References
- Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers CG, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://www.globocan.iarc.fr.
- Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:https://doi.org/10.3322/caac.21492.
- Fidler MM, Bray F, Soerjomataram I. The global cancer burden and human development: a review. Scand J Public Health. 2018;46(1):27–36. doi:https://doi.org/10.1177/1403494817715400.
- Fidler MM, Soerjomataram I, Bray F. A global view on cancer incidence and national levels of the human development index. Int J Cancer. 2016;139(11):2436–46. doi:https://doi.org/10.1002/ijc.30382.
- Gersten O, Wilmoth JR. The cancer transition in Japan since 1951. DemRes. 2002;7:271–306. doi:https://doi.org/10.4054/DemRes.2002.7.5.
- Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA A Cancer J Clin. 2021;71(3):209–49. doi:https://doi.org/10.3322/caac.21660.
- Rahman QB, Iocca O, Kufta K, Shanti RM. Global burden of head and neck cancer. Oral Maxillofac Surg Clin North Am. 2020;32(3):367–75. doi:https://doi.org/10.1016/j.coms.2020.04.002.
- Chow LQ. Head and neck cancer. N Engl J Med. 2020;382(1):60–72. doi:https://doi.org/10.1056/NEJMra1715715.
- Pai SI, Westra WH. Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment. Annu Rev Pathol. 2009;4:49–70. doi:https://doi.org/10.1146/annurev.pathol.4.110807.092158.
- Ologe FE, Adeniji KA, Segun-Busari S. Clinicopathological study of head and neck cancers in Ilorin, Nigeria. Trop Doct. 2005;35(1):2–4. doi:https://doi.org/10.1258/0049475053001949.
- Weber AL, Rahemtullah A, Ferry JA. Hodgkin and non-Hodgkin lymphoma of the head and neck: clinical, pathologic, and imaging evaluation. Neuroimaging Clin N Am. 2003;13(3):371–92. doi:https://doi.org/10.1016/S1052-5149(03)00039-X.
- Nwawolo CC, Ajekigbe AT, Oyeneyin JO, Nwankwo KC, Okeowo PA. Pattern of head and neck cancers among. Nigerians in Lagos. WAJM. 2001;20(2):111–6.
- Sturgis EM, Potter BO. Sarcomas of the head and neck region. Curr Opin Oncol. 2003;15(3):239–52. doi:https://doi.org/10.1097/00001622-200305000-00011.
- Steenbergen RD, Snijders PJ, Heideman DA, Meijer CJ. Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions. Nat Rev Cancer. 2014;14(6):395–405. doi:https://doi.org/10.1038/nrc3728.
- Rieth KK, Gill SR, Lott-Limbach AA, Merkley MA, Botero N, Allen PD, et al. Prevalence of high-risk human papillomavirus in tonsil tissue in healthy adults and colocalization in biofilm of tonsillar crypts. JAMA Otolaryngol Head Neck Surg. 2018;144(3):231–7. doi:https://doi.org/10.1001/jamaoto.2017.2916.
- Mirabello L, Clarke MA, Nelson CW, Dean M, Wentzensen N, Yeager M, et al. The intersection of HPV epidemiology, genomics and mechanistic studies of HPV-mediated carcinogenesis. Viruses. 2018;10(2):80. doi:https://doi.org/10.3390/v100200.
- Liederbach E, Kyrillos A, Wang CH, Liu JC, Sturgis EM, Bhayani MK. The national landscape of human papillomavirus-associated oropharynx squamous cell carcinoma. Int J Cancer. 2017;140(3):504–12. doi:https://doi.org/10.1002/ijc.30442.
- Li LK, Rola AS, Kaid FA, Ali AM, Alabsi AM. Goniothalamin induces cell cycle arrest and apoptosis in H400 human oral squamous cell carcinoma: a caspase-dependent mitochondrial-mediated pathway with downregulation of NF-κβ. Arch Oral Biol. 2016;64:28–38. doi:https://doi.org/10.1016/j.archoralbio.2015.12.002.
- The European Collection of Authenticated Cell Cultures (ECACC) of Culture Collection of Public Health England (PHE). Available from: https://www.phe-culturecollections.org.uk/collections/ecacc.aspx.
- Yee M, Kim S, Sethi P, Düzgüneş N, Konopka K. Porphyromonas gingivalis stimulates IL-6 and IL-8 secretion in GMSM-K, HSC-3 and H413 oral epithelial cells. Anaerob. 2014;28:62–7. doi:https://doi.org/10.1016/j.anaerobe.2014.05.011.
- Leibniz Institute DSMZ- German Collection of Microorganism and Cell culture (GmbH)[Internet]. Available from: https://www.dsmz.de/.
- Martin CL, Reshmi SC, Ried T, Gottberg W, Wilson JW, Reddy JK, et al. Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature. Oral Oncol. 2008;44(4):369–82. doi:https://doi.org/10.1016/j.oraloncology.2007.05.003.
- White JS, Weissfeld JL, Ragin CC, Rossie KM, Martin CL, Shuster M, et al. The influence of clinical and demographic risk factors on the establishment of head and neck squamous cell carcinoma cell lines. Oral Oncol. 2007;43(7):701–12. doi:https://doi.org/10.1016/j.oraloncology.2006.09.001.
- Paterson IC, Davies M, Stone A, Huntley S, Smith E, Pring M, et al. TGF-beta1 acts as a tumor suppressor of human malignant keratinocytes independently of Smad 4 expression and ligand-induced G(1) arrest. Oncogene. 2002;21(10):1616–24. doi:https://doi.org/10.1038/sj.onc.1205217.
