251
Views
18
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLES Clinical Translational Therapeutics

AFP Promoter Enhancer Increased Specific Expression of the Human Sodium Iodide Symporter (hNIS) for Targeted Radioiodine Therapy of Hepatocellular Carcinoma

, &
Pages 673-681 | Published online: 20 Jul 2009

REFERENCES

  • Levin B., Amos C. Therapy of unresectable hepatocellular carcinoma. N Engl J Med 1995; 332(19)1294–1296
  • el-Serag H. B. Epidemiology of hepatocellular carcinoma. Clin Liver Dis 2001; 5(1)87–107
  • Chan D. W., Kelsten M., Rock R., Bruzek D. Evaluation of a monoclonal immunoenzymometric assay for alpha-fetoprotein. Clin Chem 1986; 32(7)1318–1322
  • Johnson P. J. Role of alpha-fetoprotein in the diagnosis and management of hepatocellular carcinoma. J Gastroenterol Hepatol 1999; 14(Suppl.)32–36
  • Watanabe K., Saito A., Tamaoki T. Cell-specific enhancer activity in a far upstream region of the human alpha-fetoprotein gene. J Bio1 Chem 1987; 262(10)4812–4818
  • Ido A., Nakata K., Kato Y., Nakao K., Murata K., Fujita M., Ishii N., Tamaoki T., Shiku H., Nagataki S. Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of the human α -fetoprotein gene promoter. Cancer Res 1995; 55(14)3105–3109
  • Nettelbeck D. M., Jérôme V., Müller R. A strategy for enhancing the transcriptional activity of weak cell type-specific promoters. Gene Ther 1998; 5(12)1656–1664
  • Takikawa H., Mafune K., Hamada H., Nettelbeck D. M., Müller R., Makuuchi M., Kaminishi M. An advanced strategy of enhanced specific gene expression for hepatocellular carcinoma. Int J Oncol 2003; 22(5)1051–1056
  • Ido A., Uto H., Moriuchi A., Nagata K., Onaga Y., Onaga M., Hori T., Hirono S., Hayashi K., Tamaoki T. Tsubouchi, H. Gene therapy targeting for hepatocellular carcinoma: selective and enhanced suicide gene expression regulated by a hypoxia-inducible enhancer linked to a human a-fetoprotein promoter. Cancer Res 2001; 61(7)3016–3021
  • Byeong-Cheol A., Min Jeong R., Sohn Joo A., Sun Mi Y., Seung Hee C., Jeongsoo Y., In-Kyu L., Jae-Tae L., Kyu-Bo L. Construction of a highly hepatoma specific adenoviral vector system carrying NIS gene activated by AFP enhancer. J Nucl Med 2006; 47(Suppl. 1)409P
  • Vieja A. D.L., Dohan O., Levy O., Carrasco N. Molecular analysis of the sodium/iodide symporter: impact on thyroid and extrathyroid pathophysiology. Physiol Rev 2000; 80(3)1083–1105
  • Dai G., Levy O., Carrasco N. Cloning and characterization of the thyroid iodide transporter. Nature 1996; 379(6564)458–460
  • Dohán O., De la Vieja A., Paroder V., Riedel C., Artani M., Reed M., Ginter C. S., Carrasco N. The Sodium/iodide symporter (NIS): characterization, regulation, and medical significance. Endocr Rev 2003; 24(1)48–77, [PMID: 12588808]
  • Spitzweg C., Harrington K. J., Pinke L. A., Vile R. G., Morris J. C. The sodium/iodide symporter and its potential role in cancer therapy. J Clin Endocrinol Metab 2001; 86(7)3327–3335
  • Mandell R. B., Mandell L. Z., Link C. J., Jr. Radioisotope concentrator gene therapy using the sodium/iodide symporter gene. Cancer Res 1999; 59(3)661–668
  • Boland A., Ricard M., Opolon P., Bidart J. M., Yeh P., Filetti S., Schlumberger M., Perricaudet M. Adenovirus-mediated transfer of the thyroid sodium/iodide symporter gene into tumors for a targeted radiotherapy. Cancer Res 2000; 60(13)3484–3492
  • Nakamoto Y., Saga T., Misaki T., Kobayashi H., Sato N., Ishimori T., Kosugi S., Sakahara H., Konishi J. Establishment and characterization of a breast cancer cell line expressing Na/I symporters for radioiodide concentrator gene therapy. J Nucl Med 2000; 41(11)1898–1904
  • Haberkorn U., Henze M., Altmann A., Jiang S., Morr I., Mahmut M., Peschke P., Kübler W., Debus J., Eisenhut M. Transfer of the human NaI symporter gene enhances iodide uptake in hepatoma cells. J Nucl Med 2001; 42(2)317–325
