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Articles

The commercialization of molecular biology: Walter Gilbert and the Biogen startup

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References

  • Adams, Daniel D. “Oral History.” Life Sciences Foundation, 2011.
  • Alafi, Moshe. “Oral History.” Biogen, Inc., 2000.
  • Biogen S. A. “Memorandum of Private Placement” (May 19, 1978).
  • Cawthorn, Rob. “Oral History.” Biogen, Inc., 2001.
  • D’Andrade, Hugh. “Oral history.” Chemical Heritage Foundation, 1998.
  • Donis-Keller, Helen. “Oral History.” Life Sciences Foundation, 2013.
  • Flavell, Richard. “Oral History.” Life Sciences Foundation, 2013.
  • Flavell, Richard. “Oral History.” Biogen, Inc., 2000.
  • Gelfand, David. “Oral History.” Life Sciences Foundation, 2012.
  • Gilbert, Walter. “Oral History.” Biogen, Inc., 2000.
  • Gilbert, Walter. “Oral History.” Life Sciences Foundation, 2013.
  • Hartley, Brian. “Oral History.” Biogen, Inc., 2000.
  • Haseltine, William. “Oral History.” Life Sciences Foundation, 2012.
  • Hofschneider, Peter-Hans. “Oral History.” Biogen, Inc., 2000.
  • Kamen, Robert. “Oral History.” Life Sciences Foundation, 2014.
  • Mach, Bernard. “Oral History.” Biogen, Inc., 2000.
  • Murray, Kenneth. “Oral History.” Biogen, Inc., 2000.
  • Rosen, Joe. “Oral History.” Biogen, Inc., 2000.
  • Schaller, Heinz. “Oral History.” Biogen, Inc., 2003.
  • Sharp, Phillip A. “Oral History.” Chemical Heritage Foundation, 2003.
  • Sharp, Philip A. “Oral History.” Life Sciences Foundation, 2012.
  • Sharp, Phillip A. “Oral History.” Biogen, Inc., 2000.
  • Skaletsky, Mark. “Oral History.” Life Sciences Foundation, 2013.
  • Taunton-Rigby, Alison. “Oral History.” Life Sciences Foundation, 2013.
  • Vincent, Jim. “Oral History.” Life Sciences Foundation, 2013.
  • Vincent, Jim. “Oral History.” Biogen, Inc., 2000.
  • Weissmann, Charles. “Oral History.” Biogen, Inc., 2000.
  • Weissmann, Charles. “Oral History.” Life Sciences Foundation, 2012.

  • Abir-Am, Pnina. “Molecular Biology in the Context of British, French, and American Cultures.” International Social Science Journal 53 (2001): 187–199.10.1111/issj.2001.53.issue-168
  • Abir-Am, Pnina. “The Politics of Macromolecules: Molecular Biologists, Biochemists, and Rhetoric.” Osiris 7 (1992): 164–191.10.1086/368709
  • Abir-Am, Pnina. “The Rockefeller Foundation and the Rise of Molecular Biology.” Molecular Cell Biology 3 (2002): 63–70.
  • Alafi, Moshe. “Biotech Pioneer and Entrepreneur.” Oral history conducted by Sally Smith Hughes. Berkeley: University of California, 2013.
  • Allen, Ernest M. “Early Years of NIH Research Grants.” NIH Alumni Association Newsletter 2 (April 1980): 6–8.
  • Appel, Toby A., and Shaping Biology. The National Science Foundation and American Biological Research, 1945–1975. Baltimore, MD: Johns Hopkins University Press, 2000.
  • Bauer, Nancy F. “The Ptashne Fiasco.” The Harvard Crimson (June 4, 1981).
  • Beer, John J., and W. David Lewis. “Aspects of the Professionalization of Science.” Daedalus 92 (Fall 1963): 764–784.
  • Ben-David, Joseph. “The Universities and the Growth of Science in Germany and the United States.” Minerva 7 (Autumn–Winter 1968–1969): 1–35.10.1007/BF01096806
  • Berg, Paul, and Janet E. Mertz. “Personal Reflections on the Origins and Emergence of Recombinant DNA Technology.” Genetics 184 (2010): 9–17.10.1534/genetics.109.112144
  • Berman, Elizabeth Popp. Creating the Market University: How Academic Science Became an Economic Engine. Princeton, NJ: Princeton University Press, 2011.
