Genomics of Detoxification: How Genomics can be Used for Targeting Potential Intervention and Prevention Strategies Including Nutrition for Environmentally Acquired Illness

References

• Clancy S, Brown W. Translation: DNA to mRNA to protein. Nat Educ. 2008;1(1):101.
   Google Scholar
• Cooper GM. Regulation of transcription in eukaryotes. In The cell: A molecular approach. 2nd ed. Sunderland (MA): Sinauer Associates; 2000. Available from: https://www.ncbi.nlm.nih.gov/books/NBK9904/.
   Google Scholar
• Ray PD, Huang BW, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal. 2012;24(5):981–990. doi:10.1016/j.cellsig.2012.01.008.
   PubMed Web of Science ®Google Scholar
• Kohchi C, Inagawa H, Nishizawa T, Soma GI. ROS and innate immunity. Anticancer Res. 2009;29(3):817–821.
   PubMed Web of Science ®Google Scholar
• Sharma P, Jha AB, Dubey RS, Pessarakli M. Reactive oxygen species, oxidative damage, and antioxidative defense mechanism in plants under stressful conditions. J Bot. 2012;2012:1–26. doi:10.1155/2012/217037.
   Google Scholar
• Paz y, Mino C, Munoz MJ, Maldonado A, Valladares C, Cumbal N, Herrera C, Robles P, Sanchez ME, Lopez Cortes A. Baseline determination in social, health, and genetic areas in communities affected by glyphosate aerial spraying on the northeastern Ecuadorian border. Rev Environ Health. 2011;26(1):45–51. doi:10.1515/reveh.2011.007.
   PubMedGoogle Scholar
• Cimbaljevic S, Suvakov S, Matic M, Pljesa-Ercegovac M, Pekmezovic T, Radic T, Coric V, Damjanovic T, Dimkovic N, Markovic R, et al. Association of GSTO1 and GSTO2 polymorphism with risk of end-stage renal disease development and patient survival. J Med Biochem. 2016;35(3):302–311. doi:10.1515/jomb-2016-0009.
   PubMed Web of Science ®Google Scholar
• Jiang Z, Liang K, Zhang Q, Tao L. Glutathione S-transferases polymorphisms confer susceptibility to senile cortical cataract in the Han Chinese population. Mol Vis. 2012;18:1247–1252.
   PubMed Web of Science ®Google Scholar
• Yang X, Qiu MT, Hu JW, Wang XX, Jiang F, Yin R, Xu L. GSTT1 null genotype contributes to lung cancer risk in Asian populations: a meta-analysis of 23 studies. PLoS One. 2013;8(4):e62181. doi:10.1371/journal.pone.0062181.
   PubMed Web of Science ®Google Scholar
• Parchami Barjui S, Reiisi S, Bayati A. Human glutathione s-transferase enzyme gene variations and risk of multiple sclerosis in Iranian population cohort. Mult Scler Relat Disord. 2017;17:41–46. doi:10.1016/j.msard.2017.06.016.
   PubMed Web of Science ®Google Scholar
• Longo GS, Pinhel MS, Sado CL, Gregorio ML, Amorim GS, Florim GS, Mazeti CM, Martins DP, Oliveira FN, Tognola WA, et al. Exposure to pesticides and heterozygote genotype of GSTP1-Alw26I are associated to Parkinson's disease. Arq Neuro-Psiquiatr. 2013;71(7):446–452. doi:10.1590/0004-282X20130060.
   PubMed Web of Science ®Google Scholar
• Andreoli V, Sprovieri F. Genetic aspects of susceptability to mercury toxicity: an overview. IJERPH. 2017;14(1):93. doi:10.3390/ijerph14010093.
   Google Scholar
• Buraczynska M, Buraczynska K, Dragan M, Ksiazek A. Pro198Leu polymorphism in the glutathione peroxidase 1 gene contributes to diabetic peripheral neuropathy in type 2 diabetes patients. Neuromol Med. 2017;19(1):147–153. doi:10.1007/s12017-016-8438-2.
   PubMed Web of Science ®Google Scholar
• Cao M, Mu X, Jiang C, Yang G, Chen H, Xue W. Single-nucleotide polymorphisms of GPX1 and MnSOD and susceptibility to bladder cancer: a systematic review and meta-analysis. Tumor Biol. 2014;35(1):759–764. doi:10.1007/s13277-013-1103-6.
