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Articles

Plasma D-Dimer and Fibrinogen Levels Correlates with Tumor Size and Disease Progression in Nigerian Breast Cancer Patients

ORCID Icon, , &
Pages 597-606 | Received 26 Oct 2020, Accepted 23 Mar 2021, Published online: 08 Jul 2021

References

  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA A Cancer J Clin. 2019;69(1):7–34. doi:10.3322/caac.21551.
  • Falanga A, Marchetti M. Hemostatic biomarkers in cancer progression. Thromb Res. 2018;164:S54–S61. doi:10.1016/j.thromres.2018.01.017.
  • Chew HK, Wun T, Harvey DJ, Zhou H, White RH. Incidence of venous thromboembolism and the impact on survival in breast cancer patients. J Clin Oncol. 2007;26(1):70–76. doi:10.1200/JCO.2006.07.4393.
  • Kirwan CC, McDowell G, McCollum CN, Kumar S, Byrne GJ. Early changes in the haemostatic and procoagulant systems after chemotherapy for breast cancer. Br J Cancer. 2008;99(7):1000–1006. doi:10.1038/sj.bjc.6604620.
  • Lal I, Dittus K, Holmes CE. Platelets, coagulation and fibrinolysis in breast cancer progression. Breast Cancer Res. 2013;15(4):207. doi:10.1186/bcr3425.
  • Diao D, Wang Z, Cheng Y, Zhang H, Guo Q, Song Y, et al. D-Dimer: not just an indicator of venous thrombosis but a predictor of asymptomatic hematogenous metastasis in gastric cancer patients. PLoS One. 2014;9(7):e101125. doi:10.1371/journal.pone.0101125.
  • Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, et al. Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells. Blood. 2005;105(1):178–185. doi:10.1182/blood-2004-06-2272.
  • Tang L, Liu K, Wang J, Wang C, Zhao P, Liu J, et al. High preoperative plasma fibrinogen levels are associated with distant metastases and impaired prognosis after curative resection in patients with colorectal cancer. J Surg Oncol. 2010;102(5):428–432. doi:10.1002/jso.21668.
  • Mei Y, Zhao S, Lu X, Liu H, Li X, Ma R, et al. Clinical and prognostic significance of preoperative plasma fibrinogen levels in patients with operable breast cancer. PLoS One. 2016;11(1):e0146233. doi:10.1371/journal.pone.0146233.
  • Zhang X, Long Q. Elevated serum plasma fibrinogen is associated with advanced tumor stage and poor survival in hepatocellular carcinoma patients. Medicine. 2017;96(17):e6694. doi:10.1097/MD.0000000000006694.
  • Dirix LY, Salgado R, Weytjens R, Colpaert C, Benoy I, Huget P, et al. Plasma fibrin D-dimer levels correlate with tumour volume, progression rate and survival in patients with metastatic breast cancer. Br J Cancer. 2002;86(3):389–395. doi:10.1038/sj.bjc.6600069.
  • Lin Y, Liu Z, Qiu Y, Zhang J, Wu H, Liang R, et al. Clinical significance of plasma D-dimer and fibrinogen in digestive cancer: a systematic review and meta-analysis. Eur J Surg Oncol. 2018;44(10):1494–1503. doi:10.1016/j.ejso.2018.07.052.
  • Falanga A, Russo L. Epidemiology, risk and outcomes of venous thromboembolism in cancer. Hamostaseologie. 2012;32(2):115–125. doi:10.5482/ha-1170.
  • Rak J, Yu JL, Luyendyk J, Mackman N. Oncogenes, trousseau syndrome, and cancer-related changes in the coagulome of mice and humans. Cancer Res. 2006;66(22):10643–10646. doi:10.1158/0008-5472.CAN-06-2350.
  • Sutherland DE, Weitz IC, Liebman HA. Thromboembolic complications of cancer: epidemiology, pathogenesis, diagnosis, and treatment. Am J Hematol. 2003;72(1):43–52. doi:10.1002/ajh.10263.
  • Kyriazi V. Breast cancer as an acquired thrombophilic state. J Breast Cancer. 2012;15(2):148–156. doi:10.4048/jbc.2012.15.2.148.
  • Hu C, Huang L, Gest C, Xi X, Janin A, Soria C, et al. Opposite regulation by PI3K/Akt and MAPK/ERK pathways of tissue factor expression, cell-associated procoagulant activity and invasiveness in MDA-MB-231 cells. J Hematol Oncol. 2012;5:16. doi:10.1186/1756-8722-5-16.
