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Original Article

Instability of the Phosphodiester-Amide Interribonucleotide Bond in Neutral Aqueous Solution

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Pages 45-60 | Received 18 Nov 1983, Published online: 19 Dec 2006

References and Notes

  • Presented in part at the International Conference on “Synthetic Oligonucleotides in Molecular Biology,” Uppsala, Sweden, August 16–20, 1982, Abstracts p. 51 .
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  • Juodka , B. A. and Smrt , J. 1974 . Collect. Czech. Chem. Commun. , 39 : 963
  • Tomasz , J. and Simoncsits , A. 1981 . Tetrahedron Lett. , 22 : 3905
  • Ohtsuka , E and Ikehara , M. 1974 . Nucleic Acids Res. , 1 : 1351 This blocking group has been introduced into the synthetic oligonucleotide chemistry by
  • Ohtsuka , E. , Tanaka , S. and Ikehara , M. 1977 . Chem. Pharm. Bull. , 25 : 949
  • Ohtsuka , E. , Wakabayashi , T. , Tanaka , S. , Tanaka , T. , Oshie , K. , Hasegawa , A. and Ikehara , M. 1981 . Chem. Pharm. Bull. , 29 : 318
  • Ikehara , M. , Oshie , K. , Hasegawa , A. and Ohtsuka , E. 1981 . Nucleic Acids Res. , 9 : 2003
  • Verheyden , J. P. and Moffatt , J. G. 1968 . Synthetic Procedures in Nucleic Acid Chemistry Edited by: Zorbach , W. W. and Tipson , R. S. Vol. I , 383
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  • Lebedev , A. V. and Rezvukhin , A. I. 1975 . Izv. Sib. Otd. Akad. Nauk SSR, ser. khim. nauk , 2 : 149
  • Tomasz , J. 1981 . J. Carbohydrates-Nucleosides-Nucleotides , 8 : 551
  • Tomasz , J. 1983 . Nucleosides and Nucleotides , 2 : 63
  • van Wazer , J. R , Shoolery , J. N. and Jones , R. C. 1956 . J. Am. Chem. Soc. , 78 : 5715
  • Nielsen , M. L. and Pustinger , J. V. 1964 . J. Phys. Chem. , 68 : 152
  • Blackburn , G. M. and Cohen , J. S. 1964 . Lord Todd Tetrahedron Lett. , : 2873
  • Drutsa , V. F. , Zarytova , V. F. , Knorre , D. G. , Lebedev , A. V. , Sokolova , N. I. and Shabarova , Z. A. 1978 . Nucleic Acids Res. , 5 : 185
  • Zarytova , V. F. , Ryte , V. C. and Chernikova , T. S. 1977 . Bioorg. Khim. , 3 : 1626
  • Scheme 3 is basically similar to that proposed by Shabarova for the alkaline degradation of N(P) alkylated diribo-nucleoside phosphoramidates2
  • Nemer , M. J. and Ogilvie , K. K. 1980 . Tetrahedron Lett. , 21 : 4149
  • Jurovcik , M. and Smrt , J. 1981 . FEBS Lett. , 133 : 178

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