  • Schipper M. L., Weber A., Béhé M., Göke R., Joba W., Schmidt H., Bert T., Simon B., Arnold R., Heufelder A. E., Behr T. M. Radioiodide treatment after sodium iodide symporter gene transfer is a highly effective therapy in neuroendocrine tumor cells. Cancer Res 2003; 63(6)1333–1338
  • Kakinuma H., Bergert E. R., Spitzweg C., Cheville J. C., Lieber M. M., Morris J. C. Probasin promoter (ARR2PB)-driven, prostate-specific expression of the human sodium iodide symporter (h-NIS) for targeted radioiodine therapy of prostate cancer. Cancer Res 2003; 63(22)7840–7844
  • Huang R., Kuang A., Yu H., Ma C., Tang G. Construction of the recombinant adenovirus carrying sodium/iodide symporter gene. J Biomed Eng 2005; 22(4)765–768
  • Ueki T., Nakata K., Mawatari F., Tsuruta S., Ido A., Ishikawa H., Nakao K., Kato Y., Ishii N., Eguchi K. Retrovirus-mediated gene therapy for human hepatocellular carcinoma transplanted in athymic mice. Int J Mol Med 1998; 1(4)671–675
  • Uto H., Ido A., Hori T., Hirono S., Hayashi K., Tamaoki T., Tsubouchi H. Hepatoma-specific gene therapy through retrovirus- mediated and targeted gene transfer using an adenovirus carrying the ecotropic receptor gene. Biochem Biophys Res Commun 1999; 265(2)550–555
  • Nakabayashi H., Watanabe K., Saito A., Otsuru A., Sawadaishi K., Tamaoki T. Transcriptional regulation of α -fetoprotein expression by dexamethasone in human hepatoma cells. J Biol Chem 1989; 264(1)266–271
  • Nakabayashi H., Hashimoto T., Miyao Y., Tjong K. K., Chan J., Tamaoki T. A position-dependent silencer plays a major role in repressing α -fetoprotein expression in human hepatoma. Mol Cell Biol 1991; 11(12)5885–5893
  • Mawatari F., Tsuruta S., Ido A., Ueki T., Nakao K., Kato Y., Tamaoki T., Ishii N., Nakata K. Retrovirus-mediated gene therapy for hepatocellular carcinoma: selective and enhanced suicide gene expression regulated by human α -fetoprotein enhancer directly linked to its promoter. Cancer Gene Ther 1998; 5(5)301–306
  • Ishikawa H., Nakata K., Mawatari F., Ueki T., Tsuruta S., Ido A., Nakao K., Kato Y., Ishii N., Eguchi K. Utilization of variant-type of human α -fetoprotein promoter in gene therapy targeting for the hepatocellular carcinoma. Gene Ther 1999; 6(4)465–470
  • Cao G., Kuriyama S., Tsujinoue H., Chen Q. L. Akira Mrroro, ZH Qi. A novel approach for inducing enhanced and selective transgene expression in hepatocellular carcinoma cells. Int J Cancer 2000; 87(2)247–252
  • Cao G., Kuriyama S., Gao J., Nakatani T., Chen Q., Yoshiji H., Zhao L., Kojima H., Dong Y., Fukui H., Hou J. Gene therapy for hepatocellular carcinoma based on tumor-selective suicide gene expression using the alpha-fetoprotein (AFP) enhancer and a housekeeping gene promoter. Eur J Cancer 2001; 37(1)140–147
  • Spitzweg C., Zhang S., Bergert E. R., Castro M. R., McIver B., Heufelder A. E., Tindall D. J., Young C. Y., Morris J. C. Prostate-specific antigen (PSA) promoter-driven androgen-inducible expression of sodium iodide symporter in prostate cancer cell lines. Cancer Res 1999; 59(9)2136–2141
  • Kang J. H., Chung J. K., Lee Y. J., Shin J. H., Jeong J. M., Lee D. S., Lee M. C. Establishment of a human hepatocellular carcinoma cell line highly expressing sodium iodide symporter for radionuclide gene therapy. J Nucl Med 2004; 45(9)1571–1576
  • Haberkorn U., Henze M., Altmann A., Jiang S., Morr I., Mahmut M., Peschke P., Kübler W., Debus J., Eisenhut M. Transfer of the human NaI symporter gene enhances iodide uptake in hepatoma cells. J Nucl Med 2001; 42(2)317–325
  • Shimura H., Haraguchi A., Miyazaki A., Endo T., Onaya T. Iodide uptake and 131I experimental therapy in transplanted undifferentiated thyroid cancer cells expressing the Na/I symporter gene. Endocrinology 1997; 138(10)4493–4496

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.