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Research Articles

Randomized Double-Blind Controlled Trial of Freeze-Dried Strawberry Powder Supplementation in Adults with Overweight or Obesity and Elevated Cholesterol

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Pages 148-158 | Received 28 Aug 2021, Accepted 30 Nov 2021, Published online: 23 Feb 2022

References

  • World Health Organization. The top 10 causes of death, 2018.
  • Centers for Disease Control. National vital statistics report – Deaths: Leading causes for 2017, 2019.
  • Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Delling FN, et al. American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee, et al. Heart disease and stroke statistics-2020 update: a report from the American Heart Association. Circulation. 2020;141(9):e139–e596.
  • 2015 Dietary Guidelines Advisory Committee, Scientific report of the 2015 dietary guidelines advisory committee, 2015.
  • Eckel RH, Jakicic JM, Ard JD, de Jesus JM, Houston Miller N, Hubbard VS, Lee I-M, Lichtenstein AH, Loria CM, Millen BE, et al. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;63(25):2960–84. doi:10.1016/j.jacc.2013.11.003.
  • Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, Himmelfarb CD, Khera A, Lloyd-Jones D, McEvoy JW, et al. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2019;74(10):1376–414. doi:10.1016/j.jacc.2019.03.009.
  • Basu A. Role of berry bioactive compounds on lipids and lipoproteins in diabetes and metabolic syndrome. Nutrients. 2019;11(9):1983. doi:10.3390/nu11091983.
  • Kishimoto Y, Tani M, Kondo K. Pleiotropic preventive effects of dietary polyphenols in cardiovascular diseases. Eur J Clin Nutr. 2013;67(5):532–5. doi:10.1038/ejcn.2013.29.
  • Speer H, D’Cunha NM, Botek M, McKune AJ, Sergi D, Georgousopoulou E, Mellor DD, Naumovski N. The effects of dietary polyphenols on circulating cardiovascular disease biomarkers and iron status: a systematic review. Nutr Metab Insights. 2019;12:1178638819882739.
  • Tome-Carneiro J, Visioli F. Polyphenol-based nutraceuticals for the prevention and treatment of cardiovascular disease: review of human evidence. Phytomed Int J Phytother Phytopharmacol. 2016;23(11):1145–74. doi:10.1016/j.phymed.2015.10.018.
  • Carlsen MH, Halvorsen BL, Holte K, Bøhn SK, Dragland S, Sampson L, Willey C, Senoo H, Umezono Y, Sanada C, et al. The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutr J. 2010;9:3.
  • Murphy MM, Barraj LM, Herman D, Bi X, Cheatham R, Randolph RK. Phytonutrient intake by adults in the United States in relation to fruit and vegetable consumption. J Acad Nutr Diet. 2012;112(2):222–9. doi:10.1016/j.jada.2011.08.044.
  • Bachman JL, Reedy J, Subar AF, Krebs-Smith SM. Sources of food group intakes among the US population, 2001–2002. J Am Diet Assoc. 2008;108(5):804–14. doi:10.1016/j.jada.2008.02.026.
  • Hadi A, Askarpour M, Miraghajani M, Symonds ME, Sheikhi A, Ghaedi E. Effects of strawberry supplementation on cardiovascular risk factors: a comprehensive systematic review and meta-analysis of randomized controlled trials. Food Funct. 2019;10(11):6987–98. doi:10.1039/C9FO01684H.
  • Basu A, Fu DX, Wilkinson M, Simmons B, Wu M, Betts NM, Du M, Lyons TJ. Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome. Nutr Res. 2010;30(7):462–9. doi:10.1016/j.nutres.2010.06.016.
  • Basu A, Wilkinson M, Penugonda K, Simmons B, Betts NM, Lyons TJ. Freeze-dried strawberry powder improves lipid profile and lipid peroxidation in women with metabolic syndrome: baseline and post intervention effects. Nutr J. 2009;8(1):1. doi:10.1186/1475-2891-8-43.
  • Zunino SJ, Parelman MA, Freytag TL, Stephensen CB, Kelley DS, Mackey BE, Woodhouse LR, Bonnel EL. Effects of dietary strawberry powder on blood lipids and inflammatory markers in obese human subjects. Br J Nutr. 2012;108(5):900–9. doi:10.1017/S0007114511006027.
  • Amani R, Moazen S, Shahbazian H, Ahmadi K, Jalali MT. Flavonoid-rich beverage effects on lipid profile and blood pressure in diabetic patients. World J Diabetes. 2014;5(6):962–8. doi:10.4239/wjd.v5.i6.962.
  • Burton-Freeman B, Linares A, Hyson D, Kappagoda T. Strawberry modulates LDL oxidation and postprandial lipemia in response to high-fat meal in overweight hyperlipidemic men and women. J Am Coll Nutr. 2010;29(1):46–54. doi:10.1080/07315724.2010.10719816.
