Long-Term Results of Intensity-Modulated Radiotherapy for T4 Nasopharyngeal Carcinoma: New Insight into the Value of Concurrent Chemotherapy

References

• Pan JJ, Ng WT, Zong JF, Chan LL, O’Sullivan B, Lin SJ, et al. Proposal for the 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity-modulated radiotherapy. Cancer. 2016;122(4):546–558. doi:10.1002/cncr.29795.
   PubMed Web of Science ®Google Scholar
• Lu H, Yao M. The current status of intensity-modulated radiation therapy in the treatment of nasopharyngeal carcinoma. Cancer Treat Rev. 2008;34(1):27–36. doi:10.1016/j.ctrv.2007.08.004.
   PubMed Web of Science ®Google Scholar
• Xia P, Fu KK, Wong GW, Akazawa C, Verhey LJ. Comparison of treatment plans involving intensity-modulated radiotherapy for nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys. 2000;48(2):329–337. doi:10.1016/s0360-3016(00)00585-x.
   PubMed Web of Science ®Google Scholar
• Cheng JCH, Chao KC, Low D. Comparison of intensity modulated radiation therapy (IMRT) treatment techniques for nasopharyngeal carcinoma. Int J Cancer. 2001;96(2):126–132. doi:10.1002/ijc.1004.
   PubMed Web of Science ®Google Scholar
• Hunt MA, Zelefsky MJ, Wolden S, Chui C-S, LoSasso T, Rosenzweig K, et al. Treatment planning and delivery of intensity-modulated radiation therapy for primary nasopharynx cancer. Int J Radiat Oncol Biol Phys. 2001;49(3):623–632. doi:10.1016/s0360-3016(00)01389-4.
   PubMed Web of Science ®Google Scholar
• Kam MK, Chau RM, Suen J, Choi PH, Teo PM. Intensity-modulated radiotherapy in nasopharyngeal carcinoma: dosimetric advantage over conventional plans and feasibility of dose escalation. Int J Radiat Oncol Biol Phys. 2003;56(1):145–157. doi:10.1016/s0360-3016(03)00075-0.
   PubMed Web of Science ®Google Scholar
• Lai S-Z, Li W-F, Chen L, Luo W, Chen Y-Y, Liu L-Z, et al. How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? Int J Radiat Oncol Biol Phys. 2011;80(3):661–668. doi:10.1016/j.ijrobp.2010.03.024.
   PubMed Web of Science ®Google Scholar
• Chen L, Zhang Y, Lai SZ, Li WF, Hu WH, Sun R, et al. 10-Year results of therapeutic ratio by intensity-modulated radiotherapy versus two-dimensional radiotherapy in patients with nasopharyngeal carcinoma. Oncologist. 2019; 24:e38–e45. doi:10.1634/theoncologist.2017-0577.
   PubMed Web of Science ®Google Scholar
• Kwong DL, Pow EH, Sham JS, McMillan AS, Leung LH, Leung WK, et al. Intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: a prospective study on disease control and preservation of salivary function. Cancer. 2004;101(7):1584–1593. doi:10.1002/cncr.20552.
   PubMed Web of Science ®Google Scholar
• Su S-F, Han F, Zhao C, Chen C-Y, Xiao W-W, Li J-X, et al. Long-term outcomes of early-stage nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy alone. Int J Radiat Oncol Biol Phys. 2012;82(1):327–333. doi:10.1016/j.ijrobp.2010.09.011.
   PubMed Web of Science ®Google Scholar
• Xiao WW, Huang SM, Han F, Wu SX, Lu LX, Lin CG, et al. Local control, survival, and late toxicities of locally advanced nasopharyngeal carcinoma treated by simultaneous modulated accelerated radiotherapy combined with cisplatin concurrent chemotherapy: long-term results of a phase 2 study. Cancer. 2011;117(9):1874–1883. doi:10.1002/cncr.25754.
   PubMed Web of Science ®Google Scholar
• Chen J-Y, Huang Y-S, Kuo S, Chen Y-F, Hong R-L, Ko J-Y, et al. Intensity-modulated radiation therapy for T4 nasopharyngeal carcinoma. Treatment results and locoregional recurrence. Strahlenther Onkol. 2013;189(12):1001–1008. doi:10.1007/s00066-013-0429-8.