  • Bloom, Floyd E., and Mark A. Randolph, eds. Funding Health Sciences Research: A Strategy for Restoring Balance. Washington, DC: National Academies Press, 1990.
  • Bok, Derek. Beyond the Ivory Tower: Social Responsibilities of the Modern University. Cambridge, MA: Harvard University Press, 1982.
  • Bourne, Henry R. Paths to Innovation: Discovering Recombinant DNA, Oncogenes, and Prions in One Medical School, Over One Decade. Berkeley: University of California Press, 2011.
  • Boyer, Herbert. “Recombinant DNA Research at UCSF and Its Commercialization at Genentech.” Oral history conducted by Sally Smith Hughes. Berkeley: University of California, 2001.
  • Bulkeley, William M. “Biogen’s Gilbert Resigns Top Posts, Acting Chief Picked.” Wall Street Journal (December 18, 1984): 1.
  • Bush, Vannevar. Science: The Endless Frontier. Washington, DC: United States Government Printing Office, 1945.
  • Cambrosio, Alberto, and Peter Keating. Exquisite Specificity: The Monoclonal Antibody Revolution. Oxford: Oxford University Press, 1995.
  • Cape, Ronald. “Biotech Pioneer and Founder of Cetus.” Oral history conducted by Sally Smith Hughes. Berkeley: University of California, 2006.
  • Carlson, Bernard W. “Academic Entrepreneurship and Engineering Education: Dugald C. Jackson and the MIT-GE Cooperative Engineering Course, 1907–1932.” Technology and Culture 29 (1988): 356–367.
  • de Chadarevian, Soraya. Designs for Life: Molecular Biology after World War II. Cambridge: Cambridge University Press, 2002.
  • de Chadarevian, Soraya. “Using Interviews to Write the History of Science.” In The Historiography of Contemporary Science and Technology, edited by Thomas Söderqvist, 51–70. Amsterdam: Harwood Academic Publishers, 1997.
  • Cohen, Stanley N. “DNA Cloning: A Personal View after Forty Years.” Proceedings of National Academy of Sciences 110 (2013): 15521–15529.10.1073/pnas.1313397110
  • Cohen, Stanley N. “The Manipulation of Genes.” Scientific American 233 (July 1975): 24–33.10.1038/scientificamerican0775-24
  • Cohen, Stanley N. “Science, Biotechnology, and Recombinant DNA: A Personal History.” Oral history conducted by Sally Smith Hughes. Berkeley: University of California, 2009.
  • Davies, Julian. “Gathering No Moss.” Annual Review of Microbiology 57 (2003): 1–27.10.1146/annurev.micro.57.030502.090949
  • Delbrück, Max. “A Physicist’s Renewed Look at Biology – Twenty Years Later.” Science 168 (June 12, 1970): 1312–1315.10.1126/science.168.3937.1312
  • Delbrück, Max. Oral History Conducted by Carolyn Harding. Pasadena, CA: California Institute of Technology Archives Oral History Project, 1978.
  • Demain, Arnold L. “History of Industrial Biotechnology.” In Industrial Biotechnology: Sustainable Growth and Economic Success, edited by Wim Soetaert and Erick J. Vandamme, 17–77. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2010.10.1002/9783527630233
  • Etzkowitz, Henry. “Entrepreneurial Science in the Academy: A Case of the Transformation of Norms.” Social Problems 36 (1989): 14–29.10.2307/800547
  • Etzkowitz, Henry. MIT and the Rise of Entrepreneurial Science. London: Routledge, 2002.10.4324/9780203216675
  • Etzkowitz, Henry. “Research Groups as ‘Quasi-Firms’: The Invention of the Entrepreneurial University.” Research Policy 32 (2003): 109–121.10.1016/S0048-7333(02)00009-4
  • Etzkowitz, Henry. The Triple Helix: University-Industry-Government Innovation in Action. New York: Routledge, 2008.10.4324/9780203929605
  • Fisher, Lawrence M. “The Rocky Road from Startup to Big-Time Player: Biogen’s Triumph against the Odds.” Strategy+Business (July 1, 1997): 55–63.
