Somatic Alterations of the Serine/Threonine Kinase LKB1 Gene in Squamous Cell (SCC) and Large Cell (LCC) Lung Carcinoma

REFERENCES

• Hemminki A., Markie D., Tomlinson I., Avizienyte E., Roth S., Loukola A., Bignell G., Warren W., Aminoff M., Höglund P., Järvinen H., Kristo P., Pelin K., Ridanpää M., Salovaara R., Toro T., Bodmer W., Olschwang S., Olsen A. S., Stratton M. R., de la Chapelle A., Aaltonen L. A. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 1998; 391(6663)184–187
   PubMed Web of Science ®Google Scholar
• Jishage K., Nezu J., Kawase Y., Iwata T., Watanabe M., Miyoshi A., Ose A., Habu K., Kake T., Kamada N., Ueda O., Kinoshita M., Jenne D. E., Shimane M., Suzuki H. Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis. Proc. Natl. Acad. Sci. USA 2002; 99(13)8903–8908
   PubMed Web of Science ®Google Scholar
• Yoo L. I., Chung D. C., Yuan J. LKB1–a master tumour suppressor of the small intestine and beyond. Nat. Rev. Cancer 2002; 2(7)529–535
   PubMed Web of Science ®Google Scholar
• Karuman P., Gozani O., Odze R. D., Zhou X. C., Zhu H., Shaw R., Brien T. P., Bozzuto C. D., Ooi D., Cantley L. C., Yuan J. The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol. Cell 2001; 7(6)1307–1319
   PubMed Web of Science ®Google Scholar
• Tiainen M., Vaahtomeri K., Ylikorkala A., Makela T. P. Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1). Hum. Mol. Genet. 2002; 11(13)1497–1504
   PubMed Web of Science ®Google Scholar
• Sapkota G. P., Deak M., Kieloch A., Morrice N., Goodarzi A. A., Smythe C., Shiloh Y., Lees-Miller S.P., Alessi D. R. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. Biochem. J. 2002; 368(Pt 2)507–516
   PubMed Web of Science ®Google Scholar
• Sapkota G. P., Kieloch A., Lizcano J. M., Lain S., Arthur J. S., Williams M. R., Morrice N., Deak M., Alessi D. R. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90 (RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth. J. Biol. Chem. 2001; 362(Pt 2)481–490
   Google Scholar
• Ji H., Ramsey M. R., Hayes D. N., Fan C., McNamara K., Kozlowski P., Torrice C., Wu M. C., Shimamura T., Perera S. A., Liang M. C., Cai D., Naumov G. N., Bao L., Contreras C. M., Li D., Chen L., Krishnamurthy J., Koivunen J., Chirieac L. R., Padera R. F., Bronson R. T., Lindeman N. I., Christiani D. C., Lin X., Shapiro G. I., Jänne P. A., Johnson B. E., Meyerson M., Kwiatkowski D. J., Castrillon D. H., Bardeesy N., Sharpless N. E., Wong K. K. LKB1 modulates lung cancer differentiation and metastasis. Nature 2007; 448(7155)807–810
   PubMed Web of Science ®Google Scholar
• Dong S. M., Kim K. M., Kim S. Y., Shin M. S., Na E. Y., Lee S. H., Park W. S., Yoo N. J., Jang J. J., Yoon C. Y., Kim J. W., Kim S. Y., Yang Y. M., Kim S. H., Kim C. S., Lee J. Y. Frequent somatic mutations in serine/threonine kinase 11/Peutz-eghers syndrome gene in left-sided colon cancer. Cancer Res. 1998; 58(17)3787–3790
   PubMed Web of Science ®Google Scholar
• Avizienyte E., Loukola A., Roth S., Hemminki A., Tarkkanen M., Salovaara R., Arola J., Bützow R., Husgafvel-Pursiainen K., Kokkola A., Järvinen H., Aaltonen L. A. LKB1 somatic mutations in sporadic tumors. Am. J. Pathol. 1999; 154(3)677–681
   PubMed Web of Science ®Google Scholar
• Sanchez-Cespedes M. A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome. Oncogene 2007; 26(57)7825–7832
   PubMed Web of Science ®Google Scholar
• Sanchez-Cespedes M., Parrella P., Esteller M., Nomoto S., Trink B., Engles J. M., Westra W. H., Herman J. G., Sidransky D. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res. 2002; 62(13)3659–3662
   PubMed Web of Science ®Google Scholar
• Carretero J., Medina P. P., Pio R., Montuenga L. M., Sanchez-Cespedes M. Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene. Oncogene 2004; 23(22)4037–4040
   PubMed Web of Science ®Google Scholar