   PubMed Web of Science ®Google Scholar
• Cao C-N, Luo J-W, Gao L, Yi J-L, Huang X-D, Wang K, et al. Clinical outcomes and patterns of failure after intensity-modulated radiotherapy for T4 nasopharyngeal carcinoma. Oral Oncol. 2013;49(2):175–181. doi:10.1016/j.oraloncology.2012.08.013.
   PubMed Web of Science ®Google Scholar
• Cao CN, Luo JW, Gao L, Yi JL, Huang XD, Wang K, et al. Update report of T4 classification nasopharyngeal carcinoma after intensity-modulated radiotherapy: an analysis of survival and treatment toxicities. Oral Oncol. 2015;51(2):190–194. doi:10.1016/j.oraloncology.2014.11.009.
   PubMed Web of Science ®Google Scholar
• Kong F-F, Ying H, Du C-R, Huang S, Zhou J-J, Hu C-S. Effectiveness and toxicities of intensity-modulated radiation therapy for patients with T4 nasopharyngeal carcinoma. PLoS One. 2014;9(3):e91362. doi:10.1371/journal.pone.0091362.
   PubMed Web of Science ®Google Scholar
• Sanguineti G, Geara FB, Garden AS, Tucker SL, Ang KK, Morrison WH, et al. Carcinoma of the nasopharynx treated by radiotherapy alone: determinants of local and regional control. Int J Radiat Oncol Biol Phys. 1997;37(5):985–996. doi:10.1016/s0360-3016(97)00104-1.
   PubMed Web of Science ®Google Scholar
• Yi J-L, Gao L, Huang X-D, Li S-Y, Luo J-W, Cai W-M, et al. Nasopharyngeal carcinoma treated by radical radiotherapy alone: ten-year experience of a single institution. Int J Radiat Oncol Biol Phys. 2006;65(1):161–168. doi:10.1016/j.ijrobp.2005.12.003.
   PubMed Web of Science ®Google Scholar
• Wu L-R, Liu Y-T, Jiang N, Fan Y-X, Wen J, Huang S-F, et al. Ten-year survival outcomes for patients with nasopharyngeal carcinoma receiving intensity-modulated radiotherapy: an analysis of 614 patients from a single center. Oral Oncol. 2017;69:26–32. doi:10.1016/j.oraloncology.2017.03.015.
   PubMed Web of Science ®Google Scholar
• Lin S, Lu JJ, Han L, Chen Q, Pan J. Sequential chemotherapy and intensity-modulated radiation therapy in the management of locoregionally advanced nasopharyngeal carcinoma: experience of 370 consecutive cases. BMC Cancer. 2010;10:39. doi:10.1186/1471-2407-10-39.
   PubMed Web of Science ®Google Scholar
• Tian YM, Liu MZ, Zeng L, Bai L, Lin C, Huang SM, et al. Long-term outcome and pattern of failure for patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy. Head Neck. 2019;41:1246–1252. doi:10.1002/hed.25545.
   PubMed Web of Science ®Google Scholar
• Cao C, Jiang F, Jin Q, Jin T, Huang S, Hu Q, et al. Locoregional extension and patterns of failure for nasopharyngeal carcinoma with intracranial extension. Oral Oncol. 2018;79:27–32. doi:10.1016/j.oraloncology.2018.02.004.
   PubMed Web of Science ®Google Scholar
• Gou X, Duan B, Shi H, Qin L, Xiao J, Chen N. The relations of dosimetric parameters with long-term outcomes and late toxicities in advanced T-stage nasopharyngeal carcinoma with IMRT. Head Neck. 2020;42(1):85–92. doi:10.1002/hed.25986.
   PubMed Web of Science ®Google Scholar
• Sun X, Su S, Chen C, Han F, Zhao C, Xiao W, et al. Long-term outcomes of intensity-modulated radiotherapy for 868 patients with nasopharyngeal carcinoma: an analysis of survival and treatment toxicities. Radiother Oncol. 2014;110(3):398–403. doi:10.1016/j.radonc.2013.10.020.
