Synthesis of 2,2′-Anhydro-1 - (3′ -deoxy -3′ -iodo-β-D-arabino-furanosyl) thymine and Its Derivatives as Versatile Synthetic Intermediates

References

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• Although DMF can also be used, chloroform is recommended in order to avoid decomposition of the product during lengthy evaporation
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• Compound 2 is also rather unstable even in neutral solutions, especially under light, giving 1 as one of the decomposition products
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• In our experiments, both 4a and 4b were not crystalline in non-solvated form, the former being a foam and the latter an amorphous powder (The mono-ethyl acetate of 4a is crystalline17). However, msp of non-solvated 4a17,18 and 4b25 are described. Moreover, no convincing information for comparison with our compounds are available from the ill-resolved 1H NMR data18,25 and the erroneous chemical formula of 4a.18
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• We have encountered other similar results in the reactions of 2 with various nucleophiles
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