References
- Jabeur I, Pereira E, Barros L, Calhelha RC, Sokovic M, Oliveira MBPP, Ferreira ICFR. Hibiscus sabdariffa L. as a source of nutrients, bioactive compounds and colouring agents. Food Res Int. 2017;100(Pt 1):717–23. doi:https://doi.org/10.1016/j.foodres.2017.07.073.
- Santos-Buelga C, González-Paramás AM. Reference module in food science. 2018. https://doi.org/10.1016/B978-0-08-100596-5.21609-0.
- Fernández-Arroyo S, Rodríguez-Medina IC, Beltrán-Debón R, Pasini F, Joven J, Micol V, Segura-Carretero A, Fernández-Gutiérrez A. Quantification of the polyphenolic fraction and in vitro antioxidant and in vivo anti-hyperlipemic activities of Hibiscus sabdariffa aqueous extract. Food Res Int. 2011;44(5):1490–5.
- Ali BH, Al Wabel N, Blunden G. Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: a review. Phytother Res. 2005;19(5):369–75. doi:https://doi.org/10.1002/ptr.1628.
- Joshi SS, Dice L, D'Souza DH. Aqueous extracts of hibiscus sabdariffa calyces decrease hepatitis A virus and human norovirus surrogate titers. Food Environ Virol. 2015;7(4):366–73. doi:https://doi.org/10.1007/s12560-015-9209-1.
- Domingo JL, Gómez M, Llobet JM, Corbella J. Citric, malic and succinic acids as possible alternatives to deferoxamine in aluminum toxicity. J Toxicol Clin Toxicol. 1988;26(1-2):67–79. doi:https://doi.org/10.3109/15563658808995398.
- Domingo JL, Llobet JM, Corbella J. Relative efficacy of chelating agents as antidotes for acute gallium nitrate intoxication. Arch Toxicol. 1987;59(5):382–3. doi:https://doi.org/10.1007/BF00295095.
- Cort WM. Ascorbic acid: chemistry, metabolism, and uses. In: Seib PA, Tolbert BM, editors. Advances in chemistry. Vol. 200. American Chemical Society; 1982. p. 533–50.doi:https://doi.org/10.1021/ba-1982-0200.ch022.
- Frankel EN. Food factors for cancer prevention. Tokyo: Springer; 1997. p. 613–6.
- Makhsudova B, Pakudina ZP, Sadykov AS. The flavonoids of Hibiscus. Chem Nat Compd. 1967;3(1):8–10. doi:https://doi.org/10.1007/BF01171712.
- Khan ZA, Naqvi SA-R, Mukhtar A, Hussain Z, Shahzad SA, Mansha A, Ahmad M, Zahoor AF, Bukhari IH, Ashraf-Janjua MR-S, et al. Antioxidant and antibacterial activities of Hibiscus Rosa-sinensis Linn flower extracts. Pak J Pharm Sci. 2014;27(3):469–74.,
- Borrás-Linares I, Fernandez-Arroyo S, Arraez-Roman D, Palmeros-Suarez PA, Del Val-Diaz R, Andrade-Gonzales I, Fernandez-Gutierrez A, Gomez-Leyva JF, Segura-Carretero A. Characterization of phenolic compounds, anthocyanidin, antioxidant and antimicrobial activity of 25 varieties of Mexican Roselle (Hibiscus sabdariffa). Ind Crops Prod. 2015;69:385–94. doi:https://doi.org/10.1016/j.indcrop.2015.02.053.
- Sawabe A, Nesumi C, Morita M, Matsumoto S, Matsubara Y, Komemushi S. Glycosides in African dietary leaves, Hibiscus sabdariffa. J Oleo Sci. 2005;54(3):185–91. doi:https://doi.org/10.5650/jos.54.185.
- Da-Costa-Rocha I, Bonnlaender B, Sievers H, Pischel I, Heinrich M. Hibiscus sabdariffa L. - a phytochemical and pharmacological review. Food Chem. 2014;165:424–43. doi:https://doi.org/10.1016/j.foodchem.2014.05.002.
