208
Views
16
CrossRef citations to date
0
Altmetric
Original Research

Microalgal Oil from Schizochytrium sp. Prevents HFD-Induced Abdominal Fat Accumulation in Mice

, PhD, , MS, , MS, , PhD, , MS, , MS, , MS, , BS, , MS, , MS, , MS, , PhD, Prof & , PhD, Prof show all
Pages 347-356 | Received 02 Dec 2016, Accepted 01 Mar 2017, Published online: 26 May 2017

References

  • Kelly T, Yang W, Chen CS, Reynolds K, He J: Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond) 32:1431–1437, 2008.
  • NCD Risk Factor Collaboration: Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants. Lancet 10026:1377–1396, 2016.
  • Bhaskaran K, Douglas I, Forbes H, Dos-Santos-Silva I, Leon DA, Smeeth L: Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5.24 million UK adults. Lancet 384:755–765, 2014.
  • Mohamed GA, Ibrahim SRM, Elkhayat ES, Dine RSE: Natural anti-obesity agents. Bulletin Faculty of Pharmacy Cairo University 52:269–284, 2014.
  • Bender N, Portmann M, Heg Z, Hofmann K, Zwahlen M, Egger M: Fish or n3-PUFA intake and body composition: a systematic review and meta-analysis. Obes Rev 15:657–665, 2014.
  • Bhaswant M, Poudyal H, Brown L: Mechanisms of enhanced insulin secretion and sensitivity with n-3 unsaturated fatty acids. J Nutr Biochem 26:571–584, 2015.
  • Flachs P, Rossmeisl M, Kopecky J: The effect of n-3 fatty acids on glucose homeostasis and insulin sensitivity. Physiol Res 63(Suppl 1):S93–S118, 2014.
  • Lenihan-Geels G, Bishop KS, Ferguson LR: Alternative sources of omega-3 fats: can we find a sustainable substitute for fish? Nutrients 5:1301–1315, 2013.
  • Martins DA, Custodio L, Barreira L, Pereira H, Ben-Hamadou R, Varela J, Abu-Salah KM: Alternative sources of n-3 long-chain polyunsaturated fatty acids in marine microalgae. Mar Drugs 11:2259–2281, 2013.
  • Salem N Jr, Eggersdorfer M: Is the world supply of omega-3 fatty acids adequate for optimal human nutrition. Curr Opin Clin Nutr Metab Care 2:147–154, 2015.
  • Kagan ML, Levy A, Leikin-Frenkel A: Comparative study of tissue deposition of omega-3 fatty acids from polar–lipid rich oil of the microalgae Nannochloropsis oculata with krill oil in rats. Food Funct 6:186–192, 2015.
  • Neff LM, Culiner J, Cunningham-Rundles S, Seidman C, Meehan D, Maturi J, Wittkowski KM, Levine B, Breslow JL: Algal docosahexaenoic acid affects plasma lipoprotein particle size distribution in overweight and obese adults. J Nutr 141:207–213, 2011.
  • Go RE, Hwang KA, Park GT, Lee HM, Lee GA, Kim CW, Jeon SY, Seo JW, Hong WK, Choi KC: Effects of microalgal polyunsaturated fatty acid oil on body weight and lipid accumulation in the liver of C57BL/6 mice fed a high fat diet. J Biomed Res 30:234–242, 2016.
  • Yook JS, Kim KA, Park JE, Lee SH, Cha YS: Microalgal oil supplementation has an anti-obesity effect in C57BL/6J mice fed a high fat diet. Prev Nutr Food Sci 20:230–237, 2015.
  • Hu XC, Ren LJ, Chen SL, Zhang L, Ji XJ, Huang H: The roles of different salts and a novel osmotic pressure control strategy for improvement of DHA production by Schizochytrium sp. Bioprocess Biosyst Eng 38:2129–2136, 2015.
  • Lewis KD, Uang W, Zheng X, Jiang Y, Feldman RS, Falk MC: Toxicological evaluation of arachidonic acid (ARA)-rich oil and docosahexaenoic acid (DHA)-rich oil. Food Chem Toxicol 96:133–144, 2016.
