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Cancer Investigation Volume 26, 2008 - Issue 4
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ORIGINAL ARTICLE Imaging, Diagnosis, Prognosis

Role of Desmoplasia in Recurrence of Stage II Colorectal Cancer within Five Years after Surgery and Therapeutic Implication

Pietro Crispino Gastroenterology Unit, Department of Clinical Sciences, University “La Sapienza” of Rome, Italy
,
Giorgio De Toma Surgery Unit, Department of surgery “Pietro Valdoni”, University “La Sapienza” of Rome, Italy
,
Antonio Ciardi Pathology Unit, Department of Surgery “Pietro Valdoni”, University “La Sapienza” of Rome, Italy
,
Antonino Bella Statistical Unit, Istituto Superiore di Sanità, Roma, Italy
,
Margherita Rivera Gastroenterology Unit, Department of Clinical Sciences, University “La Sapienza” of Rome, Italy
,
Giuseppe Cavallaro Surgery Unit, Department of surgery “Pietro Valdoni”, University “La Sapienza” of Rome, Italy
,
Andrea Polistena Surgery Unit, Department of surgery “Pietro Valdoni”, University “La Sapienza” of Rome, Italy
,
Francesca Fornari Surgery Unit, Department of surgery “Pietro Valdoni”, University “La Sapienza” of Rome, Italy
,
Hans Unim Gastroenterology Unit, Department of Clinical Sciences, University “La Sapienza” of Rome, Italy
,
Roberta Pica Gastroenterology Unit, Department of Clinical Sciences, University “La Sapienza” of Rome, Italy
,
Claudio Cassieri Gastroenterology Unit, Department of Clinical Sciences, University “La Sapienza” of Rome, Italy
,
Pietro Luigi Mingazzini Pathology Unit, Department of Surgery “Pietro Valdoni”, University “La Sapienza” of Rome, Italy
&
Paolo Paoluzi Gastroenterology Unit, Department of Clinical Sciences, University “La Sapienza” of Rome, Italy
 show all
Pages 419-425 | Published online: 11 Jun 2009

REFERENCES

  • Kinzler K. W., Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996; 87: 159–170
  • Compton CC. Colorectal carcinoma: diagnostic, prognostic, and molecular features. Mod Pathol 2003; 16: 376–388
  • Hewitt R. E., Powe D. G., Carter I., et al. Desmoplasia and its relevance to colorectal tumour invasion. Int J Cancer 1993; 52: 62–9
  • Lunevicius R., Nakamishi H., Ito S., et al. Clinicopathological significance of fibrotic capsule formation around liver metastasis from colorectal cancer. J Cancer Res Clin Oncol 2001; 127: 193–9
  • Caporale A., Vestri A. R., Benvenuto E., et al. Is Desmoplasia a protective factor for survival in patients with colorectal carcinoma. Clin Gastroent and Hepatol 2005; 3: 370–5
  • Jass J. R., Atkin W. S., Cuzick J., et al. The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases. Histopathol 1986; 10: 437–459
  • Liotta L. A., Rao C. N., Barsky J. N. Tumour invasion of extracellular matrix. Lab Invest 1983; 49: 636–49
  • Nakada I., Tasaki T., Ubukata H., et al. Desmoplastic response in biopsy specimens of early carcinoma is predictive of deep submucosal invasion. Dis Colon Rectum 1988; 41: 896–900
  • Nishimura R., Hesebe T., Tsubno J., et al. The fibrotic focus in advanced colorectal carcinoma: a hitherto unrecognized historical predictor for liver metastasis. Virchows Arch 1998; 433: 517–22
  • Gabbert H., Wagner R., Moll R., et al. Tumour dedifferentiation: an important step in tumour invasion. Int J Cancer 1993; 52: 62–9
  • Ueno H., Jones A. M., Wilkinson K. A., et al. Histological categorisation of fibrotic cancer stroma in advanced rectal cancer. Gut 2004; 53: 581–6
  • Martin M., Pujuguet P., Martin F. Role of stromal myofibroblast infiltrating colon cancer in tumour invasion. Pathol Res Pract 1996; 192: 712–7
  • Hauptmann S., Budianto D., Denkert C., et al. Adhesion and migration of HRT-18 colorectal carcinoma cells on extracellular matrix components typical for the desmoplastic stroma of colorectal adenocarcinomas. Oncol 2003; 65: 174–81
  • Lieubeau B., Heynam M. F., Henry F., et al. Immunomodulatory effect of tumour-associated fibroblast in colorectal-tumour development. Int J Cancer 1999; 81: 629–36
  • Kapiteijn E., Corrie M., Nagtegaal I. D., et al. Preoperative Radiotherapy Combined with Total Mesorectal Excision for resectable rectal Cancer. N Engl J Med 2001; 345: 638–646
  • Krook J. E., Moertel C. G., Gunderson L. L., et al. Effective surgical adjuvant therapy for high risk rectal carcinoma. N Engl J Med 1991; 324: 709–715
  • Marsh P. J., James R. D., Schofield P. F., et al. Adjuvant preoperative radiotherapy for locally advanced rectal carcinoma. Results of a prospective randomized trial. Dis Colon Rectum 1994; 37: 1205–1214
  • Medical Research Council Rectal Cancer Working Party. Randomized trial of surgery alone versus radiotherapy followed by surgery for mobile cancer of the rectum. Lancet 1996; 348: 1610–1614
  • Medical Research Council Rectal Cancer Working Party. Randomized trial of surgery alone versus surgery followed by radiotherapy for mobile cancer of the rectum. Lancet 1996; 348: 1605–1610
  • TNM classification of malignant tumours. Sixth Edition, L. H. Sobin, C H Wittekind. JB Lippincott, Philadelphia 2002
  • Ueno H., Jones A., Jass J. R., et al. Clinicopathological significance of the “keloid like” collagen and myxoid stroma in advanced rectal cancer. Histopathol 2002; 40: 327–34
  • Prall F., Nizze H., Barten M. Tumour budding as prognostic factor in stage I/II colorectal carcinoma. Histopathol 2005; 47: 17–24
  • Mescoli C., Rugge M., Pucciarelli S., et al. High prevalence of isolated tumour cells tumour cells in regional lymph nodes from pN0 colorectal cancer. J Clin Pathol 2006; 59: 870–4
  • Eisenberg B., Decosse J. J., Harford F., et al. Carcinoma of the colon and rectum: the natural history reviewed in 1704 patients. Cancer 1982; 49: 1131–4
  • Shurlch W., Seenarer T. A., Gabbiani G. Histology for pathologist, 2nd ed, S Sternberg. Lippincott-Raven Publishers, Philadelphia 1997; 129–65
  • Heinen E., Corwann N., Kinet-Denoel C. The Limph-follicle: a hard nut to crack. Immunol Today 1988; 9: 240–3
  • Unaue E. R., Allen P. M. The basis of the immunoregulatory role of macrophages and of the accessory cells. Science 1987; 236: 551–7
  • Sandel M. H., Dadabayev A. R., Menon A. G., et al. Prognostic value of Tumor-infiltrating dendritic celles in Colorectal Cancer: Role of maturation status and intratumoral localisation. Clin Cancer Res 2005; 11: 2576–82
  • Chau I., Cunnigham D. Adjuvant therapy in colorectal cancer: current status and future directions. Cancer Treat Rev 2002; 28: 223–36

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