The Synthetic Triterpenoid CDDO-Im Inhibits Fatty Acid Synthase Expression and Has Antiproliferative and Proapoptotic Effects in Human Liposarcoma Cells

REFERENCES

• Mack T. M. Sarcomas and other malignancies of soft tissue, retroperitoneum, peritoneum, pleura, heart, mediastinum, and spleen. Cancer 1995; 75: 211–244
   PubMed Web of Science ®Google Scholar
• Patel S. R., Burgess M. A., Plager C., Papadopoulos N. E., Linke K. A., Benjamin R. S. Myxoid liposarcoma. experience with chemotherapy. Cancer 1994; 74: 1265–1269
   PubMed Web of Science ®Google Scholar
• Baird K., Davis S., Antonescu C. R., Harper U. L., Walker R. L., Chen Y., Glatfelter A. A., Duray P. H., Meltzer P. S. Gene expression profiling of human sarcomas: Insights into sarcoma biology. Cancer Res. 2005; 65(20)9226–9235
   PubMed Web of Science ®Google Scholar
• Wabitsch M., Bruderlein S., Melzner I., Braun M., Mechtersheimer G., Moller P. LiSa-2, a novel human liposarcoma cell line with a high capacity for terminal adipose differentiation. Int. J. Cancer. 2000; 88(6)889–894
   PubMed Web of Science ®Google Scholar
• Rosen E. D., Spiegelman B. M. Molecular regulation of adipogenesis. Annu. Rev. Cell Dev. Biol. 2000; 16: 145–171
   PubMed Web of Science ®Google Scholar
• Wells W. A., Schwartz G. N., Morganelli P. M., Cole B. F., Gibson J. J., Kinlaw W. B. Expression of “spot 14” (THRSP) predicts disease free survival in invasive breast cancer: Immunohistochemical analysis of a new molecular marker. Breast Cancer Res. Treat. 2006; 98(2)231–240
   PubMed Web of Science ®Google Scholar
• Chang Y., Wang J., Lu X., Thewke D. P., Mason R. J. KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells. J. Lipid Res. 2005; 46(12)2624–2635
   PubMed Web of Science ®Google Scholar
• Kuhajda F. P. Fatty-acid synthase and human cancer: New perspectives on its role in tumor biology. Nutrition. 2000; 16(3)202–208
   PubMed Web of Science ®Google Scholar
• Martel P. M., Bingham C. M., McGraw C. J., Baker C. L., Morganelli P. M., Meng M. L., Armstrong J. M., Moncur J. T., Kinlaw W. B. S14 protein in breast cancer cells: Direct evidence of regulation by SREBP-1c, superinduction with progestin, and effects on cell growth. Exp. Cell Res. 2006; 312(3)278–288
   PubMed Web of Science ®Google Scholar
• Place A. E., Suh N., Williams C. R., Risingsong R., Honda T., Honda Y., Gribble G. W., Leesnitzer L. M., Stimmel J. B., Willson T. M., Rosen E., Sporn M. B. The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo. Clin. Cancer Res. 2003; 9(7)2798–2806
   PubMed Web of Science ®Google Scholar
• Suh N., Wang Y., Honda T., Gribble G. W., Dmitrovsky E., Hickey W. F., Maue R. A., Place A. E., Porter D. M., Spinella M. J., Williams C. R., Wu G., Dannenberg A. J., Flanders K. C., Letterio J. J., Mangelsdorf D. J., Nathan C. F., Nguyen L., Porter W. W., Ren R. F., Roberts A. B., Roche N. S., Subbaramaiah K., Sporn M. B. A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity. Cancer Res. 1999; 59(2)336–341
   PubMed Web of Science ®Google Scholar
• Konopleva M., Tsao T., Estrov Z., Lee R. M., Wang R. Y., Jackson C. E., McQueen T., Monaco G., Munsell M., Belmont J., Kantarjian H., Sporn Andreeff M. B., The M. synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and-independent apoptosis in acute myelogenous leukemia. Cancer Res. 2004; 64(21)7927–7935
   PubMed Web of Science ®Google Scholar
• Lapillonne H., Konopleva M., Tsao T., Gold D., McQueen T., Sutherland R. L., Madden Andreeff T., Activation M. of peroxisome proliferator-activated receptor gamma by a novel synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest and apoptosis in breast cancer cells. Cancer Res. 2003; 63(18)5926–5939
   PubMed Web of Science ®Google Scholar
• Wang Y., Porter W. W., Suh N., Honda T., Gribble G. W., Leesnitzer L. M., Plunket K. D., Mangelsdorf D. J., Blanchard S. G., Willson T. M., Sporn M. B. A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma. Mol. Endocrinol. 2000; 14(10)1550–1556
   PubMed Web of Science ®Google Scholar
• Samudio I., Konopleva M., Hail N., Jr., Shi Y. X., McQueen T., Hsu T., Evans R., Honda T., Gribble G. W., Sporn M., Gilbert H. F., Safe S., Andreeff M. 2-cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer. J. Biol. Chem. 2005; 280(43)36273–36282
