Exercise interventions to combat cancer-related fatigue in cancer patients undergoing treatment: a review

References

• Hilfiker R, Meichtry A, Eicher M, Nilsson Balfe L, Knols RH, Verra ML, Taeymans J. Exercise and other non-pharmaceutical interventions for cancer-related fatigue in patients during or after cancer treatment: a systematic review incorporating an indirect-comparisons meta-analysis. Br J Sports Med. 2018;52(10):651–8. doi:10.1136/bjsports-2016-096422.
   PubMed Web of Science ®Google Scholar
• Mustian KM, Alfano CM, Heckler C, Kleckner AS, Kleckner IR, Leach CR, et al. Comparison of pharmaceutical, psychological, and exercise treatments for cancer-related fatigue: a meta-analysis. JAMA Oncol. 2017;3(7):961–8. doi:10.1001/jamaoncol.2016.6914.
   PubMed Web of Science ®Google Scholar
• Mohandas H, Jaganathan S, Mani M, Ayyar M, Rohini Thevi G. Cancer-related fatigue treatment: An overview. J Cancer Res Ther. 2017;13(6):916–29.
   PubMed Web of Science ®Google Scholar
• Matura LA, Malone S, Jaime-Lara R, Riegel B. A systematic review of biological mechanisms of fatigue in chronic illness. Biol Res Nurs. 2018;20(4):410–21.
   PubMed Web of Science ®Google Scholar
• Ma Y, He B, Jiang M, Yang Y, Wang C, Huang C, Han L. Prevalence and risk factors of cancer-related fatigue: a systematic review and meta-analysis. International Journal of Nursing Studies. 2020;111:103707. doi:10.1016/j.ijnurstu.2020.103707.
   PubMed Web of Science ®Google Scholar
• Smets EMA, Garssen B, Bonke B, DE Haes JCJM. The multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosom Res. 1995;39(3):315–25. doi:10.1016/0022-3999(94)00125-O.
   PubMed Web of Science ®Google Scholar
• Cella D, Lai J-S, Chang C-H, Peterman A, Slavin M. Fatigue in cancer patients compared with fatigue in the general United States population. Cancer. 2002;94(2):528–38. doi:10.1002/cncr.10245.
   PubMed Web of Science ®Google Scholar
• Weis J. Cancer-related fatigue: Prevalence, assessment and treatment strategies. Expert Rev Pharmacoecon Outcomes Res. 2011;11(4):441–6. doi:10.1586/erp.11.44.
   PubMed Web of Science ®Google Scholar
• Roila F, Fumi G, Ruggeri B, Antonuzzo A, Ripamonti C, Fatigoni SN, et al. Prevalence, characteristics, and treatment of fatigue in oncological cancer patients in Italy: a cross-sectional study of the Italian Network for Supportive Care in Cancer (NICSO). Support Care Cancer. 2019;27(3):1041–7. & doi:10.1007/s00520-018-4393-9.
   PubMed Web of Science ®Google Scholar
• Cella D, Davis K, Breitbart W, Curt G, Fatigue C, for the Fatigue Coalition. Cancer-related fatigue: prevalence of proposed diagnostic criteria in a United States sample of cancer survivors. JCO. 2001;19(14):3385–91. doi:10.1200/JCO.2001.19.14.3385.
   PubMed Web of Science ®Google Scholar
• Maass S, Brandenbarg D, Boerman L, Verhaak P, G, de Bock, Berendsen A. Fatigue among long-term breast cancer survivors: a controlled cross-sectional study. Eur J Cancer. 2020;138:S1–S2. doi:10.1016/S0959-8049(20)30533-5.
   PubMed Web of Science ®Google Scholar
• Braun IM, Greenberg DB, Pirl WF. Evidenced-based report on the occurrence of fatigue in long-term cancer survivors. J Natl Compr Canc Netw. 2008;6(4):347–54. doi:10.6004/jnccn.2008.0029.
   PubMedGoogle Scholar
• Forlenza MJ, Hall P, Lichtenstein P, Evengard B, Sullivan PF. Epidemiology of cancer-related fatigue in the Swedish twin registry. Cancer. 2005;104(9):2022–31. doi:10.1002/cncr.21373.
   PubMed Web of Science ®Google Scholar
• Hofman M, Ryan JL, Figueroa‐Moseley CD, Jean‐Pierre P, Morrow GR. Cancer‐related fatigue: the scale of the problem. The Oncologist. 2007;12(S1):4–10. doi:10.1634/theoncologist.12-S1-4.