  • Blann AD, Dunmore S. Arterial and venous thrombosis in cancer patients. Cardiol Res Pract. 2011;2011:394740. doi:10.4061/2011/394740.
  • Rickles FR, Falanga A. Activation of clotting factors in cancer. Cancer Treat Res. 2009;148:31–41. doi:10.1007/978-0-387-79962-9_3.
  • Dai H, Zhou H, Sun Y, Xu Z, Wang S, Feng T, et al. D‑dimer as a potential clinical marker for predicting metastasis and progression in cancer. Biom Rep. 2018;9:453–457. doi:10.3892/br.2018.1151.
  • Wu J, Fu Z, Liu G, et al. Clinical significance of plasma D-dimer in ovarian cancer - a meta analysis. Medicine. 2017;96:25.
  • Ay C, Dunkler D, Pirker R, Thaler J, Quehenberger P, Wagner O, et al. High D-dimer levels are associated with poor prognosis in cancer patients. Haematologica. 2012;97(8):1158–1164. doi:10.3324/haematol.2011.054718.
  • Chaari M, Ayadi I, Rousseau A, Lefkou E, Van Dreden P, Sidibe F, et al. Impact of breast cancer stage, time from diagnosis and chemotherapy on plasma and cellular biomarkers of hypercoagulability. BMC Cancer. 2014;14:991. doi:10.1186/1471-2407-14-991.
  • Blackwell K, Haroon Z, Broadwater G, Berry D, Harris L, Iglehart JD, et al. Plasma D-dimer levels in operable breast cancer patients correlate with clinical stage and axillary lymph node status. J Clin Oncol. 2000;18(3):600–608. doi:10.1200/JCO.2000.18.3.600.
  • Ghadhban BR. Plasma d-dimer level correlated with advanced breast carcinoma in female patients. Ann Med Surg. 2018;36:75–78. doi:10.1016/j.amsu.2018.10.025.
  • Liu L, Zhang X, Yan B, Gu Q, Zhang X, Jiao J, et al. Elevated plasma D-dimer levels correlates with long term survival of gastric cancer patients. PLoS One. 2014;9(3):e90547. doi:10.1371/journal.pone.0090547.
  • Palumbo JS, Kombrinck KW, Drew AF, Grimes TS, Kiser JH, Degen JL, et al. Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells. Blood. 2000;96(10):3302–3309.
  • Batschauer APB, Figueiredo CP, Bueno EC, Ribeiro MA, Dusse LMS, Fernandes AP, et al. D-dimer as a possible prognostic marker of operable hormone receptor-negative breast cancer. Ann Oncol. 2010;21(6):1267–1272. doi:10.1093/annonc/mdp474.
  • Harish S, Raxith Sringeri R, Sarath Chandra P. Role of plasma D-dimer levels in breast cancer patients and its correlation with clinical and histopathological stage. Indian J Surg Oncol. 2018;9(3):307–311. doi:10.1007/s13193-017-0682-x.
  • Pabinger I, Van Es N, Heinze G, et al. A clinical prediction model for cancer-associated venous thromboembolism: a development and validation study in two independent prospective cohorts. Lancet Haematol. 2018;5(7):e289–e298.
  • Ay C, Dunkler D, Marosi C, Chiriac A-L, Vormittag R, Simanek R, et al. Prediction of venous thromboembolism in cancer patients. Blood. 2010;116(24):5377–5382. doi:10.1182/blood-2010-02-270116.
  • Chandler WL, Rodgers GM, Sprouse JT, Thompson AR. Elevated hemostatic factor levels as potential risk factors for thrombosis. Arch Pathol Lab Med. 2002;126(11):1405–1414. doi:10.5858/2002-126-1405-EHFLAP.
  • Ghanim B, Hoda MA, Klikovits T, Winter M-P, Alimohammadi A, Grusch M, et al. Circulating fibrinogen is a prognostic and predictive biomarker in malignant pleural mesothelioma. Br J Cancer. 2014;110(4):984–990. doi:10.1038/bjc.2013.815.
  • Wen J, Yang Y, Ye F, Huang X, Li S, Wang Q, et al. The preoperative plasma fibrinogen level is an independent prognostic factor for overall survival of breast cancer patients who underwent surgical treatment. The Breast. 2015;24(6):745–750. doi:10.1016/j.breast.2015.09.007.
