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Cancer Investigation Volume 39, 2021 - Issue 1
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Articles

Course of Sars-CoV2 Infection in Patients with Cancer Treated with anti-PD-1: A Case Presentation and Review of the Literature

Laura Palaa Division of Medical Oncology for Melanoma, Sarcoma, and Rare Tumors, IEO, European Institute of Oncology IRCCS, Milan, ItalyCorrespondence[email protected]
,
Fabio Confortia Division of Medical Oncology for Melanoma, Sarcoma, and Rare Tumors, IEO, European Institute of Oncology IRCCS, Milan, Italy
,
Emilia Cocorocchioa Division of Medical Oncology for Melanoma, Sarcoma, and Rare Tumors, IEO, European Institute of Oncology IRCCS, Milan, Italy
,
Pierfrancesco Ferruccia Division of Medical Oncology for Melanoma, Sarcoma, and Rare Tumors, IEO, European Institute of Oncology IRCCS, Milan, Italy
,
Martino Tommaso De Pasa Division of Medical Oncology for Melanoma, Sarcoma, and Rare Tumors, IEO, European Institute of Oncology IRCCS, Milan, Italy
,
Sara Stucchia Division of Medical Oncology for Melanoma, Sarcoma, and Rare Tumors, IEO, European Institute of Oncology IRCCS, Milan, Italy;b Research Nurses Team, IEO, European Institute of Oncology IRCCS, Milan, Italy
,
Matteo Repettoc Division of Early Drug Development for Innovative Therapy, IEO, European Institute of Oncology IRCCS, Milan, Italy;d Department of Oncology and Haematology, University of Milan, Milan, Italy
,
Maristella Saponaraa Division of Medical Oncology for Melanoma, Sarcoma, and Rare Tumors, IEO, European Institute of Oncology IRCCS, Milan, Italy
&
Paola Queiroloa Division of Medical Oncology for Melanoma, Sarcoma, and Rare Tumors, IEO, European Institute of Oncology IRCCS, Milan, Italy
 show all
Pages 9-14 | Received 03 Jul 2020, Accepted 28 Oct 2020, Published online: 06 Nov 2020

References

  • Berlin DA, Gulick RM, Martinez F. Severe COVID-19. N Engl J Med. 2020. doi:10.1056/NEJMcp2009575
  • Liang W, Guan W, Chen R, Wang W, Li J, Xu K, et al. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol. 2020;21(3):335–337. doi:10.1016/S1470-2045(20)30096-6.
  • Koralnik IJ. Can immune checkpoint inhibitors keep JC virus in check? N Engl J Med. 2019;380(17):1667–1668. doi:10.1056/NEJMe1904140.
  • Ceschi A, Noseda R, Palin K, Verhamme K. Immune checkpoint inhibitor-related cytokine release syndrome: analysis of WHO global pharmacovigilance database. Front Pharmacol. 2020;11:557. doi:10.3389/fphar00557
  • Su Q, Zhu EC, Wu JB, Li T, Hou Yl, Wang DY, Gao ZH. Risk of pneumonitis and pneumonia associated with immune checkpoint inhibitors for solid tumors: a systematic review and meta. Analysis. Front. Immunol. 2019;10:108. doi:10.3389/fimmu.2019.00108.
  • Wang B, Li R, Lu Z, Huang Y. Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis. Aging (Albany NY). 2020;12(7):6049–6057. doi:10.18632/aging.103000.
  • Zheng HY, Zhang M, Yang CX, Zhang N, Wang XC, Yang XP, et al. Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients. Cell Mol Immunol. 2020;17(5):541–543. doi:10.1038/s41423-020-0401-3
  • Ahn E, Araki K, Hashimoto M, Li W, Riley JL, Cheung J, et al. Role of PD-1 during effector CD8 T cell differentiation. Proc Natl Acad Sci USA. 2018;115(18):4749–4754. doi:10.1073/pnas.1718217115.
  • da Costa CM, de Souza ZS, Real Salgues AC, Harada G, Marino Rodrigues Ayres PP, Vieira Nunes DB, et al. COVID-19 in a patient with advanced Merkel cell carcinoma receiving immunotherapy. Immunotherapy. 2020;12(15):1133–1138. doi:10.2217/imt-2020-0193.
  • Di Giacomo AM, Gambale E, Monterisi S, Valente M, Maio M. SARS-COV-2 infection in patients with cancer undergoing checkpoint blockade: Clinical course and outcome. Eur J Cancer. 2020;133:1–3. doi:10.1016/j.ejca.2020.04.026
  • Kuderer NM, Choueiri TK, Shah DP, et al. Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study.  Lancet. 2020;395(10241):1907–1918.
  • Luo J, Rizvi H, Egger JV, Preeshagul IR, Wolchok JD, Hellmann MD. Impact of PD-1 blockade on severity of COVID-19 in patients with lung cancers. Cancer Discov. 2020;10(8):1121–1128. doi:10.1158/2159-8290.CD-20-0596
  • Zhang L, Zhu F, Xie L, Wang C. The experience of treating patients with cancer during the COVID-19 pandemic in China. Presented at: American Association for Cancer Research (AACR) Virtual Annual Meeting I 2020; April 27-28, 2020.
  • Rogiers A, Tondini C, Grimes JM, et al. Clinical characteristics and outcomes of coronavirus 2019 disease (COVID-19) in cancer patients treated with immune checkpoint inhibitors. 2020 AACR Virtual Meeting: COVID-19 and Cancer. Symposium 2.
  • Garassino MC, Whisenant JG, Huang L-C, Trama A, Torri V, Agustoni F, TERAVOLT investigators, et al. COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study. Lancet Oncol. 2020;21(7):914–922.
  • Lee LY, Cazier J-B, Angelis V, Arnold R, Bisht V, Campton NA, et al. COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study. Lancet. 2020;395(10241):1919–1926.
  • Robilotti EV, Babady NE, Mead PA, Rolling T, Perez-Johnston R, Bernardes M, et al. Determinants of COVID-19 disease severity in patients with cancer. Nat Med. 2020;26(8):1218–1223. doi:10.1038/s41591-020-0979-0.
  • Dai M, Liu D, Liu M, Zhou F, Li G, Chen Z, et al. Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak. Cancer Discov. 2020;10(6):783–791. doi:10.1158/2159-8290.CD-20-0422.
  • Au L, Boos LA, Swerdlow A, Byrne F, Shepherd STC, Fendler A, CAPTURE investigators, et al. Cancer, COVID-19, and Antiviral Immunity: The CAPTURE Study. Cell. 2020;183(1):4–10. doi:10.1016/j.cell.2020.09.005.

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