   PubMedGoogle Scholar
• Nail LM. My get up and go got up and went: fatigue in people with cancer. JNCI Monographs. 2004;2004(32):72–5. 2004, doi:10.1093/jncimonographs/lgh021.
   Google Scholar
• Bower JE. Cancer-related fatigue–mechanisms, risk factors, and treatments. Nat Rev Clin Oncol. 2014;11(10):597–609.
   PubMed Web of Science ®Google Scholar
• Donovan KA, Small BJ, Andrykowski MA, Munster P, Jacobsen PB. Utility of a cognitive-behavioral model to predict fatigue following breast cancer treatment. Health Psychol. 2007;26(4):464–72. doi:10.1037/0278-6133.26.4.464.
   PubMed Web of Science ®Google Scholar
• Miller AH, Ancoli-Israel S, Bower JE, Capuron L, Irwin MR. Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer. JCO. 2008;26(6):971–82. doi:10.1200/JCO.2007.10.7805.
   PubMed Web of Science ®Google Scholar
• Seruga B, Zhang H, Bernstein LJ, Tannock IF. Cytokines and their relationship to the symptoms and outcome of cancer. Nat Rev Cancer. 2008;8(11):887–99. doi:10.1038/nrc2507.
   PubMed Web of Science ®Google Scholar
• Arpin D, Perol D, Blay J-Y, Falchero L, Claude L, Vuillermoz-Blas S, et al. Early variations of circulating interleukin-6 and interleukin-10 levels during thoracic radiotherapy are predictive for radiation pneumonitis. J Clin Oncol. 2005;23(34):8748–56.
   PubMed Web of Science ®Google Scholar
• Bower J, Ganz P, Irwin M, Kwan L, Breen E, Cole S. Inflammation and behavioral symptoms after breast cancer treatment: do fatigue, depression, and sleep disturbance share a common underlying mechanism. JCO. 2011;29(26):3517–22. doi:10.1200/JCO.2011.36.1154.
   PubMed Web of Science ®Google Scholar
• Wang XS, Shi Q, Williams LA, Mao L, Cleeland CS, Komaki RR, et al. Inflammatory cytokines are associated with the development of symptom burden in patients with NSCLC undergoing concurrent chemoradiation therapy. Brain Behav Immunity. 2010;24(6):968–74. doi:10.1016/j.bbi.2010.03.009.
   PubMed Web of Science ®Google Scholar
• Wang XS, Williams LA, Krishnan S, Liao Z, Liu P, Mao L, et al. Serum sTNF-R1, IL-6, and the development of fatigue in patients with gastrointestinal cancer undergoing chemoradiation therapy. Brain Behav Immunity. 2012;26(5):699–705. doi:10.1016/j.bbi.2011.12.007.
   PubMed Web of Science ®Google Scholar
• Sha F, Zhuang S, Zhou L, Zhang L, Yang Y, Zhang S, et al. Biomarkers for cancer‑related fatigue and adverse reactions to chemotherapy in lung cancer patients. Mol Clin Oncol. 2015;3(1):163–6. doi:10.3892/mco.2014.439.
   PubMedGoogle Scholar
• Bower JE, Ganz PA, Aziz N, Fahey JL. Fatigue and proinflammatory cytokine activity in breast cancer survivors. Psychosom Med. 2002;64(4):604–11. doi:10.1097/00006842-200207000-00010.
   PubMed Web of Science ®Google Scholar
• Collado-Hidalgo A, Bower JE, Ganz PA, Cole SW, Irwin MR. Inflammatory biomarkers for persistent fatigue in breast cancer survivors. Clinical Cancer Res. 2006;12(9):2759–66. doi:10.1158/1078-0432.CCR-05-2398.
   PubMed Web of Science ®Google Scholar
• Schrepf A, Clevenger L, Christensen D, Degeest K, Bender D, Ahmed A, et al. Cortisol and inflammatory processes in ovarian cancer patients following primary treatment: relationships with depression, fatigue, and disability. Brain Behav and Immunity. 2013;30:S126–S134. doi:10.1016/j.bbi.2012.07.022.
   PubMed Web of Science ®Google Scholar
• Raison CL, Miller AH. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. AJP. 2003;160(9):1554–65. doi:10.1176/appi.ajp.160.9.1554.
   Google Scholar
• Bower JE, Ganz PA, Dickerson SS, Petersen L, Aziz N, Fahey JL. Diurnal cortisol rhythm and fatigue in breast cancer survivors. Psychoneuroendocrinology. 2005;30(1):92–100.
