Perineural Invasion as a Predictive Biomarker of Groin Metastases and Survival Outcomes in Vulvar Cancer: A Meta-Analysis

References

• Capria A, Tahir N, Fatehi M. Vulva cancer. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022.
   Google Scholar
• Bray F, Laversanne M, Weiderpass E, Arbyn M. Geographic and temporal variations in the incidence of vulvar and vaginal cancers. Int J Cancer. 2020;147(10):2764–2771.
   PubMedGoogle Scholar
• Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2021. CA A Cancer J Clin. 2021;71(1):7–33.
   PubMed Web of Science ®Google Scholar
• Khadraoui H, Thappa S, Smith M, Davidov A, Castellanos MR. Age-associated trends of vulvar cancer in the US. Menopause. 2021;28(2):119–125.
   Google Scholar
• Oonk MHM, Planchamp F, Baldwin P, Bidzinski M, Brännström M, Landoni F, et al. European Society of Gynaecological Oncology guidelines for the management of patients with vulvar cancer. Int J Gynecol Cancer. 2017;27(4):832–837.
   PubMedGoogle Scholar
• Morrison J, Baldwin P, Buckley L, Cogswell L, Edey K, Faruqi A, et al. British Gynaecological Cancer Society (BGCS) vulval cancer guidelines: recommendations for practice. Eur J Obstet Gynecol Reprod Biol. 2020;252:502–525.
   PubMedGoogle Scholar
• Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS. Perineural invasion and perineural tumor spread in head and neck cancer. Int J Radiat Oncol Biol Phys. 2019;103(5):1109–1124.
   PubMed Web of Science ®Google Scholar
• Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol. 2009;62(10):e1–e34.
   PubMed Web of Science ®Google Scholar
• Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev. 2016;5(1):210.
   PubMedGoogle Scholar
• Palas D, Ehlinger V, Alberge C, Truffert P, Kayem G, Goffinet F, et al. Efficacy of antenatal corticosteroids in preterm twins: the EPIPAGE-2 cohort study. BJOG. 2018;125(9):1164–1170.
   PubMed Web of Science ®Google Scholar
• Wells GA, Wells G, Shea B, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2014. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
   Google Scholar
• Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods. 2010;1(2):97–111.
   PubMed Web of Science ®Google Scholar
• IntHout J, Ioannidis JPA, Borm GF. The Hartung-Knapp-Sidik-Jonkman method for random effects meta-analysis is straightforward and considerably outperforms the standard DerSimonian-Laird method. BMC Med Res Methodol. 2014;14(1):25.
   PubMedGoogle Scholar
• Rowley KC, Gallion HH, Donaldson ES, van Nagell JR, Higgins RV, Powell DE, et al. Prognostic factors in early vulvar cancer. Gynecol Oncol. 1988;31(1):43–9.
   PubMedGoogle Scholar
• Yoder BJ, Rufforny I, Massoll NA, Wilkinson EJ. Stage IA vulvar squamous cell carcinoma: an analysis of tumor invasive characteristics and risk. Am J Surg Pathol. 2008;32(5):765–772.
   PubMedGoogle Scholar
• Lavorato-Rocha AM, de Melo Maia B, Rodrigues IS, Stiepcich MMÁ, Baiocchi G, Cestari F. M d S, et al. Prognostication of vulvar cancer based on p14ARF status: molecular assessment of transcript and protein. Ann Surg Oncol. 2013;20(1):31–39.
   PubMedGoogle Scholar
• Baiocchi G, Mantoan H, de Brot L, Badiglian-Filho L, Kumagai LY, Faloppa CC, et al. How important is the pathological margin distance in vulvar cancer? Eur J Surg Oncol. 2015;41(12):1653–1658.
   PubMedGoogle Scholar
• Holthoff ER, Jeffus SK, Gehlot A, Stone R, Erickson SW, Kelly T, et al. Perineural Invasion is an independent pathologic indicator of recurrence in vulvar squamous cell carcinoma. Am J Surg Pathol. 2015;39(8):1070–1074.
   PubMedGoogle Scholar
• Ferrari F, Forte S, Ardighieri L, Bonetti E, Fernando B, Sartori E, et al. Multivariate analysis of prognostic factors in primary squamous cell vulvar cancer: the role of perineural invasion in recurrence and survival. Eur J Surg Oncol. 2019;45(11):2115–2119.
