Dietary Reference Intakes for Calcium and Vitamin D.” Washington, DC: The National Academies Press, 2011.
   Google Scholar
• Food and Nutrition Board, Institute of Medicine: “Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc.” Washington, DC: The National Academies Press, 2003.
   Google Scholar
• Food and Nutrition Board, Institute of Medicine: “Dietary Reference Intakes (DRIs) for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids.” Washington, DC: The National Academies Press, 2005.
   Google Scholar
• Leite LD, Rocha EDM, Almeida MG, Rezende AA, da Silva CA, França MC, Marchini JS, Brandão-Neto J: Sensitivity of zinc kinetics and nutritional assessment of children submitted to venous zinc tolerance test. J Am Coll Nutr 28:405–412, 2009.
   PubMed Web of Science ®Google Scholar
• Dedoussis GV, Louizou E, Papoutsakis C, Skenderi KP, Yannakoulia M: Dairy intake associates with the IGF rs680 polymorphism to height variation in periadolescent children. Eur J Clin Nutr 64:253–258, 2010.
   PubMed Web of Science ®Google Scholar
• Ekbote V, Khadilkar A, Chiplonkar S, Mughal Z, Khadilkar V: Enhanced effect of zinc and calcium supplementation on bone status in growth hormone-deficient children treated with growth hormone: a pilot randomized controlled trial. Endocrine 43:686–695, 2013.
   PubMed Web of Science ®Google Scholar
• Moran VH, Stammers A-L, Medina MW, Patel S, Dykes F, Souverein OW, Dullemeijer C, Pérez-Rodrigo C, Serra-Majem L, Nissensohn M, Lowe NM: The relationship between zinc intake and serum/plasma zinc concentration in children: a systematic review and dose–response meta-analysis. Nutrients 4:841–858, 2012.
   Google Scholar
• Hamza RT, Hamed AI, Sallam MT: Effect of zinc supplementation on growth hormone insulin growth factor axis in short Egyptian children with zinc deficiency. Ital J Pediatr 38:21, 2012.
   PubMedGoogle Scholar
• Estefan V, Mendonça BB, Arnhold IJP, Nicolau W, Brandão-Neto J: Effects of acute and chronic zinc administration on growth velocity in patients with hypopituitarism. Nutr Res 18:1865–1877, 1998.
   Web of Science ®Google Scholar
• Petkovic V, Miletta MC, Mullis P-E: Endoplasmic reticulum to secretory granules: role of zinc in the secretory pathway of growth hormone. Endocr Dev 23:96–108, 2012.
   PubMedGoogle Scholar
• Ninh NX, Maiter D, Lause P, Chrzanowska B, Underwood LE, Ketelslegers JM, Thissen JP: Continuous administration of growth hormone does not prevent the decrease of IGF-I gene expression in zinc-deprived rats despite normalization of liver GH binding. Growth Horm IGF Res 8:465–472, 1998.
   PubMed Web of Science ®Google Scholar
• Ohisson C, Bengtsson BA, Isaksson OG, Andreassen TT, Slootweg MC: Growth hormone and bone. Endocr Rev 19:55–79, 1998.
   PubMed Web of Science ®Google Scholar
• Clegg MS, Keen CL, Donovan SM: Zinc deficiency induced anorexia influences the distribution of serum insulin-like growth factor–binding proteins in the rat. Metabolism 44:1495–1501, 1995.
   PubMed Web of Science ®Google Scholar
• Zadik Z, Sinai T, Zung A, Golander A, Reifen R: “Functional food” for acceleration of growth in short children born small for gestational age. J Pediatr Endocrinol Metab 23:435–441, 2010.
   PubMed Web of Science ®Google Scholar
• Yamaguchi M, Hashizume M: Effect of β-alanyl-l-histidinato zinc on protein components in osteoblastic MC3T3-El cells: increase in osteocalcin, insulin-like growth factor-I and transforming growth factor-β. Mol Cell Biochem 136:163–169, 1994.
   PubMed Web of Science ®Google Scholar
• Maser RE, Stabley JN, Lenhard MJ, Owusu-Griffin P, Provost-Craig MA, Farquhar WB: Zinc intake and biochemical markers of bone turnover in type 1 diabetes. Diabetes Care 31:2279–2280, 2008.
   PubMed Web of Science ®Google Scholar