- Sáyago-Ayerdi SG, Arranz S, Serrano J, Goñi I. Dietary fiber content and associated antioxidant compounds in Roselle flower (Hibiscus sabdariffa L.) beverage. J Agric Food Chem. 2007;55(19):7886–90. doi:https://doi.org/10.1021/jf070485b.
- Díaz-Rubio ME, Saura-Calixto F. Dietary fiber in brewed coffee. J Agric Food Chem. 2007;55(5):1999–2003. doi:https://doi.org/10.1021/jf062839p.
- Díaz-Rubio ME, Elena Díaz-Rubio M, Saura-Calixto F. Dietary fiber complex in beer. J Am Soc Brew Chem. 2009;67(1):38–43. doi:https://doi.org/10.1094/asbcj-2008-1219-01.
- Oboh G, Adewuni TM, Ademiluyi AO, Olasehinde TA, Ademosun AO. Phenolic constituents and inhibitory effects of Hibiscus sabdariffa L. (Sorrel) calyx on cholinergic, monoaminergic, and purinergic enzyme activities. J Diet Suppl. 2018;15(6):910–22. doi:https://doi.org/10.1080/19390211.2017.1406426.
- Sinela A, Rawat N, Mertz C, Achir N, Fulcrand H, Dornier M. Anthocyanins degradation during storage of Hibiscus sabdariffa extract and evolution of its degradation products. Food Chem. 2017;214:234–41. doi:https://doi.org/10.1016/j.foodchem.2016.07.071.
- Yin G, Cao L, Xu P, Jeney G, Nakao M. Hepatoprotective and antioxidant effects of Hibiscus sabdariffa extract against carbon tetrachloride-induced hepatocyte damage in Cyprinus carpio. In Vitro Cell Dev Biol Anim. 2011;47(1):10–5. doi:https://doi.org/10.1007/s11626-010-9359-2.
- Mohamed R, Fernandez J, Pineda M, Aguilar M. Roselle (Hibiscus sabdariffa) seed oil is a rich source of gamma-tocopherol. J Food Sci. 2007;72(3):S207–S211. doi:https://doi.org/10.1111/j.1750-3841.2007.00285.x.
- McKay DL, Chen CY, Saltzman E, Blumberg JB. Hibiscus sabdariffa L. tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults. J Nutr. 2010;140(2):298–303. doi:https://doi.org/10.3945/jn.109.115097.
- Herrera-Arellano A, Miranda-Sánchez J, Avila-Castro P, Herrera-Alvarez S, Jiménez-Ferrer JE, Zamilpa A, Román-Ramos R, Ponce-Monter H, Tortoriello J. Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, lisinopril-controlled clinical trial. Planta Med. 2007;73(1):6–12. doi:https://doi.org/10.1055/s-2006-957065.
- Mozaffari-Khosravi H, Jalali-Khanabadi BA, Afkhami-Ardekani M, Fatehi F, Noori-Shadkam M. The effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetes. J Hum Hypertens. 2009;23(1):48–54. doi:https://doi.org/10.1038/jhh.2008.100.
- Serban C, Sahebkar A, Ursoniu S, Andrica F, Banach M. Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension: a systematic review and meta-analysis of randomized controlled trials. J Hypertens. 2015;33(6):1119–27. doi:https://doi.org/10.1097/hjh.0000000000000585.
- Aliyu B, Oyeniyi YJ, Mojiminiyi FB, Isezuo SA, Alada AR. The aqueous calyx extract of Hibiscus sabdariffa lowers blood pressure and heart rate via sympathetic nervous system dependent mechanisms. Niger J Physiol Sci. 2014;29(2):131–6.
- Ajay M, Chai HJ, Mustafa AM, Gilani AH, Mustafa MR. Mechanisms of the anti-hypertensive effect of Hibiscus sabdariffa L. calyces. J Ethnopharmacol. 2007;109(3):388–93. doi:https://doi.org/10.1016/j.jep.2006.08.005.
- Jonadet M, Bastide J, Bastide P, Boyer B, Carnat AP, Lamaison JL. In vitro enzyme inhibitory and in vivo cardioprotective activities of hibiscus (Hibiscus sabdariffa L.). J Pharm Belg. 1990;45(2):120–4.