   PubMedGoogle Scholar
• Paz y, Mino C, Munoz MJ, Lopez-Cortes A, Cabrera A, Palacios A, Castro B, Paz y, Mino N, Sanchez ME. Frequency of polymorphisms pro198leu in GPX-1 gene and ile58thr in MnSOD gene in the altitude Ecuadorian population with bladder cancer. Oncol Res. 2010;18(8):395–400. doi:10.3727/096504010X12644422320780.
   PubMed Web of Science ®Google Scholar
• Liu YJ, Huang PL, Chang YF, Chen YH, Chiou YH, Xu ZL, Wong RH. GSTP1 genetic polymorphism is associated with a higher risk of DNA damage in pesticide-exposed fruit growers. Cancer Epidemiol Biomarkers Prev. 2006;15(4):659–666. doi:10.1158/1055-9965.EPI-05-0617.
   PubMed Web of Science ®Google Scholar
• Melen E, Nyberg F, Lindgren CM, Berflind N, Zucchelli M, Nordling E, Hallberg J, Svartengren M, Morgenstern R, Kere J, et al. Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease. Environ Health Perspect. 2008;116(8):1077–1084. doi:10.1289/ehp.11117.
   PubMed Web of Science ®Google Scholar
• Ge B, Song Y, Zhang Y, Liu X, Wen Y, Guo X. Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) null polymorphisms and the risk of hypertension: a meta-analysis. PLoS One. 2015;10(3):e0118897. doi:10.1371/journal.pone.0118897.
   PubMed Web of Science ®Google Scholar
• Nasseri G, Zahedi T, Mousavi-Kazerooni F, Saadat M. Prevalence of null genotypes of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) in seven Iranian populations. Iran J Public Health. 2015;44(12):1655–1661.
   PubMed Web of Science ®Google Scholar
• Welch C. Melting arctic permafrost could release tons of toxic mercury. National Geographic, 2018.
   Google Scholar
• Gordeeva LA, Voronina EN, Sokolova EA, Ermolenko NA, Gareeva JV, Sutulina IM, Simonova TA, Filipenko ML, Glushkov AN. Association GSTT1, GSTM1, and GSTP1 (Ile105Val) genetic polymorphisms in mothers with risk of congenital malformations in their children in Western Siberia: a case-control study. Prenat Diagn. 2013;33(11):1095–1101. doi:10.1002/pd.4204.
   PubMed Web of Science ®Google Scholar
• Ercegovac M, Jovic N, Sokic D, Savic-Radojevic A, Coric V, Radic T, Nikolic D, Kecmanovic M, Matic M, Simic T, Pljesa-Ercegovac M. GSTA1, GSTM1, GSTP1 and GSTT1 polymorphisms in progressive myoclonus epilepsy: a Serbian case-control study. Seizure. 2015;32:30–36. doi:10.1016/j.seizure.2015.08.010.
   PubMed Web of Science ®Google Scholar
• Wang M, Li Y, Lin L, Song G, Deng T. GSTM1 null genotype and GSTP1 Ile105Val polymorphism are associated with Alzheimer’s disease: a meta-analysis. Mol Neurobiol. 2016;53(2):1355–1364. doi:10.1007/s12035-015-9092-7.
   PubMed Web of Science ®Google Scholar
• De Mendonca E, Salazar Alcala E, Fernandez-Mestre M. Role of genes GSTM1, GSTT1, and MnSOD in the development of late-onset Alzheimer disease and their relationship with APOE*4. Neurologia. 2016;31(8):535–542.
   PubMed Web of Science ®Google Scholar
• Allocati N, Masulli M, Di Ilio C, Federici L. Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases. Oncogenesis. 2018;7(1):8. doi:10.1038/s41389-017-0025-3.
   PubMedGoogle Scholar
• Liu X, Lv K. Cruciferous vegetables intake is inversely associated with risk of breast cancer: a meta-analysis. The Breast. 2013;22(3):309–313. doi:10.1016/j.breast.2012.07.013.
   PubMed Web of Science ®Google Scholar
• Lee SA, Fowke JH, Lu W, Ye C, Zheng Y, Cai Q, Gu K, Gao YT, Shu XO, Zheng W. Cruciferous vegetables, the GSTP1 Ile 105 Val genetic polymorphism, and breast cancer risk. Am J Clin Nutr. 2008;87(3):753–760. doi:10.1093/ajcn/87.3.753.
   PubMed Web of Science ®Google Scholar
• Riedl MA, Saxon A, Diaz-Sanchez D. Oral sulforaphane increases phase II antioxidant enzymes in the human upper airway. Clin Immunol. 2009;130(3):244–251. doi:10.1016/j.clim.2008.10.007.
