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Original Articles

Synthesis of 2′,3′-Dideoxyuridine Via the Corey-Winter Reaction

Pages 35-41 | Received 11 Dec 1987, Published online: 24 Oct 2006

References

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  • The isomerization of N4-Acetyl-5′-O-TBDMS cytidine 2′,3′-O-thiocarbonate is complete after 10 minutes under the conditions of the Corey-Winter procedure. The main product was tentatively characterized as N4-acetyl-2′-deoxy-2′-thio-5′-O-TBDMS cytidine 2′,3′-S,O-carbonate by NMR, UV and elemental analysis, and isolated in pure form in 70% yield (to be published).
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