- Abdel-Rahman RF, Hessin AF, Abdelbaset M, Ogaly HA, Abd-Elsalam RM, Hassan SM. Antihypertensive effects of roselle-olive combination in L-NAME-induced hypertensive rats. Oxid Med Cell Longev. 2017;2017:9460653 doi:https://doi.org/10.1155/2017/9460653.
- Kim JK, So H, Youn MJ, Kim HJ, Kim Y, Park C, Kim SJ, Ha YA, Chai KY, Kim SM, et al. Hibiscus sabdariffa L. water extract inhibits the adipocyte differentiation through the PI3-K and MAPK pathway. J Ethnopharmacol. 2007;114(2):260–7. doi:https://doi.org/10.1016/j.jep.2007.08.028.
- Christian KR, Nair MG, Jackson JC. Antioxidant and cyclooxygenase inhibitory activity of sorrel (Hibiscus sabdariffa). J Food Compos Anal. 2006;19(8):778–83. doi:https://doi.org/10.1016/j.jfca.2006.04.004.
- Obiefuna PCM, Owolabi OA, Adegunloye BJ, Obiefuna IP, Sofola OA. The petal extract of Hibiscus sabdariffa produces relaxation of isolated rat aorta. Int J Pharmacogn. 1994;32(1):69–74. doi:https://doi.org/10.3109/13880209409082975
- Alarcón-Alonso J, Zamilpa A, Alarcón Aguilar F, Herrera-Ruiz M, Tortoriello J, Jimenez-Ferrer E. Pharmacological characterization of the diuretic effect of Hibiscus sabdariffa Linn (Malvaceae) extract. J Ethnopharmacol. 2012;139(3):751–6. doi:https://doi.org/10.1016/j.jep.2011.12.005.
- Chen CH, Lin JY, Lin CN, Hsu SY. Inhibition of angiotensin-I-converting enzyme by tetrahydroxyxanthones isolated from Tripterospermum lanceolatum. J Nat Prod. 1992;55(5):691–5. doi:https://doi.org/10.1021/np50083a025.
- Lacaille-Dubois MA, Franck U, Wagner H. Search for potential Angiotensin Converting Enzyme (ACE)-inhibitors from plants. Phytomedicine. 2001;8:47–52. doi:https://doi.org/10.1078/0944-7113-00003.
- Bormann H, Melzig MF. Inhibition of metallopeptidases by flavonoids and related compounds. Pharmazie. 2000;55(2):129–32.
- Bastien M, Poirier P, Lemieux I, Despres JP. Overview of epidemiology and contribution of obesity to cardiovascular disease. Prog Cardiovasc Dis. 2014;56(4):369–81. doi:https://doi.org/10.1016/j.pcad.2013.10.016.
- Hurtubise J, McLellan K, Durr K, Onasanya O, Nwabuko D, Fomusi Ndisang J. The different facets of dyslipidemia and hypertension in atherosclerosis. Curr Atheroscler Rep. 2016;18(12):82. doi:https://doi.org/10.1007/s11883-016-0632-z.
- Kim MS, Kim JK, Kim HJ, Moon SR, Shin BC, Park KW, Yang HO, Kim SM, Park R. Hibiscus extract inhibits the lipid droplet accumulation and adipogenic transcription factors expression of 3T3-L1 preadipocytes. J Altern Complement Med. 2003;9(4):499–504. doi:https://doi.org/10.1089/107555303322284785.
- Jiménez-Ferrer E, Alarcón-Alonso J, Aguilar-Rojas A, Zamilpa A, Jiménez-Ferrer I, Tortoriello J, Herrera-Ruiz M. Diuretic effect of compounds from Hibiscus sabdariffa by modulation of the aldosterone activity. Planta Med. 2012;78(18):1893–8. doi:https://doi.org/10.1055/s-0032-1327864.
- Niisato N, Eaton DC, Marunaka Y. Involvement of cytosolic Cl − in osmoregulation of α-ENaC gene expression. Am J Physiol Renal Physiol. 2004;287(5):F932–F939. doi:https://doi.org/10.1152/ajprenal.00131.2004.
- Ochani PC, D'Mello P. Antioxidant and antihyperlipidemic activity of Hibiscus sabdariffa Linn. leaves and calyces extracts in rats. Indian J Exp Biol. 2009;47(4):276–82.