   PubMed Web of Science ®Google Scholar
• Sporn M. B., Suh N., Mangelsdorf D. J. Prospects for prevention and treatment of cancer with selective PPARgamma modulators (SPARMs). Trends Mol. Med. 2001; 7(9)395–400
   PubMed Web of Science ®Google Scholar
• Debrock G., Vanhentenrijk V., Sciot R., Debiec-Rychter M., Oyen R., Van Oosterom A. A phase II trial with rosiglitazone in liposarcoma patients. Br. J. Cancer. 2003; 89(8)1409–1412
   PubMed Web of Science ®Google Scholar
• Demetri G. D., Fletcher C. D., Mueller E., Sarraf P., Naujoks R., Campbell N., Spiegelman Singer B. M., Induction S. of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. Proc. Natl. Acad. Sci. U.S.A. 1999; 96(7)3951–3956
   PubMed Web of Science ®Google Scholar
• Brusselmans K., De Schrijver E., Verhoeven G., Swinnen J. V. RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells. Cancer Res. 2005; 65(15)6719–6725
   PubMed Web of Science ®Google Scholar
• Wise L. S., Green H. Participation of one isozyme of cytosolic glycerophosphate dehydrogenase in the adipose conversion of 3T3 cells. J. Biol. Chem. 1979; 254(2)273–275
   PubMed Web of Science ®Google Scholar
• Rago R., Mitchen Wilding J., DNA G. fluorometric assay in 96-well tissue culture plates using hoechst 33258 after cell lysis by freezing in distilled water. Anal. Biochem. 1990; 191(1)31–34
   PubMed Web of Science ®Google Scholar
• Swinnen J. V., Ulrix W., Heyns W., Verhoeven G. Coordinate regulation of lipogenic gene expression by androgens: Evidence for a cascade mechanism involving sterol regulatory element binding proteins. Proc. Natl. Acad. Sci. U.S.A. 1997; 94(24)12975–12980
   PubMed Web of Science ®Google Scholar
• Hasselbaink D. M., Glatz J. F., Luiken J. J., Roemen T. H., Van der Vusse G. J. Ketone bodies disturb fatty acid handling in isolated cardiomyocytes derived from control and diabetic rats. Biochem. J. 2003; 371: 753–760, (Pt 3)
   PubMed Web of Science ®Google Scholar
• Konopleva M., Tsao T., Ruvolo P., Stiouf I., Estrov Z., Leysath C. E., Zhao S., Harris D., Chang S., Jackson C. E., Munsell M., Suh N., Gribble G., Honda T., May W. S., Sporn Andreeff M. B., Novel M. triterpenoid CDDO-me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia. Blood. 2002; 99(1)326–335
   PubMed Web of Science ®Google Scholar
• Pizer E. S., Chrest F. J., DiGiuseppe J. A., Han W. F. Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines. Cancer Res. 1998; 58(20)4611–4615
   PubMed Web of Science ®Google Scholar
• Kuhajda F. P., Pizer E. S., Li J. N., Mani N. S., Frehywot G. L., Townsend C. A. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc. Natl. Acad. Sci. U.S.A. 2000; 97(7)3450–3454
   PubMed Web of Science ®Google Scholar
• Kuhajda F. P., Jenner K., Wood F. D., Hennigar R. A., Jacobs L. B., Dick J. D., Pasternack G. R. Fatty acid synthesis: A potential selective target for antineoplastic therapy. Proc. Natl. Acad. Sci.U.S.A. 1994; 91(14)6379–6383
   PubMed Web of Science ®Google Scholar
• Ito Y., Pandey P., Sporn M. B., Datta R., Kharbanda Kufe S., The D. novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism. Mol. Pharmacol. 2001; 59(5)1094–1099
   PubMed Web of Science ®Google Scholar
• Pairault J., Green H. A study of the adipose conversion of suspended 3T3 cells by using glycerophosphate dehydrogenase as differentiation marker. Proc. Natl. Acad. Sci. U.S.A. 1979; 76(10)5138–5142
   PubMed Web of Science ®Google Scholar
• Vance D. E., Vance J. Biochemistry of Lipids, Lipoproteins and Membranes. Elsevier, New York 1996
   Google Scholar
• Omura S. The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis. Bacteriol. Rev. 1976; 40(3)681–697
   PubMedGoogle Scholar
• Menendez J. A., Vellon L., Mehmi I., Oza B. P., Ropero S., Colomer Lupu R., Inhibition R. of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2004; 101(29)10715–10720
   PubMed Web of Science ®Google Scholar
• Weiss L., Hoffmann G. E., Schreiber R., Andres H., Fuchs E., Korber E., Kolb H. J. Fatty-acid biosynthesis in man, a pathway of minor importance. purification, optimal assay conditions, and organ distribution of fatty-acid synthase. Biol.Chem.Hoppe Seyler. 1986; 367(9)905–912
   PubMed Web of Science ®Google Scholar