   PubMed Web of Science ®Google Scholar
• Whillier S, Raftos JE, Chapman B, Kuchel PW. Role of N-acetylcysteine and cystine in glutathione synthesis in human erythrocytes. Redox Rep. 2009;14(3):115–124. doi:10.1179/135100009X392539.
   PubMed Web of Science ®Google Scholar
• Amin AF, Shaaban OM, Bediawy MA. N-acetyl cysteine for treatment of recurrent unexplained pregnancy loss. Reprod Biomed Online. 2008;17(5):722–726. doi:10.1016/S1472-6483(10)60322-7.
   PubMed Web of Science ®Google Scholar
• Marnewick JL, Joubert E, Swart P, Van Der Westhuizen F, Gelderblom WC. Modulation of hepatic drug metabolizing enzymes and oxidative status by rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia), green and black (Camellia sinensis) teas in rats. J Agric Food Chem. 2003;51(27):8113–8119. doi:10.1021/jf0344643.
   PubMed Web of Science ®Google Scholar
• Hodges RE, Minich DM. Modulation of metabolic detoxification pathways using foods and food-derived components: a scientific review with clinical application. J Nutr Metab. 2015;2015:1–23. doi:10.1155/2015/760689.
   Google Scholar
• Dong Z, Shang H, Chen YQ, Pan LL, Bhatia M, Sun J. Sulforaphane protects pancreatic acinar cell injury by modulating Nrf2-mediated oxidative stress and NLRP3 inflammatory pathway. Oxid Med Cell Longevity. 2016;2016:12. doi:10.1155/2016/7864150.
   Google Scholar
• Cardoso B, Apolinario D, da Silva Bandeira V, Busse AL, Magaldi RM, Jacob-Filho W, Cozzolino SM. Effects of Brazil nut consumption on selenium status and cognitive performance in older adults with mild cognitive impairment: a randomized controlled pilot trial. Eur J Nutr. 2016;55(1):107–116. doi:10.1007/s00394-014-0829-2.
   PubMed Web of Science ®Google Scholar
• Ivanov IV, Mappes T, Schaupp P, Lappe C, Wahl S. Ultraviolet radiation oxidative stress affects eye health. J Biophotonics. 2018;11(7):e201700377. doi:10.1002/jbio.201700377.
   PubMed Web of Science ®Google Scholar
• Stamenkovic M, Radic T, Stefanovic I, Coric V, Sencanic I, Pljesa-Ercegovac M, Matic M, Jaksic V, Simic T, Savic-Radojevic A. Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation. Clin Experiment Ophthalmol. 2014;42(3):277–283. doi:10.1111/ceo.12180.
   PubMed Web of Science ®Google Scholar
• Ravindran RD, Vashist P, Gupta SK, Young IS, Maraini G, Camparini M, Jayanthi R, John N, Fitzpatrick KE, Chakravarthy U, et al. Inverse association of vitamin C with cataract in older people in India. Ophthalmology. 2011;118(10):1958–1965. doi:10.1016/j.ophtha.2011.03.016.
   PubMed Web of Science ®Google Scholar
• Ross D, Siegel D. Functions of NQO1 in cellular protection and CoQ10 metabolism and its potential role as a redox sensitive molecular switch. Front Physiol. 2017;8:595doi:10.3389/fphys.2017.00595.
   PubMed Web of Science ®Google Scholar
• Siegel D, Yan C, Ross D. NAD(P)H: Quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. Biochem Pharmacol. 2012;83(8):1033–1040. doi:10.1016/j.bcp.2011.12.017.
   PubMed Web of Science ®Google Scholar
• Trevors JT, Basaraba J. Toxicity of benzoquinone and hydroquinone in short-term bacterial bioassays. Bull Environ Contam Toxicol. 1980;25(1):672–675. doi:10.1007/BF01985590.
   PubMedGoogle Scholar
• Xie Z, Zhang Y, Guliaev AB, Shen H, Hang B, Singer B, Wang Z. The p-benzoquinone DNA adducts derived from benzene are highly mutagenic. DNA Repair (Amst). 2005;4(12):1399–1409. doi:10.1016/j.dnarep.2005.08.012.
   PubMed Web of Science ®Google Scholar
• Moran JL, Siegel D, Ross D. A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity. Proc Natl Acad Sci USA. 1999;96(14):8150–8155. doi:10.1073/pnas.96.14.8150.
   PubMed Web of Science ®Google Scholar
• Rothman N, Smith MT, Hayes RB, Traver RD, Hoener B, Campleman S, Li GL, Dosemeci M, Linet M, Zhang L, et al. Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C→T mutation and rapid fractional excretion of chlorzoxazone. Cancer Res. 1997;57(14):2839–2842.
