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Cancer Investigation Volume 40, 2022 - Issue 8
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Articles

Jurkat T Cells are Immunophenotypically Distinct from T-Cell Acute Lymphoblastic Leukemia Cells Due to High-Level Surface Expression of CD5

Kulwant Singha Department of Hematology, Stem Cell Research Center, Sanjay Gandhi Post Graduate Institute Medical Sciences, Lucknow, IndiaView further author information
,
Smita Kumarib Department of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, Allahabad, IndiaView further author information
,
Bharat Singhb Department of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, Allahabad, IndiaView further author information
,
Ranjeet Bahadur Choubeyb Department of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, Allahabad, IndiaView further author information
,
Dipendra Kumar Mitrac Department of Transplant Immunology and Immunogenetics, Cellular Immunology Laboratory, All India Institute of Medical Sciences, New Delhi, IndiaView further author information
&
Ambak Kumar Raib Department of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, Allahabad, IndiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6564-6342View further author information
ORCID Icon
Pages 675-679 | Received 05 Oct 2021, Accepted 24 Jun 2022, Published online: 05 Jul 2022

Reference

  • Schneider U, Schwenk HU, Bornkamm G. Characterization of EBV‐genome negative “null” and “T” cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non‐Hodgkin lymphoma. Int J Cancer. 1977; 19(5):621–626. doi:10.1002/ijc.2910190505.
  • Gillis S, Watson J. Biochemical and biological characterization of lymphocyte regulatory molecules. V. Identification of an interleukin 2-producing human leukemia T cell line. J Exp Med. 1980;152(6):1709–1719. doi:10.1084/jem.152.6.1709.
  • Abraham RT, Weiss A. Jurkat T cells and development of the T-cell receptor signalling paradigm. Nat Rev Immunol. 2004;4(4):301–308. doi:10.1038/nri1330.
  • Astoul E, Edmunds C, Cantrell DA, Ward SG. PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models. Trends Immunol. 2001;22(9):490–496. doi:10.1016/S1471-4906(01)01973-1.
  • Sengar M, Rai AK, Saxena A, Singh A, Raina V, Seth T, et al. Acute leukemia: diagnosis improved by flow cytometry in addition to morphology. Asia-Pacific J Clin Oncol. 2009;5(1):55–65. doi:10.1111/j.1743-7563.2009.01188.x.
  • Dairaghi DJ, Soo KS, Oldham ER, Premack BA, Kitamura T, Bacon KB, et al. RANTES-induced T cell activation correlates with CD3 expression. J Immunol. 1998;160(1):426–433.
  • Van Dongen JJ, Krissansen GW, Wolvers-Tettero IL, Comans-Bitter WM, Adriaansen HJ, Hooijkaas H, et. al. Cytoplasmic expression of the CD3 antigen as a diagnostic marker for immature T-cell malignancies. Blood. 1988;71(3):603–612. doi: 10.1182/blood.V71.3.603.603.
  • Rai AK, Singh A, Saxena A, Seth T, Raina V, Mitra DK, et al. Exonal switch down‐regulates the expression of CD5 on blasts of acute T cell leukaemia. Clin Exp Immunol. 2017;190(3):340–350. doi:10.1111/cei.13019.
  • Ohashi PS, Mak TW, Van den Elsen P, Yanagi Y, Yoshikai Y, Calman AF, et al. Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer. Nature. 1985;316(6029):606–609. doi:10.1038/316606a0.
  • Weiss A, Imboden J, Shoback D, Stobo J. Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium. Proc Natl Acad Sci USA. 1984;81(13):4169–4173. doi:10.1073/pnas.81.13.4169.
  • Weiss A, Stobo J. Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line. J Exp Med. 1984;160(5):1284–1299. doi:10.1084/jem.160.5.1284.
  • Weiss A, Wiskocil R, Stobo J. The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level. J Immunol. 1984;133(1):123–128.
  • Cantrell D. T cell antigen receptor signal transduction pathways. Annu Rev Immunol. 1996;14(1):259–274. doi:10.1146/annurev.immunol.14.1.259.
  • Kane LP, Lin J, Weiss A. Signal transduction by the TCR for antigen. Curr Opin Immunol. 2000;12(3):242–249. doi:10.1016/S0952-7915(00)00083-2.
  • Koretzky GA, Picus J, Schultz T, Weiss A. Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production. Proc Natl Acad Sci USA. 1991;88(6):2037–2041. doi:10.1073/pnas.88.6.2037.
  • Voisinne G, Gonzalez de Peredo A, Roncagalli R. CD5, an undercover regulator of TCR signaling. Front Immunol. 2018;9:2900.

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