  • Fedorova-Dahmsa I, Maroneb PA, Bailey-Halla E, Ryana AS: Safety evaluation of algal oil from Schizochytrium sp. Food Chem Toxicol 49:70–77, 2011.
  • Komprda T, Skultety O, Krizkova S, Zornikova G, Rozikova V, Krobot R: Effect of dietary Schizochytrium microalga oil and fish oil on plasma cholesterol level in rats. J Anim Physiol Anim Nutr (Berl) 99:308–316, 2014.
  • Komprda T, Sladek Z, Skultety O, Krizkova S, Rozikova V, Nemcova B, Sustrova T, Valova M: Effect of dietary Schizochytrium microalga oil on selected markers of low-grade inflammation in rats. J Anim Physiol Anim Nutr (Berl) 100:1169–1178, 2016.
  • Buckley JD, Howe PRC: Anti-obesity effects of long-chain omega-3 polyunsaturated fatty acids. Obes Rev 6:648–659, 2009.
  • Delarue J, LeFoll C, Corporeau C, Lucas D: n-3 Long chain polyunsaturated fatty acids: a nutritional tool to prevent insulin resistance associated to type 2 diabetes and obesity? Reprod Nutr Dev 44:289–299, 2004.
  • Yi T, Li S, Fan J, Fan L, Zhang Z, Luo P, Zhang X, Wang J, Zhu L, Zhao Z, Chen H: Comparative analysis of EPA and DHA in fish oil nutritional capsules by GC-MS. Lipids Health Dis 13:190–195, 2014.
  • Cleland LG, James MJ, Proudman SM: Fish oil: what the prescriber needs to know. Arthritis Res Ther 1:202–211, 2006.
  • Taltavull N, Muñoz-Cortés M, Lluís L, Jové M, Fortuño À, Molinar-Toribio E, Torres JL, Pazos M, Medina I, Nogués MR: Eicosapentaenoic acid docosahexaenoic acid 1:1 ratio improves histological alteration in obese rats. Lipids Health Dis 31:1–11, 2014.
  • Wu Y, Liu C, Sun H, Vijayakumar A, Giglou PR, Qiao R, Oppenheimer J, Yakar S, Leroith D: Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice. J Clin Invest 121:2422–2426, 2011.
  • Pacifici F, Arriga R, Sorice GP, Capuani B, Scioli MG, Pastore D, Donadel G, Bellia A, Caratelli S, Coppola A, Ferrelli F, Federici M, Sconocchia G, Tesauro M, Sbraccia P, Della-Morte D, Giaccari A, Orlandi A, Lauro D: Peroxiredoxin 6, a novel player in the pathogenesis of diabetes. Diabetes 63:3210–3220, 2014.
  • Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−delta c(t)) method. Methods 25:402–408, 2001.
  • Golub N, Geba D, Mousa S, Williams G, Block R: Greasing the wheels of managing overweight and obesity with omega-3 fatty acids. Med Hypotheses 6:1114–1120, 2011.
  • Djoussé L, Gaziano JM, Buring JE, Lee I: Dietary omega-3 fatty acids and fish consumption and risk of type 2 diabetes. Am J Clin Nutr. 1:143–150, 2011.
  • Després J, Lemieux I: Abdominal obesity and metabolic syndrome. Nature 444:881–887, 2006.
  • Takahashi Y, Ide T: Dietary n-3 fatty acids affect mRNA level of brown adipose tissue uncoupling protein 1, and white adipose tissue leptin and glucose transporter 4 in the rat. Br J Nutr 84:175–184, 2000.
  • Dossia CG, Tapiaa GS, Espinosab A, Videlaa LA, D'Espessailles A: Reversal of high-fat diet–induced hepatic steatosis by n-3 LCPUFA: Role of PPAR-α and SREBP-1c. J Nutr Biochem 25:977–984, 2014.
  • Lin N, Shi JJ, Li YM, Zhang XY, Chen Y, Calder PC, Tang LJ: What is the impact of n-3 PUFAs on inflammation markers in type 2 diabetic mellitus populations?: a systematic review and meta-analysis of randomized controlled trials. Lipids Health Dis 15:133–140, 2016.