  • Fishlock, David. “Biogen Attracts Staff with and Atmosphere of Freedom.” Globe and Mail (May 4, 1984): 1.
  • Gaudillière, Jean-Paul. “Professional or Industrial Order? Patents, Biological Drugs, and Pharmaceutical Capitalism in Early Twentieth Century Germany.” History and Technology 24 (2008): 107–133.10.1080/07341510701810922
  • Geiger, Roger L. To Advance Knowledge: The Growth of American Research Universities. New York: Oxford University Press, 1986.
  • Geison, Gerald L. The Private Science of Louis Pasteur. Princeton, NJ: Princeton University Press, 1995.
  • Gilbert, Walter. “Protein Synthesis.” US Patent 4411994A, filed June 8, 1978.
  • Ginzberg, Eli, and Anna B. Dutka. The Financing of Biomedical Research. Baltimore, MD: Johns Hopkins University Press, 1989.
  • Gradmann, Christoph. “Money and Microbes: Robert Koch, Tuberculin, and the Foundation of the Institute for Infectious Diseases in Berlin in 1891.” History and Philosophy of the Life Sciences 22 (2000): 59–79.
  • Grant, Charley. “What Can Stop the World’s Best-Selling Drug?” Wall Street Journal (April 28, 2017): 1.
  • Gros, Francois, Howard Hiatt, Walter Gilbert, Chuck G. Kurland, R. W. Risebrough, and James D. Watson. “Unstable Ribonucleic Acid Revealed by Pulse-Labeled Escherichia Coli.” Nature 190 (1961): 581–585.10.1038/190581a0
  • Guagnini, Anna. “Ivory Towers? The Commercial Activity of British Professors of Engineering and Physics, 1880–1914.” History and Technology 33 (2017): 70–108.
  • Hall, Stephen S. “Biologist in the Boardroom.” Science 85, no. 6 (January/February 1985): 42–50.
  • Hall, Stephen. Invisible Frontiers: The Race to Synthesize a Human Gene. New York: Atlantic Monthly Press, 1987.
  • “Harvard, Biogen in Patent Deal.” 1983. The New York Times, November 29: p. D5.
  • “Harvard Considers Commercial Role in DNA Research.” 1980. The New York Times, October 27: p. A1.
  • Harwood, Jonathan. “Universities.” In The Cambridge History of Science, Volume 6: Modern Life and Earth Sciences, edited by Peter J. Bowler and John V. Pickstone, 90–107. Cambridge: Cambridge University Press, 2009.10.1017/CHOL9780521572019
  • Hilts, Philip J. “The Gold Rush of Companies in Biotechnology is Waning.” Washington Post (November 3, 1981): A1.
  • Hoddeson, Lillian. “The Conflict of Memories and Documents: Pragmatics and Dilemmas of Oral History.” In The Historiography of Contemporary Science, Technology, and Medicine: Writing Recent Science, edited by Ronald E. Doel and Thomas Söderqvist, 187–200. New York: Routledge, 2006.
  • Hofschneider, Peter-Hans, and Kenneth Murray. “Combining Science and Business: From Recombinant DNA to Vaccines against Hepatitis B Virus.” In Recombinant Protein Drugs, edited by P. Buckel, 43–64. Basel: Birkhäuser, 2001.10.1007/978-3-0348-8346-7
  • Hughes, Sally Smith. Genentech: The Beginnings of Biotech. Chicago, IL: University of Chicago Press, 2011.10.7208/chicago/9780226359205.001.0001
  • Hughes, Sally Smith. “Making Dollars out of DNA: The First Major Patent in Biotechnology and the Commercialization of Molecular Biology, 1974–1980.” Isis (2001): 541–575.10.1086/385281
  • Jones, Mark. 2013. “The Invention of Recombinant DNA Technology.” LSF Magazine, Summer: pp. 48–75.
  • Judson, Horace Freeland. The Eighth Day of Creation: Makers of the Revolution in Biology. New York: Simon & Schuster, 1979.
  • Katzir, Shaul. “Technological Entrepreneurship from Patenting to Commercializing: A Survey of Late Nineteenth and Early Twentieth Century Physics Lecturers.” History and Technology 33(2017): 109–125.
