137
Views
18
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE Cellular and Molecular Biology

FKBP51 Expressed by Both Normal Epithelial Cells and Adenocarcinoma of Colon Suppresses Proliferation of Colorectal Adenocarcinoma

, , , , , , , , , & show all
Pages 385-390 | Published online: 11 Jun 2009

REFERENCES

  • Bierer B. E., Hollander G., Fruman D., Burakoff S. J., Cyclosporin A. and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology. Curr Opin Immunol 1993; 5: 763–773
  • Abraham R. T., Wiederrecht G. J. Immunopharmacology of rapamycin. Annu Rev Immunol 1996; 14: 483–510
  • Liu J., Farmer J. D., Lane W. S., Friedman J., Weissman I., Schreiber S. L. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 1991; 66: 807–815
  • O'Keefe S. J., Tamura J., Kincaid R. L., Tocci M. J., O'Neill E. A. FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 1992; 357: 692–694
  • Baughman G., Wiederrecht G. J., Chang F., Martin M. M., Bourgeois S. Tissue distribution and abundance of human FKBP51.; an FK506-binding protein that can mediate calcineurin inhibition. Biochem Biophys Res Commun 1997; 232: 437–443
  • Tai P. K., Albers M. W., Chang H., Faber L. E., Schreiber S. L. Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. Science 1992; 256: 1315–1318
  • Beato M., Herrlich P., Schutz G. Steroid hormone receptors: many actors in search of a plot. Cell 1995; 83: 851–857
  • Karin M. New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable?. Cell 1998; 93: 487–490
  • Denny W. B., Valentine D. L., Reynolds P. D., Smith D. F., Scammell J. G. Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding. Endocrinology 2000; 141: 4107–4113
  • Giraudier S., Chagraoui H., Komura E., Barnache S., Blanchet B., LeCouedic J. P., Smith D. F., Larbret F., Taksin F., Moreau-Gachelin F., Casadevall N., Tulliez M., Hulin A., Debili N., Vainchenker W. Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors. Blood 2002; 100: 2932–2940
  • Bouwmeester T., Bauch A., Ruffner H., Angrand P. O., Bergamini G., Croughton K., Cruciat C., Eberhard D., Gagneur J., Ghidelli S., Hopf C., Huhse B., Mangano R., Michon A. M., Schirle M., Schlegl J., Schwab M., Stein M. A., Bauer A., Casari G., Drewes G., Gavin A. C., Jackson D. B., Joberty G., Neubauer G., Rick J., Kuster B., Superti-Furga G. A physical and functional map of human TNA-α NF-κ B signal transduction pathway. Nat Cell Biol 2006; 6: 97–105
  • Komura E., Tonetti C., Penard-Lacronique V., Chagraoui H., Lacout C., LeCouedic J. P., Rameau P., Debili N., Vainchenker W., Stephane G. Role for nuclear factor κ B pathway in transforming growth factor-β 1 production in idiopathic myelofibrosis: possible relationship with FK506 binding protein 51 overexpression. Cancer Res 2005; 65: 3281–3289
  • Adachi Y., Taketani S., Oyaizu H., Ikebukuro K., Tokunaga R., Ikehara S. Apoptosis of colorectal adenocarcinoma induced by 5-FU and/or IFN-gamma through caspase 3 and caspase 8. Int J Oncol 1999; 15: 1191–1196
  • Bock O., Neusch M., Busche G., Mengel M., Kreipe H. Constitutive expression of the FK506 binding protein 51 (FKBP51) in bone marrow cells and megakaryocytes derived from idiopathic myelofibrosis and non-neoplastic haematopoiesis. Eur J Haematol 2004; 72: 239–244
  • Tutton P. J., Barkla D. H. Effects of glucocorticoid hormones on cell proliferation in dimethylhydrazine-induced tumors in rat colon. Virchows Arch B Cell Pathol Incl Mol Pathol 1981; 38: 247–251
  • Fauci A. S. Mechanisms of the immunosuppressive and anti-inflammatory effects of glucocorticosteroids. J Immunopharmacol 1978–1979; 1: 1–25
  • Swartz S. L., Dluhy R. G. Corticosteroids: clinical pharmacology and therapeutic use. Drugs 1978; 16: 238–255
  • Yemelyanov A., Czwornog J., Chebotaev D., Karseladze A., Kulevitch E., Yang X., Budunova I. Tumor suppressor activity of glucocorticoid receptor in the prostate. Oncogene 2006; 26: 1885–1896
  • Smith R. G., Syms A. J., Nag A., Lerner S., Norris J. S. Mechanism of the glucocorticoid regulation of growth of the androgen-sensitive prostate-derived R3327H-G8-A1 tumor cell. J Biol Chem 1985; 260: 12454–12463
  • Cook P. W., Edwards C. P., Haraguchi T., Firestone G. L. Partial characterization of a glucocorticoid suppressible mitogenic activity secreted from a rat hepatoma cell line hypersensitivity to the antiproliferative effects of glucocorticoids. J Biol Chem 1989; 264: 14151–14158
  • Hatakeyama S., Sashima M., Shirasuna K., Satoh M., Suzuki A. Glucocorticoid-induced growth inhibition with enhanced expression of ductal epithelium of human salivary gland adenocarcinoma cells transplanted into athymic nude mice. Cancer 1988; 62: 716–722
  • Joly E., Vignon F., Rochefort H. Growth regulation of two rat adenocarcinoma cell lines by dexamethsone and progesterone. Breast Cancer Res Treat 1981; 1: 381–389
  • Curtis R. E., Rowlings P. A., Deeg H. J., Shriner D. A., Socie G., Travis L. B., Horowitz M. M., Witherspoon R. P., Hoover R. N., Sobocinski K. A., Fraumeni J. F., Jr., Boice J. D., Jr. Solid cancers after bone marrow transplantation. N Engl J Med 1997; 336: 897–904

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.