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Original Articles

Nucleosides. Part 3.1 Synthesis of 2-N-Substituted 1-β-D-Arabinofuranosylisocytosine Derivatives by The Reaction of 2′,5′-Dichloro-2′,5′-Dideoxyuridine with Amines

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Pages 681-694 | Received 26 May 1985, Published online: 03 Jan 2007

References

  • For part 2, see Ref. 6: This paper is part 56 of a series entitled “Pyrimidines'', part 55: see Ref. 6
  • Hirota , K. , Kitade , Y. , Iwami , F. and Senda , S. 1984 . Chem. Pharm. Bull. , 32 : 2591
  • Hirota , K. , Kitade , Y. , Iwami , F. , Senda , S. and Maki , Y. 1983 . Synthesis , : 121
  • Hrebabecky , H. and Beranek , J. 1978 . Collect. Czech. Chem. Commun. , 43 : 3268 Idem, Nucleic Acids Res., 5, 1029 (1978).
  • Hirota , K. , Kitade , Y. , Tomishi , T. and Maki , Y . 1984 . J. Chem. Soc., Chem. Commun. , : 108
  • Hirota , K. , Kitade , Y. , Tomishi , T. and Maki , Y. in press . Chem. Pharm. Bull. ,
  • Cook , A. F. 1977 . J. Med. Chem. , 20 : 344
  • Delia , T. J. and Beranek , J. 1977 . J. Carbohydrates Nucleosides Nucleotides , 4 : 349
  • Beranek , J. and Acton , E. M. 1985 . Collect. Czech. Chem. Commun. , 48 : 2551
  • The isocytosine derivatives have two possible tautomers, 2-amino form and 2-imino form, and the 2-N-acetylated isocytosines (2,7,8) were determined to be a imino tautomer on the basis of their NMR spectra (see experimental section)
  • Hrebabecky , H. , Brokes , J. and Beranek , J. 1982 . Collect. Czech. Chem. Commun. , 47 : 2961
  • Meresz , M. , Sohar , P. and Kuszmann , J. 1977 . Tetrahedron , 33 : 2131

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