- Farombi EO, Ige OO. Hypolipidemic and antioxidant effects of ethanolic extract from dried calyx of Hibiscus sabdariffa in alloxan-induced diabetic rats. Fundam Clin Pharmacol. 2007;21(6):601–9. doi:https://doi.org/10.1111/j.1472-8206.2007.00525.x.
- Lin TL, Lin HH, Chen CC, Lin MC, Chou MC, Wang CJ. Hibiscus sabdariffa extract reduces serum cholesterol in men and women. Nutr Res. 2007;27(3):140–5. doi:https://doi.org/10.1016/j.nutres.2007.01.007.
- Lingesh A, Paul D, Naidu VGM, Satheeshkumar N. AMPK activating and anti adipogenic potential of Hibiscus rosa sinensis flower in 3T3-L1 cells. J Ethnopharmacol. 2019;233:123–30. doi:https://doi.org/10.1016/j.jep.2018.12.039.
- Herranz-López M, Olivares-Vicente M, Encinar JA, Barrajón-Catalán E, Segura-Carretero A, Joven J, Micol V. Multi-targeted molecular effects of Hibiscus sabdariffa polyphenols: an opportunity for a global approach to obesity. Nutrients. 2017;9(8):907. doi:https://doi.org/10.3390/nu9080907.
- Herranz-López M, Fernández-Arroyo S, Pérez-Sanchez A, Barrajón-Catalán E, Beltrán-Debón R, Menéndez JA, Alonso-Villaverde C, Segura-Carretero A, Joven J, Micol V. Synergism of plant-derived polyphenols in adipogenesis: perspectives and implications. Phytomedicine. 2012;19(3–4):253–61. doi:https://doi.org/10.1016/j.phymed.2011.12.001.
- Yang MY, Peng CH, Chan KC, Yang YS, Huang CN, Wang CJ. The hypolipidemic effect of Hibiscus sabdariffa polyphenols via inhibiting lipogenesis and promoting hepatic lipid clearance. J Agric Food Chem. 2010;58(2):850–9. doi:https://doi.org/10.1021/jf903209w.
- Joven J, Espinel J, Rull A, Aragonès G, Rodríguez-Gallego E, Camps J, Micol V, Herranz-López M, Menéndez A, Borrás J, et al. Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice. Biochim Biophys Acta. 2012;1820(7):894–9. doi:https://doi.org/10.1016/j.bbagen.2012.03.020.
- Carling D, Mayer FV, Sanders MJ, Gamblin SJ. AMP-activated protein kinase: nature's energy sensor. Nat Chem Biol. 2011;7(8):512–8. doi:https://doi.org/10.1038/nchembio.610.
- Henin N, Vincent MF, Gruber HE, Van den Berghe G. Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase. Faseb J. 1995;9(7):541–6.
- Ferre P, Foufelle F. Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c. Diabetes Obes Metab. 2010;12(Suppl 2):83–92. doi:https://doi.org/10.1111/j.1463-1326.2010.01275.x.
- Kao ES, Tseng TH, Lee HJ, Chan KC, Wang CJ. Anthocyanin extracted from Hibiscus attenuate oxidized LDL-mediated foam cell formation involving regulation of CD36 gene. Chem Biol Interact. 2009;179(2-3):212–8. doi:https://doi.org/10.1016/j.cbi.2009.01.009.
- Villalpando-Arteaga EV, Mendieta-Condado E, Esquivel-Solís H, Canales-Aguirre AA, Gálvez-Gastélum FJ, Mateos-Díaz JC, Rodríguez-Gonzáleza JA, Márquez-Aguirre AL. Hibiscus sabdariffa L. aqueous extract attenuates hepatic steatosis through down-regulation of PPAR-γ and SREBP-1c in diet-induced obese mice . Food Funct. 2013;4(4):618–26. doi:https://doi.org/10.1039/c3fo30270a.
- Chen CC, Hsu JD, Wang SF, Chiang HC, Yang MY, Kao ES, Ho YC, Wang CJ. Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. J Agric Food Chem. 2003;51(18):5472–7. doi:https://doi.org/10.1021/jf030065w.