   PubMed Web of Science ®Google Scholar
• Saligan LN, Olson K, Filler K, Larkin D, Cramp F, Sriram Y, Multinational association of supportive care in cancer fatigue study group-biomarker working, G, et al. The biology of cancer-related fatigue: a review of the literature. Support Care Cancer. 2015;23(8):2461–78. doi:10.1007/s00520-015-2763-0.
   PubMed Web of Science ®Google Scholar
• Crosswell AD, Lockwood KG, Ganz PA, Bower JE. Low heart rate variability and cancer-related fatigue in breast cancer survivors. Psychoneuroendocrinology. 2014;45:58–66. doi:10.1016/j.psyneuen.2014.03.011.
   PubMed Web of Science ®Google Scholar
• Fagundes CP, Murray DM, Hwang BS, Gouin J-P, Thayer JF, Sollers JJ, et al. Sympathetic and parasympathetic activity in cancer-related fatigue: More evidence for a physiological substrate in cancer survivors. Psychoneuroendocrinology. 2011;36(8):1137–47. doi:10.1016/j.psyneuen.2011.02.005.
   PubMed Web of Science ®Google Scholar
• Solomayer E-F, Feuerer M, Bai L, Umansky V, Beckhove P, Meyberg GC, et al. Influence of adjuvant hormone therapy and chemotherapy on the immune system analysed in the bone marrow of patients with breast cancer. Clin Cancer Res. 2003;9(1):174–80.
   PubMed Web of Science ®Google Scholar
• Bower JE, Ganz PA, Aziz N, Fahey JL, Cole SW. T-cell homeostasis in breast cancer survivors with persistent fatigue. JNCI. 2003;95(15):1165–8. doi:10.1093/jnci/djg0019.
   PubMedGoogle Scholar
• Reinertsen KV, Cvancarova M, Loge JH, Edvardsen H, Wist E, Fosså SD. Predictors and course of chronic fatigue in long-term breast cancer survivors. J Cancer Surviv. 2010;4(4):405–14.
   PubMed Web of Science ®Google Scholar
• Thong MSY, VAN Noorden CJF, Steindorf K, Arndt V. Cancer-related fatigue: causes and current treatment options. Curr Treat Options Oncol. 2020;21(2):17.
   PubMed Web of Science ®Google Scholar
• Minton O, Stone P. A systematic review of the scales used for the measurement of cancer-related fatigue (CRF). Ann Oncol. 2009;20(1):17–25.
   PubMed Web of Science ®Google Scholar
• Bennett S, Pigott A, Beller E, Haines T, Meredith P, Delaney C. Educational interventions for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev. 2016;11:CD008144.
   PubMedGoogle Scholar
• Yates P, Aranda S, Hargraves M, Mirolo B, Clavarino A, Mclachlan S, Skerman H. Randomized controlled trial of an educational intervention for managing fatigue in women receiving adjuvant chemotherapy for early-stage breast cancer. J Clin Oncol. 2005;23(25):6027–36.
   PubMed Web of Science ®Google Scholar
• Escalante CP, Manzullo EF. Cancer-related fatigue: the approach and treatment. J Gen Intern Med. 2009;24(S2):412–S416. doi:10.1007/s11606-009-1056-z.
   Google Scholar
• Minton O, Richardson A, Sharpe M, Hotopf M, Stone P. A systematic review and meta-analysis of the pharmacological treatment of cancer-related fatigue. J Natl Cancer Inst. 2008;100(16):1155–66.
   PubMedGoogle Scholar
• Aapro M, Spivak JL. Update on erythropoiesis-stimulating agents and clinical trials in oncology. The Oncologist. 2009;14(S1):6–15. doi:10.1634/theoncologist.2009-S1-6.
   PubMedGoogle Scholar
• Campos MPO, Hassan BJ, Riechelmann R, & DEL, Giglio A. Cancer-related fatigue: a practical review. Ann Oncol. 2011;22(6):1273–9.
   PubMed Web of Science ®Google Scholar
• Breitbart W, Alici Y. Psychostimulants for cancer-related fatigue. J Natl Compr Canc Netw. 2010;8(8):933–42.
   PubMed Web of Science ®Google Scholar
• Bruera E, Driver L, Barnes EA, Willey J, Shen L, Palmer JL, Escalante C. Patient-controlled methylphenidate for the management of fatigue in patients with advanced cancer: a preliminary report. JCO. 2003;21(23):4439–43. doi:10.1200/JCO.2003.06.156.