- Gokulan R, Halagowder D. Expression pattern of Notch intracellular domain (NICD) and Hes-1 in preneoplastic and neoplastic human oral squamous epithelium: their correlation with c-Myc, clinicopathological factors and prognosis in Oral cancer. Med Oncol. 2014;31(8):126. doi:https://doi.org/10.1007/s12032-014-0126-1.
- Olthof NC, Huebbers CU, Kolligs J, Henfling M, Ramaekers FC, Cornet I, et al. Viral load, gene expression and mapping of viral integration sites in HPV16‐associated HNSCC cell lines. Int J Cancer. 2015;136(5):E207–18. doi:https://doi.org/10.1002/ijc.29112.
- Walline HM, Goudsmit CM, McHugh JB, Tang AL, Owen JH, Teh BT, et al. Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines. Head Neck. 2017;39(5):840–52. doi:https://doi.org/10.1002/hed.24729.
- Moncharmont C, Guy JB, Wozny AS, Gilormini M, Battiston-Montagne P, Ardail D, et al. Carbon ion irradiation withstands cancer stem cells' migration/invasion process in Head and Neck Squamous Cell Carcinoma (HNSCC). Oncotarget. 2016;7(30):47738–49. doi:https://doi.org/10.18632/oncotarget.10281.
- Chang SS, Jiang WW, Smith I, Poeta LM, Begum S, Glazer C, et al. MicroRNA alterations in head and neck squamous cell carcinoma. Int J Cancer. 2008;123(12):2791–7. doi:https://doi.org/10.1002/ijc.23831.
- Iida S, Shimada J, Sakagami H. Cytotoxicity induced by docetaxel in human oral squamous cell carcinoma cell lines. In Vivo. 2013;27(3):321–32.
- Rikimaru K, Toda H, Tachikawa N, Kamata N, Enomoto S. Growth of the malignant and nonmalignant human squamous cells in a protein-free defined medium. In Vitro Cell Dev Biol. 1990;26(9):849–56. doi:https://doi.org/10.1007/BF02624609.
- Wengst A, Reichl S. RPMI 2650 epithelial model and three-dimensional reconstructed human nasal mucosa as in vitro models for nasal permeation studies. Eur J Pharm Biopharm. 2010;74(2):290–7. doi:https://doi.org/10.1016/j.ejpb.2009.08.008.
- Xie Y, Peng X. [Effects of chrysin on the apoptosis in oral squamous carcinoma KB cell line and the underlying mechanisms]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2019;44(5):522–7. doi:https://doi.org/10.11817/j.issn.1672-7347.2019.05.008.
- Japanese Collection of Research Biosources Cell Bank (JCRB) of National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) [Internet]. Available from: https://cellbank.nibiohn.go.jp/english/cellsearch_e/.
- Domae E, Hirai Y, Ikeo T, Goda S, Tsuji K. Human Vγ9Vδ2 T cells show potent antitumor activity against zoledronate-sensitized OSCC cell lines. J Buon. 2018;23(7):132–8.
- Saito K, Uzawa K, Kasamatsu A, Shinozuka K, Sakuma K, Yamatoji M, et al. Oncolytic activity of Sindbis virus in human oral squamous carcinoma cells. Br J Cancer. 2009;101(4):684–90. doi:https://doi.org/10.1038/sj.bjc.6605209.
- Tachibana H, Sho R, Takeda Y, Zhang X, Yoshida Y, Narimatsu H, et al. Circulating miR-223 in oral cancer: its potential as a novel diagnostic biomarker and therapeutic target. PLOS One. 2016;11(7):e0159693. doi:https://doi.org/10.1371/journal.pone.0159693.
- Kimura Y. [Studies on lactate dehydrogenase isoenzymes in a cell line (Ca 9-22) derived from carcinoma of the gingiva (author's transl)]). Kokubyo Gakkai Zasshi. 1978;45(1):20–35. doi:https://doi.org/10.5357/koubyou.45.20.
- Yeh CC, Tseng CN, Yang JI, Huang HW, Fang Y, Tang JY, et al. Antiproliferation and induction of apoptosis in Ca9-22 oral cancer cells by ethanolic extract of Gracilariatenuistipitata. Molecules. 2012;17(9):10916–27. doi:https://doi.org/10.3390/molecules170910916.
- Busch CJ, Becker B, Kriegs M, Gatzemeier F, Kruger K, Mockelmann N, et al. Similar cisplatin sensitivity of HPV-positive and-negative HNSCC cell lines. Oncotarget. 2016;7(24):35832–42. doi:https://doi.org/10.18632/oncotarget.9028.
- Expasy Cellosaurus – a knowledge resource on cell lines [Internet]. Available from: https://web.expasy.org/cellosaurus/.
- Ghosh RD, Ghuwalewala S, Das P, Mandloi S, Alam SK, Chakraborty J, et al. MicroRNA profiling of cisplatin-resistant oral squamous cell carcinoma cell lines enriched with cancer-stem-cell-like and epithelial-mesenchymal transition-type features. Sci Rep. 2016;6:23932. doi:https://doi.org/10.1038/srep23932.
- Bano N, Yadav M, Mohania D, Das BC. The role of NF-κB and miRNA in oral cancer and cancer stem cells with or without HPV16 infection. PLoS One. 2018;13(10):e0205518. doi:https://doi.org/10.1371/journal.pone.0205518.
- Brenner JC, Graham MP, Kumar B, Saunders LM, Kupfer R, Lyons RH, et al. Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines. Head Neck. 2010;32(4):417–26. doi:https://doi.org/10.1002/hed.21198.
