218
Views
47
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLEClinical Translational Therapeutics

Gemcitabine Combined with Gefitinib in Patients with Inoperable or Metastatic Pancreatic Cancer: A Phase II Study of the Hellenic Cooperative Oncology Group with Biomarker Evaluation

, , , , , , , , , , , , & show all
Pages 784-793 | Published online: 11 Jun 2009

REFERENCES

  • Jemal A., Siegel R., Ward E., Murray T., Xu J., Smigal C., Thun M. J. Cancer statistics, 2006. CA Cancer J. Clin. 2006; 56: 106–130
  • Sultana A., Smith C. T., Cunningham D., Starling N., Neoptolemos J. P., Ghaneh P. Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer. J. Clin. Oncol. 2007; 25: 2607–2615
  • Van Cutsem E., van de Velde H., Karasek P., Oettle H., Vervenne W. L., Szawlowski A., Schoffski P., Post S., Verslypse C., Neumann H., Safran H., Humblet Y., Perez Ruixo J., Ma Y., Von Hoff D. Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J. Clin. Oncol. 2004; 22: 1430–1438
  • Louvet C., Labianca R., Hammel P., Liedo G., Zampino M. G., Andre T., Zaniboni A., Ducreux M., Aitini E., Taieb J., Faroux R., Lepere C., de Gramont A. GERCOR; GISCAD. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial. J. Clin. Oncol. 2005; 23(15)3509–3516
  • Hochster H. S., Haller D. G., de Gramont A., Berlin J. D., Philip P. A., Moore M. J., Ajani J. A. Consensus report of the international society of gastrointestinal oncology on therapeutic progress in advanced pancreatic cancer. Cancer 2006; 107(4)676–685
  • Xie D. R., Liang H. L., Wang Y., Guo S. S., Yang Q. Meta-analysis on inoperable pancreatic cancer: a comparison between gemcitabine-based combination therapy and gemcitabine alone. World. J. Gastroenterol. 2006; 12(43)6973–81
  • Overholser J. P., Prewett M. C., Hooper A. T., Waksal H. W., Hicklin D. J. Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice. Cancer 2000; 89(1)74–82
  • Yamanaka Y., Friess H., Kobrin M. S., Buchler M., Beger H. G., Korc M. Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness. Anticancer Res. 1993; 3(3)565–569
  • Bruns C. J., Solorzano C. C., Harbison M. T., Ozawa S., Tsan R., Fan D., Abbruzzese J., Traxler P., Buchdunger E., Radinsky R., Fidler I. J. Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res. 2000; 60(11)2926–2935
  • Bruns C. J., Harbison M. T., Davis D. W., Portera C. A., Tsan R., McConkey D. J., Evans D. B., Abbruzzese J. L., Hicklin D. J., Radinsky R. Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms. Clin. Cancer Res. 2000; 6(5)1936–1948
  • Li J., Kleeff J., Giese N., Buchler M. W., Korc M., Friess H. Gefitinib (‘Iressa’, ZD1839), a selective epidermal growth factor receptor tyrosine kinase inhibitor, inhibits pancreatic cancer cell growth, invasion, and colony formation. Int. J. Oncol. 2004; 25(1)203–210
  • Therasse P., Arbuck S. G., Eisenhauer E. A., Wanders J., Kaplan R. S., Rubinstein L., Verweij J., Van Glabbeke M., van Oosterom A. T., Christian M. C., Gwyther S. G. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J. Natl. Cancer Inst. 2000; 92(3)205–216
  • Ajani J. A., Welch S. R., Raber M. N., Fields W. S., Krakoff I. H. Comprehensive criteria for assessing therapy-induced toxicity. Cancer Invest. 1990; 8(2)147–59
  • Pallares J., Bussaglia E., Martinez-Guitarte J. L., Dolcet X., Llobet. D., Rue M., Sanchez-Verde L., Palacios J., Prat J., Matias-Guiu X. Immunohistochemical analysis of PTEN in endometrial carcinoma: a tissue microarray study with a comparison of four commercial antibodies in correlation with molecular abnormalities. Modern. Pathol. 2005; 18: 719–727