   PubMed Web of Science ®Google Scholar
• Wu JM, Oraee A, Doonan BB, Pinto JT, Hsieh TC. Activation of NQO1 in NQO1*2 polymorphic human leukemic HL-60 cells by diet-derived sulforaphane. Exp Hematol Oncol. 2015;5(1):27. doi:10.1186/s40164-016-0056-z.
   PubMedGoogle Scholar
• Tsai CW, Lin CY, Wang YJ. Carnosic acid induces the NAD(P)H: quinone oxidoreductase 1 expression in rat clone 9 cells through the p38/nuclear factor erythroid-2 related factor 2 pathway. J Nutr. 2011;141(12):2119–2125. doi:10.3945/jn.111.146779.
   PubMed Web of Science ®Google Scholar
• El Batsh MM, Zakaria SS, Gaballah HH. Protective effects of alpha-lipoic acid against benzene induced toxicity in experimental rats. Eur Rev Med Pharmacol Sci. 2015;19(14):2717–2724.
   PubMed Web of Science ®Google Scholar
• Zarth AT, Murphy SE, Hecht SS. Benzene oxide is a substrate for glutathione S-transferases. Chem Biol Interact. 2015;242:390–395. doi:10.1016/j.cbi.2015.11.005.
   PubMed Web of Science ®Google Scholar
• Boesch-Saadatmandi C, Egert S, Schrader C, Coumoul X, Coumol X, Barouki R, Muller MJ, Wolffram S, Rimbach G. Effect of quercetin on paraoxonase 1 activity- studies in cultured cells, mice and humans. J Physiol Pharmacol. 2010;61(1):99–105.
   PubMed Web of Science ®Google Scholar
• Baralic I, Djordjevic B, Dikic N, Kotur-Stevuljevic J, Spasic S, Jelic-Ivanovic Z, Radivojevic N, Andjelkovic M, Pejic S. Effect of astaxanthin supplementation on paraoxonase 1 activities and oxidative stress status in young soccer players. Phytother Res. 2013;27(10):1536–1542. doi:10.1002/ptr.4898.
   PubMed Web of Science ®Google Scholar
• Montgomery MP, Postel E, Umbach DM, Richards M, Watson M, Blair A, Chen H, Sandler DP, Schmidt S, Kamel F. Pesticide use and age-related macular degeneration in the agricultural health study. Environ Health Perspect. 2017;125(7):77013.
   Web of Science ®Google Scholar
• Lou-Bonafonte JM, Gabas-Rivera C, Navarro MA, Osada J. The search for dietary supplements to elevate or activate circulating paraoxonases. IJMS. 2017;18(2):416. doi:10.3390/ijms18020416.
   Google Scholar
• Volotinen M, Maenpaa J, Kankuri E, Oksala O, Pelkonen O, Nakajima M, Yokoi T, Hakkola J. Expression of cytochrome P450 (CYP) enzymes in human nonpigmented ciliary epithelial cells: induction of CYP1B1 expression by TCDD. Invest Ophthalmol Vis Sci. 2009;50(7):3099–3105. doi:10.1167/iovs.08-2790.
   PubMed Web of Science ®Google Scholar
• Estabrook RW. A passion for P450s (rememberances of the early history of research on cytochrome P450. Drug Metab Dispos. 2003;31(12):1461–1473. doi:10.1124/dmd.31.12.1461.
   PubMed Web of Science ®Google Scholar
• Srogi K. Monitoring of environmental exposure to polycyclic aromatic hydrocarbons: a review. Environ Chem Lett. 2007;5(4):169–195. doi:10.1007/s10311-007-0095-0.
   PubMed Web of Science ®Google Scholar
• Sansom GT, Kirsch KR, Stone KW, McDonald TJ, Horney JA. Domestic exposures to polycyclic aromatic hydrocarbons in a Houston, Texas, environmental justice neighborhood. Environ Justice. 2018;11(5):183–191. doi:10.1089/env.2018.0004.
   PubMed Web of Science ®Google Scholar
• Gibis M. Heterocyclic aromatic amines in cooked meat products: causes, formation, occurrence, and risk assessment. Compr Rev Food Sci Food Saf. 2016;15(2):269–302. doi:10.1111/1541-4337.12186.
   PubMed Web of Science ®Google Scholar
• Konorev D, Koopmeiners JS, Tang Y, Franck Thompson EA, Jensen JA, Hatsukami DK, Turesky RJ. Measurement of the heterocyclic amines 2-amino-9H-pyrido[2,3-b]indole and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in urine: effects of cigarette smoking. Chem Res Toxicol. 2015;28(12):2390–2399. doi:10.1021/acs.chemrestox.5b00401.
