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Cancer Investigation Volume 27, 2009 - Issue 4
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ORIGINAL ARTICLES Cellular and Molecular Biology

Nkx3.1 and p27KIP1 Cooperate in Proliferation Inhibition and Apoptosis Induction in Human Androgen–Independent Prostate Cancer Cells

Ping Wang Department of Urology, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China
,
Qi Ma Department of Urology, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China
,
JinDan Luo Department of Urology, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China
,
Ben Liu Department of Urology, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China
,
FuQing Tan Department of Urology, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China
,
ZhiGen Zhang Department of Urology, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China
&
ZhaoDian Chen Department of Urology, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China
 show all
Pages 369-375 | Published online: 20 Jul 2009

REFERENCES

  • Nelson W.G., De Marzo A.M., Isaacs W.B. Prostate cancer. N Engl J Med 2003; 349(4)366–381
  • Bieberich C.J., Fujita K., He W.W., Jay G. Prostate-specific and androgen-dependent expression of a novel homeobox gene. J Biol Chem 1996; 271(50)31779–31782
  • Prescott J.L., Blok L., Tindall D.J. Isolation and androgen regulation of the human homeobox cDNA, Nkx3.1. Prostate 1998; 35(1)71–80
  • Vocke C.D., Pozzatti R.O., Bostwick D.G., Florence C.D., Jennings S.B., Strup S.E., Duray P.H., Liotta L.A., Emmert-Buck M.R., Linehan W.M. Analysis of 99 microdissected prostate carcinoma reveals a high frequency of allelic loss on chromosome 8p21-22. Cancer Res 1996; 56(10)2411–2416
  • Swalwell J.I., Vocke C.D., Yang Y., Walker J.R., Grouse L., Myers S.H., Gillespie J.W., Bostwick D.G., Duray P.H., Linehan W.M., Emmert-Buck M.R. Determination of a minimal deletion interval on chromosome band 8p21 in sporatic prostate cancer. Genes Chrom Cancer 2002; 33(2)201–205
  • Voeller H.J., Augustus M., Madike V., Bova G.S., Carter K.C., Gelmann E.P. Coding region of Nkx3.1, prostate-specific homeo-box gene on 8P21, is not mutuated in human prostate cancers. Cancer Res 1997; 57(20)4455–4459
  • Bowen C., Bubendorf L., Voeller H.J., Slack R., Willi N., Sauter G., Gasser T.C., Koivisto P., Lack E.E., Kononen J., Kallioniemi O.P., Gelmann E.P. Loss of Nkx3.1 expression in human prostate cancers correlates with tumor progression. Cancer Res 2000; 60(21)6111–6115
  • Korkmaz C.G., Korkmaz K.S., Manola J., Xi Z., Risberg B., Danielsen H., Kung J., Sellers W.R., Loda M., Saatcioglu F. Analysis of androgen regulated homeobox gene Nkx3.1 during prostate carcinogenesis. J Urol 2004; 172(3)1134–1139
  • Kim M.J., Cardiff R.D., Desai N., Banach-Petrosky W.A., Parsons R., Shen M.M., Abate-Shen C. Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis. Proc Natl Acad Sci USA 2002; 99(5)2884–2889
  • Eder I.E., Bektic J., Haag P., Bartsch G., Klocker H. Genes differentially expressed in prostate cancer. BJU Int 2004; 93(8)1151–1155
  • Katner A.L., Hoang Q.B., Gootam P., Jaruga E., Ma Q., Gnarra J., Rayford W. Induction of cell cycle arrest and apoptosis in human prostate carcinoma cells by a recombinant adenovirus expressing p27KIP1. Prostate 2002; 53(1)77–87
  • Di Cristofano A., De Acetis M., Koff A., Cordon-Cardo C., Pandolfi P.P. Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse. Nat Genet 2001; 27(2)222–224
  • Gary B., Azuero R., Mohanty G.S., Bell W.C., Eltoum I.E., Abdulkadir S.A. Interaction of Nkx3.1 and p27KIP1 in prostate tumor initiation. Am J Pathol 2004; 164(5)1607–1614
  • Santos A.F., Huang H., Tindall D.J. The androgen receptor: a potential target for therapy of prostate cancer. Steroids 2004; 69(2)79–85
  • Bhatia-Gaur R., Donjacour A.A., Sciavolino P.J., Kim M., Desai N., Young P., Norton C.R., Gridley T., Cardiff R.D., Cunha G.R., Abate-Shen C., Shen M.M. Roles for Nkx3.1 in prostate development and cancer. Genes Dev 1999; 13(8)966–977
  • Shen M.M., Abate-Shen C. Roles of the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis. Dev Dyn 2003; 228(4)767–778
  • Katner A.L., Gnarra J.R., Rayford W. A recombinant adenovirus expressing p27(KIP) induces cell cycle arrest and apoptosis in human renal carcinoma cells. J Urol 2002; 168(2)766–773
  • Matsunobu T., Tanaka K., Matsumoto Y., Nakatani F., Sakimura R., Hanada M., Li X., Oda Y., Naruse I., Hoshino H., Tsuneyoshi M., Miura H., Iwamoto Y. The prognostic and therapeutic relevance of p27kip1 in Ewing's family tumors. Clin Cancer Res 2004; 10(3)1003–1012
  • Schreiber M., Muller W.J., Singh G., Graham F.L. Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p21WAFKIP1, and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity. Oncogene 1999; 18(9)1663–1676
  • Naruse I., Hoshino H., Dobashi K., Minato K., Saito R., Mori M. Over-expression of p27Kip1 induces growth arrest and apoptosis mediated by changes of pRb expression in lung cancer cell lines. Int J Cancer 2000; 88(3)377–383
  • Gao H., Ouyang X., Banach-Petrosky W., Borowsky A.D., Lin Y., Kim M., Lee H., Shih W.J., Cardiff R.D., Shen M.M., Abate-Shen C. A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis. Proc Natl Acad Sci. USA 2004; 101(49)17204–17209
  • Wolf B.B., Green D.R. Suicidal tendencies:apoptotic cell death by caspase family proteinases. J Biol Chem 1999; 274(43)20049–20052
  • Haldar S., Jena N., Croce C.M. Inactivation of Bcl-2 by phosphorylation. Proc Natl Acad Sci USA 1995; 92(10)4507–4511

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