  • Kay, Lily E. The Molecular Vision of Life: Caltech, the Rockefeller Foundation, and the Rise of the New Biology. New York: Oxford University Press, 1993.
  • Kenney, Martin. Biotechnology: The University-Industrial Complex. New Haven, CT: Yale University Press, 1988.
  • Kenney, Martin, ed. Understanding Silicon Valley: The Anatomy of an Entrepreneurial Region. Stanford, CA: Stanford University Press, 2000.
  • Kimmelman, Barbara A. “The American Breeders’ Association: Genetics and Eugenics in an Agricultural Context 1903–13.” Social Studies of Science 13 (1983): 163–204.10.1177/030631283013002001
  • Knight, Michael. 1980. “Harvard Rules out Role for Now in Genetic Engineering Company.” The New York Times, November 18: p. A1.
  • Kohler, Robert E. From Medicinal Chemistry to Biochemistry: The Making of a Biomedical Discipline. Cambridge: Cambridge University Press, 1982.10.1017/CBO9780511897313
  • Kohler, Robert E. Partners in Science: Foundations and Natural Scientists, 1900–1945. Chicago, IL: University of Chicago Press, 1991.
  • Kohler, Robert E. Lords of the Fly: Drosophila Genetics and the Experimental Life. Chicago, IL: University of Chicago Press, 1994.
  • König, Wolfgang. “Engineering Professors as Entrepreneurs: The Case of Franz Reuleaux (1829–1905) and Alois Riedler (1850–1936).” History and Technology 33 (2017): 53–69.
  • Krimsky, Sheldon, James G. Ennis, and Robert Weissman. “Academic-Corporate Ties in Biotechnology: A Quantitative Study.” Science, Technology & Human Values 16 (1991): 275–287.10.1177/016224399101600301
  • Lécuyer, Christophe. Making Silicon Valley: Innovation and the Growth of High Tech, 1930–1970. Cambridge, MA: MIT Press, 2007.
  • Linton, Derek S. Emil Von Behring: Infectious Disease, Immunology, and Serum Therapy. Philadelphia, PA: American Philosophical Society, 2005.
  • Mach, Bernard. “The ‘Paradox’ of Today’s Biotechnology Companies.” Technology by Bilan (October 2011): 8.
  • MacLeod, Christine. “Reluctant Entrepreneurs: Patents and State Patronage in New Technosciences, circa 1879–1930.” Isis 103 (2012): 328–339.10.1086/666359
  • Maxam, Allan M., and Walter Gilbert. “A New Method for DNA Sequencing.” Proceedings of the National Academy of Sciences 74 (1977): 560–564.10.1073/pnas.74.2.560
  • Mercelis, Joris. “Commercializing Academic Knowledge and Reputation in the Late Nineteenth and Early Twentieth Centuries: Photography and Beyond.” History and Technology 33(2017): 23–52.
  • Mirowski, Philip. Science-Mart: Privatizing American Science. Cambridge, MA: Harvard University Press, 2011.10.4159/harvard.9780674061132
  • Mirowski, Philip and Esther-Mirjam Sent. “The Commercialization of Science and the Response of STS.” In The Handbook of Science and Technology Studies, 3rd ed., edited by Edward J. Hackett, Olga Amsterdamska, Michael Lynch, and Judy Wajcman, 635–689. Cambridge, MA: MIT Press, 2008.
  • Morange, Michael. A History of Molecular Biology. Translated by Matthew Cobb. Cambridge, MA: Harvard University Press, 1998.
  • Moses, Vivian, and Ronald E. Cape, eds. “The Science and the Business: An Introduction.” In Biotechnology: The Science and the Business, edited by Vivian Moses and Ronald E. Cape, 1–10. Amsterdam: Harwood Academic Publishers, 1991.
  • Olby, R. C. The Path to the Double Helix. New York: Macmillan, 1974.
  • Palladino, Paolo. “Between Craft and Science: Plant Breeding, Mendelian Genetics, and Universities, British 1900–1920.” Technology & Culture 34 (1993): 300–323.10.2307/3106538
  • Podolsky, Scott H. “Metchnikoff and the Microbiome.” The Lancet 380 (November 24,2012): 1810–1811.10.1016/S0140-6736(12)62018-2
  • Porter, Dorothy, ed. The History of Public Health and the Modern State. Amsterdam: Editions Rodopi B.V., 1994.