   PubMed Web of Science ®Google Scholar
• Jean-Pierre P, Morrow GR, Roscoe JA, Heckler C, Mohile S, Janelsins M, et al. A phase 3 randomized, placebo-controlled, double-blind, clinical trial of the effect of modafinil on cancer-related fatigue among 631 patients receiving chemotherapy. Cancer. 2010;116(14):3513–20. doi:10.1002/cncr.25083.
   PubMed Web of Science ®Google Scholar
• Spathis A, Fife K, Blackhall F, Dutton S, Bahadori R, Wharton R, et al. Modafinil for the treatment of fatigue in lung cancer: results of a placebo-controlled, double-blind, randomized trial. J Clin Oncol. 2014;32(18):1882–8.
   PubMed Web of Science ®Google Scholar
• Stout NL, Baima J, Swisher AK, Winters-Stone KM, Welsh J. A systematic review of exercise systematic reviews in the cancer literature (2005-2017). PM & R. 2017;9:S347–S384. doi:10.1016/j.pmrj.2017.07.074.
   PubMedGoogle Scholar
• Kim H-IN, Lim H, Moon AREE. Sex differences in cancer: epidemiology, genetics and therapy. Biomol Ther (Seoul)). 2018;26(4):335–42. doi:10.4062/biomolther.2018.103.
   PubMed Web of Science ®Google Scholar
• Tian L, Lu HJ, Lin L, Hu Y. Effects of aerobic exercise on cancer-related fatigue: a meta-analysis of randomized controlled trials. Support Care Cancer. 2016;24(2):969–83.
   PubMed Web of Science ®Google Scholar
• Chang P-H, Lai Y-H, Shun S-C, Lin L-Y, Chen M-L, Yang Y, et al. Effects of a walking intervention on fatigue-related experiences of hospitalized acute myelogenous leukemia patients undergoing chemotherapy: a randomized controlled trial. J Pain Symptom Manage. 2008;35(5):524–34.
   PubMed Web of Science ®Google Scholar
• Windsor PM, Nicol KF, Potter J. A randomized, controlled trial of aerobic exercise for treatment-related fatigue in men receiving radical external beam radiotherapy for localized prostate carcinoma. Cancer. 2004;101(3):550–7. doi:10.1002/cncr.20378.
   PubMed Web of Science ®Google Scholar
• Payne JK, Held J, Thorpe J, Shaw H. Effect of exercise on biomarkers, fatigue, sleep disturbances, and depressive symptoms in older women with breast cancer receiving hormonal therapy. Oncol Nurs Forum. 2008;35(4):635–42.
   PubMed Web of Science ®Google Scholar
• Mock V, Pickett M, Ropka ME, Lin EM, Stewart KJ, Rhodes VA, et al. Fatigue and quality of life outcomes of exercise during cancer treatment. Cancer Pract. 2001;9(3):119–27.
   PubMedGoogle Scholar
• Monga U, Garber SL, Thornby J, Vallbona C, Kerrigan AJ, Monga TN, Zimmermann KP. Exercise prevents fatigue and improves quality of life in prostate cancer patients undergoing radiotherapy. Arch Phys Med Rehab. 2007;88(11):1416–22. doi:10.1016/j.apmr.2007.08.110.
   PubMed Web of Science ®Google Scholar
• Headley JA, Ownby KK, John LD. The effect of seated exercise on fatigue and quality of life in women with advanced breast cancer. Oncol Nurs Forum. 2004;31(5):977–83. doi:10.1188/04.ONF.977-983.
   PubMed Web of Science ®Google Scholar
• Dimeo FC, Stieglitz R-D, Novelli-Fischer U, Fetscher S, Keul J. Effects of physical activity on the fatigue and psychologic status of cancer patients during chemotherapy. Cancer. 1999;85(10):2273–7. doi:10.1002/(SICI)1097-0142(19990515)85:10<2273::AID-CNCR24>3.0.CO;2-B.
   PubMed Web of Science ®Google Scholar
• Courneya KS, Sellar CM, Stevinson C, Mcneely ML, Peddle CJ, Friedenreich CM, et al. Randomized controlled trial of the effects of aerobic exercise on physical functioning and quality of life in lymphoma patients. JCO. 2009;27(27):4605–12. doi:10.1200/JCO.2008.20.0634.