• Matsumoto S., Iwakawa R., Takahashi K., Kohno T., Nakanishi Y., Matsuno Y., Suzuki K., Nakamoto M., Shimizu E., Minna J. D., Yokota J. Prevalence and specificity of LKB1 genetic alterations in lung cancers. Oncogene 2007; 26(40)5911–5918
   PubMed Web of Science ®Google Scholar
• Amos C. I., Keitheri-Cheteri M.B., Sabripour M., Wei C., McGarrity T.J., Seldin M. F., Nations L., Lynch P. M., Fidder H. H., Friedman E., Frazier M. L. Genotype-phenotype correlations in Peutz-Jeghers syndrome. J. Med. Genet. 2004; 41(5)327–333
   PubMed Web of Science ®Google Scholar
• Fernandez P., Carretero J., Medina P. P., Jimenez A. I., Rodriguez-Perales S., Paz M. F., Cigudosa J. C., Esteller M., Lombardia L., Morente M., Sanchez-Verde L., Sotelo T., Sanchez-Cespedes M. Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations. Oncogene 2004; 23(29)5084–5091
   PubMed Web of Science ®Google Scholar
• Upadhyay S., Liu C., Chatterjee A., Hoque M. O., Kim M. S., Engles J., Westra W., Trink B., Ratovitski E., Sidransky D. LKB1/STK11 suppresses Cyclooxygenase-2 induction and cellular invasion through PEA3 in lung cancer. Cancer Res. 2006; 66(16)7870–7879
   PubMed Web of Science ®Google Scholar
• Yamanoshita O., Kubota T., Hou J., Ping Y. M., Zhang X. L., Li X. P., Li S. S., Li X. X., Zhu D. C., Fukushima Y., Nakajima T. DHPLC is superior to SSCP in screening p53 mutations in esophageal cancer tissues. Int. J. Cancer 2005; 114(1)74–79
   PubMed Web of Science ®Google Scholar
• König E. A., Köves I., Ranariu A., Popp A. R., Kusser W. C., Soyonki K., Kovács A., Glickman B. W., Jeney A., Marcsek Z. L. Alterations of K-ras and p53 mutations in colorectal cancer patients in Central Europe. J. Toxicol. Environ. Health A 2001; 62(5)333–347
   PubMed Web of Science ®Google Scholar
• Onozato R., Kosaka T., Achiwa H., Kuwano H., Takahashi T., Yatabe Y., Mitsudomi T. LKB1 gene mutations in Japanese lung cancer patients. Cancer Sci. 2007; 98(11)1747–1751
   PubMed Web of Science ®Google Scholar
• von Herbay A., Arens N., Friedl W., Vogt-Moykopf I., Kayser K., Müller K. M., Back W. Bronchioloalveolar carcinoma: a new cancer in Peutz-Jeghers syndrome. Lung Cancer 2005; 47(2)283–288
   PubMed Web of Science ®Google Scholar
• Launonen V., Avizienyte E., Loukola A., Laiho P., Salovaara R., Järvinen H., Mecklin J. P., Oku A., Shimane M., Kim H. C., Kim J. C., Nezu J., Aaltonen L. A. No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas. Cancer Res. 2000; 60(3)546–548
   PubMed Web of Science ®Google Scholar
• Launonen V. Mutations in the human LKB1/STK11 gene. Hum. Mutat. 2005; 26(4)291–297
   PubMed Web of Science ®Google Scholar
• Mehenni H., Gehrig C., Nezu J., Oku A., Shimane M., Rossier C., Guex N., Blouin J.L., Scott H. S., Antonarakis S. E. Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity. Am. J. Hum. Genet. 1998; 63(6)1641–1650
   PubMed Web of Science ®Google Scholar
• Ylikorkala A., Avizienyte E., Tomlinson I. P., Tiainen M., Roth S., Loukola A., Hemminki A., Johansson M., Sistonen P., Markie D., Neale K., Phillips R., Zauber P., Twama T., Sampson J., Järvinen H., Mäkelä T. P., Aaltonen L. A. Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. Hum. Mol. Genet. 1999; 8(1)45–51
   PubMed Web of Science ®Google Scholar
• Hawley S. A., Boudeau J., Reid J. L., Mustard K. J., Udd L., Mäkelä T. P., Alessi D. R., Hardie D. G. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2003; 2(74)28
   PubMedGoogle Scholar
• Boudeau J., Sapkota G. Alessi, DR. LKB1, a protein kinase regulating cell proliferation and polarity. FEBS Lett 2003; 546(1)159–165
   PubMed Web of Science ®Google Scholar
• Wei C., Amos C. I., Rashid A., Sabripour M., Nations L., McGarrity T.J., Frazier M. L. Correlation of staining for LKB1 and COX-2 in hamartomatous polyps and carcinomas from patients with Peutz-Jeghers syndrome. J. Histochem. Cytochem. 2003; 51(12)1665–1672
   PubMed Web of Science ®Google Scholar