   PubMed Web of Science ®Google Scholar
• Lin S, Pan J, Han L, Guo Q, Hu C, Zong J, et al. Update report of nasopharyngeal carcinoma treated with reduced-volume intensity-modulated radiation therapy and hypothesis of the optimal margin. Radiother Oncol. 2014;110(3):385–389. doi:10.1016/j.radonc.2014.01.011.
   PubMed Web of Science ®Google Scholar
• Peng H, Chen L, Li W-F, Zhang Y, Liu L-Z, Tian L, et al. Optimize the cycle of neoadjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma treated with intensity-modulated radiotherapy: a propensity score matching analysis. Oral Oncol. 2016;62:78–84. doi:10.1016/j.oraloncology.2016.10.014.
   PubMed Web of Science ®Google Scholar
• Fangzheng W, Chuner J, Zhimin Y, Quanquan S, Tongxin L, Min X, et al. Association of the neoadjuvant chemotherapy cycle with survival outcomes in patients with locoregionally advanced nasopharyngeal carcinoma: a propensity-matched analysis. Oncotarget. 2017;8(55):94117–94128. doi:10.18632/oncotarget.21587.
   PubMedGoogle Scholar
• Wei J, Gao Y, Feng H, Xiao W, Wang Q, Qiu B, et al. Cycle number of neoadjuvant chemotherapy might influence survival of patients with T1-4N2-3M0 nasopharyngeal carcinoma. Chin J Cancer Res. 2018;30(1):51–60. doi:10.21147/j.issn.1000-9604.2018.01.06.
   PubMed Web of Science ®Google Scholar
• Zhou G-Q, Yu X-L, Chen M, Guo R, Lei Y, Sun Y, et al. Radiation-induced temporal lobe injury for nasopharyngeal carcinoma: a comparison of intensity-modulated radiotherapy and conventional two-dimensional radiotherapy. PLoS One. 2013;8(7):e67488. doi:10.1371/journal.pone.0067488.
   PubMed Web of Science ®Google Scholar
• Anteunis LJ, Wanders SL, Hendriks JJ, Langendijk JA, Manni JJ, de Jong JM. A prospective longitudinal study on radiation-induced hearing loss. Am J Surg. 1994;168(5):408–411. doi:10.1016/s0002-9610(05)80086-8.
   PubMed Web of Science ®Google Scholar
• Grau C, Møler K, Overgaard M, Overgaard J, Elbønd O. Auditory brain stem responses in patients after radiation therapy for nasopharyngeal carcinoma. Cancer. 1992;70(10):2396–2401. doi:10.1002/1097-0142(19921115)70:10 < 2396::aid-cncr2820701004 > 3.0.co;2-o.
   PubMed Web of Science ®Google Scholar
• Moretti JA. Sensori-neural hearing loss following radiotherapy to the nasopharynx . Laryngoscope. 1976;86(4):598–602. doi:10.1288/00005537-197604000-00018.
   PubMed Web of Science ®Google Scholar
• Zhu W, Chen F, Li J, Wang W, Zhang H, Yang G, et al. Dosimetric parameters associated with conductive or sensorineural hearing loss 5 years after intensity-modulated radiation therapy in nasopharyngeal carcinoma. Acta Otolaryngol. 2019;139(3):263–268. doi:10.1080/00016489.2019.1566778.
   PubMed Web of Science ®Google Scholar
• Petsuksiri J, Sermsree A, Thephamongkhol K, Keskool P, Thongyai K, Chansilpa Y, et al. Sensorineural hearing loss after concurrent chemoradiotherapy in nasopharyngeal cancer patients. Radiat Oncol. 2011;6:19. doi:10.1186/1748-717X-6-19.
   PubMed Web of Science ®Google Scholar
• Lee AW, Ng WT, Pan JJ, Chiang C-L, Poh SS, Choi HC, et al. International guideline on dose prioritization and acceptance criteria in radiation therapy planning for nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys. 2019;105(3):567–580. doi:10.1016/j.ijrobp.2019.06.2540.
   PubMed Web of Science ®Google Scholar