  • Feresin RG, Johnson SA, Pourafshar S, Campbell JC, Jaime SJ, Navaei N, Elam ML, Akhavan NS, Alvarez-Alvarado S, Tenenbaum G, et al. Impact of daily strawberry consumption on blood pressure and arterial stiffness in pre- and stage 1-hypertensive postmenopausal women: a randomized controlled trial. Food Funct. 2017;8(11):4139–49. doi:10.1039/c7fo01183k.
  • Paquette M, Medina Larqué AS, Weisnagel SJ, Desjardins Y, Marois J, Pilon G, Dudonné S, Marette A, Jacques H. Strawberry and cranberry polyphenols improve insulin sensitivity in insulin-resistant, non-diabetic adults: a parallel, double-blind, controlled and randomised clinical trial. Br J Nutr. 2017;117(4):519–31. doi:10.1017/S0007114517000393.
  • Roman MJ, Devereux RB, Kizer JR, Lee ET, Galloway JM, Ali T, Umans JG, Howard BV. Central pressure more strongly relates to vascular disease and outcome than does brachial pressure: the Strong Heart Study. Hypertension. 2007;50(1):197–203. doi:10.1161/HYPERTENSIONAHA.107.089078.
  • Basu A, Betts NM, Nguyen A, Newman ED, Fu D, Lyons TJ. Freeze-dried strawberries lower serum cholesterol and lipid peroxidation in adults with abdominal adiposity and elevated serum lipids. J Nutr. 2014;144(6):830–7. doi:10.3945/jn.113.188169.
  • Richter CK, Skulas-Ray AC, Gaugler TL, Meily S, Petersen KS, Kris-Etherton PM. Effects of cranberry juice supplementation on cardiovascular disease risk factors in adults with elevated blood pressure: a randomized controlled trial. Nutrients. 2021;13(8):2618. doi:10.3390/nu13082618.
  • Chobanian AV. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA. 2003;289(19):2560–72. doi:10.1001/jama.289.19.2560.
  • Skulas-Ray AC. Omega-3 fatty acids and inflammation: A perspective on the challenges of evaluating efficacy in clinical research. Prostagland Other Lipid Mediator. 2015;116:6390–404.
  • Ridker PM. Cardiology patient page. C-reactive protein: a simple test to help predict risk of heart attack and stroke. Circulation. 2003;108(12) :e81–e85. doi:10.1161/01.CIR.0000093381.57779.67.
  • Zasowska-Nowak A, Nowak PJ, Bialasiewicz P, Prymont-Przyminska A, Zwolinska A, Sarniak A, Wlodarczyk A, Markowski J, Rutkowski KP, Nowak D, et al. Strawberries added to the usual diet suppress fasting plasma paraoxonase activity and have a weak transient decreasing effect on cholesterol levels in healthy nonobese subjects. J Am Coll Nutr. 2016;35(5):422–35. doi:10.1080/07315724.2015.1065523.
  • Alvarez-Suarez JM, Giampieri F, Tulipani S, Casoli T, Di Stefano G, González-Paramás AM, Santos-Buelga C, Busco F, Quiles JL, Cordero MD, et al. One-month strawberry-rich anthocyanin supplementation ameliorates cardiovascular risk, oxidative stress markers and platelet activation in humans. J Nutrition Biochem. 2014;25(3):289–94. doi:10.1016/j.jnutbio.2013.11.002.
  • Sampson M, Ling C, Sun Q, Harb R, Ashmaig M, Warnick R, Sethi A, Fleming JK, Otvos JD, Meeusen JW, et al. A new equation for calculation of low-density lipoprotein cholesterol in patients with normolipidemia and/or hypertriglyceridemia. JAMA Cardiol. 2020;5(5):540., doi:10.1001/jamacardio.2020.0013.
  • Brownstein AJ, Martin SS. More accurate LDL-C calculation: externally validated, guideline endorsed. Clin Chim Acta Int J Clin Chem. 2020;506:149–53. doi:10.1016/j.cca.2020.03.030.
  • Brown L, Rosner B, Willett WW, Sacks FM. Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr. 1999;69(1):30–42. doi:10.1093/ajcn/69.1.30.
  • Jenkins DJ, Kendall CW, Vuksan V. Viscous fibers, health claims, and strategies to reduce cardiovascular disease risk. Am J Clin Nutr. 2000;71(2):401–2. doi:10.1093/ajcn/71.2.401.
  • Basu A, Rhone M, Lyons TJ. Berries: emerging impact on cardiovascular health. Nutr Rev. 2010;68(3):168–77. doi:10.1111/j.1753-4887.2010.00273.x.
  • Marlett JA, Vollendorf NW. Dietary fiber content and composition of different forms of fruits. Food Chem. 1994;51(1):39–44. doi:10.1016/0308-8146(94)90045-0.