- Erdem NF, Carlson ER, Gerard DA. Characterization of gene expression profiles of 3 different human oral squamous cell carcinoma cell lines with different invasion and metastatic capacities. J Oral Maxillofac Surg. 2008;66(5):918–27. doi:https://doi.org/10.1016/j.joms.2007.12.036.
- Nagel R, Martens-de Kemp SR, Buijze M, Jacobs G, Braakhuis BJ, Brakenhoff RH. Treatment response of HPV-positive and HPV-negative head and neck squamous cell carcinoma cell lines. Oral Oncol. 2013;49(6):560–6. doi:https://doi.org/10.1016/j.oraloncology.2013.03.446.
- Mohanta S, Siddappa G, Valiyaveedan SG, Dodda Thimmasandra Ramanjanappa R, Das D, Pandian R, et al. Cancer stem cell markers in patterning differentiation and in prognosis of oral squamous cell carcinoma. Tumour Biol. 2017;39(6):101042831770365. doi:https://doi.org/10.1177/1010428317703656.
- Berstad MB, Cheung LH, Berg K, Peng Q, Fremstedal AS, Patzke S, et al. Design of an EGFR-targeting toxin for photochemical delivery: in vitro and in vivo selectivity and efficacy. Oncogene. 2015;34(44):5582–92. doi:https://doi.org/10.1038/onc.2015.15.
- Rastogi B, Kumar A, Raut SK, Panda NK, Rattan V, Joshi N, et al. Downregulation of miR-377 promotes oral squamous cell carcinoma growth and migration by Targeting HDAC9. Cancer Invest. 2017;35(3):152–62. doi:https://doi.org/10.1080/07357907.2017.1286669.
- Verhees F, Legemaate D, Demers I, Jacobs R, Haakma WE, Rousch M, et al. The antiviral agent cidofovir induces DNA damage and mitotic catastrophe in HPV-positive and-negative head and neck squamous cell carcinomas in vitro. Cancers. 2019;11(7):919. doi:https://doi.org/10.3390/cancers11070919.
- Roy S, Roy S, Kar M, Padhi S, Saha A, Anuja K, et al. Role of p38 MAPK in disease relapse and therapeutic resistance by maintenance of cancer stem cells in head and neck squamous cell carcinoma. J Oral Pathol Med. 2018;47(5):492–501. doi:https://doi.org/10.1111/jop.12707.
- Liu YS, Wei B. Over-expression of Bcl2-associated athanogene 2 in oral cancer promotes cellular proliferation and is associated with poor prognosis. Arch Oral Biol. 2019;102:164–70. doi:https://doi.org/10.1016/j.archoralbio.2019.04.015.
- Wang Y, Zuo Z, Chow MS. HO-1-u-1 model for screening sublingual drug delivery-Influence of pH, osmolarity and permeation enhancer. Int J Pharm. 2009;370(1-2):68–74. doi:https://doi.org/10.1016/j.ijpharm.2008.11.010.
- Dziedzic A, Kubina R, Kabała-Dzik A, Tanasiewicz M. Induction of cell cycle arrest and apoptotic response of head and neck squamous carcinoma cells (Detroit 562) by caffeic acid and caffeic acid phenethyl ester derivative. Evid Based Complement Alternat Med. 2017;2017:6793456. doi:https://doi.org/10.1155/2017/6793456.
- Guy JB, Méry B, Ollier E, Espenel S, Vallard A, Wozny AS, et al. Dual "mAb" HER family blockade in head and neck cancer human cell lines combined with photon therapy. Sci Rep. 2017;7(1):12207. doi:https://doi.org/10.1038/s41598-017-12367-7.
- Van Driel PB, Van de Giessen M, Boonstra MC, Snoeks TJ, Keereweer S, Oliveira S, et al. Characterization and evaluation of the Artemis camera for fluorescence-guided cancer surgery. Mol Imaging Biol. 2015;17(3):413–423. doi:https://doi.org/10.1007/s11307-014-0799-z.
- Oh JS, Kim TH, Park JH, Lim H, Cho IA, You JS, et al. Formononetin induces apoptotic cell death through the suppression of mitogen-activated protein kinase and nuclear factor-κB phosphorylation in FaDu human head and neck squamous cell carcinoma cells. Oncol Rep. 2020;43(2):700–710. doi:https://doi.org/10.3892/or.2019.7432.
- Lin GC, Smajlhodzic M, Bandian AM, Friedl HP, Leitgeb T, Oerter S, et al. An in vitro barrier model of the human submandibular salivary gland epithelium based on a single cell clone of cell line HTB-41: establishment and application for biomarker transport studies. Biomedicines. 2020;8(9):302. doi:https://doi.org/10.3390/biomedicines8090302.
- Miyazaki K, Takaku H, Umeda M, Fujita T, Huang W, Kimura T, et al. Potent growth inhibition of human tumor cells in culture by arginine deiminase purified from a culture medium of a mycoplasma-infected cell line. Cancer Res. 1990;50(15):4522–7.
- Noto Z, Yoshida T, Okabe M, Koike C, Fathy M, Tsuno H, et al. CD44 and SSEA-4 positive cells in an oral cancer cell line HSC-4 possess cancer stem-like cell characteristics. Oral Oncol. 2013;49(8):787–95. doi:https://doi.org/10.1016/j.oraloncology.2013.04.012.
- Kawahara E, Okada Y, Nakanishi I, Iwata K, Kojima S, Kumagai S, et al. The expression of invasive behavior of differentiated squamous carcinoma cell line evaluated by an in vitro invasion model. Jpn J Cancer Res. 1993;84(4):409–18. Doi:https://doi.org/10.1111/j.1349-7006.1993.tb00151.x
- Kitahara H, Hirai M, Kato K, Bou-Gharios G, Nakamura H, Kawashiri S. Eribulin sensitizes oral squamous cell carcinoma cells to cetuximab via induction of mesenchymal-to-epithelial transition. Oncol Rep. 2016;36(6):3139–44. doi:https://doi.org/10.3892/or.2016.5189.