   PubMedGoogle Scholar
• Long Y, Yao DS, Wei YS, Wei CH, Chen XY. Prognostic significance of perineural invasion in vulvar squamous cell carcinoma. Cancer Manag Res. 2019;11:4461–4469.
   PubMed Web of Science ®Google Scholar
• Salcedo MP, Sood AK, dos Reis R, Ramalingam P, Chen C, Frumovitz M, et al. Perineural invasion (PNI) in vulvar carcinoma: a review of 421 cases. Gynecol Oncol. 2019;152(1):101–5.
   PubMedGoogle Scholar
• Baiocchi G, de Freitas RR, Bovolim G, Badiglian-Filho L, da Costa A, De Brot L. Immunohistochemical expression of ErbB/HER family proteins in patients with vulvar cancer. Int J Gynaecol Obstet. 2021;157(1):102–109.
   Google Scholar
• Gadducci A, Pistolesi S, Cosio S, Comunale C, Fanucchi A, Naccarato AG. Perineural invasion correlates with common pathological variables and clinical outcomes of patients with squamous cell carcinoma of the vulva treated with primary radical surgery and inguinal-femoral lymphadenectomy. In Vivo. 2021;35(2):1051–1056.
   PubMedGoogle Scholar
• Micheletti L, Borella F, Preti M, Frau V, Cosma S, Privitera S, et al. Perineural invasion in vulvar squamous-cell carcinoma is an independent risk factor for cancer-specific survival, but not for locoregional recurrence: results from a single Tertiary Referral Center. Cancers. 2021;14(1):124.
   PubMedGoogle Scholar
• Cochrane: general methods for cochrane reviews. Interpreting results and conclusions. Interpreting results of statistical analyses. 12.4.1. Confidence intervals. Available February 2022 from: https://handbook-5-1.cochrane.org/chapter_12/12_4_1_confidence_intervals.html.
   Google Scholar
• Carter JB, Johnson MM, Chua TL, Karia PS, Schmults CD. Outcomes of primary cutaneous squamous cell carcinoma with perineural invasion: an 11-year cohort study. JAMA Dermatol. 2013;149(1):35–42.
   PubMed Web of Science ®Google Scholar
• Farasat S, Yu SS, Neel VA, Nehal KS, Lardaro T, Mihm MC, et al. A new American Joint Committee on cancer staging system for cutaneous squamous cell carcinoma: creation and rationale for inclusion of tumor (T) characteristics. J Am Acad Dermatol. 2011;64(6):1051–1059.
   PubMedGoogle Scholar
• Chen S-H, Zhang B-Y, Zhou B, Zhu C-Z, Sun L-Q, Feng Y-J. Perineural invasion of cancer: a complex crosstalk between cells and molecules in the perineural niche. Am J Cancer Res. 2019;9(1):1–21.
   PubMed Web of Science ®Google Scholar
• Zhao C-M, Hayakawa Y, Kodama Y, Muthupalani S, Westphalen CB, Andersen GT, et al. Denervation suppresses gastric tumorigenesis. Sci Transl Med. 2014;6(250):250ra115.
   PubMed Web of Science ®Google Scholar
• Sarkar C, Chakroborty D, Basu S. Neurotransmitters as regulators of tumor angiogenesis and immunity: the role of catecholamines. J Neuroimmune Pharmacol. 2013;8(1):7–14.
   PubMedGoogle Scholar
• Weissenrieder JS, Neighbors JD, Mailman RB, Hohl RJ. Cancer and the dopamine D2 receptor: a pharmacological perspective. J Pharmacol Exp Ther. 2019;370(1):111–126.
   PubMed Web of Science ®Google Scholar
• Lale A, Yur M, Özgül H, Alkurt EG, Yıldırım N, Aygen E, et al. Predictors of non-sentinel lymph node metastasis in clinical early stage (cT1-2N0) breast cancer patients with 1-2 metastatic sentinel lymph nodes. Asian J Surg. 2020;43(4):538–549.
   PubMedGoogle Scholar
• Zach D, Åvall-Lundqvist E, Falconer H, Hellman K, Johansson H, Flöter Rådestad A. Patterns of recurrence and survival in vulvar cancer: a nationwide population-based study. Gynecol Oncol. 2021;161(3):748–754.
   PubMedGoogle Scholar