  • Chareoansiri R, Kongkachuichai R. Sugar profiles and soluble and insoluble dietary fiber contents of fruits in Thailand markets. Int J Food Sci Nutr. 2009;60(sup4):126–39. doi:10.1080/09637480802609376.
  • Ramulu P, Rao PU. Effect of processing on dietary fiber content of cereals and pulses. Plant Foods Hum Nutr. 1997;50(3):249–57. doi:10.1007/BF02436061.
  • Waddell TK, Dart AM, Medley TL, Cameron JD, Kingwell BA. Carotid pressure is a better predictor of coronary artery disease severity than brachial pressure. Hypertension. 2001;38(4):927–31. doi:10.1161/hy1001.096107.
  • McAnulty LS, Collier SR, Landram MJ, Whittaker DS, Isaacs SE, Klemka JM, Cheek SL, Arms JC, McAnulty SR. Six weeks daily ingestion of whole blueberry powder increases natural killer cell counts and reduces arterial stiffness in sedentary males and females. Nutr Res. 2014;34(7):577–84. doi:10.1016/j.nutres.2014.07.002.
  • Dohadwala MM, Holbrook M, Hamburg NM, Shenouda SM, Chung WB, Titas M, Kluge MA, Wang N, Palmisano J, Milbury PE, et al. Effects of cranberry juice consumption on vascular function in patients with coronary artery disease. Am J Clin Nutr. 2011;93(5):934–40. doi:10.3945/ajcn.110.004242.
  • Habauzit V, Verny M-A, Milenkovic D, Barber-Chamoux N, Mazur A, Dubray C, Morand C. Flavanones protect from arterial stiffness in postmenopausal women consuming grapefruit juice for 6 mo: a randomized, controlled, crossover trial. Am J Clin Nutr. 2015;102(1):66–74. doi:10.3945/ajcn.114.104646.
  • Figueroa A, Wong A, Hooshmand S, Sanchez-Gonzalez MA. Effects of watermelon supplementation on arterial stiffness and wave reflection amplitude in postmenopausal women. Menopause. 2013;20(5):573–7. doi:10.1097/gme.0b013e3182733794.
  • Figueroa A, Sanchez-Gonzalez MA, Perkins-Veazie PM, Arjmandi BH. Effects of watermelon supplementation on aortic blood pressure and wave reflection in individuals with prehypertension: a pilot study. Am J Hypertens. 2011;24(1):40–4. doi:10.1038/ajh.2010.142.
  • Curtis PJ, Potter J, Kroon PA, Wilson P, Dhatariya K, Sampson M, Cassidy A. Vascular function and atherosclerosis progression after 1 y of flavonoid intake in statin-treated postmenopausal women with type 2 diabetes: a double-blind randomized controlled trial. Am J Clin Nutr. 2013;97(5):936–42. doi:10.3945/ajcn.112.043745.
  • Jovanovski E, Bosco L, Khan K, Au-Yeung F, Ho H, Zurbau A, Jenkins AL, Vuksan V. Effect of Spinach, a high dietary nitrate source, on arterial stiffness and related hemodynamic measures: a randomized, controlled trial in healthy adults. Clin Nutr Res. 2015;4(3):160–7. doi:10.7762/cnr.2015.4.3.160.
  • Lynn A, Mathew S, Moore CT, Russell J, Robinson E, Soumpasi V, Barker ME. Effect of a tart cherry juice supplement on arterial stiffness and inflammation in healthy adults: a randomised controlled trial. Plant Foods Hum Nutr. 2014;69(2):122–7. doi:10.1007/s11130-014-0409-x.
  • Johnson SA, Figueroa A, Navaei N, Wong A, Kalfon R, Ormsbee LT, Feresin RG, Elam ML, Hooshmand S, Payton ME, et al. Daily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre- and stage 1-hypertension: a randomized, double-blind, placebo-controlled clinical trial. J Acad Nutr Diet. 2015;115(3):369–77. doi:10.1016/j.jand.2014.11.001.
  • Bondonno CP, Liu AH, Croft KD, Ward NC, Yang X, Considine MJ, Puddey IB, Woodman RJ, Hodgson JM. Short-term effects of nitrate-rich green leafy vegetables on blood pressure and arterial stiffness in individuals with high-normal blood pressure. Free Radic Biol Med. 2014;77:353–62. doi:10.1016/j.freeradbiomed.2014.09.021.
  • Lynn A, Hamadeh H, Leung WC, Russell JM, Barker ME. Effects of pomegranate juice supplementation on pulse wave velocity and blood pressure in healthy young and middle-aged men and women. Plant Foods Hum Nutr. 2012;67(3):309–14. doi:10.1007/s11130-012-0295-z.