- Kawasaki G, Yanamoto S, Yoshitomi I, Yamada S, Mizuno A. Overexpression of metastasis-associated MTA1 in oral squamous cell carcinomas: correlation with metastasis and invasion. Int J Oral Maxillofac Surg. 2008;37(11):1039–46. doi:https://doi.org/10.1016/j.ijom.2008.05.020.
- Ma YS, Yao CN, Liu HC, Yu FS, Lin JJ, Lu KW, et al. Quercetin induced apoptosis of human oral cancer SAS cells through mitochondria and endoplasmic reticulum mediated signaling pathways. Oncol Lett. 2018;15(6):9663–72. doi:https://doi.org/10.3892/ol.2018.8584.
- Takahashi K. Establishment and characterization of a cell line (SAS) from poorly differentiated human squamous cell carcinoma of the tongue. J JpnStomatol Soc. 1989;38:20–8.
- Ohnishi Y, Minamino Y, Kakudo K, Nozaki M. Resistance of oral squamous cell carcinoma cells to cetuximab is associated with EGFR insensitivity and enhanced stem cell-like potency. Oncol Rep. 2014;32(2):780–6. doi:https://doi.org/10.3892/or.2014.3258.
- Owen JH, Hauff SJ, Tang AL, Graham MP, Czerwinski MJ, Kaddoura M, et al. UM-SCC-103: a unique tongue cancer cell line that recapitulates the tumorigenic stem cell population of the primary tumor. Ann Otol Rhinol Laryngol. 2014;123(9):662–72. doi:https://doi.org/10.1177/0003489414531910.
- Zhang G, Zhang J, Wang X, Yang W, Sun Z, Kumar CN, et al. Apoptosis of human tongue squamous cell carcinoma cell (CAL-27) induced by Lactobacillus sp. A-2 metabolites. J Appl Oral Sci. 2014;22(4):282–6. doi:https://doi.org/10.1590/1678-775720130645.
- Wang J, Jia L, Kuang Z, Wu T, Hong Y, Chen X, et al. The in vitro and in vivo antitumor effects of clotrimazole on oral squamous cell carcinoma. PLOS One. 2014;9(6):e98885 doi:https://doi.org/10.1371/journal.pone.0098885.
- Bauer VL, Hieber L, Schaeffner Q, Weber J, Braselmann H, Huber R, et al. Establishment and molecular cytogenetic characterization of a cell culture model of head and neck squamous cell carcinoma (HNSCC). Genes. 2010;1(3):388–412. doi:https://doi.org/10.3390/genes1030388.
- Rampias T, Giagini A, Siolos S, Matsuzaki H, Sasaki C, Scorilas A, et al. RAS/PI3K crosstalk and cetuximab resistance in head and neck squamous cell carcinoma. Clin Cancer Res. 2014;20(11):2933–46. doi:https://doi.org/10.1158/1078-0432.CCR-13-2721.
- Ardito F, Pellegrino MR, Perrone D, Troiano G, Cocco A, Muzio LL. In vitro study on anti-cancer properties of genistein in tongue cancer. OncoTargetsTher. 2017;10:5405–5415. doi:https://doi.org/10.2147/OTT.S133632.
- Bostan M, Petrică-Matei GG, Ion G, Radu N, Mihăilă M, Hainăroşie R, et al. Cisplatin effect on head and neck squamous cell carcinoma cells is modulated by ERK1/2 protein kinases. Exp Ther Med. 2019;18(6):5041–51. doi:https://doi.org/10.3892/etm.2019.8139.
- Holzhauser S, Kostopoulou ON, Ohmayer A, Lange BK, Ramqvist T, Andonova T, et al. In vitro antitumor effects of FGFR and PI3K inhibitors on human papillomavirus positive and negative tonsillar and base of tongue cancer cell lines. Oncol Lett. 2019;18(6):6249–60. doi:https://doi.org/10.3892/ol.2019.10973.
- Wang SJ, Asthana S, Van Zante A, Heaton CM, Phuchareon J, Stein L, et al. Establishment and characterization of an oral tongue squamous cell carcinoma cell line from a never-smoking patient. Oral Oncol. 2017;69:1–10. doi:https://doi.org/10.1016/j.oraloncology.2017.03.020.
- The Global Bioresource Centre- American Type Cell Culture (ATCC) [Internet]. Available from: https://www.atcc.org/.
- Broutian TR, Jiang B, Li J, Akagi K, Gui S, Zhou Z, et al. Human papillomavirus insertions identify the PIM family of serine/threonine kinases as targetable driver genes in head and neck squamous cell carcinoma. Cancer Lett. 2020;476:23–33. doi:https://doi.org/10.1016/j.canlet.2020.01.012.
- Huang P, Tong D, Sun J, Li Q, Zhang F. Generation and characterization of a human oral squamous carcinoma cell line SCC-9 with CRISPR/Cas9-mediated deletion of the p75 neurotrophin receptor. Arch Oral Biol. 2017;82:223–32. doi:https://doi.org/10.1016/j.archoralbio.2017.06.004.
- Basuony SAHAE, Hamed RS. Anti-micro RNA-221 a promising genetic therapy of oral squamous cell carcinoma (SCC-25)). Braz Dent J. 2020;31(6):634–9. doi:https://doi.org/10.1590/0103-6440202003350.