   PubMed Web of Science ®Google Scholar
• Saarto T, Marika Penttinen H, Sievänen H, Kellokumpu-Lehtinen P-L, Hakamies-Blomqvist L, Nikander RIKU, et al. Effectiveness of a 12-month exercise program on physical performance and quality of life of breast cancer survivors. Anticancer Res. 2012;32:3875–84.
   PubMed Web of Science ®Google Scholar
• Cramp F, Byron-Daniel J. 2012. Exercise for the management of cancer-related fatigue in adults. Cochrane database of systematic reviews (Online), 11, CD006145.
   Google Scholar
• Segal RJ, Reid RD, Courneya KS, Malone SC, Parliament MB, Scott CG, et al. Resistance exercise in men receiving androgen deprivation therapy for prostate cancer. JCO. 2003;21(9):1653–9. doi:10.1200/JCO.2003.09.534.
   PubMed Web of Science ®Google Scholar
• Segal RJ, Reid RD, Courneya KS, Sigal RJ, Kenny GP, Prud'Homme DG, et al. Randomized controlled trial of resistance or aerobic exercise in men receiving radiation therapy for prostate cancer. JCO. 2009;27(3):344–51. doi:10.1200/JCO.2007.15.4963.
   PubMed Web of Science ®Google Scholar
• Wiskemann J, Schmidt ME, Klassen O, Debus J, Ulrich CM, Potthoff K, Steindorf K. Effects of 12-week resistance training during radiotherapy in breast cancer patients. Scand J Med Sci Sports. 2017;27(11):1500–10. doi:10.1111/sms.12777.
   PubMed Web of Science ®Google Scholar
• Schmidt T, Weisser B, Dürkop J, Jonat W, VAN Mackelenbergh M, Röcken C, Mundhenke C. Comparing endurance and resistance training with standard care during chemotherapy for patients with primary breast cancer. Anticancer Res. 2015;35(10):5623–9.
   PubMed Web of Science ®Google Scholar
• Culos-Reed SN, Robinson JW, Lau H, Stephenson L, Keats M, Norris S, et al. Physical activity for men receiving androgen deprivation therapy for prostate cancer: benefits from a 16-week intervention. Support Care Cancer. 2010;18(5):591–9. doi:10.1007/s00520-009-0694-3.
   PubMed Web of Science ®Google Scholar
• Culos-Reed SN, Robinson JL, Lau H, O'Connor K, Keats MR. Benefits of a physical activity intervention for men with prostate cancer. J Sport Exerc Psychol. 2007;29(1):118–27. doi:10.1123/jsep.29.1.118.
   PubMed Web of Science ®Google Scholar
• Mustian KM, Peppone L, Darling TV, Palesh O, Heckler CE, Morrow GR. A 4-week home-based aerobic and resistance exercise program during radiation therapy: a pilot randomized clinical trial. J Support Oncol. 2009;7(5):158–67.
   PubMedGoogle Scholar
• Adamsen L, Quist M, Andersen C, Møller T, Herrstedt J, Kronborg D, et al. Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy: randomised controlled trial. BMJ. 2009;339(oct13 1):b3410–b3410. doi:10.1136/bmj.b3410.
   PubMedGoogle Scholar
• Hwang JH, Chang HJ, Shim YH, Park WH, Park W, Huh SJ, Yang J-H. Effects of supervised exercise therapy in patients receiving radiotherapy for breast cancer. Yonsei Med J. 2008;49(3):443–50.
   PubMed Web of Science ®Google Scholar
• Battaglini CL, Mihalik JP, Bottaro M, Dennehy C, Petschauer MA, Hairston LS, Shields EW. Effect of exercise on the caloric intake of breast cancer patients undergoing treatment. Braz J Med Biol Res. 2008;41(8):709–15. doi:10.1590/S0100-879X2008000800012.
   PubMed Web of Science ®Google Scholar
• Galvão D, Taaffe D, Spry N, Joseph D, Newton R. Combined resistance and aerobic exercise program reverses muscle loss in men undergoing androgen suppression therapy for prostate cancer without bone metastases: a randomized controlled trial. JCO. 2010;28(2):340–7. doi:10.1200/JCO.2009.23.2488.
   PubMed Web of Science ®Google Scholar
• Vulpen J, Velthuis MJ, Bisschop C, Travier N, Buijs B, Backx F, et al. Effects of an exercise program in colon cancer patients undergoing chemotherapy. Med Sci Sports Exercise. 2015;48:1.
   Google Scholar