  • Italiano A., Saint-Paul M. C., Caroli-Bosc F. X., Francois E., Bourgeon A., Benchimol D., Gugenheim J., Michiels J. F. Epidermal growth factor receptor (EGFR) status in primary colorectal tumors correlates with EGFR expression in related metastatic sites: biological and clinical implications. Ann. Oncol. 2005; 16: 1503–1507
  • Choe G., Horvath S., Cloughesy T. F., Crosby K., Seligson D., Palotie A., Inge L., Smith B. L., Sawyers C. L., Mischel. P. S. Analysis of the phosphatidylinositol 3′-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res. 2003; 63: 2742–2746
  • Perren A., Weng L. P., Boag A. H., et al. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast. Am. J. Pathol. 1999; 155: 1253–1260
  • Fountzilas G., Karkavelas G., Kalogera-Fountzila A., Karina M., Ignatiadis M., Koukoulis G., Plataniotis G., Misailidou D., Bobos M., Pectasides D., Razis E., Karavelis A., Selviaridis P. Post-operative combined radiation and chemotherapy with temozolomide and irinotecan in patients with high-grade astrocytic tumors. A phase II study with biomarker evaluation. Anticancer Res. 2006; 26: 4675–4686
  • Sunpaweravong P., Sunpaweravong S., Puttawibul P., Mitarnun W., Zeng C., Baron A. E., Franklin W., Said S., Varella-Garcia M. Epidermal growth factor receptor and cyclin D1 are independently amplified and overexpressed in esophageal squamous cell carcinoma. J. Cancer Res. Clin. Oncol. 2005; 131: 111–119
  • Murray S., Timotheadou E., Linardou H., Vrettou A. V., Kostopoulos I., Skrickova J., Papakostantinou C., Christodoulou C., Pectasides D., Samantas E., Papakostas P., Skarlos D. V., Kosmidis P., Fountzilas G. Mutations of the epidermal growth factor receptor tyrosine kinase domain and associations with clinicopathological features in non-small cell lung cancer patients. Lung Cancer 2006; 52: 225–233
  • Travis W. D., Colby T. V., Corrin B., Shimosato Y., Brambilla E. Histological typing of lung and pleural tumors 3rd edition. Springer Verlag, Berlin 1999
  • Pao W., Wang T. Y., Riely G. J., Miller V. A., Pan Q., Ladanyi M., Zakowski M. F., Heelan R. T., Kris M. G., Varmus H. E. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS. Med. 2005; 2: 57–61
  • Moore M. J., Goldstein D., Hamm J., Figer A., Hecht J. R., Gallinger S., Au H. J., Murawa P., Walde D., Wolff R. A., Campos D., Lim R., Ding K., Clark G., Voskoglou-Nomikos T., Ptasynski M., Parulekar W. National Cancer Institute of Canada Clinical Trials Group. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 2007; 25: 1960–1966
  • Shadad F., Phase I I. study of gefitinib and docetaxel as salvage therapy in patients with advanced pancreatic adenocarcinoma. J. Clin. Oncol. 2006; 24((Suppl 18)), (Abstr 4120)
  • Cascinu S., Berardi R., Siena S., La bianca R., Falcone A., Aitini E., Barni S., Di Costanzo F., Frontini L., Tonini G., Zaniboni A. The impact of cetuximab on the gemcitabine/cisplatin combination in first-line treatment of EGFR-positive advanced pancreatic cancer (APC): A randomized phase II trial of GISCAD. J. Clin. Oncol. 2007; 25((Suppl 18)), (Abstr 4544)
  • Abou-Alfa G. K., Letourneau R., Harker G., Modiano M., Hurwitz H., Tchekmedyian N. S., Feit K., Ackerman J., De Jager R. L., Eckhardt S. G., O'Reilly E. M. Randomized phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic cancer. J. Clin. Oncol. 2006; 24(27)4441–4447