- Gavish A, Krayzler E, Nagler R. Tumor growth and cell proliferation rate in human oral cancer. Arch Med Res. 2016;47(4):271–274. doi:https://doi.org/10.1016/j.arcmed.2016.07.007.
- Han Y, Cui Z, Li YH, Hsu WH, Lee BH. In vitro and in vivo anticancer activity of pardaxin against proliferation and growth of oral squamous cell carcinoma. Mar Drugs. 2015;14(1):2. Doi:https://doi.org/10.3390/md14010002.
- Li Q, Wen J, Yu K, Shu Y, He W, Chu H, et al. Aloe-emodin induces apoptosis in human oral squamous cell carcinoma SCC15 cells. BMC Complement Altern Med. 2018;18(1):1–5. doi:https://doi.org/10.1186/s12906-018-2353-z.
- Stenmark MH, McHugh JB, Schipper M, Walline HM, Komarck C, Feng FY, et al. Nonendemic HPV-positive nasopharyngeal carcinoma: association with poor prognosis. Int J RadiatOncolBiol Phys. 2014;88(3):580–8. doi:https://doi.org/10.1016/j.ijrobp.2013.11.246.
- Scheel A, Bellile E, McHugh JB, Walline HM, Prince ME, Urba S, et al. Classification of TP53 mutations and HPV predict survival in advanced larynx cancer. Laryngoscope. 2016;126(9):E292–9. doi:https://doi.org/10.1002/lary.25915.
- Kobayashi K, Hisamatsu K, Suzui N, Hara A, Tomita H, Miyazaki T. A review of HPV-related head and neck cancer. JCM. 2018;7(9):241. doi:https://doi.org/10.3390/jcm7090241.
- Greaney-Davies FS, Risk JM, Robinson M, Liloglou T, Shaw RJ, Schache AG. Essential characterisation of human papillomavirus positive head and neck cancer cell lines. Oral Oncol. 2020;103:104613. doi:https://doi.org/10.1016/j.oraloncology.2020.104613.
- Vaughan L, Glanzel W, Korch C, Capes-Davis A. Widespread use of misidentified cell line KB (HeLa): incorrect attribution and its impact revealed through mining the scientific literature. Cancer Res. 2017;77(11):2784–8. doi:https://doi.org/10.1158/0008-5472.CAN-16-2258.
- Khan E, Shelton RM, Cooper PR, Hamburger J, Landini G. Architectural characterization of organotypic cultures of H400 and primary rat keratinocytes. J Biomed Mater Res A. 2012;100(12):3227–38. doi:https://doi.org/10.1002/jbm.a.34263.
- Spiegelberg D, Dascalu A, Mortensen AC, Abramenkovs A, Kuku G, Nestor M, et al. The novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells. Oncotarget. 2015;6(34):35652–35666. doi:https://doi.org/10.18632/oncotarget.5363.
- Kulasinghe A, Perry C, Boyle GM, O'Byrne K, Davies A, Jovanovic L, et al. Epithelial-mesenchymal axis in head and neck cancer cell lines. J Solid Tumors. 2016;6(1):28–37. doi:https://doi.org/10.5430/jst.v6n1p28.
- Sievers D, Bunzendahl J, Frosch A, Perske C, Hemmerlein B, Schliephake H, et al. Generation of highly differentiated BHY oral squamous cell carcinoma multicellular spheroids. Mol Clin Oncol. 2018;8(2):323–5. doi:https://doi.org/10.3892/mco.2017.1514.
- Berndt A, Hyckel P, KonnekerAKatenkamp D, Kosmehl H, et al. Oral squamous cell carcinoma invasion is associated with a laminin-5 matrix re-organization but independent of basement membrane and hemidesmosome formation. clues from an in vitro invasion model. Invasion Metastasis. 1997;17(5):251–8.
- Santi M, Mapanao AK, Cappello V, Voliani V. Production of 3D tumor models of head and neck squamous cell carcinomas for nanotheranostics assessment. ACS Biomater Sci Eng. 2020;6(9):4862–9. doi:https://doi.org/10.1021/acsbiomaterials.0c00617.
- Olek M, Kasperski J, Skaba D, Wiench R, Cieślar G, Kawczyk-Krupka A, et al. Photodynamic therapy for the treatment of oral squamous carcinoma-clinical implications resulting from in vitro research. Photodiagnosis Photodyn Ther. 2019;27:255–67. doi:https://doi.org/10.1016/j.pdpdt.2019.06.012.
- Dalley AJ, AbdulMajeed AA, Upton Z, Farah CS. Organotypic culture of normal, dysplastic and squamous cell carcinoma-derived oral cell lines reveals loss of spatial regulation of CD44 and p75 NTR in malignancy. J Oral Pathol Med. 2013;42(1):37–46. doi:https://doi.org/10.1111/j.1600-0714.2012.01170.x.
- Vitti ET, Kacperek A, Parsons JL. Targeting DNA double-strand break repair enhances radiosensitivity of HPV-positive and HPV-negative head and neck squamous cell carcinoma to photons and protons. Cancers. 2020;12(6):1490. doi:https://doi.org/10.3390/cancers12061490.
- Kadletz L, Heiduschka G, Domayer J, Schmid R, Enzenhofer E, Thurnher D. Evaluation of spheroid head and neck squamous cell carcinoma cell models in comparison to monolayer cultures. Oncol Lett. 2015;10(3):1281–6. doi:https://doi.org/10.3892/ol.2015.3487.
- Bruningk SC, Rivens I, Box C, Box C, Oelfke U, Ter Haar G, et al. 3D tumour spheroids for the prediction of the effects of radiation and hyperthermia treatments. Sci Rep. 2020;10(1):1–3. doi:https://doi.org/10.1038/s41598-020-58569-4.
