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Original Articles

Substrates of DNA polymerases with planar conformation of sugar: model of substrate transition state?

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Pages 1153-1162 | Published online: 21 Aug 2006

REFERENCES

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  • It may be argued that ACG-TP is not a substrate for HIV reverse transcriptase but is a substrate of HSV DNA polymerase. Thus, these enzymes should not belong to the same class. It should be noted that nucleosides that lack an hydroxyl group in the C3′ position do not necessarily be the substrates of all the type 2 DNA polymerases. The type 1 polymerases do require 3′-OH, but all nucleosides with 3′-OH are not necessarily the substrates. Thus, some nucleosides are more selective to a particular polymerase than others of the same category

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