  • Richter CK, Skulas-Ray AC, Gaugler TL, Lambert JD, Proctor DN, Kris-Etherton PM. Incorporating freeze-dried strawberry powder into a high-fat meal does not alter postprandial vascular function or blood markers of cardiovascular disease risk: a randomized controlled trial. Am J Clin Nutr. 2017;105(2):313–22. doi:10.3945/ajcn.116.141804.
  • Ahuja KD, Robertson IK, Ball MJ. Acute effects of food on postprandial blood pressure and measures of arterial stiffness in healthy humans. Am J Clin Nutr. 2009;90(2):298–303. doi:10.3945/ajcn.2009.27771.
  • Greenfield JR, Samaras K, Chisholm DJ, Campbell LV. Effect of postprandial insulinemia and insulin resistance on measurement of arterial stiffness (augmentation index). Int J Cardiol. 2007;114(1):50–6. doi:10.1016/j.ijcard.2005.12.007.
  • Berry SEE, Tucker S, Banerji R, Jiang B, Chowienczyk PJ, Charles SM, Sanders TAB. Impaired postprandial endothelial function depends on the type of fat consumed by healthy men. J Nutr. 2008;138(10):1910–4. doi:10.1093/jn/138.10.1910.
  • Phillips LK, Peake JM, Zhang X, Hickman IJ, Kolade O, Sacre JW, Huang BE, Simpson P, Li SH, Whitehead JP, et al. The effect of a high-fat meal on postprandial arterial stiffness in men with obesity and type 2 diabetes. J Clin Endocrinol Metab. 2010;95(9):4455–9. doi:10.1210/jc.2010-0413.
  • Basu A, Kurien BT, Tran H, Byrd BAna, Maher J, Schell J, Masek E, Barrett JR, Lyons TJ, Betts NM, et al. Strawberries decrease circulating levels of tumor necrosis factor and lipid peroxides in obese adults with knee osteoarthritis. Food Funct. 2018;9(12):6218–26. doi:10.1039/C8FO01194J.
  • Jenkins DJA, Nguyen TH, Kendall CWC, Faulkner DA, Bashyam B, Kim IJ, Ireland C, Patel D, Vidgen E, Josse AR, et al. The effect of strawberries in a cholesterol-lowering dietary portfolio. Metabolism. 2008;57(12):1636–44. doi:10.1016/j.metabol.2008.07.018.
  • Jie Z, Xia H, Zhong S-L, Feng Q, Li S, Liang S, Zhong H, Liu Z, Gao Y, Zhao H, et al. The gut microbiome in atherosclerotic cardiovascular disease. Nat Commun. 2017;8(1):845.
  • Tang WH, Hazen SL. The gut microbiome and its role in cardiovascular diseases. Circulation. 2017;135(11):1008–10. doi:10.1161/CIRCULATIONAHA.116.024251.
  • Tang WH, Hazen SL. Microbiome, trimethylamine N-oxide, and cardiometabolic disease. Transl Res. 2017;179:108–15. doi:10.1016/j.trsl.2016.07.007.
  • Blumberg JB, Basu A, Krueger CG, Lila MA, Neto CC, Novotny JA, Reed JD, Rodriguez-Mateos A, Toner CD. Impact of cranberries on gut microbiota and cardiometabolic health: proceedings of the cranberry health research conference 2015. Adv Nutr. 2016;7(4):759S–70S. doi:10.3945/an.116.012583.
  • Rodriguez-Morato J, et al. Cranberries attenuate animal-based diet-induced changes in microbiota composition and functionality: a randomized crossover controlled feeding trial. J Nutrition Biochem. 2018;62:76–86.
  • Bekiares N, Krueger CG, Meudt JJ, Shanmuganayagam D, Reed JD. Effect of sweetened dried cranberry consumption on urinary proteome and fecal microbiome in healthy human subjects. OMICS. 2018;22(2):145–53. doi:10.1089/omi.2016.0167.
  • Tuohy KM, Conterno L, Gasperotti M, Viola R. Up-regulating the human intestinal microbiome using whole plant foods, polyphenols, and/or fiber. J Agric Food Chem. 2012;60(36):8776–82. doi:10.1021/jf2053959.
  • Petersen C, Wankhade UD, Bharat D, Wong K, Mueller JE, Chintapalli SV, Piccolo BD, Jalili T, Jia Z, Symons JD, et al. Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut ­microbiome in diabetic mice. J Nutrition Biochem. 2019;66:63–9. doi:10.1016/j.jnutbio.2019.01.004.
  • Wojdyło A, Figiel A, Oszmiański J. Effect of drying methods with the application of vacuum microwaves on the bioactive compounds, color, and antioxidant activity of strawberry fruits. J Agric Food Chem. 2009;57(4):1337–43. doi:10.1021/jf802507j.