- Rustamov V, Rudolf R, Yagublu V, Kuhn HM, Vitacolonna M, Hafner M. Long-term 3D culture of the SCC4 cell line using three different culture methods and initial seeding densities. JCB. 2017;3(1):41–50. doi:https://doi.org/10.3233/JCB-179005.
- Noman AS, Parag RR, Rashid MI, Islam S, Rahman MZ, Chowdhury AA, et al. Chemotherapeutic resistance of head and neck squamous cell carcinoma is mediated by EpCAM induction driven by IL-6/p62 associated Nrf2-antioxidant pathway activation. Cell Death Dis. 2020;11(8):1–5. doi:https://doi.org/10.1038/s41419-020-02907-x.
- Essid N, Chambard JC, Elgaaied AB. Induction of epithelial-mesenchymal transition (EMT) and Gli1 expression in head and neck squamous cell carcinoma (HNSCC) spheroid cultures. Bosn J Basic Med Sci. 2018;18(4):336–346. doi:https://doi.org/10.17305/bjbms.2018.3243.
- Iannelli F, Zotti AI, Roca MS, Grumetti L, Lombardi R, Moccia T, et al. Valproic acid synergizes with cisplatin and cetuximab in vitro and in vivo in head and neck cancer by targeting the mechanisms of resistance. Front Cell Dev Biol. 2020;8:732. doi:https://doi.org/10.3389/fcell.2020.00732.
- Noi M, Mukaisho KI, Yoshida S, Murakami S, Koshinuma S, Adachi T, et al. ERK phosphorylation functions in invadopodia formation in tongue cancer cells in a novel silicate fibre-based 3D cell culture system. Int J Oral Sci. 2018;10(4):1–0. doi:https://doi.org/10.1038/s41368-018-0033-y.
- Kii T, Sakuma K, Tanaka A. Optimal contact concentration of paclitaxel in the collagen gel droplet-embedded culture drug sensitivity test for human oral squamous cell carcinoma and evaluation of combination with cetuximab. Chemotherapy. 2020;65(5–6):147–57. doi:https://doi.org/10.1159/000512542.
- Fujibayashi E, Yabuta N, Nishikawa Y, Uchihashi T, Miura D, Kurioka K, et al. Isolation of cancer cells with augmented spheroid-forming capability using a novel tool equipped with removable filter. Oncotarget. 2018;9(74):33931–33946. doi:https://doi.org/10.18632/oncotarget.26092.
- Hayyan M, Looi CY, Hayyan A, Wong WF, Hashim MA. In vitro and in vivo toxicity profiling of ammonium-based deep eutectic solvents. PLOS One. 2015;10(2):e0117934. doi:https://doi.org/10.1371/journal.pone.0117934.
- Brand TM, Hartmann S, Bhola NE, Peyser ND, Li H, Zeng Y, et al. Human papillomavirus regulates HER3 expression in head and neck cancer: implications for targeted HER3 therapy in HPV + patients. Clin Cancer Res. 2017;23(12):3072–83. doi:https://doi.org/10.1158/1078-0432.CCR-16-2203.
- Araki K, Ahmad SM, Li G, Bray DA, Saito K, Wang D, et al. Retinoblastoma RB94 enhances radiation treatment of head and neck squamous cell carcinoma. Clin Cancer Res. 2008;14(11):3514–9. doi:https://doi.org/10.1158/1078-0432.CCR-07-4538.
- Yasukawa M, Fujihara H, Fujimori H, Kawaguchi K, Yamada H, Nakayama R, et al. Synergetic effects of PARP inhibitor AZD2281 and cisplatin in oral squamous cell carcinoma in vitro and in vivo. Int J Mol Sci. 2016;17(3):272. doi:https://doi.org/10.3390/ijms17030272.
- Seto K, Shoda J, Horibe T, Warabi E, Ishige K, Yamagata K, et al. Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in head and neck squamous cell carcinoma. Oncol Rep. 2013;29(6):2147–53. doi:https://doi.org/10.3892/or.2013.2387.
- Fukuoka A, Matsushita K, Morikawa T, Adachi T, Yasuda K, Kiyonari H, et al. Human cystatin SN is an endogenous protease inhibitor that prevents allergic rhinitis. J Allergy Clin Immunol. 2019;143(3):1153–62. doi:https://doi.org/10.1016/j.jaci.2018.06.035.
- Tsai WC, Tsai ST, Jin YT, Wu LW. Cyclooxygenase-2 is involved in S100A2-mediated tumor suppression in squamous cell carcinoma. Mol Cancer Res. 2006;4(8):539–47. doi:https://doi.org/10.1158/1541-7786.MCR-05-0266.
- Hirabayashi F, Iwanaga K, Okinaga T, Takahashi O, Ariyoshi W, Suzuki R, et al. Epidermal growth factor receptor-targeted sonoporation with microbubbles enhances therapeutic efficacy in a squamous cell carcinoma model. PloS One. 2017;12(9):e0185293. doi:https://doi.org/10.1371/journal.pone.0185293.
- Ueno S, Kimura T, Yamaga T, Kawada A, Ochiai T, Endou H, et al. Metformin enhances anti-tumor effect of L-type amino acid transporter 1 (LAT1) inhibitor. J Pharmacol Sci. 2016;131(2):110–7. doi:https://doi.org/10.1016/j.jphs.2016.04.021.
- Shirako Y, Taya Y, Sato K, Chiba T, Imai K, Shimazu Y, et al. Heterogeneous tumor stromal microenvironments of oral squamous cell carcinoma cells in tongue and nodal metastatic lesions in a xenograft mouse model. J Oral Pathol Med. 2015;44(9):656–68. doi:https://doi.org/10.1111/jop.12318.