  • Erdem S, Amasyali AS, Aytac O, Onem K, Issever H, Sanli O, et al. Increased preoperative levels of plasma fibrinogen and D-dimer in patients with renal cell carcinoma is associated with poor survival and adverse tumor characteristics. Urol Oncol. 2014;32 (7):1031–1040. doi:10.1016/j.urolonc.2014.03.013.
  • Famodu ESO, Fakoya AA, Barhua FJT, Osime CO, Egwaikhide E, Egbagbe EE, et al. Effects of breast cancer and mastectomy on fibrinolytic activity in african women. African J Reprod Health. 2006;10(3):114. doi:10.2307/30032478.
  • Simmonds MJ, Meiselman HJ, Baskurt OK. Blood rheology and aging. J Geriatr Cardiol. 2013;10(3):291–301. doi:10.3969/j.issn.1671-5411.2013.03.010.
  • Mosesson MW. Fibrinogen and fibrin structure and functions. J Thromb Haemost. 2005;3(8):1894–1904. doi:10.1111/j.1538-7836.2005.01365.x.
  • Sahni A, Simpson-Haidaris PJ, Sahni SK, Vaday GG, Francis CW. Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2 (FGF-2). J Thromb Haemost. 2008;6(1):176–183. doi:10.1111/j.1538-7836.2007.02808.x.
  • Shu Y-J, Weng H, Bao R-F, Wu X-S, Ding Q, Cao Y, et al. Clinical and prognostic significance of preoperative plasma hyperfibrinogenemia in gallbladder cancer patients following surgical resection: a retrospective and in vitro study. BMC Cancer. 2014;14(1):566. doi:10.1186/1471-2407-14-566.
  • He L, Zhou X, Qu C, Hu L, Tang Y, Zhang Q, et al. Musashi2 predicts poor prognosis and invasion in hepatocellular carcinoma by driving epithelial-mesenchymal transition. J Cell Mol Med. 2014;18(1):49–58. doi:10.1111/jcmm.12158.
  • Jensen T, Kierulf P, Sandset PM, Klingenberg O, Joø GB, Godal HC, et al. Fibrinogen and fibrin induce synthesis of proinflammatory cytokines from isolated peripheral blood mononuclear cells. Thromb Haemost. 2007;97(5):822–829. doi:10.1160/th07-01-0039.
  • Smiley ST, King JA, Hancock WW. Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol. 2001;167(5):2887–2894. doi:10.4049/jimmunol.167.5.2887.
  • Hwang K-T, Chung JK, Roh EY, Kim J, Oh S, Kim YA, et al. Prognostic influence of preoperative fibrinogen to albumin ratio for breast cancer. J Breast Cancer. 2017;20(3):254–263. doi:10.4048/jbc.2017.20.3.254.
  • Wuillemin WA, Korte W, Waser G, Lämmle B. Usefulness of the D-dimer/fibrinogen ratio to predict deep venous thrombosis. J Thromb Haemost. 2005;3(2):385–387. doi:10.1111/j.1538-7836.2004.01121.x.
  • Cai HX, Li XQ, Wang SF. Prognostic value of fibrinogen and D-dimer-fibrinogen ratio in resectable gastrointestinal stromal tumors. Worl J Gastroenterol. 2018;24(44):5046–5056. doi:10.3748/wjg.v24.i44.5046.
  • DeFeo K, Hayes C, Chernick M, Ryn JV, Gilmour SK. Use of dabigatran etexilate to reduce breast cancer progression. Cancer Biol Ther. 2010;10(10):1001–1008. doi:10.4161/cbt.10.10.13236.
  • Klerk CPW, Smorenburg SM, Otten H-M, Lensing AWA, Prins MH, Piovella F, et al. The effect of low molecular weight heparin on survival in patients with advanced malignancy. J Clin Oncol. 2005;23(10):2130–2135. doi:10.1200/JCO.2005.03.134.
  • Kuderer NM, Ortel TL, Francis CW. Impact of venous thromboembolism and anticoagulation on cancer and cancer survival. J Clin Oncol. 2009;27(29):4902–4911. doi:10.1200/JCO.2009.22.4584.
  • Lu Y, Zhang LY, Zhang Q, Zhang YJ, Chen DB, Lou JJ, et al. The association of D-dimer with clinicopathological features of breast cancer and its usefulness in differential diagnosis: a systematic review and meta-analysis. PLoS One. 2019;14(9):e0221374. doi:10.1371/journal.pone.0221374.
  • Zhang Y, Cao J, Deng Y, Huang Y, Li R, Lin G, et al. Pretreatment plasma fibrinogen level as a prognostic biomarker for patients with lung cancer. Clinics. 2020;75:e993. doi:10.6061/clinics/2020/e993.

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