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Nucleosides and Nucleotides Volume 17, 1998 - Issue 1-3
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Original Articles

Efficient Syntheses of (E)-5-(2-Bromovinyl)-2′-deoxy-4-thiouridine; A Nucleoside Analogue with Potent Biological Activity

I. Basnak School of Chemistry, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
,
G. P. Otter School of Chemistry, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
,
R. J. Duncombe School of Chemistry, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
,
N. B. Westwood School of Chemistry, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
,
M. Pietrarelli School of Chemistry, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
,
G. W. Hardy Glaxo Wellcome Research and Development, Gunnels Wood Road, Stevenage, Herts. SG1 2NY, UK
,
G. Mills Glaxo Wellcome Research and Development, Gunnels Wood Road, Stevenage, Herts. SG1 2NY, UK
,
S. G. Rahim Glaxo Wellcome Research and Development, Gunnels Wood Road, Stevenage, Herts. SG1 2NY, UK
&
R. T. Walker School of Chemistry, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
 show all
Pages 29-38 | Published online: 22 Aug 2006

References

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  • De Clercq , E. , Descamps , J. , De Somer , P. , Barr , P. J. , Jones , A. S. and Walker , R. T. 1979 . Proc. Natl. Acad. Sci. USA , 76 : 2947 – 2591 .
  • Desgranges , C. , Razaka , G. , Rabaud , M. , Bricaud , H. , Balzarini , J. and De Clercq , E. 1983 . Biochem. Pharmac. , 32 : 3583 – 3590 .
  • De Clercq , E. , Descamps , J. , Maudgal , P. C. , Missotten , L. , Leyten , R. , Verhelst , G. , Jones , A. S. , Walker , R. T. , Busson , R. , Vanderhaeghe , H. and De Somer , P. 1980 . Developments in Antiviral Chemotherapy , Edited by: Collier , L. H. and Oxford , J. 21 – 42 . Academic Press .
  • Dyson , M. R. , Coe , P. L. and Walker , R. T. 1991 . J. Chem. Soc. Chem. Commun. , : 741 – 742 .
  • Rahim , S. G. , Littler , E. , Powell , K. L. , Collins , P. , Coe , P. L. , Dyson , M. R. and Walker , R. T. 31st ICAAC . Chicago. pp. 1232
  • Balzarini , J. 1996 . Nucleosides Nucleotides , 15 : 821 – 831 .
  • Degrève , B. , Andrei , G. , Izquierdo , M. , Piette , J. , Knaus , E. E. , Wiebe , L. I. , Basnak , I. , Walker , R. T. , De Clercq , E. and Balzarini , J. Submitted
  • Dyson , M. R. , Coe , P. L. and Walker , R. T. 1991 . J. Med. Chem. , 34 : 2782 – 2786 .
  • Basnak , I. , Takatori , S. and Walker , R. T. Tetrahedron Lett. , In the press
  • Rahim , S. G. , Trivedi , N. , Bogunovic-Batchelor , M. V. , Hardy , G. W. , Mills , G. , Selway , J. W.T. , Snowden , W. , Littler , E. , Coe , P. L. , Basnak , I. , Whale , R. F. and Walker , R. T. 1996 . J. Med. Chem. , 39 : 789 – 795 .
  • Jones , A. S. , Verhelst , G. and Walker , R. T. 1979 . Tetrahedron Lett. , : 4415 – 4418 .
  • Secrist , J. A. , Tiwari , K. N. , Riordan , J. M. and Montgomery , J. A. 1991 . J. Med. Chem. , 34 : 2361 – 2366 .
  • Fu , Y.-L. and Bobek , M. 1976 . J. Org. Chem. , 41 : 3831 – 3834 .
  • Secrist , J. A. , Parker , W. B. , Tiwari , K. N. , Messini , L. , Shaddix , S. C. , Rose , L. M. , Bennett , L. L. and Montgomery , J. A. 1995 . Nucleosides Nucleotides , 14 : 675 – 686 .
  • Shaw-Ponter , S. , Mills , G. , Robertson , M. , Bostwick , R. D. , Hardy , G. W. and Young , R. J. 1996 . Tetrahedron Lett. , 37 : 1867 – 1871 .
  • Walker , R. T. 1997 . “ Recent Advances in the Chemistry of Anti-infective Agents ” . In Royal Society of Chemistry Edited by: Bentley , P. H. and O'Hanlon , P. J. 203 – 237 .
  • Bärwolf , D. and Langen , P. 1975 . Nucleic Acids Research Special Publ. , 1 : s29 – s31 .
  • Bärwolf , D. German (East) Patent, DD 247,663, 15 . Jul 1987 .
  • Chem. Abs. , 109 129605x
  • Wyatt , P. G. , Anslow , A. S. , Coomber , B. A. , Cousins , R. P.C. , Evans , D. N. , Gilbert , V. S. , Humber , D. C. , Paternoster , I. L. , Sollis , S. L. , Tapolczay , D. J. and Weingarten , G. G. 1995 . Nucleosides Nucleotides , 14 : 2039 – 2049 .
  • Dyson , M. R. , Coe , P. L. and Walker , R. T. 1991 . Carbohydrate Res. , 216 : 237 – 248 .
  • Hancox , E. L. and Walker , R. T. 1996 . Nucleosides Nucleotides , 15 : 135 – 148 .

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