- Rostami A, Lambie M, Yu CW, Stambolic V, Waldron JN, Bratman SV, et al. Senescence, necrosis, and apoptosis govern circulating cell-free DNA release kinetics. Cell Rep. 2020;31(13):107830. doi:https://doi.org/10.1016/j.celrep.2020.107830.
- Kawamata H, Nakashiro KI, Uchida D, Harada K, Yoshida H, Sato M. Possible contribution of active MMP2 to lymph‐node metastasis and secreted cathepsin L to bone invasion of newly established human oral‐squamous‐cancer cell lines. Int J Cancer. 1997;70(1):120–7. doi:https://doi.org/10.1002/(SICI)1097-0215(19970106)70:1 < 120:AID-IJC18 > 3.0.CO;2-P.
- Sakuma K, Tanaka A, Mataga I. Collagen gel droplet-embedded culture drug sensitivity testing in squamous cell carcinoma cell lines derived from human oral cancers: optimal contact concentrations of cisplatin and fluorouracil. Oncol Lett. 2016;12(6):4643–50. doi:https://doi.org/10.3892/ol.2016.5238.
- Hickinson DM, Klinowska T, Speake G, Vincent J, Trigwell C, Anderton J, et al. AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer. Clin Cancer Res. 2010;16(4):1159–69. doi:https://doi.org/10.1158/1078-0432.CCR-09-2353.
- Harris M, Wang XG, Jiang Z, Goldberg GL, Casadevall A, Dadachova E. Radioimmunotherapy of experimental head and neck squamous cell carcinoma (HNSCC) with E6-specific antibody using a novel HPV-16 positive HNSCC cell line. Head Neck Oncol. 2011;3(1):9–7. doi:https://doi.org/10.1186/1758-3284-3-9.
- Harris M, Wang XG, Jiang Z, Phaeton R, Koba W, Goldberg GL, et al. Combined treatment of the experimental human papilloma virus-16-positive cervical and head and neck cancers with cisplatin and radioimmunotherapy targeting viral E6 oncoprotein. Br J Cancer. 2013;108(4):859–65. doi:https://doi.org/10.1038/bjc.2013.43.
- Eberlein C, Kendrew J, McDaid K, Alfred A, Kang JS, Jacobs VN, et al. A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo. Oncogene. 2013;32(37):4406–16. doi:https://doi.org/10.1038/onc.2012.460.
- Lee JW, Parameswaran J, Sandoval-Schaefer T, Eoh KJ, Yang DH, Zhu F, et al. Combined aurora kinase A (AURKA) and WEE1 inhibition demonstrates synergistic antitumor effect in squamous cell carcinoma of the head and neck. Clin Cancer Res. 2019;25(11):3430–42. doi:https://doi.org/10.1158/1078-0432.CCR-18-0440.
- Basheer HA, Pakanavicius E, Cooper PA, Shnyder SD, Martin L, Hunter KD, et al. Hypoxia modulates CCR7 expression in head and neck cancers. Oral Oncol. 2018;80:64–73. doi:https://doi.org/10.1016/j.oraloncology.2018.03.014.
- Zheng Q, Sun J, Li W, Li S, Zhang K. Cordycepin induces apoptosis in human tongue cancer cells in vitro and has antitumor effects in vivo. Arch Oral Biol. 2020;118:104846. doi:https://doi.org/10.1016/j.archoralbio.2020.104846.
- Zhang KL, Li RP, Zhang BP, Gao ST, Li B, Huang CJ, et al. Efficacy of a new oncolytic adenovirus armed with IL-13 against oral carcinoma models. Onco Targets Ther. 2019;12:6515–6523. doi:https://doi.org/10.2147/OTT.S203638.
- Epperly MW, Lai SY, Kanai AJ, Mason N, Lopresi B, Dixon T, et al. Effectiveness of combined modality radiotherapy of orthotopic human squamous cell carcinomas in Nu/Nu mice using cetuximab, tirapazamine and MnSOD-plasmid liposome gene therapy. In Vivo. 2010;24(1):1–8.
- Chang CC, Lin BR, Chen ST, Hsieh TH, Li YJ, Kuo MY. HDAC2 promotes cell migration/invasion abilities through HIF-1α stabilization in human oral squamous cell carcinoma. J Oral Pathol Med. 2011;40(7):567–575. Doi:https://doi.org/10.1111/j.1600-0714.2011.01009.x.
- Lin YC, Chen KC, Chen CC, Cheng AL, Chen KF. CIP2A-mediated Akt activation plays a role in bortezomib-induced apoptosis in head and neck squamous cell carcinoma cells. Oral Oncol. 2012;48(7):585–93. doi:https://doi.org/10.1016/j.oraloncology.2012.01.012.
- Yang IH, Jung JY, Kim SH, Yoo ES, Cho NP, Lee H, et al. ABT-263 exhibits apoptosis-inducing potential in oral cancer cells by targeting C/EBP-homologous protein. Cell Oncol. 2019;42(3):357–68. doi:https://doi.org/10.1007/s13402-019-00431-5.
- Hoshikawa H, Mori T, Mori N. In vitro and in vivo effects of D-allose: up-regulation of thioredoxin-interacting protein in head and neck cancer cells. Ann Otol Rhinol Laryngol. 2010;119(8):567–71. doi:https://doi.org/10.1177/000348941011900810.