  • Quirke, Viviane, and Jean-Paul Gaudillière. “The Era of Biomedicine: Science, Medicine, and Public Health in Britain and France after the Second World War.” Medical History 52 (2008): 441–452.10.1017/S002572730000017X
  • Rasmussen, Nicolas. Gene Jockeys: Life Sciences and the Making of the First Biotech Drugs. Baltimore, MD: Johns Hopkins University Press, 2014.
  • Rasmussen, Nicolas. “The Forgotten Promise of Thiamin: Merck, Caltech Biologists, and Plant Hormones in a 1930s Biotechnology Project.” Journal of the History of Biology 32 (1999): 245–261.10.1023/A:1004635500408
  • Reimers, Niels. “Tiger by the Tail.” ChemTech (August 1987): 464–471.
  • Reiner, Martha Louise. The Transformation of Venture Capital: A History of Venture Capital Organizations in the United States. Berkeley: University of California, 1989.
  • Rheinberger, Hans-Jörg. “What Happened to Molecular Biology?” B.I.F. Futura 22 (2007): 214–217.
  • Rosegrant, Susan, and David R. Lampe. Route 128: Lessons from Boston’s High-Tech Community. New York: Basic Books, 1992.
  • Sampat, Bhaven N. “Patenting and US Academic Research in the 20th Century: The World before and after Bayh-Dole.” Research Policy 35 (2006): 772–789.10.1016/j.respol.2006.04.009
  • Schaefer, Chris H., and Raymond H. Schaefer. Biotech Visionary. Mansfield, CT: Java, 2012.
  • Schrödinger, Erwin. What is Life? The Physical Aspect of the Living Cell. Cambridge: Cambridge University Press, 1944.
  • Shapin, Steven. “The Ivory Tower: The History of a Figure of Speech and Its Culture Uses.” British Journal of the History of Science 45 (2012): 1–27.10.1017/S0007087412000118
  • Shapin, Steven. The Scientific Life: A Moral History of a Late Modern Vocation. Chicago, IL: University of Chicago Press, 2008.10.7208/chicago/9780226750170.001.0001
  • Slaughter, Sheila, and Larry L. Leslie. Academic Capitalism: Politics, Policies, and the Entrepreneurial University. Baltimore, MD: The Johns Hopkins University Press, 1997.
  • Starr, Paul. The Social Transformation of American Medicine. New York: Basic Books, 1982.
  • Strasser, Bruno J. “Institutionalizing Molecular Biology in Postwar Europe: A Comparative Study.” Studies in History and Philosophy of Biological and Biomedical Sciences 33 (2002): 515–546.10.1016/S1369-8486(02)00016-X
  • Swanson, Robert A. “Co-founder, CEO, and Chairman of Genentech Inc, 1976–1996.” Oral history conducted by Sally Smith Hughes. Berkeley: University of California, 2001.
  • Weaver, Warren. “Molecular Biology: The Origin of the Term.” Science 170 (1970): 581–582.10.1126/science.170.3958.581-a
  • Weiner, Charles. “Patenting and Academic Research: Historical Case Studies.” Science, Technology, & Human Values 12 (1987): 50–62.
  • Weissmann, Charles. “The End of the Road.” Prion 6 (2012): 1–8.
  • Weissmann, Charles. “The Cloning of Interferon and Other Mistakes.” In Interferon 3, edited by I. Gresser, 101–134. New York: Academic Press, 1981.
  • Wright, Susan. “Recombinant DNA Technology and Its Social Transformation, 1972–1982.” Osiris 2 (1986): 303–360.10.1086/368659
  • Yi, Doogab. The Recombinant University: Genetic Engineering and the Emergence of Stanford Biotechnology. Chicago, IL: University of Chicago Press, 2015.10.7208/chicago/9780226216119.001.0001
  • Zucker, Lynne G., and Michael R. Darby. “Star Scientists and Institutional Transformation: Patterns of Invention and Innovation in the Formation of the Biotechnology Industry.” Proceedings of the National Academy of Sciences 93 (1996): 12709–12716.10.1073/pnas.93.23.12709

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