   PubMed Web of Science ®Google Scholar
• Song P, Wu L, Guan W. Dietary nitrates, nitrites, and nitrosamines intake and the risk of gastric cancer: a meta-analysis. Nutrients. 2015;7(12):9872–9895. doi:10.3390/nu7125505.
   PubMed Web of Science ®Google Scholar
• Ramana KV, Srivastava S, Singhal SS. Lipid peroxidation products in human health and disease (editorial). Oxid Med Cell Longev. 2013;2013:1–3. doi:10.1155/2013/583438.
   Google Scholar
• Sottero B, Rossin D, Poli G, Biasi F. Lipid oxidation products in the pathogenesis of inflammation-related gut diseases. Curr Med Chem. 2018;25(11):1311–1326. doi:10.2174/0929867324666170619104105.
   PubMed Web of Science ®Google Scholar
• Sahiner UM, Birben E, Erzurum S, Sackesen C, Kalayci O. Oxidative stress in asthma. World Allergy Organ J. 2011;4(10):151–158. doi:10.1097/WOX.0b013e318232389e.
   PubMedGoogle Scholar
• Joshi YB, Pratico D. Lipid peroxidation in psychiatric illness: overview of clinical evidence. Oxid Med Cell Longev. 2014;2014:828702. doi:10.1155/2014/828702.
   PubMed Web of Science ®Google Scholar
• Poon CH, Wong TY, Wang Y, Tsuchiya Y, Nakajima M, Yokoi T, Leung LK. The citrus flavanone naringenin suppresses CYP1B1 transactivation through antagonising xenobiotic-responsive element binding. Br J Nutr. 2013;109(9):1598–1605. doi:10.1017/S0007114512003595.
   PubMed Web of Science ®Google Scholar
• Beedanagari SR, Bebenek I, Bui P, Hankinson O. Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes. Toxicol Sci. 2009;110(1):61–67. [published correction appears in Toxicol Sci. 2010;116(2):693]. doi:10.1093/toxsci/kfp079.
   PubMed Web of Science ®Google Scholar
• Mikstacka R, Przybylska D, Rimando AM, Baer-Dubowska W. Inhibition of human recombinant cytochromes P450 CYP1A1 and CYP1B1 by trans-resveratrol methyl ethers. Mol Nutr Food Res. 2007;51(5):517–524. doi:10.1002/mnfr.200600135.
   PubMed Web of Science ®Google Scholar
• Li F, Zhu W, Gonzalez FJ. Potential role of CYP1B1 in the development and treatment of metabolic diseases. Pharmacol Ther. 2017;178:18–30. doi:10.1016/j.pharmthera.2017.03.007.
   PubMed Web of Science ®Google Scholar
• Jin J, Lin F, Liao S, Bao Q, Ni L. Effects of SNPs (CYP1B1*2 G355T, CYP1B1*3 C4326G, and CYP2E1*5 G-1293C), smoking, and drinking on susceptibility to laryngeal cancer among Han Chinese. PLoS One. 2014;9(10):e106580. doi:10.1371/journal.pone.0106580.
   PubMed Web of Science ®Google Scholar
• Leung TM, Lu Y. Alcoholic liver disease: from CYP2E1 to CYP2A5. Curr Mol Pharmacol. 2017;10(3):172–178. doi:10.2174/1874467208666150817111846.
   PubMed Web of Science ®Google Scholar
• Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, et al. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Hepatol Commun. 2017;1(10):1043–1057. doi:10.1002/hep4.1115.
   PubMed Web of Science ®Google Scholar
• Caito S, Yu Y, Aschner M. Differential response to acrylonitrile toxicity in rat primary astrocytes and microglia. Neurotoxicology. 2013;37:93–99. doi:10.1016/j.neuro.2013.04.007.
   PubMed Web of Science ®Google Scholar
• Garcia-Suastegui WA, Ramos-Chavez LA, Rubio-Osornio M, Calvillo-Velasco M, Atzin-Mendez JA, Guevara J, Silva-Adaya D. The role of CYP2E1 in the drug metabolism or bioactivation in the brain. Oxid Med Cell Longev. 2017;2017:1–14. doi:10.1155/2017/4680732.
   Google Scholar
• Iketani M, Ohsawa I. Molecular hydrogen as a neuroprotective agent. Curr Neuropharmacol. 2017;15(2):324–331. doi:10.2174/1570159X14666160607205417.
   PubMed Web of Science ®Google Scholar