- el-Saadany SS, Sitohy MZ, Labib SM, el-Massry RA. Biochemical dynamics and hypocholesterolemic action of Hibiscus sabdariffa (Karkade). Nahrung. 1991;35(6):567–76. doi:https://doi.org/10.1002/food.19910350603.
- Gurrola-Díaz CM, García-López PM, Sánchez-Enríquez S, Troyo-Sanromán R, Andrade-González I, Gómez-Leyva JF. Effects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy). Phytomedicine. 2010;17(7):500–5. doi:https://doi.org/10.1016/j.phymed.2009.10.014.
- Hirunpanich V, Utaipat A, Morales NP, Bunyapraphatsara N, Sato H, Herunsale A, Suthisisang C. Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats. J Ethnopharmacol. 2006;103(2):252–60. doi:https://doi.org/10.1016/j.jep.2005.08.033.
- Peng CH, Chyau CC, Chan KC, Chan TH, Wang CJ, Huang CN, Hibiscus sabdariffa polyphenolic extract inhibits hyperglycemia, hyperlipidemia, and glycation-oxidative stress while improving insulin resistance. J Agric Food Chem. 2011;59(18):9901–9. doi:https://doi.org/10.1021/jf2022379.
- Huang CN, Chan KC, Lin WT, Su SL, Wang CJ, Peng CH. Hibiscus sabdariffa inhibits vascular smooth muscle cell proliferation and migration induced by high glucose-a mechanism involves connective tissue growth factor signals. J Agric Food Chem. 2009;57(8):3073–9. doi:https://doi.org/10.1021/jf803911n.
- Peng CH, Yang YS, Chan KC, Wang CJ, Chen ML, Huang CN. Hibiscus sabdariffa polyphenols alleviate insulin resistance and renal epithelial to mesenchymal transition: a novel action mechanism mediated by type 4 dipeptidyl peptidase. J Agric Food Chem. 2014;62(40):9736–43. doi:https://doi.org/10.1021/jf5024092.
- Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, et al. Inflammation and Alzheimer's disease. Neurobiol Aging. 2000;21(3):383–421. doi:https://doi.org/10.1016/s0197-4580(00)00124-x.
- Rajab NF, Musa SM, Munawar MA, Mun LL, Yen HK, Ibrahim FW, Meng CK. Anti-neuroinflammatory effects of Hibiscus sabdariffa Linn. (Roselle) on lipopolysaccharides-induced microglia and neuroblastoma cells. JSKM. 2016;14(02):111–7. doi:https://doi.org/10.17576/jskm-2016-1402-13.
- El Bayani FG, Marpaung NL, Simorangkird DAS, Sianipar IR, Ibrahim N, Neng K, Indra-Gusti M, Purba J, Ilyas E. Anti-inflammatory effects of Hibiscus Sabdariffa Linn. on the IL-1β/IL-1ra ratio in plasma and hippocampus of overtrained rats and correlation with spatial memory. Kobe J Med Sci. 2018;64:E73–83.
- De la Monte SM, Wands JR. Alzheimer's disease is type 3 diabetes-evidence reviewed. J Diabetes Sci Technol. 2008;2(6):1101–13. doi:https://doi.org/10.1177/193229680800200619.
- Seung TW, Park SK, Kang JY, Kim JM, Park SH, Kwon BS, Lee CJ, Kang JE, Kim DO, Lee U, et al. Ethyl acetate fraction from Hibiscus sabdariffa L. attenuates diabetes-associated cognitive impairment in mice. Food Res Int. 2018;105:589–98. doi:https://doi.org/10.1016/j.foodres.2017.11.063.
- Al-Anbaki M, Nogueira RC, Cavin AL, Al-Hadid M, Al-Ajlouni I, Shuhaiber L, Graz B. Treating Uncontrolled Hypertension with Hibiscus sabdariffa When Standard Treatment Is Insufficient: Pilot Intervention. J Altern Complement Med. 2019;25(12):1200–5. doi:https://doi.org/10.1089/acm.2019.0220.
- Yusni Y, Meutia F. Action mechanism of Rosella (Hibiscus sabdariffa L.) used to treat metabolic syndrome in elderly women. Evid Based Complement Alternat Med. 2020;2020:5351318 doi:https://doi.org/10.1155/2020/5351318.