  • Perez-Soler R., Delord J. P., Halpern A., Kelly K., Krueger J., Sureda B. M., von Pawel J., Temel J., Siena S., Soulieres D., Saltz L., Leyden J. HER1/EGFR inhibitor-associated rash: future directions for management and investigation outcomes from the HER1/EGFR inhibitor rash management forum. Oncologist. 2005; 10(5)345–356, Review
  • Lynch T. J., Jr, Kim E. S., Eaby B., Garey J., West D. P., Lacouture M. E. Epidermal growth factor receptor inhibitor-associated cutaneous toxicities: an evolving paradigm in clinical management. Oncologist 2007; 12: 610–621
  • El-Rayes B. F., Ali S., Ali I. F., Philip P. A., Abbruzzese J., Sarkar F. H. Potentiation of the effect of erlotinib by genistein in pancreatic cancer: the role of Akt and nuclear factor-kappaB. Cancer Res. 2006; 66: 10553–10559
  • Safran H., Steinhoff M., Mangray S., Rathore R., King T. C., Chai L., Berzein K., Moore T., Iannitti D., Reiss P., Pasquariello T., Akerman P., Quirk D., Mass R., Goldstein L., Tantravahi U. Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma. Am. J. Clin. Oncol. 2001; 24(5)496–499
  • Fernandez M., Eng C. The expanding role of PTEN in neoplasia: a molecule for all seasons? Commentary. Clin. Cancer Res. 2002; 8(6)1695–1698
  • Ohgaki H., Kleihues P. Genetic pathways to primary and secondary glioblastoma. Am. J. Pathol. 2007; 170: 1445–1453
  • Hayes M. P., Wang H., Espinal-Witter R., Douglas W., Solomon G. J., Baker S. J., Ellenson L. H. PIK3CA and PTEN mutations in uterine endometrioid carcinoma and complex atypical hyperplasia. Clin. Cancer Res. 2006; 12: 5932–5935
  • Asano T., Yao Y., Zhu J., Li D., Abbruzzese J. L., Reddy S. A.G., The P I. 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kB and c-Myc in pancreatic cancer cells. Oncogene. 2004; 23: 8571–8580
  • She Q. B., Solit D., Basso A., Moasser M. M. Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3'-kinase/Akt pathway signaling. Clin. Cancer Res. 2003; 9: 4340–4346
  • Haas-Kogan D. A., Prados M. D., Tihan T., Eberhard D. A., Jelluma N., Arvold N. D., Baumber R., Lamborn K. R., Kapadia A., Malec M., Berger M. S., Stokoe D. J. Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib. Natl. Cancer Inst. 2005; 97(12)880–887
  • Yano S., Matsuyama H., Hirata H., Inoue R., Matsumoto H., Ohmi C., Miura K., Shirai M., Iizuka N., Naito K. Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol. Rep. 2006; 15(6)1453–1460
  • Han S. W., Kim T. Y., Jeon Y. K., Hwang P. G., Im S. A., Lee K. H., Kim J. H., Kim D. W., Heo D. S., Kim N. K., Chung D. H., Bang Y. J. Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation. Clin. Cancer Res. 2006; 12: 2538–2544
  • Kwak E. L., Jankowski J., Thayer S. P., Lauwers G. Y., Brannigan B. W., Harris P. L., Okimoto R. A., Haserlat S. M., Driscoll D. R., Ferry D., Muir B., Settleman J., Fuchs C. S., Kulke M. H., Ryan D. P., Clark J. W., Sgroi D. C., Haber D. A., Bell D. W. Epidermal growth factor receptor kinase domain mutation in esophageal and pancreatic adenocarcinomas. Clin. Cancer Res. 2006; 12: 4283–4287
  • Lee J., Jang K. T., Ki C. S., Lim T., Park Y. S., Lim H. Y., Choi D. W., Kang W. K., Park K., Park J. O. Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma. Cancer 2007; 109: 1561–1569
  • Paez J. G., Janne P. A., Lee J. C., Tracy S., Greulich H., Gabriel S., Herman P., Kaye F. J., Lindeman N., Boggon T. J., Naoki K., Sasaki H., Fujii Y., Eck M. J., Sellers W. R., Johnson B. E., Meyerson M. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004; 304: 1497–1500

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.