CARBOCYCLIC SUBSTRATES AND INHIBITORS FOR THE BIFUNCTIONAL LYASE OF PURINE NUCLEOTIDE BIOSYNTHESIS

REFERENCES

• Abbreviations used: ASL, adenylosuccinate lyase; AICAR, aminoimidazole carboxamide ribonucleotide; BSA, bovine serum albumin; CAICAR, carbocyclic aminoimidazole carboxamide ribonucleotide; CF3-HOBT, 6-trifluoromethyl-1-hydroxybenzotriazole; mCPBA, meta-chloroperbenzoic acid; DEAD, diethyi azodicarboxylate; DCC, dicyclohexylcarbodiimide; ddATP, 2′,3′-dideoxyadenosine triphosphate; ddl, 2′,3′ dideoxyinosine; DMA, dimethylacetamide; GAICAR, glutaroaminoimidazole carboxamide ribonucleotide; C-GAICAR, carbocyclic glutaroaminoimidazole carboxamide ribonucleotide; SAICAR, succinoaminoimidazole carboxamide ribonucleotide; C-SAICAR, carbocyclic succinoamino imidazole carboxamide ribonucleotide; TBAF, tetrabutylammonium fluoride; TFA, trifluoroacetic acid; THF, tetrahydrofuran; TLC, thin layer chromatography; TMS, tetramethylsilane
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