  • Sugimoto S, Nakajima H, Kosaka K, Hosoi H: Review: miglitol has potential as a therapeutic drug against obesity. Nutr Metab 12:51–57, 2015.
  • Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerback S, Nuutila P: Functional brown adipose tissue in healthy adults. N Engl J Med 360:1518–1525, 2009.
  • Oudart H, Groscolas R, Calgari C, Nibbelink M, Leray C, Le Maho Y, Malan A: Brown fat thermogenesis in rats fed high-fat diets enriched with n-3 polyunsaturated fatty acids. Int J Obes 21:955–962, 1997.
  • Bargut TC, Silva-e-Silva AC, Souza-Mello V, Mandarim-de-Lacerda CA, Aguila MB: Mice fed fish oil diet and upregulation of brown adipose tissue thermogenic markers. Eur J Nutr 55:159–169, 2016.
  • Bernstein AM, Ding EL, Willett WC, Rimm EB: A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. J Nutr 142:99–104, 2012.
  • Joseph J, Shamburek RD, Cochran EK, Gorden P, Brown RJ: Lipid regulation in lipodystrophy versus the obesity-associated metabolic syndrome: the dissociation of HDL-C and triglycerides. J Clin Endocrinol Metab 9:1676–1680, 2014.
  • Chapman MJ, Ginsberg HN, Amarenco P, Andreotti F, Borén J, Catapano AL, Descamps OS, Fisher E, Kovanen PT, Kuivenhoven JA, Lesnik P, Masana L, Nordestgaard BG, Ray KK, Reiner Z, Taskinen M, Tokgözoglu L, Tybjærg-Hansen A, Watts GF: Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J 11:1345–1361, 2011.
  • Huang L, Chen J, Cao P, Pan H, Ding C, Xiao T, Zhang P, Guo J, Su Z: Anti-obese effect of glucosamine and chitosan oligosaccharide in high-fat diet–induced obese rats. Mar Drugs 5:2732–2756, 2015.
  • Yoon Y, Chung MY, Hwang J, Han MS, Goo T, Yun E: Allomyrina dichotoma (Arthropoda: Insecta) larvae confer resistance to obesity in mice fed a high-fat diet. Nutrients 3:1978–1991, 2015.
  • Xie X, Zhang T, Zhao S, Li W, Ma L, Ding M, Liu Y: Effects of n-3 polyunsaturated fatty acids high fat diet intervention on the synthesis of hepatic high-density lipoprotein cholesterol in obesity–insulin resistance rats. Lipids Health Dis 15:81–87, 2016.
  • le Morvan V, Dumon M, Palos-Pinto A, Bérard AM: n-3 FA increase liver uptake of HDL-cholesterol in mice. Lipids 8:767–772, 2002.
  • Bhaswant M, Poudyal H, Brown L: Mechanisms of enhanced insulin secretion and sensitivity with n-3 unsaturated fatty acids. J Nutr Biochem 26:571–584, 2015.
  • Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB: Adipose tissue remodeling: its role in energy metabolism and metabolic disorders. Front Endocrinol (Lausanne) 30:1–16, 2016.
  • Fabbrini E, Sullivan S, Klein S: Obesity and nonalcoholic fatty liver disease: biochemical, metabolic and clinical implications. Hepatology 2:679–689, 2010.
  • Chen XJ, Mao HL, Ma XM, Liu JX: Effects of dietary corn oil and vitamin E supplementation on fatty acid profiles and expression of acetyl CoA carboxylase and stearoyl-CoA desaturase gene in Hu sheep. Anim Sci J 81:165–171, 2010.
  • Geldenhuys WJ, Lin L, Darvesh AS, Sadana P: Emerging strategies of targeting lipoprotein lipase for metabolic and cardiovascular diseases. Drug Discov Today 22:352–365, 2017.
  • Poudyal H, Panchal SK, Ward LC, Brown L: Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet–induced metabolic syndrome in rats. J Nutr Biochem 24:1041–1052, 2013.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.