112
Views
5
CrossRef citations to date
0
Altmetric
Original Articles

A New Regio-Defined Synthesis of PMEA

, &
Pages 1445-1451 | Received 03 Dec 1997, Accepted 06 Mar 1998, Published online: 21 Aug 2006

References

  • Holy , A. and Rosenberg , I. 1987 . Collect. Czech. Chem. Commun. , 52 : 2801
  • Holy , A. , Rosenberg , I. and Dvorakova , H. 1989 . Collect. Czech. Chem. Commun. , 54 : 2190
  • Bronson , J. J. , Kim , C. U. , Ghazzouli , I. , Hitchcock , M. J. M. , Kern , E. R. and Martin , J. C. 1989 . Nucleotide Analogues as Antiviral Agents , ACS Symposium Series # 401 Edited by: Martin , J. C. 72 – 81 . American Chemical Society .
  • Holy , A. 1993 . Advances in Antiviral Drug Design , Edited by: De Clercq , E. 201 – 204 . JAI press, Inc. . Some references for PMEA analogs
  • Hockova , D. , Masojidkova , M. and Holy , A. 1996 . Collect. Czech. Chem. Commun. , 61 : 1538 references cited therein
  • Liboska , R. 1996 . Collect. Czech. Chem. Commun. , 61 : S72 special issue
  • Rosenberg , I. and Kralikova , S. 1996 . Collect. Czech. Chem. Commun. , 61 : S81 special issue
  • Rejman , D. and Rosenberg , I. 1996 . Collect. Czech. Chem. Commun. , 61 : S122 special issue
  • Chen , W. , Flavin , M. T. , Filler , R. and Xu , Z. 1996 . Tetrahedron Lett. , 37 : 8975
  • During our initial PMEA synthesis according to Holy's procedure,1a we experienced problem with the purification of PMEA diethyl ester. The reported crystallization protocol could not be reproduced in our hand. We speculated that the unreacted adenine and the presence of N-7 isomer could be hindering the product crystallization, which prompted us to look for alternative PMEA synthesis
  • Montgomery , J. A. and Temple , C. 1957 . J. Am. Chem. Soc. , 79 : 5238
  • Holy , A. , Rosenberg , I. and Dvorakova , H. 1989 . Collect. Czech. Chem. Commun. , 54 : 2190
  • No yield optimization was conducted for any of the reaction steps
  • Holy , A. , Zidek , Z. and Votruba , I. 1996 . Collect. Czech. Chem. Commun. , 61 : S182 special issue

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.