- Xie J-J, Jiang Y-Y, Jiang Y, Li C-Q, Lim M-C, An O, et al. Super-enhancer-driven long non-coding RNA LINC01503, regulated by TP63, is over-expressed and oncogenic in squamous cell carcinoma. Gastroenterology. 2018;154(8):2137–51. doi:https://doi.org/10.1053/j.gastro.2018.02.018.
- Li W, Tao C, Wang J, Le Y, Zhang J. MMP-responsive in situ forming hydrogel loaded with doxorubicin-encapsulated biodegradable micelles for local chemotherapy of oral squamous cell carcinoma. RSC Adv. 2019;9(54):31264–73. doi:https://doi.org/10.1039/C9RA04343H.
- Ho YT, Yang JS, Lu CC, Chiang JH, Li TC, Lin JJ, et al. Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model. Phytomedicine. 2009;16(9):887–90. doi:https://doi.org/10.1016/j.phymed.2009.02.015.
- Shang HS, Chen KW, Chou JS, Peng SF, Chen YL, Chen PY, et al. Casticin inhibits in vivo growth of xenograft tumors of human oral cancer SCC-4 cells. In Vivo. 2020;34(5):2461–7. doi:https://doi.org/10.21873/invivo.12061.
- Viet CT, Dang D, Achdjian S, Ye Y, Katz SG, Schmidt BL. Decitabine rescues cisplatin resistance in head and neck squamous cell carcinoma. PLOS One. 2014;9(11):e112880. doi:https://doi.org/10.1371/journal.pone.0112880.
- Chen H, Sa G, Li L, He S, Wu T. In vitro and in vivo synergistic anti-tumor effect of LIN28 inhibitor and metformin in oral squamous cell carcinoma. Eur J Pharmacol. 2021;891:173757. doi:https://doi.org/10.1016/j.ejphar.2020.173757.
- Pozzi V, Sartini D, Rocchetti R, Santarelli A, Rubini C, Morganti S, et al. Identification and characterization of cancer stem cells from head and neck squamous cell carcinoma cell lines. Cell Physiol Biochem. 2015;36(2):784–98. doi:https://doi.org/10.1159/000430138.
- Riley A, Green V, Cheah R, McKenzie G, Karsai L, England J, et al. A novel microfluidic device capable of maintaining functional thyroid carcinoma specimens ex vivo provides a new drug screening platform. BMC Cancer. 2019;19(1):1–3. doi:https://doi.org/10.1186/s12885-019-5465-z.
- Kennedy R, Kuvshinov D, Sdrolia A, Kuvshinova E, Hilton K, Crank S, et al. A patient tumour-on-a-chip system for personalised investigation of radiotherapy-based treatment regimens. Sci Rep. 2019;9(1):632. doi:https://doi.org/10.1038/s41598-019-42745-2.
- Cheah R, Srivastava R, Stafford ND, Beavis AW, Green V, Greenman J. Measuring the response of human head and neck squamous cell carcinoma to irradiation in a microfluidic model allowing customized therapy. Int J Oncol. 2017;51(4):1227–38. doi:https://doi.org/10.3892/ijo.2017.4118.
- Al-Samadi A, Poor B, Tuomainen K, Liu V, Hyytiäinen A, Suleymanova I, et al. In vitro humanized 3D microfluidic chip for testing personalized immunotherapeutics for head and neck cancer patients. Exp Cell Res. 2019;383(2):111508. doi:https://doi.org/10.1016/j.yexcr.2019.111508.
- Ong LJ, Zhu L, Tan GJ, Toh YC. Quantitative image-based cell viability (QuantICV) assay for microfluidic 3D tissue culture applications. Micromachines. 2020;11(7):669. doi:https://doi.org/10.3390/mi11070669.
- Jin D, Ma X, Luo Y, Fang S, Xie Z, Li X, et al. Application of a microfluidic-based perivascular tumor model for testing drug sensitivity in head and neck cancers and toxicity in endothelium. RSC Adv. 2016;6(35):29598–607. doi:https://doi.org/10.1039/C6RA01456A.
- Tentler JJ, Tan AC, Weekes CD, Jimeno A, Leong S, Pitts TM, et al. Patient-derived tumour xenografts as models for oncology drug development. Nat Rev Clin Oncol. 2012;9(6):338–50. doi:https://doi.org/10.1038/nrclinonc.2012.61.
- Sun S, Zhang Z. Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research and a new co-clinical model for treatment optimization. Front Med. 2016;10(1):104–10. doi:https://doi.org/10.1007/s11684-016-0432-4.
- Hidalgo M, Amant F, Biankin AV, Budinská E, Byrne AT, Caldas C, et al. Patient-derived xenograft models: an emerging platform for translational cancer research. Cancer Discov. 2014;4(9):998–1013. doi:https://doi.org/10.1158/2159-8290.CD-14-0001.
- Pauli C, Hopkins BD, Prandi D, Shaw R, Fedrizzi T, Sboner A, et al. Personalized in vitro and in vivo cancer models to guide precision medicine. Cancer Discov. 2017;7(5):462–77. doi:https://doi.org/10.1158/2159-8290.CD-16-1154.
- Tanaka N, Osman AA, Takahashi Y, Lindemann A, Patel AA, Zhao M, et al. Head and neck cancer organoids established by modification of the CTOS method can be used to predict in vivo drug sensitivity. Oral Oncol. 2018;87:49–57. doi:https://doi.org/10.1016/j.oraloncology.2018.10.018.
- Azharuddin M, Roberg K, Kumar Dhara A, Darcy P, Hinkula J, Slater NK, et al. Dissecting multi drug resistance in head and neck cancer cells using multicellular tumor spheroids. Sci Rep. 2019;9(1):20066. doi:https://doi.org/10.1038/s41598-019-56273-6.